目的:探讨全麻诱导插管期间,体重指数对患者呼吸暂停安全时限的影响。方法:选择年龄21～63岁,ASAⅠ-Ⅱ级择期手术的全麻病人80例。根据其体重指数(Body mass index,BMI)分为Ⅰ组(正常体重组)20例、Ⅱ组(超重组)20例、Ⅲ组(1°肥胖组...目的:探讨全麻诱导插管期间,体重指数对患者呼吸暂停安全时限的影响。方法:选择年龄21～63岁,ASAⅠ-Ⅱ级择期手术的全麻病人80例。根据其体重指数(Body mass index,BMI)分为Ⅰ组(正常体重组)20例、Ⅱ组(超重组)20例、Ⅲ组(1°肥胖组)20例和Ⅳ组(2°肥胖组)20例。常规静脉麻醉诱导,诱导期间以10L/min的氧流量充分吸氧去氮4min,诱导结束行气管插管,插管完毕后继续脱氧观察,待脉搏氧饱和度(SpO2)降至90%时,接入麻醉机呼吸回路行控制呼吸。记录麻醉诱导末到SpO2下降至90%时的呼吸暂停时限,采集入室初、吸氧去氮后和SpO2降至90%时3个时间点的动脉血作血气分析。结果:各组患者呼吸暂停安全时限明显不同,其时限分别为(542.47±48.24)s(Ⅰ组)、(465.77±32.20)s(Ⅱ组)、(355.13±44.36)s(Ⅲ组)、(227.53±34.23)s(Ⅳ组),组间比较具有显著性差异(P<0.05)。结论:体重指数不同,患者耐受呼吸暂停时限明显不同,随着体重指数的增加,患者耐受呼吸暂停的时限逐渐缩短。展开更多
AIM: To identify the independent predictors of hepatic fibrosis in 69 children with nonalcoholic steatohepatitis (NASH) due to nonalcoholic fatty liver disease (NAFLD). METHODS: All patients with clinically suspected ...AIM: To identify the independent predictors of hepatic fibrosis in 69 children with nonalcoholic steatohepatitis (NASH) due to nonalcoholic fatty liver disease (NAFLD). METHODS: All patients with clinically suspected NASH underwent liver biopsy as a confirmatory test. The following clinical and biochemical variables at baseline were examined as likely predictors of fibrosis at histology: age, body mass index (BMI), systolic blood pressure (SBP), dyastolic blood pressure (DBP), fasting glucose, fasting insulin, homeostatic model assessment for insulin resistence (HOMA-IR), cholesterol, tryglicerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST/ALT ratio, gamma glutamil transferase (GT), platelet count, prothrombin time (PT). RESULTS: At histology 28 (40.6%) patients had no fibrosis and 41 (59.4%) had mild to bridging fibrosis. At multivariate analysis, BMI > 26.3 was the only independent predictor of fibrosis (OR = 5.85, 95% CI = 1.6-21). CONCLUSION: BMI helps identify children with NASH who might have fibrotic deposition in the liver.展开更多
OBJECTIVE:To compare the effects of a basic traditional Chinese diet with a Western standard diet on body mass index(BMI),lean body mass(LBD),and eating and hunger behaviours.METHODS:A sample of 284 patients were rand...OBJECTIVE:To compare the effects of a basic traditional Chinese diet with a Western standard diet on body mass index(BMI),lean body mass(LBD),and eating and hunger behaviours.METHODS:A sample of 284 patients were randomized into 2 groups:group A(n = 142) followed a basic traditional Chinese diet(BCTD) and group B(n =142) followed a Western standard diet(WSD).Both diets were set at approximately 1200 calories.The patients enrolled were compared before treatment and 6 weeks after treatment,and then follow-ups were made at 1 year and 5 years.RESULTS:In the BCTD group,BMI decreased by0.46 kg/m2 and LBM by 0.25 kg,versus respectively0.28 kg/m2 and 0.41 kg in the WSD group.Findings of eating self-assessment,hunger measurement and psychophysical indices of health were also in favour of the BCTD.CONCLUSION:Outcomes show that the BCTD has a better effect on BMI and LBM,as well as over the medium/long term,and provides stronger psychophysical support to obese patients.展开更多
文摘目的:探讨全麻诱导插管期间,体重指数对患者呼吸暂停安全时限的影响。方法:选择年龄21～63岁,ASAⅠ-Ⅱ级择期手术的全麻病人80例。根据其体重指数(Body mass index,BMI)分为Ⅰ组(正常体重组)20例、Ⅱ组(超重组)20例、Ⅲ组(1°肥胖组)20例和Ⅳ组(2°肥胖组)20例。常规静脉麻醉诱导,诱导期间以10L/min的氧流量充分吸氧去氮4min,诱导结束行气管插管,插管完毕后继续脱氧观察,待脉搏氧饱和度(SpO2)降至90%时,接入麻醉机呼吸回路行控制呼吸。记录麻醉诱导末到SpO2下降至90%时的呼吸暂停时限,采集入室初、吸氧去氮后和SpO2降至90%时3个时间点的动脉血作血气分析。结果:各组患者呼吸暂停安全时限明显不同,其时限分别为(542.47±48.24)s(Ⅰ组)、(465.77±32.20)s(Ⅱ组)、(355.13±44.36)s(Ⅲ组)、(227.53±34.23)s(Ⅳ组),组间比较具有显著性差异(P<0.05)。结论:体重指数不同,患者耐受呼吸暂停时限明显不同,随着体重指数的增加,患者耐受呼吸暂停的时限逐渐缩短。
文摘AIM: To identify the independent predictors of hepatic fibrosis in 69 children with nonalcoholic steatohepatitis (NASH) due to nonalcoholic fatty liver disease (NAFLD). METHODS: All patients with clinically suspected NASH underwent liver biopsy as a confirmatory test. The following clinical and biochemical variables at baseline were examined as likely predictors of fibrosis at histology: age, body mass index (BMI), systolic blood pressure (SBP), dyastolic blood pressure (DBP), fasting glucose, fasting insulin, homeostatic model assessment for insulin resistence (HOMA-IR), cholesterol, tryglicerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST/ALT ratio, gamma glutamil transferase (GT), platelet count, prothrombin time (PT). RESULTS: At histology 28 (40.6%) patients had no fibrosis and 41 (59.4%) had mild to bridging fibrosis. At multivariate analysis, BMI > 26.3 was the only independent predictor of fibrosis (OR = 5.85, 95% CI = 1.6-21). CONCLUSION: BMI helps identify children with NASH who might have fibrotic deposition in the liver.
文摘目的无创产前诊断(noninvasive prenatal testing,NIPT)是通过提取母体外周血中游离DNA,经高通量测序技术和生物信息学分析,发现游离DNA中是否存在比例异常的染色体,进而判断胎儿是否存在染色体非整倍体。孕妇外周血中胎儿游离DNA比例是影响NIPT准确性的重要因素,评价孕妇年龄、孕周和体重指数(body mass index,BMI)对胎儿游离DNA比例的影响对提高NIPT的准确性有重要意义。方法回顾性分析了2015年3月至2016年5月苏州市立医院2563例孕有正常男性胎儿孕妇的NIPT检测结果及相关数据,提取孕妇外周血胎儿游离DNA浓度、孕妇年龄、孕周和体重指数等信息,对以上参数进行了归一化处理后再进行相关性分析,挖掘孕妇年龄、孕周和BMI对孕妇外周血中胎儿游离DNA比例的影响。结果数据显示孕妇外周血中胎儿游离DNA比例与孕周呈正相关(线性回归方程y=0.003x+0.060,R2=0.752,P=0.01144);孕妇年龄与BMI也呈正相关(线性回归方程y=0.112x+18.80,R2=0.721,P=6.46E-08);而胎儿游离DNA比例与孕妇BMI、年龄均呈负相关,且在样本量较大时相关性显著。结论孕妇年龄、BMI的增加都会相对降低孕妇外周血中胎儿游离DNA的比例,孕妇年龄越大则BMI也会相对越大,而孕周的增大会提高孕妇外周血中胎儿游离DNA比例,因此,针对高龄且高BMI值的孕妇适当延后进行NIPT的孕周可以提高NIPT检测的准确性。
文摘OBJECTIVE:To compare the effects of a basic traditional Chinese diet with a Western standard diet on body mass index(BMI),lean body mass(LBD),and eating and hunger behaviours.METHODS:A sample of 284 patients were randomized into 2 groups:group A(n = 142) followed a basic traditional Chinese diet(BCTD) and group B(n =142) followed a Western standard diet(WSD).Both diets were set at approximately 1200 calories.The patients enrolled were compared before treatment and 6 weeks after treatment,and then follow-ups were made at 1 year and 5 years.RESULTS:In the BCTD group,BMI decreased by0.46 kg/m2 and LBM by 0.25 kg,versus respectively0.28 kg/m2 and 0.41 kg in the WSD group.Findings of eating self-assessment,hunger measurement and psychophysical indices of health were also in favour of the BCTD.CONCLUSION:Outcomes show that the BCTD has a better effect on BMI and LBM,as well as over the medium/long term,and provides stronger psychophysical support to obese patients.
