Two new unsaturated alkylamides （2E,7E,9E）-N-（2-hydroxy-2-methylpropyl）-6,11-dioxo-2,7,9-dodecatrienamide （1） and （2E,6E,8E）-N-（2-hydroxy-2-methylpropyl）-10-oxo-2,6,8-decatrienamide （2） together with six k...Two new unsaturated alkylamides （2E,7E,9E）-N-（2-hydroxy-2-methylpropyl）-6,11-dioxo-2,7,9-dodecatrienamide （1） and （2E,6E,8E）-N-（2-hydroxy-2-methylpropyl）-10-oxo-2,6,8-decatrienamide （2） together with six known compounds （3-8） have been isolated from the pericarps of Zanthoxylum bungeanum. Their structures were elucidated on the basis of extensive spectroscopic analysis, including MS, IR, 1D and 2D NMR experiments.展开更多
Achillea millefolium and Achillea ptarmica are both plants belonging to the Asteracea family and are traditionally used for their medicinal properties. It has already been shown that some N-alkylamides(NAAs)are respon...Achillea millefolium and Achillea ptarmica are both plants belonging to the Asteracea family and are traditionally used for their medicinal properties. It has already been shown that some N-alkylamides(NAAs)are responsible for these pharmacological actions. Therefore, in the present study, the NAA content of the two plants was analytically characterised. Different extracts were prepared from the roots, the leaves, the stems and the flowers. The structures of NAAs have been assigned in ethanolic extracts of Achillea millefolium and Achillea ptarmica using high performance liquid chromatography – electrospray ionisation – mass spectrometry(HPLC–ESI–MS) and gas chromatography – electron impact – mass spectrometry(GC–EI–MS). Using both analytical techniques, the structures of 14 and 15 NAAs have been assigned in Achillea ptarmica and Achillea millefolium, respectively. Structures of two new NAAs, previously never observed in Achillea ptarmica,were assigned: deca-2E,6Z,8E-trienoic acid 2-methylbutylamide(homospilanthol) or a related isomeric compound and deca-2E,4E-dienoic acid N-methyl isobutylamide. The structure of homospilanthol or a related isomeric compound was also assigned in Achillea millefolium for the first time.展开更多
A novel bonded stationary phase, octadecanamido imine bonded stationary phase(ODAI), for reversed phase HPLC was prepared by bonding stearyl chloride to YWG 80 silica gel through 3 (2 aminoethylamino)propyltrimethoxys...A novel bonded stationary phase, octadecanamido imine bonded stationary phase(ODAI), for reversed phase HPLC was prepared by bonding stearyl chloride to YWG 80 silica gel through 3 (2 aminoethylamino)propyltrimethoxysilane. Hydrophobicity, selectivity and silanophilic activity of ODAI phase were evaluated by using aromatic compounds as analytes and methanol water as binary mobile phase. The organic components including acidic, basic, neutral aromatic analytes could be separated satisfactorily with an excellent selectivity and chromatographic peak shape. The asymmetry factors of basic aniline, o toluidine and N,N dimethylaniline were found to be 1 14, 1 06 and 1 01, respectively, using methanol water(volume ratio is 55∶45) as mobile phase. Aniline is eluted before phenol due to the internal masking interaction to suppress ion exchange activity of residual silanols.展开更多
基金supported by the National Natural Science Foundation of China(Nos.31171695 and 21142004)the New Century Talents Scheme of the Ministry of Education(No.NCET-08-0820)the Fundamental Research Funds for Central Universities(No.SWJTU2010ZT09)
文摘Two new unsaturated alkylamides （2E,7E,9E）-N-（2-hydroxy-2-methylpropyl）-6,11-dioxo-2,7,9-dodecatrienamide （1） and （2E,6E,8E）-N-（2-hydroxy-2-methylpropyl）-10-oxo-2,6,8-decatrienamide （2） together with six known compounds （3-8） have been isolated from the pericarps of Zanthoxylum bungeanum. Their structures were elucidated on the basis of extensive spectroscopic analysis, including MS, IR, 1D and 2D NMR experiments.
基金the Special Research Fund of Ghent University (BOF 01D23812 to Lien Taevernier)
文摘Achillea millefolium and Achillea ptarmica are both plants belonging to the Asteracea family and are traditionally used for their medicinal properties. It has already been shown that some N-alkylamides(NAAs)are responsible for these pharmacological actions. Therefore, in the present study, the NAA content of the two plants was analytically characterised. Different extracts were prepared from the roots, the leaves, the stems and the flowers. The structures of NAAs have been assigned in ethanolic extracts of Achillea millefolium and Achillea ptarmica using high performance liquid chromatography – electrospray ionisation – mass spectrometry(HPLC–ESI–MS) and gas chromatography – electron impact – mass spectrometry(GC–EI–MS). Using both analytical techniques, the structures of 14 and 15 NAAs have been assigned in Achillea ptarmica and Achillea millefolium, respectively. Structures of two new NAAs, previously never observed in Achillea ptarmica,were assigned: deca-2E,6Z,8E-trienoic acid 2-methylbutylamide(homospilanthol) or a related isomeric compound and deca-2E,4E-dienoic acid N-methyl isobutylamide. The structure of homospilanthol or a related isomeric compound was also assigned in Achillea millefolium for the first time.
文摘A novel bonded stationary phase, octadecanamido imine bonded stationary phase(ODAI), for reversed phase HPLC was prepared by bonding stearyl chloride to YWG 80 silica gel through 3 (2 aminoethylamino)propyltrimethoxysilane. Hydrophobicity, selectivity and silanophilic activity of ODAI phase were evaluated by using aromatic compounds as analytes and methanol water as binary mobile phase. The organic components including acidic, basic, neutral aromatic analytes could be separated satisfactorily with an excellent selectivity and chromatographic peak shape. The asymmetry factors of basic aniline, o toluidine and N,N dimethylaniline were found to be 1 14, 1 06 and 1 01, respectively, using methanol water(volume ratio is 55∶45) as mobile phase. Aniline is eluted before phenol due to the internal masking interaction to suppress ion exchange activity of residual silanols.
