Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus, and more than 4,000 different flavonoids have been described and categorized into flavonols, flavones, flavanones, isoflavones, ...Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus, and more than 4,000 different flavonoids have been described and categorized into flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids occurs naturally in fruits, vegetables, nuts, and beverages such as coffee, tea, and red wine, as well as in medical herbs. Flavonoids are responsible for the different colors of plant parts and are important constituents of the human diet. Flavanoids have different pharmacological activities, such as antioxidant, anti-allergic, antibacterial, anti-inflammatory, antimutagenic and anticancer activity. Naringenin belongs to the flavanones and is mainly found in fruits（grapefruit and oranges） and vegetables. Pharmacologically, it has anticancer, antimutagenic, anti-inflammatory, antioxidant, antiproliferative and antiatherogenic activities. Naringenin is used for the treatments of osteoporosis, cancer and cardiovascular diseases, and showed lipid-lowering and insulin-like properties. In the present review, detailed pharmacological and analytical aspects of naringenin have been presented, which revealed the impressive pharmacological profile and the possible usefulness in the treatment of different types of diseases in the future. The information provided in this communication will act as an important source for development of effective medicines for the treatment of various disorders.展开更多
Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 18...Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring.Harmine has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic properties.It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant effect.Harmine prevents bone loss by suppressing osteoclastogenesis.The current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases.展开更多
Plants have been used as a source for food material and natural remedies for the treatment of vast range of diseases. Nature provides us remedies for the treatment of various types of disorders ranging from simpte ait...Plants have been used as a source for food material and natural remedies for the treatment of vast range of diseases. Nature provides us remedies for the treatment of various types of disorders ranging from simpte aitments to complicated diseases. Plants are known to possess different pharmacological activities due to the presence of various phytoconstituents, Flavonoids are one of the main active phytoconstituents found in fruits, vegetables, wines, tea and cocoa. Flavonoids exhibit various pharmacological activities such as antioxidant, anti-inflammatory, anti-allergic, antibacterial, oestrogenic, cytotoxic antitumoural, hepatoprotective, antithrombotic and antiviral activity. Diosmetin （3＇, 5, 7-trihydroxy-4＇-methoxyflavone）, the aglycone part of the flavonoid glycosides diosmin occurs naturally in citrus fruit. Although it is found in herbal medicines and plays an important role in the treatment of various ailments, only limited scientific researches have been conducted. The aim of this review is to collect all available scientific literature published on diosmetin and combine it into this paper. This review contains an overview of pharmacological activities, isolation techniques and analytical techniques for diosmetin. Thus, valuable information provided in the present review will help researchers in developing alternative methods for the treatment of diseases from diosmetin.展开更多
Barbaloin is C-glucoside of aloe emodin unthrone which is found in the plant name as Aloe vera is a perennial succulenl(Liliaceal),also called the healing planl.Barbaloin have variety of pharmacological activity such ...Barbaloin is C-glucoside of aloe emodin unthrone which is found in the plant name as Aloe vera is a perennial succulenl(Liliaceal),also called the healing planl.Barbaloin have variety of pharmacological activity such as strong inhibitory effect on histamine release,anti-inflammatory,cathartic,antiviral,antimicrobial,anticancer,antioxidant activity and alternative for pharmaceutical or cosmetic applications.The peak amount of barbaloin was reached about 3 h after oral administration.Concentration of barbaloin in Aloe vera leaves was shown to depend on the leaf part,age,and position of the leaf.Young leaves contain more barbaloin compared to old one.Various researches have been done on barbaloin but still the relationship between the barbaloin and its overall effect has not been clarified.A more specific;perceptive of the pharmacological activities of barbaloin is required to develop for pharmaceutical purpose.Many attempts have been made regarding its isolation,biological activity to examine their effects,and clarify their functional mechanism.This review gives a brief idea about its uses,ethnomedicinally and commercially important analytical techniques and their pharmacological activities.展开更多
Diosgenin is a steroidal sapogenin found in plants such as Dioscorea nipponoca,Solanum incanum,Solanum xanthocarpum and Trigonella foenum graecum.Diosgenin,biologically active phytochemicals have been used for the tre...Diosgenin is a steroidal sapogenin found in plants such as Dioscorea nipponoca,Solanum incanum,Solanum xanthocarpum and Trigonella foenum graecum.Diosgenin,biologically active phytochemicals have been used for the treatment of various types of disorder such as leukemia,inflammation,hypercholesterolemia and cancer.It is also able to prevent bone loss to the same extent as that of oestrogen.It is a typical initial intermediate for synthesis of steroidal compounds,oral contraceptives and sex hormones.Dioscorea,Costus and Trigonella are mainly used for the production of diosgenin.On the basis of literature survey it divulges that diosgenin has very impressive pharmacological profile and could be used as a medicine for the treatment of different types of disorders in the future.Thus,the present work aims to provide collective information in concern with its pharmacological activity and phytoanalytical techniques.This review will be beneficial to researches for the development of an alternative method for the treatment of innumerable diseases from diosgenin.展开更多
Objective:To isolate and characterize the bioactive secondary metabolites from Aspergillus ochraceus(A.ochraceus)MP2 fungi.Methods:The anti bacterial activity of marine sponge derived fungi A.ochraceus MP2 was thoroug...Objective:To isolate and characterize the bioactive secondary metabolites from Aspergillus ochraceus(A.ochraceus)MP2 fungi.Methods:The anti bacterial activity of marine sponge derived fungi A.ochraceus MP2 was thoroughly investigated against antagonistic human pathogens.The optimum inhibitory concentration of the fungi in the elite solvent was also determined.The promising extracts that showed good antimicrobial activity were subjected to further analytical separation to get individual distinct metabolites and the eluants were further identified by GC MS instrumental analysis.The molecular characterization of the elite fungal strains were done by isolating their genomic DNA and amplify the internal transcribed spacer(US)region of 5.8s rRNA using specific ITS primer.The novelty of the strain was proved by homology search tools and elite sequences was submitted to GENBANK.Results:Three bioactive compounds were characterized to reveal their identity,chemical formula and structure.The first elutant was identified asα-Campholene aldehyde with chemical fonnula C_(10)H_(16)O and molecular weight 152 Da.The second elutant was identified as Lucenin-2 and chemical fonnula C_(27)H_(30)O_(16)and molecular weight 610Da.The third elutant was identified as 6-Ethyloct-3-yl-2-ethylhexyl ester with Chemical fonnula C_(26)H_(42)O_4 with molecular weight 418 Da.Conclusions:The isolated compounds showed significant antimicrobial activity against potential human pathogens.Microbial secondary metabolites represent a large source of compounds endowed with ingenious structures and potent biological activities.展开更多
We present a spectroscopic catalog of 93 619 M dwarfs from the first data release of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST）general survey. During sample selection, M giant contaminatio...We present a spectroscopic catalog of 93 619 M dwarfs from the first data release of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST）general survey. During sample selection, M giant contamination was eliminated using2 MASS photometry and Ca H/TiO molecular indices. For each spectrum, the spectral subtype and values are provided including radial velocity, Hα equivalent width, a series of prominent molecular band indices, and the metal–sensitive parameter ζ, as well as distances and the space motions for high S/N objects. In addition, Hα emission lines are measured to examine the magnetic activity properties of M dwarfs and 7179 active ones are found. In particular, a subsample with significant variation in magnetic activity is revealed through observations from different epochs. Finally, statistical analysis for this sample is performed, including the metallicity classification, the distribution of molecular band indices and their errors.展开更多
文摘Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus, and more than 4,000 different flavonoids have been described and categorized into flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids occurs naturally in fruits, vegetables, nuts, and beverages such as coffee, tea, and red wine, as well as in medical herbs. Flavonoids are responsible for the different colors of plant parts and are important constituents of the human diet. Flavanoids have different pharmacological activities, such as antioxidant, anti-allergic, antibacterial, anti-inflammatory, antimutagenic and anticancer activity. Naringenin belongs to the flavanones and is mainly found in fruits（grapefruit and oranges） and vegetables. Pharmacologically, it has anticancer, antimutagenic, anti-inflammatory, antioxidant, antiproliferative and antiatherogenic activities. Naringenin is used for the treatments of osteoporosis, cancer and cardiovascular diseases, and showed lipid-lowering and insulin-like properties. In the present review, detailed pharmacological and analytical aspects of naringenin have been presented, which revealed the impressive pharmacological profile and the possible usefulness in the treatment of different types of diseases in the future. The information provided in this communication will act as an important source for development of effective medicines for the treatment of various disorders.
文摘Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring.Harmine has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic properties.It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant effect.Harmine prevents bone loss by suppressing osteoclastogenesis.The current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases.
文摘Plants have been used as a source for food material and natural remedies for the treatment of vast range of diseases. Nature provides us remedies for the treatment of various types of disorders ranging from simpte aitments to complicated diseases. Plants are known to possess different pharmacological activities due to the presence of various phytoconstituents, Flavonoids are one of the main active phytoconstituents found in fruits, vegetables, wines, tea and cocoa. Flavonoids exhibit various pharmacological activities such as antioxidant, anti-inflammatory, anti-allergic, antibacterial, oestrogenic, cytotoxic antitumoural, hepatoprotective, antithrombotic and antiviral activity. Diosmetin （3＇, 5, 7-trihydroxy-4＇-methoxyflavone）, the aglycone part of the flavonoid glycosides diosmin occurs naturally in citrus fruit. Although it is found in herbal medicines and plays an important role in the treatment of various ailments, only limited scientific researches have been conducted. The aim of this review is to collect all available scientific literature published on diosmetin and combine it into this paper. This review contains an overview of pharmacological activities, isolation techniques and analytical techniques for diosmetin. Thus, valuable information provided in the present review will help researchers in developing alternative methods for the treatment of diseases from diosmetin.
文摘Barbaloin is C-glucoside of aloe emodin unthrone which is found in the plant name as Aloe vera is a perennial succulenl(Liliaceal),also called the healing planl.Barbaloin have variety of pharmacological activity such as strong inhibitory effect on histamine release,anti-inflammatory,cathartic,antiviral,antimicrobial,anticancer,antioxidant activity and alternative for pharmaceutical or cosmetic applications.The peak amount of barbaloin was reached about 3 h after oral administration.Concentration of barbaloin in Aloe vera leaves was shown to depend on the leaf part,age,and position of the leaf.Young leaves contain more barbaloin compared to old one.Various researches have been done on barbaloin but still the relationship between the barbaloin and its overall effect has not been clarified.A more specific;perceptive of the pharmacological activities of barbaloin is required to develop for pharmaceutical purpose.Many attempts have been made regarding its isolation,biological activity to examine their effects,and clarify their functional mechanism.This review gives a brief idea about its uses,ethnomedicinally and commercially important analytical techniques and their pharmacological activities.
文摘Diosgenin is a steroidal sapogenin found in plants such as Dioscorea nipponoca,Solanum incanum,Solanum xanthocarpum and Trigonella foenum graecum.Diosgenin,biologically active phytochemicals have been used for the treatment of various types of disorder such as leukemia,inflammation,hypercholesterolemia and cancer.It is also able to prevent bone loss to the same extent as that of oestrogen.It is a typical initial intermediate for synthesis of steroidal compounds,oral contraceptives and sex hormones.Dioscorea,Costus and Trigonella are mainly used for the production of diosgenin.On the basis of literature survey it divulges that diosgenin has very impressive pharmacological profile and could be used as a medicine for the treatment of different types of disorders in the future.Thus,the present work aims to provide collective information in concern with its pharmacological activity and phytoanalytical techniques.This review will be beneficial to researches for the development of an alternative method for the treatment of innumerable diseases from diosgenin.
文摘Objective:To isolate and characterize the bioactive secondary metabolites from Aspergillus ochraceus(A.ochraceus)MP2 fungi.Methods:The anti bacterial activity of marine sponge derived fungi A.ochraceus MP2 was thoroughly investigated against antagonistic human pathogens.The optimum inhibitory concentration of the fungi in the elite solvent was also determined.The promising extracts that showed good antimicrobial activity were subjected to further analytical separation to get individual distinct metabolites and the eluants were further identified by GC MS instrumental analysis.The molecular characterization of the elite fungal strains were done by isolating their genomic DNA and amplify the internal transcribed spacer(US)region of 5.8s rRNA using specific ITS primer.The novelty of the strain was proved by homology search tools and elite sequences was submitted to GENBANK.Results:Three bioactive compounds were characterized to reveal their identity,chemical formula and structure.The first elutant was identified asα-Campholene aldehyde with chemical fonnula C_(10)H_(16)O and molecular weight 152 Da.The second elutant was identified as Lucenin-2 and chemical fonnula C_(27)H_(30)O_(16)and molecular weight 610Da.The third elutant was identified as 6-Ethyloct-3-yl-2-ethylhexyl ester with Chemical fonnula C_(26)H_(42)O_4 with molecular weight 418 Da.Conclusions:The isolated compounds showed significant antimicrobial activity against potential human pathogens.Microbial secondary metabolites represent a large source of compounds endowed with ingenious structures and potent biological activities.
基金supported by the National Natural Science Foundation of China
文摘We present a spectroscopic catalog of 93 619 M dwarfs from the first data release of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST）general survey. During sample selection, M giant contamination was eliminated using2 MASS photometry and Ca H/TiO molecular indices. For each spectrum, the spectral subtype and values are provided including radial velocity, Hα equivalent width, a series of prominent molecular band indices, and the metal–sensitive parameter ζ, as well as distances and the space motions for high S/N objects. In addition, Hα emission lines are measured to examine the magnetic activity properties of M dwarfs and 7179 active ones are found. In particular, a subsample with significant variation in magnetic activity is revealed through observations from different epochs. Finally, statistical analysis for this sample is performed, including the metallicity classification, the distribution of molecular band indices and their errors.
