背景:骨性关节炎是骨科最常见的慢性疾病之一。近期研究表明软骨下骨的病变在骨性关节炎的发生发展中具有重要地位,并可能先于并加剧软骨的病变。软骨下骨的病变以异常重建为主要特征,表现为软骨下骨髓病变和软骨下骨囊肿等。当前针对...背景:骨性关节炎是骨科最常见的慢性疾病之一。近期研究表明软骨下骨的病变在骨性关节炎的发生发展中具有重要地位,并可能先于并加剧软骨的病变。软骨下骨的病变以异常重建为主要特征,表现为软骨下骨髓病变和软骨下骨囊肿等。当前针对软骨下骨囊肿的研究还不充分,探究软骨下骨囊肿的成因及临床意义有助于从软骨下骨的角度为骨性关节炎的诊治提供新的思路。目的:综述近年骨性关节炎软骨下骨囊肿的成因假说、病理学特征、临床意义、临床诊断及治疗的研究进展。方法:2位共同第一作者应用计算机检索2019年1月及以前PubMed、Embase数据库,英文检索式:(osteoarthritis OR osteoarthrosis OR osteoarthropathy)AND(subchondralcyst OR pseudocyst OR intraosseous cyst OR bone cyst),语言设定为"英语",共检索到1 224篇文献,58篇符合纳入标准,另手工检索11篇文献,最终纳入69篇文献。结果与结论:(1)软骨下骨髓病变可能是软骨下骨囊肿的"前置病变",二者属同一病理变化的不同阶段;(2)软骨下骨囊肿的形成可能与炎性骨吸收后继发反应性成骨有关;(3)软骨下骨囊肿与关节软骨的退变、关节疼痛显著相关;(4)非类固醇抗炎药、抗骨吸收药、软骨下骨成形术、关节置换术中植骨等可能对软骨下骨髓病变/软骨下骨囊肿有治疗作用,但仍需大样本临床试验证明。展开更多
Simple bone cyst （SBC）, also known as a unicameral or solitary cyst, is a benign fluid-filled cavity found primarily at the proximal ends of long bones in children. Treatment is warranted if the pain or a pathologic...Simple bone cyst （SBC）, also known as a unicameral or solitary cyst, is a benign fluid-filled cavity found primarily at the proximal ends of long bones in children. Treatment is warranted if the pain or a pathologic fracture occurs or if a child is at risk of pathologic fractures. The spectrum of treatments proposed for SBC management ranges from simple Kirschner wire drill-hole, resection or curettage with or without bone grafting to using a cannulated screw for continuous decompression, steroid injection and the latest experience of the use of percutaneous autologous marrow grafting. However, clinical practice of these treatments is limited because of their unsatisfactory effect and possible complications.展开更多
文摘背景:骨性关节炎是骨科最常见的慢性疾病之一。近期研究表明软骨下骨的病变在骨性关节炎的发生发展中具有重要地位,并可能先于并加剧软骨的病变。软骨下骨的病变以异常重建为主要特征,表现为软骨下骨髓病变和软骨下骨囊肿等。当前针对软骨下骨囊肿的研究还不充分,探究软骨下骨囊肿的成因及临床意义有助于从软骨下骨的角度为骨性关节炎的诊治提供新的思路。目的:综述近年骨性关节炎软骨下骨囊肿的成因假说、病理学特征、临床意义、临床诊断及治疗的研究进展。方法:2位共同第一作者应用计算机检索2019年1月及以前PubMed、Embase数据库,英文检索式:(osteoarthritis OR osteoarthrosis OR osteoarthropathy)AND(subchondralcyst OR pseudocyst OR intraosseous cyst OR bone cyst),语言设定为"英语",共检索到1 224篇文献,58篇符合纳入标准,另手工检索11篇文献,最终纳入69篇文献。结果与结论:(1)软骨下骨髓病变可能是软骨下骨囊肿的"前置病变",二者属同一病理变化的不同阶段;(2)软骨下骨囊肿的形成可能与炎性骨吸收后继发反应性成骨有关;(3)软骨下骨囊肿与关节软骨的退变、关节疼痛显著相关;(4)非类固醇抗炎药、抗骨吸收药、软骨下骨成形术、关节置换术中植骨等可能对软骨下骨髓病变/软骨下骨囊肿有治疗作用,但仍需大样本临床试验证明。
文摘Simple bone cyst （SBC）, also known as a unicameral or solitary cyst, is a benign fluid-filled cavity found primarily at the proximal ends of long bones in children. Treatment is warranted if the pain or a pathologic fracture occurs or if a child is at risk of pathologic fractures. The spectrum of treatments proposed for SBC management ranges from simple Kirschner wire drill-hole, resection or curettage with or without bone grafting to using a cannulated screw for continuous decompression, steroid injection and the latest experience of the use of percutaneous autologous marrow grafting. However, clinical practice of these treatments is limited because of their unsatisfactory effect and possible complications.
