The Cajanus cajan L.is a natural plant,which contains lots of potential active components.The effects of the stilbene extracts from Cajanus cajan L.（sECC） on ovariectomy（OVX）-induced bone loss in rats were identif...The Cajanus cajan L.is a natural plant,which contains lots of potential active components.The effects of the stilbene extracts from Cajanus cajan L.（sECC） on ovariectomy（OVX）-induced bone loss in rats were identified.All experimental female rats were divided into 6 groups,i.e.,sham-operated rats,OVX rats,17β-estradiol（E2）-treated rats,sECC-treated rats with three dosages,50,100,and 200(mg·kg-1),separately.Two weeks after the operation,different dosage of sECC,E2 or deionized water were given to the 6 groups of rats,respectively for another 8 weeks through stomach.Then,all rats were killed.The body weight and uterus wet weight were measured.Contents of serum E2,follicle stimulating hormone（FSH）,and luteinizing hormone（LH） were measured by radioimmunoassay.Femoral morphology was observed by HE stain.The results showed that there were no changes of the uterine weight and serum E2 concentration in sECC-treated rats compared with OVX rats.However,the serum FSH and LH concentrations reduced by 11.5% and 15.2%（P<0.05）,respectively.By HE staining,it is found that the 60% of the femur structure had been significantly improved in OVX rats treated with 200 mg·kg-1 of sECC.The trabeculae were thicker and larger than that of OVX rats.It is clear that sECC improved femoral morphological structure and decreased FSH and LH contents without affecting serum E2 level and uterine weight in OVX rats.The results suggested that sECC had potential action in treatment of postmenopausal osteoporosis.展开更多
Objective:The purpose of this study was to evaluate three-dimensional(3D) dehiscence of upper anterior alveolar bone during incisor retraction and intrusion in adult patients with maximum anchorage.Methods:Twenty adul...Objective:The purpose of this study was to evaluate three-dimensional(3D) dehiscence of upper anterior alveolar bone during incisor retraction and intrusion in adult patients with maximum anchorage.Methods:Twenty adult patients with bimaxillary dentoalveolar protrusion had the four first premolars extracted.Miniscrews were placed to provide maximum anchorage for upper incisor retraction and intrusion.A computed tomography(CT) scan was performed after placement of the miniscrews and treatment.The 3D reconstructions of pre-and post-CT data were used to assess the dehiscence of upper anterior alveolar bone.Results:The amounts of upper incisor retraction at the edge and apex were(7.64±1.68) and(3.91±2.10) mm,respectively,and(1.34±0.74) mm of upper central incisor intrusion.Upper alveolar bone height losses at labial alveolar ridge crest(LAC) and palatal alveolar ridge crest(PAC) were 0.543 and 2.612 mm,respectively,and the percentages were(6.49±3.54)% and(27.42±9.77)%,respectively.The shape deformations of LAC-labial cortex bending point(LBP) and PAC-palatal cortex bending point(PBP) were(15.37±5.20)° and(6.43±3.27)°,respectively.Conclusions:Thus,for adult patients with bimaxillary protrusion,mechanobiological response of anterior alveolus should be taken into account during incisor retraction and intrusion.Pursuit of maximum anchorage might lead to upper anterior alveolar bone loss.展开更多
文摘The Cajanus cajan L.is a natural plant,which contains lots of potential active components.The effects of the stilbene extracts from Cajanus cajan L.（sECC） on ovariectomy（OVX）-induced bone loss in rats were identified.All experimental female rats were divided into 6 groups,i.e.,sham-operated rats,OVX rats,17β-estradiol（E2）-treated rats,sECC-treated rats with three dosages,50,100,and 200(mg·kg-1),separately.Two weeks after the operation,different dosage of sECC,E2 or deionized water were given to the 6 groups of rats,respectively for another 8 weeks through stomach.Then,all rats were killed.The body weight and uterus wet weight were measured.Contents of serum E2,follicle stimulating hormone（FSH）,and luteinizing hormone（LH） were measured by radioimmunoassay.Femoral morphology was observed by HE stain.The results showed that there were no changes of the uterine weight and serum E2 concentration in sECC-treated rats compared with OVX rats.However,the serum FSH and LH concentrations reduced by 11.5% and 15.2%（P<0.05）,respectively.By HE staining,it is found that the 60% of the femur structure had been significantly improved in OVX rats treated with 200 mg·kg-1 of sECC.The trabeculae were thicker and larger than that of OVX rats.It is clear that sECC improved femoral morphological structure and decreased FSH and LH contents without affecting serum E2 level and uterine weight in OVX rats.The results suggested that sECC had potential action in treatment of postmenopausal osteoporosis.
基金Project supported by the Shandong Science and Technology Planning Project Contract Research (Nos. 2008GG30002019 and 2008GG 30001001) of Chinathe Shandong University Dental School Project Research (Nos. P2009009,P2009010,and P2010010),China
文摘Objective:The purpose of this study was to evaluate three-dimensional(3D) dehiscence of upper anterior alveolar bone during incisor retraction and intrusion in adult patients with maximum anchorage.Methods:Twenty adult patients with bimaxillary dentoalveolar protrusion had the four first premolars extracted.Miniscrews were placed to provide maximum anchorage for upper incisor retraction and intrusion.A computed tomography(CT) scan was performed after placement of the miniscrews and treatment.The 3D reconstructions of pre-and post-CT data were used to assess the dehiscence of upper anterior alveolar bone.Results:The amounts of upper incisor retraction at the edge and apex were(7.64±1.68) and(3.91±2.10) mm,respectively,and(1.34±0.74) mm of upper central incisor intrusion.Upper alveolar bone height losses at labial alveolar ridge crest(LAC) and palatal alveolar ridge crest(PAC) were 0.543 and 2.612 mm,respectively,and the percentages were(6.49±3.54)% and(27.42±9.77)%,respectively.The shape deformations of LAC-labial cortex bending point(LBP) and PAC-palatal cortex bending point(PBP) were(15.37±5.20)° and(6.43±3.27)°,respectively.Conclusions:Thus,for adult patients with bimaxillary protrusion,mechanobiological response of anterior alveolus should be taken into account during incisor retraction and intrusion.Pursuit of maximum anchorage might lead to upper anterior alveolar bone loss.
