Exploring the predator prey linkage in food chain system is the most familiar research work in population biology.Recently,some research experiments show that predator-prey interaction not only governed by direct hunt...Exploring the predator prey linkage in food chain system is the most familiar research work in population biology.Recently,some research experiments show that predator-prey interaction not only governed by direct hunting but also influenced by some indirect effect such as fear effect(felt by prey)that may change the physiological behavior of prey.Based upon this fact,we consider a tritrophic food chain model incorporating with anti-predation response(fear effect)and multiple time delays for biomass conversion from prey to middle predator and middle to top predator.We analyze the resulting delay differential equations and explore how the anti-predation response level affects the population dynamics.We also investigate the effect of delay parameters,for which the model system switches its stability through Hopf-bifurcation.We compare all of our results between two different food chain models consisting of two different functional responses.Some numerical simulations are performed to validate the effectiveness of the derived theoretical results.展开更多
由于核桃Jug r 2是核桃中的主要过敏原,Jug r 2的线性表位是引发核桃过敏反应的关键因素,因此筛选Jug r 2线性表位工作是必要的。本研究利用免疫信息学中的DNAStar Protean系统和ABCpred在线工具预测Jug r 2中的B细胞线性表位。利用体...由于核桃Jug r 2是核桃中的主要过敏原,Jug r 2的线性表位是引发核桃过敏反应的关键因素,因此筛选Jug r 2线性表位工作是必要的。本研究利用免疫信息学中的DNAStar Protean系统和ABCpred在线工具预测Jug r 2中的B细胞线性表位。利用体外模拟胃肠消化和HPLC-MS/MS对抗消化肽段的一级序列进行分析,并对两种免疫信息学工具预测得到的B细胞线性表位和抗消化肽段在Jug r 2模拟三维结构上进行定位分析。结果表明:预测得到8个B细胞线性表位(AA186~199、AA226~230、AA257~263、AA284~289、AA373~382、AA389~398、AA408~414、AA472~487)和11个抗消化肽段(AA215~220、AA250~260、AA323~337、AA351~356、AA363~388、AA428~438、AA470~483、AA488~513、AA514~526、AA527~541、AA545~572)。在抗消化肽段中,4条与预测或已知真实的B细胞线性表位序列重合,8条与已知真实的T细胞表位序列重合,并且抗消化肽段在Jug r 2三维结构的定位中表现出亲水性和柔韧性的良好抗原性质。综上,研究食物过敏原的耐消化特性可能是研究Jug r 2的线性表位的一个潜在策略。展开更多
文摘Exploring the predator prey linkage in food chain system is the most familiar research work in population biology.Recently,some research experiments show that predator-prey interaction not only governed by direct hunting but also influenced by some indirect effect such as fear effect(felt by prey)that may change the physiological behavior of prey.Based upon this fact,we consider a tritrophic food chain model incorporating with anti-predation response(fear effect)and multiple time delays for biomass conversion from prey to middle predator and middle to top predator.We analyze the resulting delay differential equations and explore how the anti-predation response level affects the population dynamics.We also investigate the effect of delay parameters,for which the model system switches its stability through Hopf-bifurcation.We compare all of our results between two different food chain models consisting of two different functional responses.Some numerical simulations are performed to validate the effectiveness of the derived theoretical results.
文摘由于核桃Jug r 2是核桃中的主要过敏原,Jug r 2的线性表位是引发核桃过敏反应的关键因素,因此筛选Jug r 2线性表位工作是必要的。本研究利用免疫信息学中的DNAStar Protean系统和ABCpred在线工具预测Jug r 2中的B细胞线性表位。利用体外模拟胃肠消化和HPLC-MS/MS对抗消化肽段的一级序列进行分析,并对两种免疫信息学工具预测得到的B细胞线性表位和抗消化肽段在Jug r 2模拟三维结构上进行定位分析。结果表明:预测得到8个B细胞线性表位(AA186~199、AA226~230、AA257~263、AA284~289、AA373~382、AA389~398、AA408~414、AA472~487)和11个抗消化肽段(AA215~220、AA250~260、AA323~337、AA351~356、AA363~388、AA428~438、AA470~483、AA488~513、AA514~526、AA527~541、AA545~572)。在抗消化肽段中,4条与预测或已知真实的B细胞线性表位序列重合,8条与已知真实的T细胞表位序列重合,并且抗消化肽段在Jug r 2三维结构的定位中表现出亲水性和柔韧性的良好抗原性质。综上,研究食物过敏原的耐消化特性可能是研究Jug r 2的线性表位的一个潜在策略。
