Objective:To examine differences among recovered Bipolar Ⅰ, Bipolar Ⅱ patients and controls. Methods: Using NEO-PI-R, HAMD and BRMS, we investigated 59 recovered bipolar patients and 59 normal controls matched for a...Objective:To examine differences among recovered Bipolar Ⅰ, Bipolar Ⅱ patients and controls. Methods: Using NEO-PI-R, HAMD and BRMS, we investigated 59 recovered bipolar patients and 59 normal controls matched for age, gender and education. Results: Compared with controls, Bipolar Ⅱ patients showed significant differences in personality traits of Neuroticism, Extraversion, and Openness to Experience. While Bipolar Ⅰ patients obtained higher scores on Gregariousness, Bipolar Ⅱ patients scored higher on traits of Depression, Impulsiveness and Aesthetics. Scores on Warmth were higher in Bipolar Ⅰ patients than in Bipolar Ⅱ patients. Conclusion: Personality traits of recovered bipolar patients were markedly different from matched controls, whereas the differences between Bipolar Ⅰ and Bipolar Ⅱ patients were small.展开更多
目的·探讨双相障碍患者攻击行为与多巴胺D4受体(dopamine D4 receptor,DRD4)基因第3外显子(exonⅢ)48 bp可变数目串联重复序列(variable number tandem repeat,VNTR)多态性及人格特征之间的关系。方法·选取2015年1月-2018年1...目的·探讨双相障碍患者攻击行为与多巴胺D4受体(dopamine D4 receptor,DRD4)基因第3外显子(exonⅢ)48 bp可变数目串联重复序列(variable number tandem repeat,VNTR)多态性及人格特征之间的关系。方法·选取2015年1月-2018年12月在上海市长宁区精神卫生中心、上海市静安区精神卫生中心、上海市徐汇区精神卫生中心和上海健康医学院附属嘉定区中心医院就诊的双相障碍患者共173例,根据修订版外显攻击行为量表(Modified Overt Aggression Scale,MOAS)评分将其分为攻击组(研究组)和非攻击组(对照组)。分别进行一般情况调查、气质性格问卷(Temperature and Character Inventory,TCI)测定;采用聚合酶链反应-限制性片断长度多态性技术检测DRD4 exonⅢ48 bp VNTR多态性位点。用SHEsis软件进行基因型Hardy-Weinberg遗传平衡度检验及组间基因型频率的差异分析,用χ~2检验和t检验分析双相障碍患者攻击行为与DRD4基因多态性及人格特征之间的关系。结果·研究组和对照组一般情况调查结果间差异无统计学意义(P>0.05)。共检测到DRD4 exonⅢ48 bp VNTR的6种等位基因和9种基因型,2组最常见的是4次重复等位基因。2组间DRD4基因的基因型及等位基因的频率分布差异有统计学意义(P=0.040,P=0.018)。研究组寻求新奇、伤害避免维度评分高于对照组(P=0.026,P=0.000),合作性、自我定向维度评分低于对照组(均P=0.000)。研究组携带长重复等位基因的患者寻求新奇、伤害避免维度评分高于携带短重复等位基因的患者(P=0.000,P=0.006),合作性维度评分低于携带短重复等位基因的患者(P=0.038)。结论·双相障碍患者攻击行为与DRD4 exonⅢ48 bp VNTR之间可能存在关联。双相障碍攻击行为患者具有冲动、寻求刺激、探索、害怕不确定、报复心强、自私自利等人格特征,携带长重复等位基因患者人格异常更显著。展开更多
BACKGROUND Bipolar disorder(BD)is a severe mental illness.BD often coexists with borderline personality disorders,making the condition more complex.AIM To explore the differences in cognitive impairment between patien...BACKGROUND Bipolar disorder(BD)is a severe mental illness.BD often coexists with borderline personality disorders,making the condition more complex.AIM To explore the differences in cognitive impairment between patients with BD and those with BD comorbid with borderline personality disorder.METHODS Eighty patients with BD and comorbid borderline personality disorder and 80 patients with BD alone were included in groups A and B,respectively,and 80 healthy volunteers were included as controls.Cognitive function in each group was evaluated using the Chinese version of the repeatable battery for the assess-ment of neuropsychological status(RBANS),the Stroop color-word test,and the Wechsler intelligence scale-revised(WAIS-RC).RESULTS The indices of the RBANS,Stroop color-word test,and WAIS-RC in groups A and B were significantly lower than those of the control group(P<0.05).Group A had significantly longer Stroop color-word test times for single-character,single-color,double-character,and double-color,lower scores of immediate memory,visual breadth,verbal function dimensions and total score of the RBANS,as well as lower scores of verbal IQ,performance IQ,and overall IQ of the WAIS-RC compared with group B(P<0.05).Compared to group B,group A exhibited significantly longer single-character time,single-color time,double-character time,and double-color time in the Stroop color-word test(P<0.05).CONCLUSION The cognitive function of patients with BD complicated with borderline personality disorder is lower than that of patients with BD.展开更多
"Melancholia" seems to be the oldest term used to describe the manifestations of depression. Throughout the history of medicine, melancholia has been the focus of consideration of many scholars who have prov..."Melancholia" seems to be the oldest term used to describe the manifestations of depression. Throughout the history of medicine, melancholia has been the focus of consideration of many scholars who have provided varying definitions of this disorder and its manifestations. This continual process has resulted in the gradual development of the concept of melancholia over time. Persian scholars were among the scientists who have studied the melancholia and contributed to its concept. One figure, Al-Akhawayni Bukhari(?-983 AD), a Persian physician whose reputation was based on the treatment of patients with mental problems, investigated this disorder. He described Melancholia and explained its clinical manifestations and treatment methods. AlAkhawayni provided an early classification of the patients suffering from this disorder. Since the medieval Persian concept of melancholia is not well-known, this paper aims to review Al-Akhawayni's 10 th century knowledge on melancholia which can represent the early concept of this disorder in the Near East.展开更多
BACKGROUND Panic disorders frequently occur with affective disorders,particularly bipolar disorder.Patients with panic disorder and bipolar disorder are more likely to present with severe symptoms,such as high rates o...BACKGROUND Panic disorders frequently occur with affective disorders,particularly bipolar disorder.Patients with panic disorder and bipolar disorder are more likely to present with severe symptoms,such as high rates of suicidal behavior,poor symptomatic and functional recovery,and poor drug responses.AIM To investigate the psychological characteristics of panic disorder patients related to bipolarity.METHODS A total of 254 patients(136 men and 118 women,mean age=33.48±3.2 years)who were diagnosed with panic disorder were included in the study.Panic disorder with bipolarity(BP+)was defined as a score of≥7 on the Korean version of the Mood Disorder Questionnaire(K-MDQ),and a score lower than 7 was considered as a panic disorder without bipolarity(BP-).Self-report questionnaires were analyzed to examine their association with bipolarity.Psychological tests used in the study were the Mood Disorder Questionnaire(MDQ),Panic Disorder Severity Scale,Beck Depression Inventory,State-Trait Anxiety Inventory(STAI),Temperament and Character Inventory(TCI),and Minnesota Multiphasic Personality Inventory(MMPI).Statistical analyses were performed to evaluate the correlation between bipolarity of panic disorder patients and various psychological test results indicative of psychological characteristics.RESULTS Patients with a K-MDQ score of 7 or more were considered to have a history of manic or hypomanic episodes(BP+group,n=128),while patients with K-MDQ scores below 7 were defined as those without bipolarity(BP-group,n=126).The BP+group were more likely to be unmarried(single 56.2%vs 44.4%,P=0.008)and younger(30.78±0.59 vs 37.11±3.21,P<0.001).Additionally,the BP+group had significantly higher scores on psychological assessment scales,such as the hypochondriasis,psychopathic deviate,masculinity-femininity,psychasthenia,schizophrenia,and hypomania(Ma)in MMPI,and novelty seeking,harm avoidance and self-transcendence in TCI,and STAI(state and trait)compared to the BP-group.In logistic regression analysis,depression in MMPI,self展开更多
文摘Objective:To examine differences among recovered Bipolar Ⅰ, Bipolar Ⅱ patients and controls. Methods: Using NEO-PI-R, HAMD and BRMS, we investigated 59 recovered bipolar patients and 59 normal controls matched for age, gender and education. Results: Compared with controls, Bipolar Ⅱ patients showed significant differences in personality traits of Neuroticism, Extraversion, and Openness to Experience. While Bipolar Ⅰ patients obtained higher scores on Gregariousness, Bipolar Ⅱ patients scored higher on traits of Depression, Impulsiveness and Aesthetics. Scores on Warmth were higher in Bipolar Ⅰ patients than in Bipolar Ⅱ patients. Conclusion: Personality traits of recovered bipolar patients were markedly different from matched controls, whereas the differences between Bipolar Ⅰ and Bipolar Ⅱ patients were small.
文摘目的·探讨双相障碍患者攻击行为与多巴胺D4受体(dopamine D4 receptor,DRD4)基因第3外显子(exonⅢ)48 bp可变数目串联重复序列(variable number tandem repeat,VNTR)多态性及人格特征之间的关系。方法·选取2015年1月-2018年12月在上海市长宁区精神卫生中心、上海市静安区精神卫生中心、上海市徐汇区精神卫生中心和上海健康医学院附属嘉定区中心医院就诊的双相障碍患者共173例,根据修订版外显攻击行为量表(Modified Overt Aggression Scale,MOAS)评分将其分为攻击组(研究组)和非攻击组(对照组)。分别进行一般情况调查、气质性格问卷(Temperature and Character Inventory,TCI)测定;采用聚合酶链反应-限制性片断长度多态性技术检测DRD4 exonⅢ48 bp VNTR多态性位点。用SHEsis软件进行基因型Hardy-Weinberg遗传平衡度检验及组间基因型频率的差异分析,用χ~2检验和t检验分析双相障碍患者攻击行为与DRD4基因多态性及人格特征之间的关系。结果·研究组和对照组一般情况调查结果间差异无统计学意义(P>0.05)。共检测到DRD4 exonⅢ48 bp VNTR的6种等位基因和9种基因型,2组最常见的是4次重复等位基因。2组间DRD4基因的基因型及等位基因的频率分布差异有统计学意义(P=0.040,P=0.018)。研究组寻求新奇、伤害避免维度评分高于对照组(P=0.026,P=0.000),合作性、自我定向维度评分低于对照组(均P=0.000)。研究组携带长重复等位基因的患者寻求新奇、伤害避免维度评分高于携带短重复等位基因的患者(P=0.000,P=0.006),合作性维度评分低于携带短重复等位基因的患者(P=0.038)。结论·双相障碍患者攻击行为与DRD4 exonⅢ48 bp VNTR之间可能存在关联。双相障碍攻击行为患者具有冲动、寻求刺激、探索、害怕不确定、报复心强、自私自利等人格特征,携带长重复等位基因患者人格异常更显著。
基金Hebei Province Medical Science Research Project,No.20221407.
文摘BACKGROUND Bipolar disorder(BD)is a severe mental illness.BD often coexists with borderline personality disorders,making the condition more complex.AIM To explore the differences in cognitive impairment between patients with BD and those with BD comorbid with borderline personality disorder.METHODS Eighty patients with BD and comorbid borderline personality disorder and 80 patients with BD alone were included in groups A and B,respectively,and 80 healthy volunteers were included as controls.Cognitive function in each group was evaluated using the Chinese version of the repeatable battery for the assess-ment of neuropsychological status(RBANS),the Stroop color-word test,and the Wechsler intelligence scale-revised(WAIS-RC).RESULTS The indices of the RBANS,Stroop color-word test,and WAIS-RC in groups A and B were significantly lower than those of the control group(P<0.05).Group A had significantly longer Stroop color-word test times for single-character,single-color,double-character,and double-color,lower scores of immediate memory,visual breadth,verbal function dimensions and total score of the RBANS,as well as lower scores of verbal IQ,performance IQ,and overall IQ of the WAIS-RC compared with group B(P<0.05).Compared to group B,group A exhibited significantly longer single-character time,single-color time,double-character time,and double-color time in the Stroop color-word test(P<0.05).CONCLUSION The cognitive function of patients with BD complicated with borderline personality disorder is lower than that of patients with BD.
文摘"Melancholia" seems to be the oldest term used to describe the manifestations of depression. Throughout the history of medicine, melancholia has been the focus of consideration of many scholars who have provided varying definitions of this disorder and its manifestations. This continual process has resulted in the gradual development of the concept of melancholia over time. Persian scholars were among the scientists who have studied the melancholia and contributed to its concept. One figure, Al-Akhawayni Bukhari(?-983 AD), a Persian physician whose reputation was based on the treatment of patients with mental problems, investigated this disorder. He described Melancholia and explained its clinical manifestations and treatment methods. AlAkhawayni provided an early classification of the patients suffering from this disorder. Since the medieval Persian concept of melancholia is not well-known, this paper aims to review Al-Akhawayni's 10 th century knowledge on melancholia which can represent the early concept of this disorder in the Near East.
基金the Institutional Review Board of Konkuk University Hospital(IRB number:KUMC 2021-01-028).
文摘BACKGROUND Panic disorders frequently occur with affective disorders,particularly bipolar disorder.Patients with panic disorder and bipolar disorder are more likely to present with severe symptoms,such as high rates of suicidal behavior,poor symptomatic and functional recovery,and poor drug responses.AIM To investigate the psychological characteristics of panic disorder patients related to bipolarity.METHODS A total of 254 patients(136 men and 118 women,mean age=33.48±3.2 years)who were diagnosed with panic disorder were included in the study.Panic disorder with bipolarity(BP+)was defined as a score of≥7 on the Korean version of the Mood Disorder Questionnaire(K-MDQ),and a score lower than 7 was considered as a panic disorder without bipolarity(BP-).Self-report questionnaires were analyzed to examine their association with bipolarity.Psychological tests used in the study were the Mood Disorder Questionnaire(MDQ),Panic Disorder Severity Scale,Beck Depression Inventory,State-Trait Anxiety Inventory(STAI),Temperament and Character Inventory(TCI),and Minnesota Multiphasic Personality Inventory(MMPI).Statistical analyses were performed to evaluate the correlation between bipolarity of panic disorder patients and various psychological test results indicative of psychological characteristics.RESULTS Patients with a K-MDQ score of 7 or more were considered to have a history of manic or hypomanic episodes(BP+group,n=128),while patients with K-MDQ scores below 7 were defined as those without bipolarity(BP-group,n=126).The BP+group were more likely to be unmarried(single 56.2%vs 44.4%,P=0.008)and younger(30.78±0.59 vs 37.11±3.21,P<0.001).Additionally,the BP+group had significantly higher scores on psychological assessment scales,such as the hypochondriasis,psychopathic deviate,masculinity-femininity,psychasthenia,schizophrenia,and hypomania(Ma)in MMPI,and novelty seeking,harm avoidance and self-transcendence in TCI,and STAI(state and trait)compared to the BP-group.In logistic regression analysis,depression in MMPI,self
