BACKGROUND The impact of body mass index(BMI)on survival in patients with esophageal squamous cell carcinoma(ESCC)undergoing surgery remains unclear.Therefore,a definition of clinically significant BMI in patients wit...BACKGROUND The impact of body mass index(BMI)on survival in patients with esophageal squamous cell carcinoma(ESCC)undergoing surgery remains unclear.Therefore,a definition of clinically significant BMI in patients with ESCC is needed.AIM To explore the impact of preoperative weight loss(PWL)-adjusted BMI on overall survival(OS)in patients undergoing surgery for ESCC.METHODS This retrospective study consisted of 1545 patients who underwent curative resection for ESCC at West China Hospital of Sichuan University between August 2005 and December 2011.The relationship between PWL-adjusted BMI and OS was examined,and a multivariate analysis was performed and adjusted for age,sex,TNM stage and adjuvant therapy.RESULTS Trends of poor survival were observed for patients with increasing PWL and decreasing BMI.Patients with BMI≥20.0 kg/m2 and PWL<8.8%were classified into Group 1 with the longest median OS(45.3 mo).Patients with BMI<20.0 kg/m2 and PWL<8.8%were classified into Group 2 with a median OS of 29.5 mo.Patients with BMI≥20.0 kg/m2 and PWL≥8.8%(HR=1.9,95%CI:1.5-2.5),were combined into Group 3 with a median OS of 20.1 mo.Patients in the three groups were associated with significantly different OS(P<0.05).In multivariate analysis,PWL-adjusted BMI,TNM stage and adjuvant therapy were identified as independent prognostic factors.CONCLUSION PWL-adjusted BMI has an independent prognostic impact on OS in patients with ESCC undergoing surgery.BMI might be an indicator for patients with PWL<8.8%rather than≥8.8%.展开更多
Tuberculosis (TB) is known as a disease of poverty and declared as a global public health emergency by World Health Organization (WHO). Pulmonary tuberculosis is the most common type of TB and is a wasting disease. It...Tuberculosis (TB) is known as a disease of poverty and declared as a global public health emergency by World Health Organization (WHO). Pulmonary tuberculosis is the most common type of TB and is a wasting disease. It is expected that the patients who lost weight during the course of disease, will gain weight during successful treatment. So the aim of this study was to assess the body weight changes through the treatment and its possible association with treatment outcome in TB patients in Nishapur, an ancient city in Razavi Khorasan province in Iran. This is an observational analytical study. Patients were selected according to inclusion and exclusion criteria and available information. Treatment Protocol for all patients was Directly Observed Treatment, short Course Strategy (at least 6 months). All patients were weighed at the beginning of treatment, after two months and at the end of treatment. Outcome of treatment was classified into: cured, completed treatment, treatment failure and death. Then the impact of weight changes during treatment was compared in subgroups. From 874 patients, 819 patients (93.9%) were new cases, 48 (5.3%) relapse, 5 patients (0.6%) patients who did not complete their treatment and 2 (0.2%) had failed prior therapy. The most common symptoms in all patients were: cough, sputum, weight loss, fever, sweats, and hemoptysis. 8.1% of patients had radiologic signs and the most common signs were cavity (2.9%). The weight change during treatment was 2.91 ± 5.59 kg in cured group, 3.3 ± 3.29 kg in completed treatment group, 2.95 ± 5.59 kg in treatment failure group and 1.02 ± 3.27 in dead group respectively. These differences were statistically significant between the four groups (p < 0.03). We can conclude that body weight change can be used as a predictor for the treatment outcome.展开更多
基金Supported by National Natural Science Foundation of China,No.81970481Sichuan Science and Technology Program,No.2018HH0150+1 种基金Chengdu Science and Technology BureauNo.2017GH00072
文摘BACKGROUND The impact of body mass index(BMI)on survival in patients with esophageal squamous cell carcinoma(ESCC)undergoing surgery remains unclear.Therefore,a definition of clinically significant BMI in patients with ESCC is needed.AIM To explore the impact of preoperative weight loss(PWL)-adjusted BMI on overall survival(OS)in patients undergoing surgery for ESCC.METHODS This retrospective study consisted of 1545 patients who underwent curative resection for ESCC at West China Hospital of Sichuan University between August 2005 and December 2011.The relationship between PWL-adjusted BMI and OS was examined,and a multivariate analysis was performed and adjusted for age,sex,TNM stage and adjuvant therapy.RESULTS Trends of poor survival were observed for patients with increasing PWL and decreasing BMI.Patients with BMI≥20.0 kg/m2 and PWL<8.8%were classified into Group 1 with the longest median OS(45.3 mo).Patients with BMI<20.0 kg/m2 and PWL<8.8%were classified into Group 2 with a median OS of 29.5 mo.Patients with BMI≥20.0 kg/m2 and PWL≥8.8%(HR=1.9,95%CI:1.5-2.5),were combined into Group 3 with a median OS of 20.1 mo.Patients in the three groups were associated with significantly different OS(P<0.05).In multivariate analysis,PWL-adjusted BMI,TNM stage and adjuvant therapy were identified as independent prognostic factors.CONCLUSION PWL-adjusted BMI has an independent prognostic impact on OS in patients with ESCC undergoing surgery.BMI might be an indicator for patients with PWL<8.8%rather than≥8.8%.
文摘Tuberculosis (TB) is known as a disease of poverty and declared as a global public health emergency by World Health Organization (WHO). Pulmonary tuberculosis is the most common type of TB and is a wasting disease. It is expected that the patients who lost weight during the course of disease, will gain weight during successful treatment. So the aim of this study was to assess the body weight changes through the treatment and its possible association with treatment outcome in TB patients in Nishapur, an ancient city in Razavi Khorasan province in Iran. This is an observational analytical study. Patients were selected according to inclusion and exclusion criteria and available information. Treatment Protocol for all patients was Directly Observed Treatment, short Course Strategy (at least 6 months). All patients were weighed at the beginning of treatment, after two months and at the end of treatment. Outcome of treatment was classified into: cured, completed treatment, treatment failure and death. Then the impact of weight changes during treatment was compared in subgroups. From 874 patients, 819 patients (93.9%) were new cases, 48 (5.3%) relapse, 5 patients (0.6%) patients who did not complete their treatment and 2 (0.2%) had failed prior therapy. The most common symptoms in all patients were: cough, sputum, weight loss, fever, sweats, and hemoptysis. 8.1% of patients had radiologic signs and the most common signs were cavity (2.9%). The weight change during treatment was 2.91 ± 5.59 kg in cured group, 3.3 ± 3.29 kg in completed treatment group, 2.95 ± 5.59 kg in treatment failure group and 1.02 ± 3.27 in dead group respectively. These differences were statistically significant between the four groups (p < 0.03). We can conclude that body weight change can be used as a predictor for the treatment outcome.
