Electromagnetic interference(EMI)shielding materials have received considerable attention in recent years.The EMI shielding effectiveness(SE)of materials depends on not only their composition but also their microstruc...Electromagnetic interference(EMI)shielding materials have received considerable attention in recent years.The EMI shielding effectiveness(SE)of materials depends on not only their composition but also their microstructures.Among various microstructure prototypes,porous structures provide the advantages of low density and high terahertz wave absorption.In this study,by using carbonised wood(CW)as a template,1-mm-thick MAX@CW composites(Ti2AlC@CW,V2A1C@CW,and Cr2AlC@CW)with a porous structure were fabricated through the molten salt method.The MAX@CW composites led to the formation of a conductive network and multilayer interface,which resulted in improved EMI SE.The average EMI SE values of the three MAX@CW composites were>45 dB in the frequency of 0.6-1.6 THz.Among the composites,V2A1C@CW exhibited the highest average EMI SE of 55 dB.展开更多
In vivo 3D fluorescent image remains a technological barrier for biologists and clinical scientists although green fluorescent protein(GFP)imaging has long been performed rather well at cellular level.Meanwhile,robust...In vivo 3D fluorescent image remains a technological barrier for biologists and clinical scientists although green fluorescent protein(GFP)imaging has long been performed rather well at cellular level.Meanwhile,robust enough portable devices are also challenging lab-on-a-chip advocators who wish their designs to be nurtured by the end users.This work is dedicated to propose a conceptually innovated transparent soft PDMS avian eggshell to directly tackle the above two goals.Here,an"egg-on-a-chip"scheme is originally developed and demonstrated by a newly developed PDMS"soft"process method.Unlike its ancestor–the conventional"lab-on-a-chip"(LOC)which is basically chemically based,the current"egg-on-a-chip",intrinsically inherited with biological natures,opens a way to integrate biological parts or whole system in a miniature sized device.Such biomimics system contains much condensed environmental evolutional tensor inside than those of the existing LOC compacted with artificial components which however are quite difficult to incorporate various life factors inside.Owning unique advantages,a series of transparent PDMS whole"eggshells"have been fabricated and applied to culture avian embryos up to 17.5 days and chimeric eggshells were engineered on normal eggs.In addition,X-stage embryos were successfully initiated in such system and pre-chorioallantoic membrane was observed.Further,limitation of the present process was interpreted and potential approach to improve it was suggested.With both high optical transparency and engineering subtlety fully integrated together,the present method not only provides an ideal transparent imaging platform for studying functional embryo development including life mystery,but also promises a future strategy for"lab-on-an-egg"technology which may be important in a wide variety of either fundamental or practical areas.展开更多
背景:肌肉骨骼损伤和退行性疾病的手术治疗常涉及肌肉骨骼界面的重建,而实现肌肉骨骼界面与周围宿主组织的生物整合的关键是制造具有精确结构和不同材料的替代物。生物打印技术获得的人工组织可与天然肌肉骨骼界面组织具有相似的物理结...背景:肌肉骨骼损伤和退行性疾病的手术治疗常涉及肌肉骨骼界面的重建,而实现肌肉骨骼界面与周围宿主组织的生物整合的关键是制造具有精确结构和不同材料的替代物。生物打印技术获得的人工组织可与天然肌肉骨骼界面组织具有相似的物理结构和生物活性。目的:介绍肌肉骨骼界面组织的结构和生物功能特性,以及生物打印技术在肌肉骨骼界面重建中的应用。方法:由第一作者以"bioprinting,musculoskeletal interface,生物打印,肌肉骨骼界面"为关键词,检索2005至2019年期间PubMed、Web of Science、Springerlink、Medline、万方、CNKI数据库中的相关文献。初检文章201篇,筛选后对60篇文章进行分析。结果与结论:理想的生物打印肌肉骨骼界面移植物必须结构上与原界面组织相对应,以维持体内多变的生物力学环境;其次,植入之后必须保持这些植入物的生物活性,以开始修复和替换缺陷区域的功能。生物打印技术的发展为解决肌肉骨骼界面的重建带来了希望,但其仍然存在许多挑战:仿生功能性界面结构机械性能的提高、多个仿生结构的整合、生物打印结构的血管化,以及对力学刺激在界面组织发育和再生中的作用缺乏深入的研究。对于未来界面组织工程的研究方向,可以预料的是将种子细胞、细胞因子和基因治疗,以及生物反应器纳入界面组织工程支架中的一大热点,为解决界面组织整合这一难题提供创新性的解决方案。展开更多
Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative medicine.In contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds bas...Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative medicine.In contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative medicine.This paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future challenges.We highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ECM.Moreover,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE applications.Finally,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.展开更多
Metal (Me=Fe(III), Mo(VI), Mn(II), Co(II), Ni(II), Zn(II) and Cu(II)) 2-hydroxy-1-naphthaldehyde thiosemicarbazone complexes (MeHNT) were synthesized and used as mimic-enzyme catalysts to mimic the active group of hor...Metal (Me=Fe(III), Mo(VI), Mn(II), Co(II), Ni(II), Zn(II) and Cu(II)) 2-hydroxy-1-naphthaldehyde thiosemicarbazone complexes (MeHNT) were synthesized and used as mimic-enzyme catalysts to mimic the active group of horseradish peroxidase (HRP). The results showed that Fe-HNT, Mo-HNT are effective catalysts, which have similar catalytic activity as HRP. The sequence of catalytic activities of tested biomimic peroxidas is Mo-HNT > Fe-HNT > Zn-HNT > Ni-HNT > Mn-HNT. Among them, Fe-HNT is used as a mimic-enzyme catalyst in determination of ascorbic acid and glucose by coupling the catalytic reaction of glucose oxidase.展开更多
In order to further confirm the biomimic properties of N-phosphoamino acids. A series of model compounds, analogue of phosphoryl amino acids, were synthesized and their biomimic mechanism was also investigated by NMR ...In order to further confirm the biomimic properties of N-phosphoamino acids. A series of model compounds, analogue of phosphoryl amino acids, were synthesized and their biomimic mechanism was also investigated by NMR and MS methods. The results indicated that the reactivity of phosphoryl biological small molecules was depended on the configuration, function groups and positions.展开更多
The reaction between D-glucose, D-ribose and 2, 2,2-trimethoxy-4, 5-diphenyl-2, 2-dihydro-1, 3, 2-dioxaphospholene were investigates by P-31 NMR and FAB-MS. The results showed that there were a lot of differences in t...The reaction between D-glucose, D-ribose and 2, 2,2-trimethoxy-4, 5-diphenyl-2, 2-dihydro-1, 3, 2-dioxaphospholene were investigates by P-31 NMR and FAB-MS. The results showed that there were a lot of differences in the reactions via pentacoordinate phosphorus compound, and it should give it significant clue to the metabolism of carbohydrate phosphate in nature.展开更多
In this contribution,inspired by the excellent resource management and material transport function of leaf veins,the electrical transport function of metallized leaf veins is mimicked from the material transport funct...In this contribution,inspired by the excellent resource management and material transport function of leaf veins,the electrical transport function of metallized leaf veins is mimicked from the material transport function of the vein networks.By electroless copper plating on real leaf vein networks with copper thickness of only several hundred nanometre up to several micrometre,certain leaf veins can be converted to transparent conductive electrodes with an ultralow sheet resistance 100 times lower than that of state-of-the-art indium tin oxide thin films,combined with a broadband optical transmission of above 80%in the UV–VIS–IR range.Additionally,the resource efficiency of the vein-like electrode is characterized by the small amount of material needed to build up the networks and the low copper consumption during metallization.In particular,the high current density transport capability of the electrode of>6000 A cm^−2 was demonstrated.These superior properties of the vein-like structures inspire the design of high-performance transparent conductive electrodes without using critical materials and may significantly reduce the Ag consumption down to<10%of the current level for mass production of solar cells and will contribute greatly to the electrode for high power density concentrator solar cells,high power density Li-ion batteries,and supercapacitors.展开更多
基金supported financially by the National Natural Science Foundation of China(Grant Nos.51902320,61831012,and U2004212)Qing Huang thanks International Partnership Program of Chinese Academy of Sciences(Grant No.174433KYSB20190019)+1 种基金the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(Grant No.2019R01003)Mian Li acknowledges the support from the fund of the State Key Laboratory of Solidification Processing in NPU(Grant No.SKLSP201917).
文摘Electromagnetic interference(EMI)shielding materials have received considerable attention in recent years.The EMI shielding effectiveness(SE)of materials depends on not only their composition but also their microstructures.Among various microstructure prototypes,porous structures provide the advantages of low density and high terahertz wave absorption.In this study,by using carbonised wood(CW)as a template,1-mm-thick MAX@CW composites(Ti2AlC@CW,V2A1C@CW,and Cr2AlC@CW)with a porous structure were fabricated through the molten salt method.The MAX@CW composites led to the formation of a conductive network and multilayer interface,which resulted in improved EMI SE.The average EMI SE values of the three MAX@CW composites were>45 dB in the frequency of 0.6-1.6 THz.Among the composites,V2A1C@CW exhibited the highest average EMI SE of 55 dB.
基金supported by the National Natural Science Foundation of China(Grant No.51376102)
文摘In vivo 3D fluorescent image remains a technological barrier for biologists and clinical scientists although green fluorescent protein(GFP)imaging has long been performed rather well at cellular level.Meanwhile,robust enough portable devices are also challenging lab-on-a-chip advocators who wish their designs to be nurtured by the end users.This work is dedicated to propose a conceptually innovated transparent soft PDMS avian eggshell to directly tackle the above two goals.Here,an"egg-on-a-chip"scheme is originally developed and demonstrated by a newly developed PDMS"soft"process method.Unlike its ancestor–the conventional"lab-on-a-chip"(LOC)which is basically chemically based,the current"egg-on-a-chip",intrinsically inherited with biological natures,opens a way to integrate biological parts or whole system in a miniature sized device.Such biomimics system contains much condensed environmental evolutional tensor inside than those of the existing LOC compacted with artificial components which however are quite difficult to incorporate various life factors inside.Owning unique advantages,a series of transparent PDMS whole"eggshells"have been fabricated and applied to culture avian embryos up to 17.5 days and chimeric eggshells were engineered on normal eggs.In addition,X-stage embryos were successfully initiated in such system and pre-chorioallantoic membrane was observed.Further,limitation of the present process was interpreted and potential approach to improve it was suggested.With both high optical transparency and engineering subtlety fully integrated together,the present method not only provides an ideal transparent imaging platform for studying functional embryo development including life mystery,but also promises a future strategy for"lab-on-an-egg"technology which may be important in a wide variety of either fundamental or practical areas.
文摘背景:肌肉骨骼损伤和退行性疾病的手术治疗常涉及肌肉骨骼界面的重建,而实现肌肉骨骼界面与周围宿主组织的生物整合的关键是制造具有精确结构和不同材料的替代物。生物打印技术获得的人工组织可与天然肌肉骨骼界面组织具有相似的物理结构和生物活性。目的:介绍肌肉骨骼界面组织的结构和生物功能特性,以及生物打印技术在肌肉骨骼界面重建中的应用。方法:由第一作者以"bioprinting,musculoskeletal interface,生物打印,肌肉骨骼界面"为关键词,检索2005至2019年期间PubMed、Web of Science、Springerlink、Medline、万方、CNKI数据库中的相关文献。初检文章201篇,筛选后对60篇文章进行分析。结果与结论:理想的生物打印肌肉骨骼界面移植物必须结构上与原界面组织相对应,以维持体内多变的生物力学环境;其次,植入之后必须保持这些植入物的生物活性,以开始修复和替换缺陷区域的功能。生物打印技术的发展为解决肌肉骨骼界面的重建带来了希望,但其仍然存在许多挑战:仿生功能性界面结构机械性能的提高、多个仿生结构的整合、生物打印结构的血管化,以及对力学刺激在界面组织发育和再生中的作用缺乏深入的研究。对于未来界面组织工程的研究方向,可以预料的是将种子细胞、细胞因子和基因治疗,以及生物反应器纳入界面组织工程支架中的一大热点,为解决界面组织整合这一难题提供创新性的解决方案。
基金supported by the National Natural Science Foundation of China(52003113,31900950,82102334,82002313,82072444)the National Key Research&Development Program of China(2018YFC2001502,2018YFB1105705)+6 种基金the Guangdong Basic and Applied Basic Research Foundation(2021A1515010745,2020A1515110356,2023A1515011986)the Shenzhen Fundamental Research Program(JCYJ20190808120405672)the Key Program of the National Natural Science Foundation of Zhejiang Province(LZ22C100001)the Natural Science Foundation of Shanghai(20ZR1469800)the Integration Innovation Fund of Shanghai Jiao Tong University(2021JCPT03),the Science and Technology Projects of Guangzhou City(202102020359)the Zigong Key Science and Technology Plan(2022ZCNKY07).SXC thanks the financial support under the Startup Grant of the University of Chinese Academy of Sciences(WIUCASQD2021026).HW thanks the Futian Healthcare Research Project(FTWS2022013)the financial support of China Postdoctoral Science Foundation(2021TQ0118).SL thanks the financial support of China Postdoctoral Science Foundation(2022M721490).
文摘Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative medicine.In contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative medicine.This paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future challenges.We highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ECM.Moreover,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE applications.Finally,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.
文摘Metal (Me=Fe(III), Mo(VI), Mn(II), Co(II), Ni(II), Zn(II) and Cu(II)) 2-hydroxy-1-naphthaldehyde thiosemicarbazone complexes (MeHNT) were synthesized and used as mimic-enzyme catalysts to mimic the active group of horseradish peroxidase (HRP). The results showed that Fe-HNT, Mo-HNT are effective catalysts, which have similar catalytic activity as HRP. The sequence of catalytic activities of tested biomimic peroxidas is Mo-HNT > Fe-HNT > Zn-HNT > Ni-HNT > Mn-HNT. Among them, Fe-HNT is used as a mimic-enzyme catalyst in determination of ascorbic acid and glucose by coupling the catalytic reaction of glucose oxidase.
文摘In order to further confirm the biomimic properties of N-phosphoamino acids. A series of model compounds, analogue of phosphoryl amino acids, were synthesized and their biomimic mechanism was also investigated by NMR and MS methods. The results indicated that the reactivity of phosphoryl biological small molecules was depended on the configuration, function groups and positions.
文摘The reaction between D-glucose, D-ribose and 2, 2,2-trimethoxy-4, 5-diphenyl-2, 2-dihydro-1, 3, 2-dioxaphospholene were investigates by P-31 NMR and FAB-MS. The results showed that there were a lot of differences in the reactions via pentacoordinate phosphorus compound, and it should give it significant clue to the metabolism of carbohydrate phosphate in nature.
基金the financial support from the BMWi within the projects TherSiTex(ZF4006804PR5)TexCool(ZF4006814BA8)
文摘In this contribution,inspired by the excellent resource management and material transport function of leaf veins,the electrical transport function of metallized leaf veins is mimicked from the material transport function of the vein networks.By electroless copper plating on real leaf vein networks with copper thickness of only several hundred nanometre up to several micrometre,certain leaf veins can be converted to transparent conductive electrodes with an ultralow sheet resistance 100 times lower than that of state-of-the-art indium tin oxide thin films,combined with a broadband optical transmission of above 80%in the UV–VIS–IR range.Additionally,the resource efficiency of the vein-like electrode is characterized by the small amount of material needed to build up the networks and the low copper consumption during metallization.In particular,the high current density transport capability of the electrode of>6000 A cm^−2 was demonstrated.These superior properties of the vein-like structures inspire the design of high-performance transparent conductive electrodes without using critical materials and may significantly reduce the Ag consumption down to<10%of the current level for mass production of solar cells and will contribute greatly to the electrode for high power density concentrator solar cells,high power density Li-ion batteries,and supercapacitors.
