AIM:To clarify both the character of the absorption and the stability of crocin in various sites along the intestinal tract,and also to determine the partition coefficient of crocin-1 in water/n-caprylic alcohol syste...AIM:To clarify both the character of the absorption and the stability of crocin in various sites along the intestinal tract,and also to determine the partition coefficient of crocin-1 in water/n-caprylic alcohol system. METHOD:The intestinal absorption and stability was investigated using in situ perfusion method in rats; Shaking flask test was used to determine the partition coefficient of crocin-1;Concentration of crocin-1 was detected by HPLC.RESULT:Decrease of Crocin-1 in various intestine segments is as follows:Duodenum 13.81%,Jejunum 9.89%,Ileum 10.07%,and Colon 10.04%,but crocin-1 can’t be found in blood; Degradation of Crocin-1 during incubation in refluxing solution of various intestinal segments is as follows:Duodenum 13.01%,Jejunum 10.11%,Ileum 9.95%,and Colon 10.45%; The partition coefficient of crocin-1 P =0.093±0.004,log P =-1.03±0.02.CONCLUSION:The results suggest that crocin is unstable and can’t be absorbed in the whole intestinal tract.展开更多
Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes,oral delivery of l...Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes,oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract,difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes.展开更多
As a renewable and environment-friendly technology for seawater desalination and wastewater purification,solar energy triggered steam generation is attractive to address the long-standing global water scarcity issues....As a renewable and environment-friendly technology for seawater desalination and wastewater purification,solar energy triggered steam generation is attractive to address the long-standing global water scarcity issues.However,practical utilization of solar energy for steam generation is severely restricted by the complex synthesis,low energy conversion efficiency,insufficient solar spectrum absorption and water extraction capability of state-of-the-art technologies.Here,for the first time,we report a facile strategy to realize hydrogen bond induced self-assembly of a polydopamine(PDA)@MXene microsphere photothermal layer for synergistically achieving wide-spectrum and highly efficient solar absorption capability(≈96%in a wide solar spectrum range of 250–1,500 nm wavelength).Moreover,such a system renders fast water transport and vapor escaping due to the intrinsically hydrophilic nature of both MXene and PDA,as well as the interspacing between core-shell microspheres.The solar-to-vapor conversion efficiencies under the solar illumination of 1 sun and 4 sun are as high as 85.2%and 93.6%,respectively.Besides,the PDA@MXene photothermal layer renders the system durable mechanical properties,allowing producing clean water from seawater with the salt rejection rate beyond 99%.Furthermore,stable light absorption performance can be achieved and well maintained due to the formation of ternary TiO2/C/MXene complex caused by oxidative degradation of MXene.Therefore,this work proposes an attractive MXene-assisted strategy for fabricating high performance photothermal composites for advanced solar-driven seawater desalination applications.展开更多
Magnetic/dielectric@porous carbon composites,derived from metal–organic frameworks(MOFs)with adjustable composition ratio,have attracted wide attention due to their unique magnetoelectric properties.In addition,MOFs-...Magnetic/dielectric@porous carbon composites,derived from metal–organic frameworks(MOFs)with adjustable composition ratio,have attracted wide attention due to their unique magnetoelectric properties.In addition,MOFs-derived porous carbon-based materials can meet the needs of lightweight feature.This paper reports a simple process for synthesizing stacked CoxNiy@C nanosheets derived from CoxNiy-MOFs nanosheets with multiple interfaces,which is good to the microwave response.The CoxNiy@C with controllable composition can be obtained by adjusting the ratio of Co^2+ and Ni^2+.It is supposed that the increased Co content is benefit to the dielectric and magnetic loss.Additionally,the bandwidth of CoNi@C nanosheets can take up almost the whole Ku band.Moreover,this composite has better environmental stability in air,which characteristic provides a sustainable potential for the practical application.展开更多
文摘AIM:To clarify both the character of the absorption and the stability of crocin in various sites along the intestinal tract,and also to determine the partition coefficient of crocin-1 in water/n-caprylic alcohol system. METHOD:The intestinal absorption and stability was investigated using in situ perfusion method in rats; Shaking flask test was used to determine the partition coefficient of crocin-1;Concentration of crocin-1 was detected by HPLC.RESULT:Decrease of Crocin-1 in various intestine segments is as follows:Duodenum 13.81%,Jejunum 9.89%,Ileum 10.07%,and Colon 10.04%,but crocin-1 can’t be found in blood; Degradation of Crocin-1 during incubation in refluxing solution of various intestinal segments is as follows:Duodenum 13.01%,Jejunum 10.11%,Ileum 9.95%,and Colon 10.45%; The partition coefficient of crocin-1 P =0.093±0.004,log P =-1.03±0.02.CONCLUSION:The results suggest that crocin is unstable and can’t be absorbed in the whole intestinal tract.
基金financially supported by National Natural Science Foundation of China (81573363 and 81690263)National Key Basic Research Program (2015CB931800)
文摘Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes,oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract,difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes.
基金supported by the National Natural Science Foundation of China(Nos.51873126,51422305,and 51721091)。
文摘As a renewable and environment-friendly technology for seawater desalination and wastewater purification,solar energy triggered steam generation is attractive to address the long-standing global water scarcity issues.However,practical utilization of solar energy for steam generation is severely restricted by the complex synthesis,low energy conversion efficiency,insufficient solar spectrum absorption and water extraction capability of state-of-the-art technologies.Here,for the first time,we report a facile strategy to realize hydrogen bond induced self-assembly of a polydopamine(PDA)@MXene microsphere photothermal layer for synergistically achieving wide-spectrum and highly efficient solar absorption capability(≈96%in a wide solar spectrum range of 250–1,500 nm wavelength).Moreover,such a system renders fast water transport and vapor escaping due to the intrinsically hydrophilic nature of both MXene and PDA,as well as the interspacing between core-shell microspheres.The solar-to-vapor conversion efficiencies under the solar illumination of 1 sun and 4 sun are as high as 85.2%and 93.6%,respectively.Besides,the PDA@MXene photothermal layer renders the system durable mechanical properties,allowing producing clean water from seawater with the salt rejection rate beyond 99%.Furthermore,stable light absorption performance can be achieved and well maintained due to the formation of ternary TiO2/C/MXene complex caused by oxidative degradation of MXene.Therefore,this work proposes an attractive MXene-assisted strategy for fabricating high performance photothermal composites for advanced solar-driven seawater desalination applications.
基金Financial supports from the National Nature Science Foundation of China(No.51971111)the foundation of Jiangsu Provincial Key Laboratory of Bionic Functional Materials are gratefully acknowledged.
文摘Magnetic/dielectric@porous carbon composites,derived from metal–organic frameworks(MOFs)with adjustable composition ratio,have attracted wide attention due to their unique magnetoelectric properties.In addition,MOFs-derived porous carbon-based materials can meet the needs of lightweight feature.This paper reports a simple process for synthesizing stacked CoxNiy@C nanosheets derived from CoxNiy-MOFs nanosheets with multiple interfaces,which is good to the microwave response.The CoxNiy@C with controllable composition can be obtained by adjusting the ratio of Co^2+ and Ni^2+.It is supposed that the increased Co content is benefit to the dielectric and magnetic loss.Additionally,the bandwidth of CoNi@C nanosheets can take up almost the whole Ku band.Moreover,this composite has better environmental stability in air,which characteristic provides a sustainable potential for the practical application.
