Exploring the structural topology of genome-based large-scale metabolic network is essential for in- vestigating possible relations between structure and functionality.Visualization would be helpful for obtaining imme...Exploring the structural topology of genome-based large-scale metabolic network is essential for in- vestigating possible relations between structure and functionality.Visualization would be helpful for obtaining immediate information about structural organization.In this work,metabolic networks of 75 organisms were investigated from a topological point of view.A spread bow-tie model was proposed to give a clear visualization of the bow-tie structure for metabolic networks.The revealed topological pattern helps to design more efficient algorithm specifically for metabolic networks.This coarse- grained graph also visualizes the vulnerable connections in the network,and thus could have important implication for disease studies and drug target identifications.In addition,analysis on the reciprocal links and main cores in the GSC part of bow-tie also reveals that the bow-tie structure of metabolic networks has its own intrinsic and significant features which are significantly different from those of random networks.展开更多
未遂事件是事故演化路径的中止状态,研究未遂事件管理方法,可有效防控事故发生。给出了长输管道未遂事件分级界定因素,提出专门的长输油气管道未遂事件上报管理流程和不安全事件领结图(Bow-tie)分析结果,从控制管道自身安全性和预防事...未遂事件是事故演化路径的中止状态,研究未遂事件管理方法,可有效防控事故发生。给出了长输管道未遂事件分级界定因素,提出专门的长输油气管道未遂事件上报管理流程和不安全事件领结图(Bow-tie)分析结果,从控制管道自身安全性和预防事件后果两方面给出安全措施。结合管道未遂事件演化特征,采用SQL Sever 2008与Visual Basic 2010设计和开发了长输管道未遂事件管理系统,将系统划分为用户管理模块、信息管理模块、管道信息模块、教育培训模块等。未遂事件管理是风险管理体系的重要内容,加强长输油气管道未遂事件管理能够有效降低事故风险水平,提高管道风险评估效能和事故应急能力。展开更多
基金Supported in part by the Ministry of Science and Technology of China(Grant Nos.2003CB715900 and 2004CB720103)National Natural Science Foundation of China(Grant Nos.30500107 and 30670953)Science and Technology Commission of Shanghai Municipality(Grant Nos.04DZ19850 and 04DZ14005)
文摘Exploring the structural topology of genome-based large-scale metabolic network is essential for in- vestigating possible relations between structure and functionality.Visualization would be helpful for obtaining immediate information about structural organization.In this work,metabolic networks of 75 organisms were investigated from a topological point of view.A spread bow-tie model was proposed to give a clear visualization of the bow-tie structure for metabolic networks.The revealed topological pattern helps to design more efficient algorithm specifically for metabolic networks.This coarse- grained graph also visualizes the vulnerable connections in the network,and thus could have important implication for disease studies and drug target identifications.In addition,analysis on the reciprocal links and main cores in the GSC part of bow-tie also reveals that the bow-tie structure of metabolic networks has its own intrinsic and significant features which are significantly different from those of random networks.
文摘未遂事件是事故演化路径的中止状态,研究未遂事件管理方法,可有效防控事故发生。给出了长输管道未遂事件分级界定因素,提出专门的长输油气管道未遂事件上报管理流程和不安全事件领结图(Bow-tie)分析结果,从控制管道自身安全性和预防事件后果两方面给出安全措施。结合管道未遂事件演化特征,采用SQL Sever 2008与Visual Basic 2010设计和开发了长输管道未遂事件管理系统,将系统划分为用户管理模块、信息管理模块、管道信息模块、教育培训模块等。未遂事件管理是风险管理体系的重要内容,加强长输油气管道未遂事件管理能够有效降低事故风险水平,提高管道风险评估效能和事故应急能力。
