目的观察依折麦布联合非诺贝特治疗混合型高脂血症的临床疗效和安全性。方法选择2012年8月-2014年10月于我院确诊的混合型高脂血症患者128例,随机分为两组各64例。对照组给予非诺贝特（200mg/d）治疗,观察组给予依折麦布（20mg/d）和非...目的观察依折麦布联合非诺贝特治疗混合型高脂血症的临床疗效和安全性。方法选择2012年8月-2014年10月于我院确诊的混合型高脂血症患者128例,随机分为两组各64例。对照组给予非诺贝特（200mg/d）治疗,观察组给予依折麦布（20mg/d）和非诺贝特（200mg/d）联合治疗3个月,检测两组患者治疗前后的总胆固醇（total cholesterol,TC）、三酰甘油（triglyceride,TG）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol,LDL-C）和高密度脂蛋白胆固醇（high density lipoprotein cholesterol,HDL-C）水平,并分析比较治疗效果和安全性。结果 1与治疗前比较,两组患者治疗后的TC、TG、LDL-C水平均明显降低,差异均有统计学意义（均P〈0.05）,而HDL-C水平明显升高,差异亦有统计学意义（P〈0.05）;与对照组比较,联合治疗后观察组的TC、TG、LDL-C水平均降低,差异均有统计学意义（均P〈0.05）,而HDL-C水平增高,差异亦有统计学意义（P〈0.05）。2观察组的总有效率（93.75%）明显高于对照组（76.56%）,差异有统计学意义（P〈0.05）。3观察组出现不良反应的总比例显著低于对照组,差异有统计学意义（P〈0.05）。结论与单用非诺贝特相比,依折麦布联合非诺贝特能更有效地降低混合型高脂血症患者的血脂水平,且安全性较高,弥补了单用贝特类药物降脂的局限性。展开更多
Obesity that is highly associated with numerous metabolic diseases has become a global health issue nowdays.Plant sesterterpenoids are an important group of natural products with great potential;thus,their bioactiviti...Obesity that is highly associated with numerous metabolic diseases has become a global health issue nowdays.Plant sesterterpenoids are an important group of natural products with great potential;thus,their bioactivities deserve extensive exploration.RNA-seq analysis indicated that leucosceptroid B,a sesterterpenoid previously discovered from the glandular trichomes of Leucosceptrum canum,significantly regulated the expression of 10 genes involved in lipid metabolism in Caenorhabditis elegans.Furthermore,leucosceptroid B was found to reduce fat storage,and downregulate the expression of two stearoyl-CoA desaturase(SCD)genes fat-6 and fat-7,and a fatty acid elongase gene elo-2 in wild-type C.elegans.In addition,leucosceptroid B significantly decreased fat accumulation in both fat-6 and fat-7 mutant worms but did not affect the fat storage of fat-6;fat-7 double mutant.These findings indicated that leucosceptroid B reduced fat storage depending on the downregulated expression of fat-6,fat-7 and elo-2 and thereby inhibiting the biosynthesis of the corresponding unsaturated fatty acid.These findings provide new insights into the development and utilization of plant sesterterpenoids as potential antilipemic agents.展开更多
文摘目的观察依折麦布联合非诺贝特治疗混合型高脂血症的临床疗效和安全性。方法选择2012年8月-2014年10月于我院确诊的混合型高脂血症患者128例,随机分为两组各64例。对照组给予非诺贝特（200mg/d）治疗,观察组给予依折麦布（20mg/d）和非诺贝特（200mg/d）联合治疗3个月,检测两组患者治疗前后的总胆固醇（total cholesterol,TC）、三酰甘油（triglyceride,TG）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol,LDL-C）和高密度脂蛋白胆固醇（high density lipoprotein cholesterol,HDL-C）水平,并分析比较治疗效果和安全性。结果 1与治疗前比较,两组患者治疗后的TC、TG、LDL-C水平均明显降低,差异均有统计学意义（均P〈0.05）,而HDL-C水平明显升高,差异亦有统计学意义（P〈0.05）;与对照组比较,联合治疗后观察组的TC、TG、LDL-C水平均降低,差异均有统计学意义（均P〈0.05）,而HDL-C水平增高,差异亦有统计学意义（P〈0.05）。2观察组的总有效率（93.75%）明显高于对照组（76.56%）,差异有统计学意义（P〈0.05）。3观察组出现不良反应的总比例显著低于对照组,差异有统计学意义（P〈0.05）。结论与单用非诺贝特相比,依折麦布联合非诺贝特能更有效地降低混合型高脂血症患者的血脂水平,且安全性较高,弥补了单用贝特类药物降脂的局限性。
基金supported by the National Science Fund for Distinguished Young Scholars(No.31525005)National Natural Science Foundation of China(Nos.21937006,31770390 and 31800298)+3 种基金Yunnan Key Research and Development Program(No.2019ZF011-2)Yunnan Innovative Research Team for Discovery and Biosynthesis of Bioactive Natural Products(No.2018HC012)Science Foundation of Yunnan(No.2018FA017)Youth Innovation Promotion Association and “Western Light” Program of CAS(awarded to LIU Yan)
文摘Obesity that is highly associated with numerous metabolic diseases has become a global health issue nowdays.Plant sesterterpenoids are an important group of natural products with great potential;thus,their bioactivities deserve extensive exploration.RNA-seq analysis indicated that leucosceptroid B,a sesterterpenoid previously discovered from the glandular trichomes of Leucosceptrum canum,significantly regulated the expression of 10 genes involved in lipid metabolism in Caenorhabditis elegans.Furthermore,leucosceptroid B was found to reduce fat storage,and downregulate the expression of two stearoyl-CoA desaturase(SCD)genes fat-6 and fat-7,and a fatty acid elongase gene elo-2 in wild-type C.elegans.In addition,leucosceptroid B significantly decreased fat accumulation in both fat-6 and fat-7 mutant worms but did not affect the fat storage of fat-6;fat-7 double mutant.These findings indicated that leucosceptroid B reduced fat storage depending on the downregulated expression of fat-6,fat-7 and elo-2 and thereby inhibiting the biosynthesis of the corresponding unsaturated fatty acid.These findings provide new insights into the development and utilization of plant sesterterpenoids as potential antilipemic agents.
