The National Strong Motion Observation Network System （NSMONS） of China is briefly introduced in this paper. The NSMONS consists of permanent free-field stations, special observation arrays, mobile observatories and...The National Strong Motion Observation Network System （NSMONS） of China is briefly introduced in this paper. The NSMONS consists of permanent free-field stations, special observation arrays, mobile observatories and a network management system. During the Wenchuan Earthquake, over 1,400 components of acceleration records were obtained from 460 permanent free-field stations and three arrays for topographical effect and structural response observation in the network system from the main shock, and over 20,000 components of acceleration records from strong aftershocks occurred before August 1, 2008 were also obtained by permanent free-field stations of the NSMONS and 59 mobile instruments quickly deployed after the main shock. The strong motion recordings from the main shock and strong aftershocks are summarized in this paper. In the ground motion recordings, there are over 560 components with peak ground acceleration （PGA） over 10 Gal, the largest being 957.7 Gal. The largest PGA recorded during the aftershock exceeds 300 Gal.展开更多
A high-density single nucleotide polymorphism （SNP） array is critically important for geneticists and molecu- lar breeders. With the accumulation of huge amounts of genomic re-sequencing data and available technolog...A high-density single nucleotide polymorphism （SNP） array is critically important for geneticists and molecu- lar breeders. With the accumulation of huge amounts of genomic re-sequencing data and available technologies for accurate SNP detection, it is possible to design high-density and high-quality rice SNP arrays. Here we report the devel- opment of a high-density rice SNP array and its utility. SNP probes were designed by screening more than 10 000 000 SNP loci extracted from the re-sequencing data of 801 rice varieties and an array named RiceSNP50 was produced on the Illumina Infinium platform. The array contained 51 478 evenly distributed markers, 68% of which were within genic regions. Several hundred rice plants with parent/F1 relationships were used to generate a high-quality cluster file for accurate SNP calling. Application tests showed that this array had high genotyping accuracy, and could be used for dif- ferent objectives. For example, a core collection of elite rice varieties was clustered with fine resolution. Genome-wide association studies （GWAS） analysis correctly identified a characterized QTL. Further, this array was successfully used for variety verification and trait introgression. As an accurate high-throughput genotyping tool, RiceSNP50 will play an important role in both functional genomics studies and molecular breeding.展开更多
Gamma ray source detection above 30 TeV is an encouraging approach for finding galactic cosmic ray sources. All sky survey for gamma ray sources using wide field of view detector is essential for population accumulati...Gamma ray source detection above 30 TeV is an encouraging approach for finding galactic cosmic ray sources. All sky survey for gamma ray sources using wide field of view detector is essential for population accumulation for various types of sources above 100 GeV. In order to target those goals, a large air shower particle detector array of 1 km^2 （the LHAASO project） at 4300 m a.s.l, is proposed, By adding two MagicⅡ- type telescopes in the array as proposed, LHAASO will be enhanced in source morphologic investigation power. The proposed array will be utilized also for energy spectrum measurement for individual cosmic ray species above 30 TeV. By re-configuring the wide field of view telescopes into fluorescence light detector array, the aperture of the detector array can be enlarged to cover an energy region above 100 PeV where the second knee is located. Cosmic ray spectrum and composition will be measured in order to transfer an energy scale to ultra high energy cosmic ray experiments.展开更多
A monodispersed latex from styrene(St), methyl methacrylate(MMA) and acrylic acid(AA) was synthesized with the soap free emulsion polymerization, and the formation of colloidal crystal by evaporating the water of the ...A monodispersed latex from styrene(St), methyl methacrylate(MMA) and acrylic acid(AA) was synthesized with the soap free emulsion polymerization, and the formation of colloidal crystal by evaporating the water of the latex was investigated. It has been confirmed that there exist two array manners, i.e., hexagonal and square array, and two packing modes, i.e., hexagonal packing and face-centered cubic packing in the forming process of colloidal crystals. The square array originated from the dislocation of the particle in the hexagonal array, the area of it depends on the temperature in the forming process. At a lower temperature such as at 0 ℃, relatively large areas of square array were observed in the formed colloidal crystal.展开更多
Objective： To investigate the effect of Qiguiyin Decoction （芪归银方, QGYD） on multidrug-resistant Pseudomonas aeruginosa infection in Sprague-Dawley （SD） rats. Methods： A pseudomonal infection model in SD rats ...Objective： To investigate the effect of Qiguiyin Decoction （芪归银方, QGYD） on multidrug-resistant Pseudomonas aeruginosa infection in Sprague-Dawley （SD） rats. Methods： A pseudomonal infection model in SD rats was established by injecting multidrug-resistant P. aeruginosa intraperitoneally. Infected rats were randomized into four groups treated with Pure water, QGYD, ceftazidime, or combined QGYD and ceftazidime. Blood samples were obtained from the abdominal aorta. Serum was then collected and analyzed by peptide array for immune responsiveness to multidrug-resistant beta-lactamase proteins, including Verona integronencoded metailo-beta-lactamase 1 （VIM-l）, Sao Paulo metallo-beta-lactamase 1 （SPM-1）, and Temoniera （TEMs）. Blood levels of interleukin-113 （IL-113）, interleukin-4 （IL-4）, and interferon-γ （IFN-γ） were assessed by enzyme-linked immunosorbent assay. Results： QGYD enhanced antibody reactivity against VIM-1 [epitopes 7-11 and 36-40] and TEM-1 [epitopes 26-27, 52-55, and 66-70]. QGYD treatment restored the compromised antibody reactivity against VIM-1 [epitopes 53-54 and 56-58] and SPM-1 [epitopes 16-19 and 82-85] following pseudomonal infection. Serum levels of IL-113 and Thl/＇l-h2 in the rats were significantly elevated following pseudomonal infection （P〈0.05 or P〈0.01）. In contrast, QGYD and combination QGYD and ceftazidime treatment restored the elevated serum IL-1β and Thl/-rh2 levels to normal （P〉0.05）. Conclusions： QGYD improves the immune response to pseudomonal infection in rats by stimulating the production of protective antibodies against drug-resistant proteins VIM-1, SPM-1, and TEM-1. In addition, it protects the immune system and maintains immune responsiveness by restoring IL-1β and Thl/Th2 levels.展开更多
基金NSFC Under Grant No. 90715038MOST of China Under Grant No. 2006BAC13B02
文摘The National Strong Motion Observation Network System （NSMONS） of China is briefly introduced in this paper. The NSMONS consists of permanent free-field stations, special observation arrays, mobile observatories and a network management system. During the Wenchuan Earthquake, over 1,400 components of acceleration records were obtained from 460 permanent free-field stations and three arrays for topographical effect and structural response observation in the network system from the main shock, and over 20,000 components of acceleration records from strong aftershocks occurred before August 1, 2008 were also obtained by permanent free-field stations of the NSMONS and 59 mobile instruments quickly deployed after the main shock. The strong motion recordings from the main shock and strong aftershocks are summarized in this paper. In the ground motion recordings, there are over 560 components with peak ground acceleration （PGA） over 10 Gal, the largest being 957.7 Gal. The largest PGA recorded during the aftershock exceeds 300 Gal.
基金grants from the National High Technology Research and Development Program of China，the National Program on Key Basic Research Project of China，the National Natural Science Foundation of China，Guangdong Innovative Research Team Program，the Ministry of Agriculture of China
文摘A high-density single nucleotide polymorphism （SNP） array is critically important for geneticists and molecu- lar breeders. With the accumulation of huge amounts of genomic re-sequencing data and available technologies for accurate SNP detection, it is possible to design high-density and high-quality rice SNP arrays. Here we report the devel- opment of a high-density rice SNP array and its utility. SNP probes were designed by screening more than 10 000 000 SNP loci extracted from the re-sequencing data of 801 rice varieties and an array named RiceSNP50 was produced on the Illumina Infinium platform. The array contained 51 478 evenly distributed markers, 68% of which were within genic regions. Several hundred rice plants with parent/F1 relationships were used to generate a high-quality cluster file for accurate SNP calling. Application tests showed that this array had high genotyping accuracy, and could be used for dif- ferent objectives. For example, a core collection of elite rice varieties was clustered with fine resolution. Genome-wide association studies （GWAS） analysis correctly identified a characterized QTL. Further, this array was successfully used for variety verification and trait introgression. As an accurate high-throughput genotyping tool, RiceSNP50 will play an important role in both functional genomics studies and molecular breeding.
基金Supported by Knowledge Innovation Fund (U-526) of IHEP,China
文摘Gamma ray source detection above 30 TeV is an encouraging approach for finding galactic cosmic ray sources. All sky survey for gamma ray sources using wide field of view detector is essential for population accumulation for various types of sources above 100 GeV. In order to target those goals, a large air shower particle detector array of 1 km^2 （the LHAASO project） at 4300 m a.s.l, is proposed, By adding two MagicⅡ- type telescopes in the array as proposed, LHAASO will be enhanced in source morphologic investigation power. The proposed array will be utilized also for energy spectrum measurement for individual cosmic ray species above 30 TeV. By re-configuring the wide field of view telescopes into fluorescence light detector array, the aperture of the detector array can be enlarged to cover an energy region above 100 PeV where the second knee is located. Cosmic ray spectrum and composition will be measured in order to transfer an energy scale to ultra high energy cosmic ray experiments.
文摘A monodispersed latex from styrene(St), methyl methacrylate(MMA) and acrylic acid(AA) was synthesized with the soap free emulsion polymerization, and the formation of colloidal crystal by evaporating the water of the latex was investigated. It has been confirmed that there exist two array manners, i.e., hexagonal and square array, and two packing modes, i.e., hexagonal packing and face-centered cubic packing in the forming process of colloidal crystals. The square array originated from the dislocation of the particle in the hexagonal array, the area of it depends on the temperature in the forming process. At a lower temperature such as at 0 ℃, relatively large areas of square array were observed in the formed colloidal crystal.
基金Supported by the Ministry of National Science and Technology Project "Significant New Drugs Creation"(No.2009ZX09103-415,2013ZX09102026)the National Natural Science Foundation of China(No.81102777)the Beijing Key Laboratory(No.bjszd003)
文摘Objective： To investigate the effect of Qiguiyin Decoction （芪归银方, QGYD） on multidrug-resistant Pseudomonas aeruginosa infection in Sprague-Dawley （SD） rats. Methods： A pseudomonal infection model in SD rats was established by injecting multidrug-resistant P. aeruginosa intraperitoneally. Infected rats were randomized into four groups treated with Pure water, QGYD, ceftazidime, or combined QGYD and ceftazidime. Blood samples were obtained from the abdominal aorta. Serum was then collected and analyzed by peptide array for immune responsiveness to multidrug-resistant beta-lactamase proteins, including Verona integronencoded metailo-beta-lactamase 1 （VIM-l）, Sao Paulo metallo-beta-lactamase 1 （SPM-1）, and Temoniera （TEMs）. Blood levels of interleukin-113 （IL-113）, interleukin-4 （IL-4）, and interferon-γ （IFN-γ） were assessed by enzyme-linked immunosorbent assay. Results： QGYD enhanced antibody reactivity against VIM-1 [epitopes 7-11 and 36-40] and TEM-1 [epitopes 26-27, 52-55, and 66-70]. QGYD treatment restored the compromised antibody reactivity against VIM-1 [epitopes 53-54 and 56-58] and SPM-1 [epitopes 16-19 and 82-85] following pseudomonal infection. Serum levels of IL-113 and Thl/＇l-h2 in the rats were significantly elevated following pseudomonal infection （P〈0.05 or P〈0.01）. In contrast, QGYD and combination QGYD and ceftazidime treatment restored the elevated serum IL-1β and Thl/-rh2 levels to normal （P〉0.05）. Conclusions： QGYD improves the immune response to pseudomonal infection in rats by stimulating the production of protective antibodies against drug-resistant proteins VIM-1, SPM-1, and TEM-1. In addition, it protects the immune system and maintains immune responsiveness by restoring IL-1β and Thl/Th2 levels.
