目的研究血管紧张素转换酶(ACE)基因I/D多态位点与动脉血栓性脑梗死的关联性及相关机制。方法选取动脉血栓性脑梗死患者112例和年龄、性别匹配的对照组180例,采用PCR-AFLP技术对ACE基因I/D位点进行分型。结果单因素分析提示病例组收缩...目的研究血管紧张素转换酶(ACE)基因I/D多态位点与动脉血栓性脑梗死的关联性及相关机制。方法选取动脉血栓性脑梗死患者112例和年龄、性别匹配的对照组180例,采用PCR-AFLP技术对ACE基因I/D位点进行分型。结果单因素分析提示病例组收缩压水平(138.1±19.7 mm Hg)显著高于对照组(126.6±20.6 mm Hg)(t=4.716,P<0.001);病例组舒张压水平(88.9±10.1 mm Hg)显著高于对照组(79.9±10.0 mm Hg)(t=7.450,P<0.001)。病例组中ACE基因I/D位点D等位基因频率和DD基因型频率分布均显著高于对照组(等位基因:χ2=4.953,P=0.026;基因型:χ2=6.303,P=0.043)。病例组和对照组中ACE基因I/D位点基因型DD携带者收缩压及舒张压水平显著高于基因型ID及II携带者。结论 ACE基因I/D位点等位基因D可能是汉族人群动脉血栓性脑梗死遗传易感基因。等位基因D可能通过升高个体血压的机制导致动脉血栓性脑梗死发生。展开更多
BACKGROUND:According to the literature,generalized seizure as a presenting sign of stroke is rare,and in the reported cases it was accompanied by a focal neurological deficit.Presentation of a small ischemic atherothr...BACKGROUND:According to the literature,generalized seizure as a presenting sign of stroke is rare,and in the reported cases it was accompanied by a focal neurological deficit.Presentation of a small ischemic atherothrombotic brain infarction with convulsive generalized seizure is very rare.METHODS:We reported a patient with acute small ischemic atherothrombotic infarction associated with an episode of generalized tonic-clonic seizure,a rare clinical manifestation in this type of stroke.The patient was treated with anti-epileptic therapy after admission.RESULTS:The patient was discharged with oral administration of phenytoin 100 mg TDS,aspirin 80 mg daily,and atorvastatin 40 mg daily.CONCLUSION:Small ischemic atherothrombotic infarction can present only with a seizure without any focal neurological deficit.展开更多
文摘目的研究血管紧张素转换酶(ACE)基因I/D多态位点与动脉血栓性脑梗死的关联性及相关机制。方法选取动脉血栓性脑梗死患者112例和年龄、性别匹配的对照组180例,采用PCR-AFLP技术对ACE基因I/D位点进行分型。结果单因素分析提示病例组收缩压水平(138.1±19.7 mm Hg)显著高于对照组(126.6±20.6 mm Hg)(t=4.716,P<0.001);病例组舒张压水平(88.9±10.1 mm Hg)显著高于对照组(79.9±10.0 mm Hg)(t=7.450,P<0.001)。病例组中ACE基因I/D位点D等位基因频率和DD基因型频率分布均显著高于对照组(等位基因:χ2=4.953,P=0.026;基因型:χ2=6.303,P=0.043)。病例组和对照组中ACE基因I/D位点基因型DD携带者收缩压及舒张压水平显著高于基因型ID及II携带者。结论 ACE基因I/D位点等位基因D可能是汉族人群动脉血栓性脑梗死遗传易感基因。等位基因D可能通过升高个体血压的机制导致动脉血栓性脑梗死发生。
文摘BACKGROUND:According to the literature,generalized seizure as a presenting sign of stroke is rare,and in the reported cases it was accompanied by a focal neurological deficit.Presentation of a small ischemic atherothrombotic brain infarction with convulsive generalized seizure is very rare.METHODS:We reported a patient with acute small ischemic atherothrombotic infarction associated with an episode of generalized tonic-clonic seizure,a rare clinical manifestation in this type of stroke.The patient was treated with anti-epileptic therapy after admission.RESULTS:The patient was discharged with oral administration of phenytoin 100 mg TDS,aspirin 80 mg daily,and atorvastatin 40 mg daily.CONCLUSION:Small ischemic atherothrombotic infarction can present only with a seizure without any focal neurological deficit.
