Starting from the oxygenated piperidine building block 20,two synthetic approaches to new building blocks (8R,8aS)-and (8R,8aR)-8-hydroxy-5-indolizidinones 19a/19b and 15a/15b have been developed,respectively. The fir...Starting from the oxygenated piperidine building block 20,two synthetic approaches to new building blocks (8R,8aS)-and (8R,8aR)-8-hydroxy-5-indolizidinones 19a/19b and 15a/15b have been developed,respectively. The first one is based on the trans-diastereoselective reductive alkylation (dr = 93:7),followed by a four-step procedure; and the second one called for the RCM reaction on the N,O-acetal derived from a vinylation,which was followed by a pyrrole formation,and a stereocontrolled cis-selective (dr = 91:9) catalytic hydrogenation. Reduction of the diastereomer 15a produced (8R,8aR)-8-indolizidinol (18).展开更多
目的探讨不同肋间神经阻滞方案对肺癌根治术患者围术期镇痛及炎症反应的影响。方法选择浙江省舟山医院2020年12月至2022年12月行肺癌根治术的肺癌患者66例,其中采用持续肋间神经阻滞33例(观察组),常规肋间神经阻滞33例(对照组)。两组患...目的探讨不同肋间神经阻滞方案对肺癌根治术患者围术期镇痛及炎症反应的影响。方法选择浙江省舟山医院2020年12月至2022年12月行肺癌根治术的肺癌患者66例,其中采用持续肋间神经阻滞33例(观察组),常规肋间神经阻滞33例(对照组)。两组患者术后均行常规镇痛。比较两组患者术后1、6、24和48 h视觉模拟评分(VAS)变化,术前和术后48 h肺功能变化,血气指标、炎症反应变化和不良反应情况。结果相比对照组,观察组术后1、6、24和48 h运动痛和静息痛VAS均显著降低(均P<0.05)。相比术前,两组术后48 h血pH比较,差异均无统计学意义(均P>0.05),PaCO_(2)均显著升高,而PaO_(2)均显著降低,差异均有统计学意义(均P<0.05);相比对照组,观察组术后48 h PaCO_(2)显著降低,PaO_(2)显著升高,差异均有统计学意义(均P<0.05)。相比术前,两组术后48 h CRP和WBC水平均显著升高(P<0.05);相比对照组,观察组术后48 h CRP和WBC水平均显著降低,差异均有统计学意义(均P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论持续肋间神经阻滞对肺癌根治术患者围术期镇痛效果显著,且对患者血气指标和炎症反应影响小。展开更多
基金the NSF of China (20672089, 20832005)the NFFTBS (J1030415)the National Basic Research Program of China (973 Program, 2010CB833200)
文摘Starting from the oxygenated piperidine building block 20,two synthetic approaches to new building blocks (8R,8aS)-and (8R,8aR)-8-hydroxy-5-indolizidinones 19a/19b and 15a/15b have been developed,respectively. The first one is based on the trans-diastereoselective reductive alkylation (dr = 93:7),followed by a four-step procedure; and the second one called for the RCM reaction on the N,O-acetal derived from a vinylation,which was followed by a pyrrole formation,and a stereocontrolled cis-selective (dr = 91:9) catalytic hydrogenation. Reduction of the diastereomer 15a produced (8R,8aR)-8-indolizidinol (18).
文摘目的探讨不同肋间神经阻滞方案对肺癌根治术患者围术期镇痛及炎症反应的影响。方法选择浙江省舟山医院2020年12月至2022年12月行肺癌根治术的肺癌患者66例,其中采用持续肋间神经阻滞33例(观察组),常规肋间神经阻滞33例(对照组)。两组患者术后均行常规镇痛。比较两组患者术后1、6、24和48 h视觉模拟评分(VAS)变化,术前和术后48 h肺功能变化,血气指标、炎症反应变化和不良反应情况。结果相比对照组,观察组术后1、6、24和48 h运动痛和静息痛VAS均显著降低(均P<0.05)。相比术前,两组术后48 h血pH比较,差异均无统计学意义(均P>0.05),PaCO_(2)均显著升高,而PaO_(2)均显著降低,差异均有统计学意义(均P<0.05);相比对照组,观察组术后48 h PaCO_(2)显著降低,PaO_(2)显著升高,差异均有统计学意义(均P<0.05)。相比术前,两组术后48 h CRP和WBC水平均显著升高(P<0.05);相比对照组,观察组术后48 h CRP和WBC水平均显著降低,差异均有统计学意义(均P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论持续肋间神经阻滞对肺癌根治术患者围术期镇痛效果显著,且对患者血气指标和炎症反应影响小。
