A possible alternative to the accelerating universe is proposed, which shows that the diminished brightness of the high red shift Type Ia supernovae can be explained by assuming light travels with reduced speed throug...A possible alternative to the accelerating universe is proposed, which shows that the diminished brightness of the high red shift Type Ia supernovae can be explained by assuming light travels with reduced speed through the dark energy of intergalactic space. It is also shown that support for the?model from baryon acoustic oscillations (BAO) studies can also be accommodated by the model. Two tables are given that compare the model with apparent magnitude differences and length differences between the?universe and the Einstein-de Sitter universe, and they show that the model yields these differences quite accurately. A third table comparing the apparent magnitude difference between?and a universe with is also given. It exhibits poor agreement with the model, and hence the model favors the need for dark energy, albeit without negative pressure. As a new approach to the “why now?” problem, and its apparent challenge to the Copernican principle, it is proposed that dark energy is a condensed form of dark matter caused by expansion cooling, rather than a different substance. A motivation for an alternative to?is presented based on a principle that rules out the cosmological term.展开更多
Background: Calotropis procera (C. procera), is an authentic plant naturally grown in the flora of Dead Sea region. Despite its toxicity, C. procera presents healing properties. However, it has not been implemented ye...Background: Calotropis procera (C. procera), is an authentic plant naturally grown in the flora of Dead Sea region. Despite its toxicity, C. procera presents healing properties. However, it has not been implemented yet in cosmetics as an active ingredient. Objective: The biological effects of C. procera callus extract on skin were elucidated solely and in combination with Dead Sea water (DSW). Methods: The capability of C. procera extract to protect against skin inflammation and irritation was tested on ex vivo human skin organ culture by LPS and SDS addition respectively. Viability and cytokine secretion were evaluated. The combination of C. procera extract with Dead Sea water was tested on full thickness skin equivalents. Gene expression and relevant biochemical markers for glycolysis, hypoxia and extracellular matrix balance were tested. Results: C. procera extract exhibits a protective biological activity against skin irritation and inflammation at the biochemical level. Furthermore, a combination of C. procera extract and DSW demonstrates a potential contribution for skin wellbeing via enhance energy production, resistance to hypoxia and extracellular matrix balance. Conclusions: Topical application of C. procera callus extract might support skin balance and wellbeing at the molecular level. Hence, it is recommended for new cosmetic formulae as standalone or in combination with Dead Sea water, in the effort to achieve anti-aging bio-activity that is working beyond skin aging symptoms, especially via skin calming effects and skin energy enhancement.展开更多
文摘A possible alternative to the accelerating universe is proposed, which shows that the diminished brightness of the high red shift Type Ia supernovae can be explained by assuming light travels with reduced speed through the dark energy of intergalactic space. It is also shown that support for the?model from baryon acoustic oscillations (BAO) studies can also be accommodated by the model. Two tables are given that compare the model with apparent magnitude differences and length differences between the?universe and the Einstein-de Sitter universe, and they show that the model yields these differences quite accurately. A third table comparing the apparent magnitude difference between?and a universe with is also given. It exhibits poor agreement with the model, and hence the model favors the need for dark energy, albeit without negative pressure. As a new approach to the “why now?” problem, and its apparent challenge to the Copernican principle, it is proposed that dark energy is a condensed form of dark matter caused by expansion cooling, rather than a different substance. A motivation for an alternative to?is presented based on a principle that rules out the cosmological term.
文摘Background: Calotropis procera (C. procera), is an authentic plant naturally grown in the flora of Dead Sea region. Despite its toxicity, C. procera presents healing properties. However, it has not been implemented yet in cosmetics as an active ingredient. Objective: The biological effects of C. procera callus extract on skin were elucidated solely and in combination with Dead Sea water (DSW). Methods: The capability of C. procera extract to protect against skin inflammation and irritation was tested on ex vivo human skin organ culture by LPS and SDS addition respectively. Viability and cytokine secretion were evaluated. The combination of C. procera extract with Dead Sea water was tested on full thickness skin equivalents. Gene expression and relevant biochemical markers for glycolysis, hypoxia and extracellular matrix balance were tested. Results: C. procera extract exhibits a protective biological activity against skin irritation and inflammation at the biochemical level. Furthermore, a combination of C. procera extract and DSW demonstrates a potential contribution for skin wellbeing via enhance energy production, resistance to hypoxia and extracellular matrix balance. Conclusions: Topical application of C. procera callus extract might support skin balance and wellbeing at the molecular level. Hence, it is recommended for new cosmetic formulae as standalone or in combination with Dead Sea water, in the effort to achieve anti-aging bio-activity that is working beyond skin aging symptoms, especially via skin calming effects and skin energy enhancement.
