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Transcutaneous Auricular Vagus Nerve Stimulation: From Concept to Application 被引量:19
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作者 Yu Wang Shao-Yuan Li +11 位作者 Dan Wang Mo-Zheng Wu Jia-Kai He Jin-Ling Zhang Bin Zhao Li-Wei Hou Jun-Ying Wang Lei Wang Yi-Fei Wang Yue Zhang Zi-Xuan Zhang Pei-Jing Rong 《Neuroscience Bulletin》 SCIE CAS CSCD 2021年第6期853-862,共10页
Whether in the West or the East,the connection between the ear and the rest of the body has been explored for a long time.Especially in the past century or more,the relevant theoretical and applied research on the ear... Whether in the West or the East,the connection between the ear and the rest of the body has been explored for a long time.Especially in the past century or more,the relevant theoretical and applied research on the ear has greatly promoted the development of ear therapy,and finally the concept of transcutaneous auricular vagus nerve stimulation(taVNS)has been proposed.The purpose of taVNS is to treat a disease non-invasively by applying electrical current to the cutaneous receptive field formed by the auricular branch of the vagus nerve in the outer ear.In the past two decades,taVNS has been a topic of basic,clinical,and transformation research.It has been applied as an alternative to drug treatment for a variety of diseases.Based on the rapid understanding of the application of taVNS to human health and disease,some limitations in the development of this field have also been gradually exposed.Here,we comprehensively review the origin and research status of the field. 展开更多
关键词 Transcutaneous auricular vagus nerve stimulation CONCEPT APPLICATION DEVELOPMENT
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耳穴电刺激配合声音掩蔽对耳鸣大鼠听觉皮层的CREB蛋白、BDNF及其受体TrkB表达的影响 被引量:15
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作者 杨松柏 彭利艳 +6 位作者 梅志刚 谭凌菁 黄亚光 冯知涛 蔡三金 马文翰 张定棋 《中国针灸》 CAS CSCD 北大核心 2019年第6期637-642,共6页
目的:探讨耳穴电刺激配合声音掩蔽对耳鸣大鼠听觉皮层的环磷酸腺苷反应元件结合蛋白(CREB)、脑源性神经营养因子(BDNF)及其受体酪氨酸蛋白激酶受体B(TrkB)表达的影响。方法:将27只成年雄性SD大鼠随机分为对照组、模型组和治疗组。模型... 目的:探讨耳穴电刺激配合声音掩蔽对耳鸣大鼠听觉皮层的环磷酸腺苷反应元件结合蛋白(CREB)、脑源性神经营养因子(BDNF)及其受体酪氨酸蛋白激酶受体B(TrkB)表达的影响。方法:将27只成年雄性SD大鼠随机分为对照组、模型组和治疗组。模型组及治疗组大鼠采取腹腔注射水杨酸钠诱导制作耳鸣模型;对照组注射0.9%NaCl溶液。造模成功后,治疗组采用耳穴"神门""胰胆"电刺激配合声音掩蔽法治疗,每天1次,治疗15d。采用声音惊吓反应监测系统监测各组大鼠的停顿声音预刺激抑制惊吓反应(GPIAS)及预刺激抑制反应(PPI),以WesternBlot法检测各组大鼠听觉皮层的BDNF及其受体TrkB,CREB和磷酸化CREB(p-CREB)蛋白表达。结果:①与对照组比较,模型组大鼠在12、16、20、28 kHz高频背景声音的GPIAS比值均下降(均P<0.05);与模型组比较,治疗组在12、16、20、28 kHz高频背景声音的GPIAS比值均升高(均P<0.05)。②与对照组比较,模型组BDNF蛋白表达、p-CREB蛋白表达均升高(均P<0.01),TrkB表达升高(P<0.05);治疗组与模型组BDNF和TrkB表达、CREB及p-CREB蛋白表达比较差异均无统计学意义(均P>0.05)。结论:耳穴电刺激配合声音掩蔽法能改善耳鸣大鼠高频背景声音的GPIAS比值变化,此作用可能与抑制耳鸣大鼠听觉皮层的BDNF/TrkB/CREB信号通路相关蛋白表达下调,进而逆转不良可塑性改变有关。 展开更多
关键词 耳鸣 耳穴 电刺激 声音掩蔽 脑源性神经营养因子 酪氨酸蛋白激酶受体B 环磷腺苷反应元件结合蛋白
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耳穴电刺激治疗抑郁症临床应用专家共识 被引量:15
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作者 荣培晶 李少源 周立群 《中国中医药信息杂志》 CAS CSCD 2021年第6期1-7,共7页
《耳穴电刺激治疗抑郁症临床应用专家共识》(以下简称《共识》)由中国针灸学会组织,并在耳穴诊治专业委员会专家组指导、监督下实施。《共识》内容主要基于循证医学原则,结合专家问卷调查、专家论证、同行征求意见等,提出耳穴电刺激治... 《耳穴电刺激治疗抑郁症临床应用专家共识》(以下简称《共识》)由中国针灸学会组织,并在耳穴诊治专业委员会专家组指导、监督下实施。《共识》内容主要基于循证医学原则,结合专家问卷调查、专家论证、同行征求意见等,提出耳穴电刺激治疗抑郁症中西医理论基础、命名及穴位选择、刺激参数、治疗时机与疗程、联合用药方案、安全性等,供中西医临床诊疗参考使用。 展开更多
关键词 耳穴 电刺激 抑郁症 专家共识
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Effect and mechanism study on transcutaneous auricular vagus nerve stimulation for functional dyspepsia model rats 被引量:11
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作者 Li-wei HOU Pei-jing RNG +5 位作者 Wei WEI Ji-liang FANG Dan WANG Wei-hang ZHAI Yu WANG Jun-ying WANG 《World Journal of Acupuncture-Moxibustion》 CSCD 2020年第1期49-56,共8页
Objective:To explore the effect and its possible mechanism of the intervention of transcutaneous auricular vagus nerve stimulation(taVNS)for the functional dyspepsia(FD)model rats.Methods:Of the 25 male SD rats,6 rats... Objective:To explore the effect and its possible mechanism of the intervention of transcutaneous auricular vagus nerve stimulation(taVNS)for the functional dyspepsia(FD)model rats.Methods:Of the 25 male SD rats,6 rats were set as blank group,the other 19 rats were established to be the functional dyspepsia(FD)model by iodoacetamide intragastric administration,and 18 FD models were successfully established.The 18 model rats were randomly divided into a model group,a shamtaVNS group,and taVNS group,with 6 rats in each group.There was no intervention applied to the rats in the blank and model groups.Whereas,the rats in sham-taVNS group received stimulation to the rim of auricular concha of both sides,and those in taVNS group received stimulation to the cavity of auricular concha of both sides,for 30 min each time,once a day,7 days in succession.After the intervention,the gastric sensitivity of the rats in each group under different pressure conditions in the stomach,the expressions of serum brain-gut peptide motilin(MTL),cholecystokinin(CCK),glucagon-likepeptidel(GLP-1),and inflammatory factors IL-4,IL-10,and IL-1βwere detected.Results:(1)Gastric sensitivity:compared with the blank group,the gastric sensitivity of the model group was higher(P<0.05).Compared with the model group,the gastric sensitivity of the taVNS group was lower(P<0.05).Compared with the sham-taVNS group,the gastric sensitivity of the taVNS group was lower(P<0.05).(2)Expression of brain-gut peptide:compared with the blank group,MTL was lower,CCK and GLP-1 were higher in the model group(all P<0.05).Compared with the model group,MTL was higher,CCK and GLP-1 were lower in the taVNS group(all P<0.05).Compared with the shamtaVNS group,CCK and GLP-1 were lower in the taVNS group(both P<0.05).(3)Expression of inflammatory factors:compared with the blank group,IL-4 and IL-10 were lower and was higher in the model group(all P<0.05).Compared with the model group,IL-10 was higher and IL-1βwas lower in the shamtaVNS group(all P<0.05),while IL-4 and IL-10 wer 展开更多
关键词 TRANSCUTANEOUS auricular VAGUS NERVE stimulation(taVNS) Functional dyspepsia(FD) VAGUS NERVE Inflammatory factor Brain-gut peptide
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耳穴结合穴位电刺激预防环状混合痔切除术后尿潴留临床观察 被引量:10
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作者 孙健 陆金根 林晖 《上海中医药杂志》 2013年第4期65-67,共3页
目的观察耳穴贴压结合穴位低频电刺激预防环状混合痔切除术后尿潴留的临床疗效。方法选取112例腰麻下行环状混合痔切除术的患者,随机分为试验组、对照组、空白组,分别予耳穴结合体穴低频电刺激、耳穴、不采用任何干预手段。观察3组治疗... 目的观察耳穴贴压结合穴位低频电刺激预防环状混合痔切除术后尿潴留的临床疗效。方法选取112例腰麻下行环状混合痔切除术的患者,随机分为试验组、对照组、空白组,分别予耳穴结合体穴低频电刺激、耳穴、不采用任何干预手段。观察3组治疗后尿潴留的发生率、术后第一次排尿及术后8 h排尿情况。结果①试验组尿潴留发生率(2.56%)低于空白组(23.68%)(P<0.01),与对照组(8.57%)比较无显著性差异(P>0.05);②试验组的临床疗效优于空白组(P<0.01),而与对照组比较差异无显著性意义(P>0.05);③试验组第一次排尿时间和排尿总积分与对照组、空白组比较,差异有统计学意义(P<0.05);④试验组术后8 h排尿总积分与空白组比较有显著性差异(P<0.05);⑤试验组术后疼痛VAS积分明显低于对照组和空白组(P<0.05)。结论耳穴结合穴位电刺激可有效预防痔术后尿潴留、减轻疼痛。 展开更多
关键词 尿潴留 痔术后 耳穴 电刺激
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Efficacy and safety of transcutaneous auricular vagus nerve stimulation combined with conventional rehabilitation training in acute stroke patients: a randomized controlled trial conducted for 1 year involving 60 patients 被引量:9
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作者 Jia-Ni Li Chen-Chen Xie +7 位作者 Chang-Qing Li Gui-Fang Zhang Hao Tang Chuan-Na Jin Jing-Xi Ma Lan Wen Ke-Ming Zhang Ling-Chuan Niu 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第8期1809-1813,共5页
Transcutaneous auricular vagus nerve stimulation(ta-VNS)is a novel noninvasive treat-ment for stroke that directly stimulates the peripheral auricular branch of the vagus nerve.There have been recent reports that ta-V... Transcutaneous auricular vagus nerve stimulation(ta-VNS)is a novel noninvasive treat-ment for stroke that directly stimulates the peripheral auricular branch of the vagus nerve.There have been recent reports that ta-VNS combined with conventional rehabilitation training promotes the recovery of neurological function of patients with acute stroke.However,these were small-sample-sized studies on the recovery of neurological function in patients after percutaneous vagus nerve stimulation in the subacute and chronic phases after stroke.This double-blinded randomized controlled trial involved 60 acute ischemic or hemorrhagic stroke patients aged 18-80 years who received treatment in the Second Affiliated Hospital of Chongqing Medical University.The subjects were randomly assigned to receive ta-VNS or sham ta-VNS combined with conventional rehabilitation training.The follow-up results over 1 year revealed that ta-VNS combined with conventional rehabilitation training greatly improved the recovery of motor and sensory functions and emotional responses compared with sham ta-VNS combined with conventional rehabilitation training.There were no obvious side effects.These findings suggest that ta-VNS combined with conventional rehabilitation training for the treatment of acute ischemic or hemorrhagic stroke patients is safe and effective. 展开更多
关键词 activity of daily living early stage treatment emotional disorder limb dysfunction neural regeneration randomized controlled clinical trial rehabilitation safety of treatment stroke transcutaneous auricular-vagus nerve stimulation
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中医外治法防治青少年近视的临床应用 被引量:7
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作者 吴丽云 窦思东 《健康研究》 CAS 2012年第5期378-380,396,共4页
文章对近年来中医外治法防治青少年近视的临床研究文献进行分析,总结多种中医外治法在近视治疗中的应用。中医外治疗法防治近视方法较多,临床疗效明显,使用方便、经济实用,一般无明显不良反应,是防治近视的有效方法之一,但这些疗法机理... 文章对近年来中医外治法防治青少年近视的临床研究文献进行分析,总结多种中医外治法在近视治疗中的应用。中医外治疗法防治近视方法较多,临床疗效明显,使用方便、经济实用,一般无明显不良反应,是防治近视的有效方法之一,但这些疗法机理研究不足,且研究方法不够规范,严重影响了这些研究成果在临床的应用。更深入、细致的工作,才能使中医在青少年近视防治工作中发挥更大的作用。 展开更多
关键词 青少年近视 中药外用 针刺 推拿按摩 灸疗 耳穴刺激
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Effect of transcutaneous auricular vagus nerve stimulation on fasting blood glucose and serum insulin concentration in Zucker diabetes fatty rats 被引量:7
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作者 Zi-xuan ZHANG Shao-yuan LI +3 位作者 Yu WANG Yue ZHANG Yi-fei WANG Pei-jing RONG 《World Journal of Acupuncture-Moxibustion》 CSCD 2021年第3期212-217,共6页
Objective:To observe the influence of transcutaneous auricular vagus nerve stimulation(taVNS) on fasting plasma glucose(FPG) and serum insulin(INS) in Zucker diabetes fatty(ZDF) rats and explore the regulatory effect ... Objective:To observe the influence of transcutaneous auricular vagus nerve stimulation(taVNS) on fasting plasma glucose(FPG) and serum insulin(INS) in Zucker diabetes fatty(ZDF) rats and explore the regulatory effect of taVNS on blood glucose in ZDF rats.Methods:A total of 20 male ZDF rats were randomized into a model group and a taVNS group,10 rats in each one.Besides,the other 10 Zucker Lean(ZL) rats were selected to be a control group.The rats in the control group were fed with common forage and those in the model group and the taVNS group were fed with high-sugar and high-fat forage.The intervention of electric stimulation was applied in the rats of taVNS group,with 2/15 Hz in frequency,disperse-dense wave and 2 mA in intensity.Each intervention lasted 30 min,once a day,consecutively for 12 weeks.No any intervention was given in the control group and the model group.The body mass and FPG level were recorded once every 2 weeks in the rats.After the experiment,the rats were sacrificed and blood sample was collected.Enzyme linked immunosorbent assay(ELISA) was adopted to determine the level of serum INS in the rats.Results:After the modeling,compared with the control group,the body mass and FPG level were all higher(P <0.05,P <0.01) and the concentration of serum INS was lower(P <0.01) in the rats of the model group.After intervention,compared with the model group,the body mass was lower in week 6 to 10(P <0.01,P <0.05),FPG level was lower in week 8 to 12(P <0.01,P <0.05) and serum INS concentration was higher(P <0.01) in the rats of the taVNS group.Conclusion:TaVNS apparently improves in hyperglycemia in ZDF rats and increases serum insulin concentration in the rats. 展开更多
关键词 Transcutaneous auricular vagus nerve stimulation Type 2 diabetes mellitus Zucker diabetic fatty rat INSULIN HYPOGLYCEMIC
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耳穴刺激结合高频重复经颅磁刺激及吞咽训练改善脑卒中后吞咽障碍的研究
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作者 杨小雯 苏辉 +4 位作者 李少雄 陈志标 杜道兵 石冰 梁少霞 《中国处方药》 2024年第1期179-182,共4页
目的探讨耳穴刺激结合高频重复经颅磁刺激(rTMS)及吞咽训练改善脑卒中后吞咽障碍的临床效果。方法选取2021年1月~2022年2月收治的76例脑卒中后吞咽障碍患者,随机数字表法分为试验组(耳穴刺激+高频rTMS+吞咽训练,38例)和对照组(单纯吞咽... 目的探讨耳穴刺激结合高频重复经颅磁刺激(rTMS)及吞咽训练改善脑卒中后吞咽障碍的临床效果。方法选取2021年1月~2022年2月收治的76例脑卒中后吞咽障碍患者,随机数字表法分为试验组(耳穴刺激+高频rTMS+吞咽训练,38例)和对照组(单纯吞咽训练,38例)。干预前后,以标准吞咽功能评价量表(SSA)评价两组吞咽功能,予以两组电视透视吞咽功能检查(VFSS),评价干预效果。结果试验组干预后SSA得分低于本组干预前与对照组干预后,VFSS得分高于本组干预前与对照组干预后,差异有统计学意义(P<0.05)。对照组干预后SSA低于干预前,VFSS评分高于干预前,差异有统计学意义(P<0.05)。试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论脑卒中后吞咽障碍患者在吞咽训练基础上联合高频rTMS和耳穴刺激治疗,三者联用可以发挥协同作用,能够进一步强化临床疗效,更好地促进患者吞咽功能恢复。 展开更多
关键词 脑卒中 吞咽障碍 耳穴刺激 高频重复经颅磁刺激 吞咽训练
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Transcutaneous auricular vagus nerve stimulation would be an alternative to implantable cervical vagus nerve stimulation in some situation 被引量:1
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作者 HE Jiakai ZHANG Jinling +11 位作者 WANG Yu LI Shaoyuan FANG Jiliang ZHANG Shuai ZHAO Yanan ZHAI Weihang GAO Deqiang LI Ran JIANG Yuhang CHEN Zehao JIA Baohui RONG Peijing 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2023年第3期627-630,共4页
Implantable cervical vagus nerve stimulation(i VNS) is a representative and promising neuromodulation.However,the invasive nature restricts its application.Traditional auricular acupuncture treatment has a long histor... Implantable cervical vagus nerve stimulation(i VNS) is a representative and promising neuromodulation.However,the invasive nature restricts its application.Traditional auricular acupuncture treatment has a long history.The auricular branch of the vagus nerve(ABVN) is a branch on the surface of the ear.Some studies demonstrates that transcutaneous auricular vagus nerve stimulation(ta VNS) would achieve similar effects as i VNS.Ta VNS and i VNS share a common anatomical basis and acting mechanism.In this article,we made a comparison between i VNS and ta VNS in indications and efficacy.The recent studies have revealed similar clinical efficacy of ta VNS,ta VNS would expand the indication of i VNS.Highquality clinical evidences are needed before ta VNS become be an alternative of i VNS. 展开更多
关键词 transcutaneous auricular vagus nerve stimulation auricular branch of vagus nerve NEUROMODULATION efficacy
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Transcutaneous auricular vagus nerve stimulation for functional dyspepsia:A randomized controlled trial 被引量:3
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作者 Dong WU Yu WANG +5 位作者 Jin-ling ZHANG Hai-hong LIAN Lu-quan CHEN Tao PENG Pei-jing RONG Li-wei HOU 《World Journal of Acupuncture-Moxibustion》 CSCD 2021年第3期165-171,共7页
Objectives:To observe the clinical long-term therapeutic effect on functional dyspepsia(FD) in the comparative study of transcutaneous auricular vagus nerve stimulation(taVNS) with transcutaneous auricular none-vagus ... Objectives:To observe the clinical long-term therapeutic effect on functional dyspepsia(FD) in the comparative study of transcutaneous auricular vagus nerve stimulation(taVNS) with transcutaneous auricular none-vagus nerve stimulation(tnVNS).Methods:A total of 90 FD patients were randomized into a taVNS group and a tnVNS group,45 cases in each one.The patients in both the taNVS group and the tnVNS group were treated 5 times a week,30 min each time,for 4 weeks totally.Before treatment,after treatment and in follow-up visit,overall symptom points,functional dyspepsia-related quality of life questionnaire(FDQOL),Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD) and self-rating depression scale(SDS) were adopted to evaluate the severity of the symptoms and observe the clinical therapeutic effect of patients.Results:Compared with the scores before treatment,the overall symptom points,FDDQL,HAMA,HAMD and SDS at each time point after treatment were all lower in the patients of the taVNS group.The scores of FDDQL after treatment were almost all higher than that before treatment in the self-comparison of each group.All of the above differences were significant statistically(all P <0.05).Compared with the tnVNS group,the overall symptom points,FDDQL, HAMA,HAMD and SDS at each time point after treatment were all lower in the taVNS group and the score of FDDQL was higher,indicating the statistical differences(all P<0.05).Conclusion:Transcutaneous auricular vagus nerve stimulation is applicable for the treatment of functional dyspepsia.Compared with the control group,taVNS obtains a better long-term effect. 展开更多
关键词 auricular acupuncture therapy Functional dyspepsia Functional dyspepsia-related quality of life questionnaire(FDQOL) Hamilton anxiety scale(HAMA) Hamilton depression scale(HAMD) Long-term effect Transcutaneous auricular vagus nerve stimulation(taVNS)
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基于数据挖掘技术探究耳穴治疗单纯性近视的选穴规律
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作者 曾铉玲 陈楠 +1 位作者 王天琳 杨星月 《云南中医药大学学报》 2023年第3期99-105,共7页
目的探索耳穴疗法治疗单纯性近视的选穴规律,并确定适宜刺激方法。方法检索建库以来至2021年9月15日7个数据库收录的耳穴治疗单纯性近视的临床试验研究文献,对纳入文献进行偏倚风险评估,对纳入耳穴处方进行耳穴集合可视化分析、耳穴网... 目的探索耳穴疗法治疗单纯性近视的选穴规律,并确定适宜刺激方法。方法检索建库以来至2021年9月15日7个数据库收录的耳穴治疗单纯性近视的临床试验研究文献,对纳入文献进行偏倚风险评估,对纳入耳穴处方进行耳穴集合可视化分析、耳穴网络分析、聚类分析等。结果纳入57组耳穴处方,涵盖23个耳穴,眼穴被应用频次最高,达到54次,其次为肝穴、屏间前穴、屏间后穴和肾穴,耳穴配伍以屏间前和屏间后最为常见。在刺激方式方面,最常用的是王不留行耳穴压籽。聚类分析将这些耳穴分成以屏间前-屏间后-眼-肝-肾-脾一心为主的4个聚类群。结论耳穴疗法治疗单纯性近视穴位组方应以眼、屏间前、屏间后为基础,同时根据脏腑、经络等选穴原则辨证选穴。 展开更多
关键词 耳穴疗法 单纯性近视 选穴规律 刺激方法 关联规则
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The mechanisms through which auricular vagus nerve stimulation protects against cerebral ischemia/reperfusion injury 被引量:3
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作者 Jing-Jun Zhao Zheng-Hui Wang +4 位作者 Ying-Jie Zhang Wen-Jing Wang Ai-Fang Cheng Pei-Jing Rong Chun-Lei Shan 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第3期594-600,共7页
Previous studies have shown that vagus nerve stimulation can improve patients' locomotor function.The stimulation of the auricular vagus nerve,which is the only superficial branch of the vagus nerve,may have simil... Previous studies have shown that vagus nerve stimulation can improve patients' locomotor function.The stimulation of the auricular vagus nerve,which is the only superficial branch of the vagus nerve,may have similar effects to vagus nerve stimulation.However,the precise mechanisms remain poorly understood.In this study,rat models of cerebral ischemia/reperfusion injury were established by modified Longa ligation.Twenty-four hours later,7-day auricular vagus nerve stimulation was performed.The results showed that auricular vagus nerve stimulation promoted the secretion of acetylcholine,inhibited the secretion of interleukin-1β,interleukin-6,and tumor necrosis factor-α,and reduced connexin 43 phosphorylation in the ischemic penumbra and motor cortex,promoting locomotor function recovery in rats with cerebral ischemia/reperfusion injury.These findings suggested that auricular vagus nerve stimulation promotes the recovery of locomotor function in rats with cerebral ischemia/reperfusion injury by altering the secretion of acetylcholine and inflammatory factors and the phosphorylation of connexin 43.This study was approved by the Animal Use and Management Committee of Shanghai University of Traditional Chinese Medicine on November 8,2019(approval No.PZSHUTCM191108014). 展开更多
关键词 auricular vagus nerve stimulation connexin 43 gap junction inflammatory factor ischemia/reperfusion injury neurological function NEUROPROTECTION STROKE
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Effects of transcutaneous auricular vagus nerve stimulation on intestinal ligandins in a rat model of functional dyspepsia 被引量:2
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作者 Li-wei HOU Ji-liang FANG +3 位作者 Jin-ling ZHANG Dong WU Jun-ying WANG Pei-jing RONG 《World Journal of Acupuncture-Moxibustion》 CSCD 2022年第1期33-39,共7页
Objective:Transcutaneous auricular vagus nerve stimulation(taVNS) can relieve the symptoms of functional dyspepsia(FD) and improve the quality of life of patients,however,the mechanism underlying this effect remains u... Objective:Transcutaneous auricular vagus nerve stimulation(taVNS) can relieve the symptoms of functional dyspepsia(FD) and improve the quality of life of patients,however,the mechanism underlying this effect remains unclear.Therefore,this study aimed to investigate the effects of taVNS on the expression of intestinal mucosal ligandins.Methods:This study was conducted on 24 specific Spathogen-free Sprague-Dawley rats(12 males and12 females).The rat model of FD was established by tail-clip stimulation.After FD was established successfully,all rats were randomized to either the normal group(n=6),model group(n=6),taVNS group(n=6),or sham-taVNS group(n=6).After two weeks of the respective intervention,the score of their general conditions,3 h food intake,gastric emptying rate,and the histology of gastric antrum tissues were observed to evaluate modeling success,and then the effect of taVNS was evaluated.Western blotting was used to assess the expression of the tight junction ligandins-ZO-1 and occludin-and the adhesion ligandin-β-catenin-in the duodenum.The effect of taVNs on the expression of intestinal mucosal barrier ligandins-ZO-1,occludin,and β-catenin-in FD rats was preliminarily investigated.Results:When the model-induced period was finished,the manifestations of FD in the model group rats were mental exhaustion,reduced activities,decreased score of the general conditions,and decreased3 h food intake,compared to the normal group rats.In addition,minimal eosinophil infiltration,without any mucosal erosion or ulcer,was observed in the gastric antrum mucosa.At the end of the study,the mental state of the FD rats improved,and their activities and gastric emptying rate increased in the taVNS group rats.Compared to the normal rats,the duodenal mucosa had less expression of the tight junction ligandins ZO-1 and occludin,but β-catenin expression remained unchangedin the model rats.The expression of the tight junction ligandins ZO-1 and occludin were increased in the duodenal mucosa of model rats after the taVNS inte 展开更多
关键词 Transcutaneous auricular vagus nerve stimulation(taVNS) Functional dyspepsia(FD) Tight ligandin Adhesion ligandin
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Efficacy and brain mechanism of transcutaneous auricular vagus nerve stimulation for adolescents with mild to moderate depression:Study protocol for a randomized controlled trial 被引量:3
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作者 Xue Xiao Xiaobing Hou +5 位作者 Zhangjing Zhang Ying Li Xue Yu Yanhui Wang Jing Tian Ke Xu 《Pediatric Investigation》 CSCD 2020年第2期109-117,共9页
Background Depression is a common mental illness in childhood and adolescence,with an incidence of 4%–5%;it can lead to impairments in learning and social functioning.Transcutaneous auricular vagus nerve stimulation(... Background Depression is a common mental illness in childhood and adolescence,with an incidence of 4%–5%;it can lead to impairments in learning and social functioning.Transcutaneous auricular vagus nerve stimulation(taVNS)is a commonly used method of auricular acupuncture point stimulation,which is regarded as an effective treatment for adults with depression.The aim of this study was to investigate the efficacy and mechanism of taVNS for adolescents with mild to moderate depression.Methods This randomized controlled clinical trial will include 120 patients aged 12–16 years,all of whom are diagnosed with mild to moderate depression.Patients will be randomly assigned to a taVNS group and a drug control group(sertraline hydrochloride)at a ratio of 1:1.Patients will be evaluated using the 17‐item Hamilton Depression Scale,Hamilton Anxiety Rating Scale,Self‐Rating Depression Scale,Self‐Rating Anxiety Scale,and Pittsburgh Sleep Quality Index scores at baseline,as well as at the 2nd,4th,6th,8th,and 12th weeks.To investigate the underlying neural mechanisms of taVNS treatment from the perspective of the default mode network,multimodal magnetic resonance imaging(MRI;i.e.,structural MRI[sMRI],resting state MRI[rsMRI],and pseudocontinuous arterial spin‐labeled[pcASL]MRI)will be used to compare cerebral images among groups.MRI data will also be collected from 40 healthy volunteers to assess whether the participants exhibit normal development of structural and functional components.Discussion Depression is the most common mental disorder in adolescence.Drug treatment can improve depression symptoms;however,the side effects of drug treatments are often severe.This study proposes a simple physiotherapy that aims to treat adolescents with mild to moderate depression.The mechanism of taVNS in the treatment of depression will also be investigated.The results of this study will provide evidence to guide the application of taVNS in adolescents with depression. 展开更多
关键词 DEPRESSION ADOLESCENT Transcutaneous auricular vagus nerve stimulation(taVNS)
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电刺激兔耳胃区对家兔胃电的影响 被引量:3
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作者 彭佩薇 周倩娜 +2 位作者 胡依平 陆美芬 卢献群 《广西中医药》 北大核心 1993年第3期42-44,共3页
采用胃窦前壁浆膜下插入不锈钢针型电极引导胃电,观察电刺激兔耳胃区对家兔胃电活动的影响。结果表明,电刺激兔耳胃区10分钟前、后及停止刺激10分钟后的胃电振幅幅值变化较大,并出现兴奋和抑制的双相效应,有非常显著的统计学意义(P<0... 采用胃窦前壁浆膜下插入不锈钢针型电极引导胃电,观察电刺激兔耳胃区对家兔胃电活动的影响。结果表明,电刺激兔耳胃区10分钟前、后及停止刺激10分钟后的胃电振幅幅值变化较大,并出现兴奋和抑制的双相效应,有非常显著的统计学意义(P<0.01);但对频率的影响不大。电刺激兔耳非胃区前、后的胃电振幅和频率无明显变化(P>0.6~0.8)。实验结果进一步证实耳穴的相对特导性是存在的,电刺激兔耳胃区对胃电活动具有双相调整作用及后作用,耳穴与内脏器官有着密切的联系。 展开更多
关键词 电刺激 兴奋 抑制 耳针疗法
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对耳穴刺激治疗高血压RCT试验报告质量的CONSORT评价 被引量:2
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作者 韩晓春 《辽宁中医药大学学报》 CAS 2012年第9期135-136,共2页
目的:采用CONSROT声明对国内利用耳穴刺激防治高血压病的随机对照试验进行科学评价。方法:系统检索中国生物医学文献数据库、中国知网、维普和万方4个数据库,将国内耳穴刺激防治高血压病的随机对照实验文献全部纳入,并采用国际公认的CON... 目的:采用CONSROT声明对国内利用耳穴刺激防治高血压病的随机对照试验进行科学评价。方法:系统检索中国生物医学文献数据库、中国知网、维普和万方4个数据库,将国内耳穴刺激防治高血压病的随机对照实验文献全部纳入,并采用国际公认的CONSORT声明进行质量评价。结果:共纳入13篇文献。根据CONSORT条目,在所有纳入文献中,有8篇(61.54%)缺乏文题和摘要;10篇(76.92%)提及受试者纳入排除标准;11篇(84.62%)谈到了研究所用的统计学方法 ;12篇(92.31%)报告了各组的人口学和临床基线资料;尚未有文献提及样本含量估计、分配隐藏、盲法及意向性分析。结论:目前国内耳穴刺激质量高血压病的研究报告质量较低。研究者应采用国际公认的CONSORT声明对临床研究进行规范报告。 展开更多
关键词 高血压 耳穴 CONSORT RCT 报告质量 评价
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Transcutaneous auricular vagus nerve stimulation for impaired glucose tolerance:a randomized controlled trial Protocol 被引量:2
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作者 Zi-xuan ZHANG Yue ZHANG +8 位作者 Shao-yuan LI Jin-ling ZHANG Zhao-hui LIU Yu-fan CHEN Dong WU Yu WANG Jun-ying WANG Yu-feng ZHAO Pei-jing RONG 《World Journal of Acupuncture-Moxibustion》 CSCD 2021年第2期160-164,共5页
Background:impaired glucose tolerance(IGT)is the early stage of diabetes and it would be deteriorated to type 2 diabetes mellitus(T2 DM)easily if no intervention provided.In western medicine,drug therapy assisted with... Background:impaired glucose tolerance(IGT)is the early stage of diabetes and it would be deteriorated to type 2 diabetes mellitus(T2 DM)easily if no intervention provided.In western medicine,drug therapy assisted with the intervention of lifestyle is predominated.However,drug therapy brings serious side effect and high prices,while lifestyle intervention is difficult to be insisted on by patients.Therefore,a green and effective intervention mode is urgently needed.Transcutaneous auricular vagus nerve stimulation(taVNS)is a noninvasive and green therapeutic method based on the theory of traditional Chinese medicine(TCM),which can regulate glucose metabolism and reduce blood glucose,but the clinical effect of it has not been clarified yet at present.Hence,this randomized controlled trial(RCT)aims at exploring the effectiveness and safety of taVNS in the treatment of IGT.Methods:a total of 158 patients with IGT will be randomized into a taVNS group and a transcutaneous non-auricular vagus nerve stimulation(tnVNS)group,79 cases in each one.In the taVNS group and the tnVNS group,electric stimulation would be applied to Yidan(胰胆pancreas and gallbladder,CO11)and Pi(脾spleen,CO13)on auricular concha and Jian(肩shoulder SF4,5)on auricular rim respectively.The electric stimulation parameters would be the same in the patients of two groups,for 30 min in each treatment,twice a day,6 weeks as one course and 2 courses of treatment required totally.In week 0,6 and 12 of intervention,the effectiveness indicators would be determined,i.e.fasting plasma glucose(FPG),2 h plasma glucose(2 hPG)and glycosylated hemoglobin(HbA1c)successively.On week 0 and 12,body mass index(BMI)would be calculated,respiration,pulse and blood pressure would be recorded separately.Discussion:through observing the regulatory effect of taVNS on FPG,2 hPG,HbAlc and BMI as well as the adverse reactions,the effectiveness and safety of taVNS in treatment of IGT would be evaluated.This study will provide a safe,effective,convenient and nontoxic side effect 展开更多
关键词 Impaired glucose tolerance transcutaneous auricular vagus nerve stimulation HYPOGLYCEMIC Clinical research PROTOCOL
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Transcutaneous auricular vague nerve stimulation improved brain connection activity on patients of disorders of consciousness: a pilot study 被引量:1
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作者 WANG Yifei YANG Yi +6 位作者 WANG Yu ZHANG Jinling ZHAI Weihang LI Shaoyuan WU Mozheng HE Jianghong RONG Peijing 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2022年第3期463-471,共9页
OBJECTIVE:To evaluate the clinical effect of transcutaneous auricular vagus nerve nerve stimulation(ta VNS)on disorders of consciousness(DOC)patients with Coma Recovery Scale-Revised(CRS-R)and cerebral cortex activity... OBJECTIVE:To evaluate the clinical effect of transcutaneous auricular vagus nerve nerve stimulation(ta VNS)on disorders of consciousness(DOC)patients with Coma Recovery Scale-Revised(CRS-R)and cerebral cortex activity by electroencephalogram(EEG)detection.METHODS:Randomized controlled methods were used to evaluate the clinical effect of ta VNS on patients with DOC.Twelve patients with initial CRS-R of 6-10 were randomly divided into the treatment group of ta VNS and control group of transcutaneous non-auricular vague nerve stimulation(tn VNS).According to clinical diagnosis,the treatment group was divided into vegetative state(VS)group and minimally conscious state(MCS)group.RESULTS:The energy of delta and beta bands is positively correlated with the brain activity of patients.ta VNS has different regulatory effects on patients with different conscious States.In ta VNS group,the energy of delta band in local brain regions changed significantly.Significant changes in brain connection activity were limited to local brain regions.While in patients with MCS in the ta VNS group,delta and beta band energy significantly changed in multiple brain regions and crossbrain connection activity also changed significantly.CONCLUSION:These findings suggest that ta VNS may be a related extra method for arousing patients’awakening by improving brain connection activity.And the effect is remarkable in MCS patients. 展开更多
关键词 consciousness disorders electroencephalography treatment outcome transcutaneous auricular vagus nerve stimulation brain connection activity
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Auricular vagus nerve acupressure for patients with emotional distress under the COVID-19 pandemic:A smartphone-based,randomized controlled trial 被引量:2
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作者 Peijing Rong Lei Wang +13 位作者 Lingling Yu Junying Wang Yan Ma Liting Wang Suxia Li Chunzhi Tang Liming Lu Liang Li Jiazi Dong Jiliang Fang Liwei Hou Zongshi Qin Xiaolan Su Zhangjin Zhang 《TMR Modern Herbal Medicine》 2021年第2期1-14,共14页
Objective: To confirm whether self-administered AVNA treatment is effective in improving emotional distressunder the COVID-19 pandemic.Methods: A smartphone-based online, randomized, controlled trial was designed from... Objective: To confirm whether self-administered AVNA treatment is effective in improving emotional distressunder the COVID-19 pandemic.Methods: A smartphone-based online, randomized, controlled trial was designed from 26 February 2020 to 28April 2020 in four study sites, including Wuhan, Beijing, Shenyang, and Guangzhou of China. Local residentswho had considerable emotional distress with a score of the Hospital Anxiety and Depression Scale (HADS) ≥9 were recruited. Participants were randomly assigned to three times of AVNA (n = 191) per day, in morning,around noon, and in evening or usual care (UC, n = 215) once daily for 14 days. The primary outcome was theresponse rate, which was the proportion of participants whose Hospital Anxiety and Depression Scale (HADS)score reduced from baseline by ≥ 50%. The assessment was conducted at baseline, 3 days, and 14 days.Results: The AVNA group had a markedly higher response rate than the UC group at 3 days (35.6% vs. 24.9%,P = 0.02) and at 14 days (70.7% vs. 60.6%, P = 0.02). The AVNA group showed significantly greater reductionin scores of HADS at the two measurement points and BAI at 3 days (P ≤ 0.03), with average respective effectsize of 0.217 and 0.195. Participants with AVNA spent less time falling asleep and rated their sleep qualitybeing remarkably higher than those with UC at endpoint.Conclusion: During COVID-19 pandemic period, treatment with self-administrated AVNA was more effectivethan UC in reducing emotional distress of isolated populations. These findings support self-administered AVNAas a treatment option for patients with emotional distress under the COVID-19 pandemic or other emergentevents. 展开更多
关键词 Neurology Psychiatry Emotional distress auricular vagus nerve stimulation COVID-19
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