目的 初步探讨脉搏血氧波形相关参数包括波幅（Amp）、曲线下面积（AUC）反映机体前负荷变化的意义.方法 观察22名清醒的健康志愿者在被动抬腿试验（PLR）过程中脉搏血氧相关参数及心率（HR）、血压的变化情况.结果 受试者基线状态下HR...目的 初步探讨脉搏血氧波形相关参数包括波幅（Amp）、曲线下面积（AUC）反映机体前负荷变化的意义.方法 观察22名清醒的健康志愿者在被动抬腿试验（PLR）过程中脉搏血氧相关参数及心率（HR）、血压的变化情况.结果 受试者基线状态下HR与PLR时比较差异无统计学意义[（72.1±11.3）次/min vs （70.1±11.3）次/min,P=0.10）;而平均动脉压（MAP）[（86.0±8.4）mm Hg vs （77.3±8.9） mm Hg,P＜0.01）、脉搏血氧波形Amp（1043±585 vs2140±1101,P＜0.01）、AUC（4931±544 vs 5612±540,P＜0.01）在基线与PLR3 min时比较差异有统计学意义.结论 脉搏血氧波形Amp与AUC在PLR中表现出明显变化,表明脉搏血氧波形波幅与AUC可以反映有效循环血容量变化,脉搏血氧波形（PPG）可能成为便捷、无创、实时的监测循环前负荷工具.展开更多
Bilharzia is vector-borne disease carried by a parasite that is hosted by fresh water snails. The distribution of the disease is concurrent with the existence of the freshwater snails and </span></span><...Bilharzia is vector-borne disease carried by a parasite that is hosted by fresh water snails. The distribution of the disease is concurrent with the existence of the freshwater snails and </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">is </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">dependent on certain suitable environmental conditions. It is difficult to identify the specific habitats of the snails as they are often inaccessible on the ground, the snails also migrate by means of flowing water, making it difficult to keep a track of the freshwater snails’ habitat. This paper aimed at using GIS, Remote Sensing and Species Distribution Modelling techniques to model the suitable habitats for the freshwater snails and to prove that the snails migrate when there are sudden changes in water levels whilst showing the population at risk of bilharzia. The SDM used is the Maximum Entropy (MAXENT) for its ability to make right predictions even with small presence sites. The AUC value of the model was 0.951. The research results showed that the environmental variables;brightness Index, elevation, temperatures were negatively correlated with the snails’ presence while the wetness index, MSAVI, greenness index and soil pH were positively correlated. The snails are observed to favor clay soils of the montmorillonite type and the crop-lands land cover. Areas consistently submerged by water especially after flooding are shown to be the most suitable areas where snails migrate by means of river or canal water. The research proves that Mwea is not the source habitat of the freshwater snails. The neighboring sub-counties within Kirinyaga County should be investigated using such models as a likely source-habitat of the freshwater snails. Destroying the source habitats will lead to complete eradication of the freshwater snails within Mwea.展开更多
文摘目的 初步探讨脉搏血氧波形相关参数包括波幅（Amp）、曲线下面积（AUC）反映机体前负荷变化的意义.方法 观察22名清醒的健康志愿者在被动抬腿试验（PLR）过程中脉搏血氧相关参数及心率（HR）、血压的变化情况.结果 受试者基线状态下HR与PLR时比较差异无统计学意义[（72.1±11.3）次/min vs （70.1±11.3）次/min,P=0.10）;而平均动脉压（MAP）[（86.0±8.4）mm Hg vs （77.3±8.9） mm Hg,P＜0.01）、脉搏血氧波形Amp（1043±585 vs2140±1101,P＜0.01）、AUC（4931±544 vs 5612±540,P＜0.01）在基线与PLR3 min时比较差异有统计学意义.结论 脉搏血氧波形Amp与AUC在PLR中表现出明显变化,表明脉搏血氧波形波幅与AUC可以反映有效循环血容量变化,脉搏血氧波形（PPG）可能成为便捷、无创、实时的监测循环前负荷工具.
文摘目的孤立性肺结节(solitary pulmonary nodule,SPN)的定性诊断十分困难,PET/CT是目前评价良、恶性病变最具优势的影像学手段之一。文中用Meta分析方法综合评价18F-脱氧葡萄糖(18Fluorodexglucose,FDG)PET/CT显像诊断恶性孤立性肺结节的价值。方法以孤立性肺结节、FDG、PET/CT等为检索词,检索1994年1月至2009年7月的Medline数据库、西文生物医学期刊文献服务系统、外文生物医学期刊全文数据库、中国学术期刊网全文数据库等相关中英文文献。对符合标准的研究进行质量评估,用MetaDisc1.4软件进行异质性检验,综合敏感性、特异性和诊断优势比,绘制汇总受试者工作特征(summary receiver operating characteristic,SROC)曲线和计算曲线下面积(the area under the curve,AUC),并进行敏感性分析。结果共检索相关文献29篇,其中11篇符合标准纳入分析,A级1篇,B级10篇,各研究之间存在异质性,按照随机效应模型合并敏感性、特异性、诊断优势比(diagnostic odds ratio,DOR)及其95%可信区间分别为91%(87%~93%)、83%(78%~87%)和51.04(23.33~111.66),AUC为0.9383,Q值为0.875 3,纳入文献稳定性较好。结论 18F-FDG PET/CT显像能灵敏、准确地诊断恶性孤立性肺结节,具有较高的临床应用价值。
文摘Bilharzia is vector-borne disease carried by a parasite that is hosted by fresh water snails. The distribution of the disease is concurrent with the existence of the freshwater snails and </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">is </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">dependent on certain suitable environmental conditions. It is difficult to identify the specific habitats of the snails as they are often inaccessible on the ground, the snails also migrate by means of flowing water, making it difficult to keep a track of the freshwater snails’ habitat. This paper aimed at using GIS, Remote Sensing and Species Distribution Modelling techniques to model the suitable habitats for the freshwater snails and to prove that the snails migrate when there are sudden changes in water levels whilst showing the population at risk of bilharzia. The SDM used is the Maximum Entropy (MAXENT) for its ability to make right predictions even with small presence sites. The AUC value of the model was 0.951. The research results showed that the environmental variables;brightness Index, elevation, temperatures were negatively correlated with the snails’ presence while the wetness index, MSAVI, greenness index and soil pH were positively correlated. The snails are observed to favor clay soils of the montmorillonite type and the crop-lands land cover. Areas consistently submerged by water especially after flooding are shown to be the most suitable areas where snails migrate by means of river or canal water. The research proves that Mwea is not the source habitat of the freshwater snails. The neighboring sub-counties within Kirinyaga County should be investigated using such models as a likely source-habitat of the freshwater snails. Destroying the source habitats will lead to complete eradication of the freshwater snails within Mwea.
