目的:观察布地奈德(Budeson ide)雾化吸入治疗急性喉炎的效果。方法:将101例急性喉炎患者随机分为两组,分别使用布地奈德雾化吸入、常规(4万单位庆大霉素∶12.5mg泼尼松龙∶20m l 0.9%NaC l溶液)超声雾化吸入,治疗后第7天进行动态喉镜...目的:观察布地奈德(Budeson ide)雾化吸入治疗急性喉炎的效果。方法:将101例急性喉炎患者随机分为两组,分别使用布地奈德雾化吸入、常规(4万单位庆大霉素∶12.5mg泼尼松龙∶20m l 0.9%NaC l溶液)超声雾化吸入,治疗后第7天进行动态喉镜复查及嗓音分析,了解声带恢复情况,比较两种治疗方法的效果。结果:布地奈德和常规超声雾化吸入的两组患者有效率分别为93.9%和78.8%。两组间疗效比较差异有显著性意义(P<0.05)。结论:布地奈德雾化吸入治疗急性喉炎的疗效优于常规超声雾化吸入。展开更多
目的:探讨血小板生成素(thrombopoietin,TPO)在不同病因引起的急性炎症反应状态下的变化情况,并进一步探讨其意义。方法:采用病例对照分析,纳入65例处于急性炎症反应状态病人作为研究组(其中急性心肌梗死病人15例,急性脑梗死病人15例,...目的:探讨血小板生成素(thrombopoietin,TPO)在不同病因引起的急性炎症反应状态下的变化情况,并进一步探讨其意义。方法:采用病例对照分析,纳入65例处于急性炎症反应状态病人作为研究组(其中急性心肌梗死病人15例,急性脑梗死病人15例,急性创伤病人25例,急性肺炎病人10例),42例健康人群作为对照组。使用独立样本t检验方法,对总炎症疾病组与对照组的外周血TPO及各系血细胞计数进行比较,评估急性炎症状态下TPO的水平是否高于健康人群;并使用独立样本Kruskal-Wallis H检验及Nemenyi法检验进一步进行亚组分析,评估在不同病因及不同水平炎症状态下TPO水平是否存在差别。结果:与对照组相比,总炎症疾病组的TPO水平明显升高(181.11±35.38 vs 96.13±9.7 pg/ml,P<0.001),且总炎症疾病组白细胞数(9.64±3.43)×10~9/L也明显高于对照组(7.35±1.49)×10~9/L(P<0.001)。然而,总炎症疾病组血小板计数与对照组相比并无统计学差异(P=0.313)。在进一步的亚组分析中发现,不同炎症水平状态下TPO水平的变化有不同。高炎症水平状态疾病(急性创伤、急性肺炎)TPO水平较低炎症水平疾病(急性心肌梗死、急性脑梗死)TPO水平明显升高(P<0.05),且各组间血小板计数并无明显统计学差异。结论:在急性炎症状态下,TPO血清水平的升高与血小板数无明显相关,但与炎症水平具有相关性,并且TPO可能作为一种急性期反应蛋白对机体产生保护性作用。展开更多
目的:比较当归不同炮制品挥发油对脂多糖(Lipopolysaccharide,LPS)致大鼠急性炎症的干预作用。方法:通过腹腔注射LPS(100μg/kg)建立大鼠急性炎症模型,通过血常规和血清炎性介质及细胞因子检测,结合肺脏和肝脏组织病理学观察,评价酒当...目的:比较当归不同炮制品挥发油对脂多糖(Lipopolysaccharide,LPS)致大鼠急性炎症的干预作用。方法:通过腹腔注射LPS(100μg/kg)建立大鼠急性炎症模型,通过血常规和血清炎性介质及细胞因子检测,结合肺脏和肝脏组织病理学观察,评价酒当归挥发油(volatile oils from parching AS with wine,J-VOAS)、当归炭挥发油(volatile oils from charred AS,C-VOAS)、生当归挥发油(volatile oils from raw AS,S-VOAS)的抗炎活性。结果:与正常对照组相比,模型组白细胞计数(white blood cell count,WBC)、中性粒细胞百分比(neutrophil percentage,NE)和血小板计数(platelet Count,PLT)显著升高(P<0.05),淋巴细胞百分比(lymphocytes percentage,LY)显著降低(P<0.05);模型组血清IL-1β、IL-6、NO、TNF-α含量极显著升高(P<0.001),IL-10含量极显著降低(P<0.01);经J-VOAS、CVOAS、S-VOAS干预后上述血常规指标和血清炎性因介质及细胞因子均显著回调(P<0.05,P<0.01,P<0.001)。组织病理学观察发现,模型组大鼠肺泡扩张,肺泡及间质中大量炎性细胞浸润,肝小叶弥散性坏死,肝索排列紊乱,部分肝细胞发生颗粒变性和水肿;经J-VOAS干预后,其病理变化明显改善。结论:当归不同炮制品挥发油对LPS所致大鼠急性炎症模型均有干预作用,其中J-VOAS干预作用最好,其次为C-VOAS和S-VOAS。展开更多
Objective:To evaluate the antiinflammatory activity of orally administered ethanolic extract of Tephrosia purpurea in acute and subacute inflammation in rats.Methods:An ethanolic extract of Tephrosia purpurea was prep...Objective:To evaluate the antiinflammatory activity of orally administered ethanolic extract of Tephrosia purpurea in acute and subacute inflammation in rats.Methods:An ethanolic extract of Tephrosia purpurea was prepared.Carrageenan induced paw edema and cotton pellet granuloma were the models for acute and subacute inflammation respectively.Four groups of rats in each model were treated orally with 2%gum acacia,100 mg /kg of aspirin,500 mg/kg and 1 000 mg/kg of ethanolic extract of Tephrosia purpurea respectively.In carrageenan induced paw edema model, subplantar injection of 1%carrageenan was made into the hind paw of the rats sixty minutes after the administration of the respective drugs.The paw volume was measured immediately after injection of carrageenan,at 3 hours and at 6 hours.Then percentage inhibition of edema was calculated.In the cotton pellet granuloma model,animals were administered drugs for six days after placing cotton pellets in the axilla on each side.On the 7th day,dry weight of granuloma was calculated.Results:The rats treated with Tephrosia purpurea did not exhibit any significant decrease in paw volume and serum ceruloplasmin levels as compared to the control and aspirin treated groups in the acute inflammation model;while,there was a significant(P 【 0.01) decrease in the weight of granuloma in Tephrosia purpurea and aspirin treated groups as compared to control in subacute inflammation.Conclusions:The ethanolic extract of orally administered Tephrosia purpurea shows significant antiinflammatory effect in subacute inflammation but not in acute inflammation in rats.展开更多
文摘目的:观察布地奈德(Budeson ide)雾化吸入治疗急性喉炎的效果。方法:将101例急性喉炎患者随机分为两组,分别使用布地奈德雾化吸入、常规(4万单位庆大霉素∶12.5mg泼尼松龙∶20m l 0.9%NaC l溶液)超声雾化吸入,治疗后第7天进行动态喉镜复查及嗓音分析,了解声带恢复情况,比较两种治疗方法的效果。结果:布地奈德和常规超声雾化吸入的两组患者有效率分别为93.9%和78.8%。两组间疗效比较差异有显著性意义(P<0.05)。结论:布地奈德雾化吸入治疗急性喉炎的疗效优于常规超声雾化吸入。
文摘目的:探讨血小板生成素(thrombopoietin,TPO)在不同病因引起的急性炎症反应状态下的变化情况,并进一步探讨其意义。方法:采用病例对照分析,纳入65例处于急性炎症反应状态病人作为研究组(其中急性心肌梗死病人15例,急性脑梗死病人15例,急性创伤病人25例,急性肺炎病人10例),42例健康人群作为对照组。使用独立样本t检验方法,对总炎症疾病组与对照组的外周血TPO及各系血细胞计数进行比较,评估急性炎症状态下TPO的水平是否高于健康人群;并使用独立样本Kruskal-Wallis H检验及Nemenyi法检验进一步进行亚组分析,评估在不同病因及不同水平炎症状态下TPO水平是否存在差别。结果:与对照组相比,总炎症疾病组的TPO水平明显升高(181.11±35.38 vs 96.13±9.7 pg/ml,P<0.001),且总炎症疾病组白细胞数(9.64±3.43)×10~9/L也明显高于对照组(7.35±1.49)×10~9/L(P<0.001)。然而,总炎症疾病组血小板计数与对照组相比并无统计学差异(P=0.313)。在进一步的亚组分析中发现,不同炎症水平状态下TPO水平的变化有不同。高炎症水平状态疾病(急性创伤、急性肺炎)TPO水平较低炎症水平疾病(急性心肌梗死、急性脑梗死)TPO水平明显升高(P<0.05),且各组间血小板计数并无明显统计学差异。结论:在急性炎症状态下,TPO血清水平的升高与血小板数无明显相关,但与炎症水平具有相关性,并且TPO可能作为一种急性期反应蛋白对机体产生保护性作用。
文摘目的:比较当归不同炮制品挥发油对脂多糖(Lipopolysaccharide,LPS)致大鼠急性炎症的干预作用。方法:通过腹腔注射LPS(100μg/kg)建立大鼠急性炎症模型,通过血常规和血清炎性介质及细胞因子检测,结合肺脏和肝脏组织病理学观察,评价酒当归挥发油(volatile oils from parching AS with wine,J-VOAS)、当归炭挥发油(volatile oils from charred AS,C-VOAS)、生当归挥发油(volatile oils from raw AS,S-VOAS)的抗炎活性。结果:与正常对照组相比,模型组白细胞计数(white blood cell count,WBC)、中性粒细胞百分比(neutrophil percentage,NE)和血小板计数(platelet Count,PLT)显著升高(P<0.05),淋巴细胞百分比(lymphocytes percentage,LY)显著降低(P<0.05);模型组血清IL-1β、IL-6、NO、TNF-α含量极显著升高(P<0.001),IL-10含量极显著降低(P<0.01);经J-VOAS、CVOAS、S-VOAS干预后上述血常规指标和血清炎性因介质及细胞因子均显著回调(P<0.05,P<0.01,P<0.001)。组织病理学观察发现,模型组大鼠肺泡扩张,肺泡及间质中大量炎性细胞浸润,肝小叶弥散性坏死,肝索排列紊乱,部分肝细胞发生颗粒变性和水肿;经J-VOAS干预后,其病理变化明显改善。结论:当归不同炮制品挥发油对LPS所致大鼠急性炎症模型均有干预作用,其中J-VOAS干预作用最好,其次为C-VOAS和S-VOAS。
文摘Objective:To evaluate the antiinflammatory activity of orally administered ethanolic extract of Tephrosia purpurea in acute and subacute inflammation in rats.Methods:An ethanolic extract of Tephrosia purpurea was prepared.Carrageenan induced paw edema and cotton pellet granuloma were the models for acute and subacute inflammation respectively.Four groups of rats in each model were treated orally with 2%gum acacia,100 mg /kg of aspirin,500 mg/kg and 1 000 mg/kg of ethanolic extract of Tephrosia purpurea respectively.In carrageenan induced paw edema model, subplantar injection of 1%carrageenan was made into the hind paw of the rats sixty minutes after the administration of the respective drugs.The paw volume was measured immediately after injection of carrageenan,at 3 hours and at 6 hours.Then percentage inhibition of edema was calculated.In the cotton pellet granuloma model,animals were administered drugs for six days after placing cotton pellets in the axilla on each side.On the 7th day,dry weight of granuloma was calculated.Results:The rats treated with Tephrosia purpurea did not exhibit any significant decrease in paw volume and serum ceruloplasmin levels as compared to the control and aspirin treated groups in the acute inflammation model;while,there was a significant(P 【 0.01) decrease in the weight of granuloma in Tephrosia purpurea and aspirin treated groups as compared to control in subacute inflammation.Conclusions:The ethanolic extract of orally administered Tephrosia purpurea shows significant antiinflammatory effect in subacute inflammation but not in acute inflammation in rats.
