The convection structure in a rectangular channel with a horizontal flow forΓ = 12 was studied. The simulations were preformed by solving the hydrodynamic equations using theSIMPLE method. The convective behavior in ...The convection structure in a rectangular channel with a horizontal flow forΓ = 12 was studied. The simulations were preformed by solving the hydrodynamic equations using theSIMPLE method. The convective behavior in an absolutely and convectively unstable regime wasstudied. The results show that the two types of convection patterns in this system appear dependingon the convection intensity and horizontal flow. A periodically localized traveling wave state wasfound in this system.展开更多
With the continuous improvement of automation,industrial robots have become an indispensable part of automated production lines.They widely used in a number of industrial production activities,such as spraying,welding...With the continuous improvement of automation,industrial robots have become an indispensable part of automated production lines.They widely used in a number of industrial production activities,such as spraying,welding,handling,etc.,and have a great role in these sectors.Recently,the robotic technology is developing towards high precision,high intelligence.Robot calibration technology has a great significance to improve the accuracy of robot.However,it has much work to be done in the identification of robot parameters.The parameter identification work of existing serial and parallel robots is introduced.On the one hand,it summarizes the methods for parameter calibration and discusses their advantages and disadvantages.On the other hand,the application of parameter identification is introduced.This overview has a great reference value for robot manufacturers to choose proper identification method,points further research areas for researchers.Finally,this paper analyzes the existing problems in robot calibration,which may be worth researching in the future.展开更多
This paper introduces the comparison of absolute gravity measurements in China during 2006-2008,and analyzing the survey and comparing the results,it shows that there is no obvious system error between the gravimeter ...This paper introduces the comparison of absolute gravity measurements in China during 2006-2008,and analyzing the survey and comparing the results,it shows that there is no obvious system error between the gravimeter of FG5/214 and FG5/232,the surveying accuracy is very high and repetition is good,and their inner surveying accuracy is about 2-3 microGal.展开更多
Over the past 10 years, the number of broadband seismic stations in China has increased significantly. The broadband seismic records contain information about shear-wave splitting which plays an important role in reve...Over the past 10 years, the number of broadband seismic stations in China has increased significantly. The broadband seismic records contain information about shear-wave splitting which plays an important role in revealing the upper mantle anisotropy in the Chinese mainland. Based on teleseismic SKS and SKKS phases recorded in the seismic stations, we used the analytical method of minimum transverse energy to determine the fast wave polarization direction and delay time of shear-wave splitting. We also collected results of shear-wave splitting in China and the surrounding regions from previously published papers. From the combined dataset we formed a shear-wave splitting dataset containing 1020 parameter pairs. These splitting parameters re- veal the complexity of the upper mantle anisotropy image. Our statistical analysis indicates stronger upper mantle anisotropy in the Chinese mainland, with an average shear-wave time delay of 0,95 s; the anisotropy in the western region is slightly larger （1.01 s） than in the eastern region （0.92 s）. On a larger scale, the SKS splitting and surface deformation data in the Tibetan Plateau and the Tianshan region jointly support the lithospheric deformation mode, i.e. the crust-lithospheric mantle coherent deformation. In eastern China, the average fast-wave direction is approximately parallel to the direction of the absolute plate motion; thus, the upper mantle anisotropy can be attributed to the asthenospheric flow. The area from the Ordos block to the Sichuan Basin in central China is the transition zone of deformation modes between the east and the west regions, where the anisotropy images are more complicated, exhibiting ＂fossil＂ anisotropy and/or two-layer anis^3trc^py. The c^llisi（3n between the Indian Plate and the Eurasian Plate is the main factor of upper mantle anisotropy in the western region of the Chinese mainland, while the upper mantle anisotropy in the eastern region is related to the subduction of the Pacific Plate and the Philippine Sea Plate be展开更多
A pair of indole alkaloid enantiomers with a novel bisindolylacetamide skeleton, insatindibisindolamides A and B（1a and 1b）, was isolated from an aqueous extract of Isatis indigotica roots. The enantiomers were sepa...A pair of indole alkaloid enantiomers with a novel bisindolylacetamide skeleton, insatindibisindolamides A and B（1a and 1b）, was isolated from an aqueous extract of Isatis indigotica roots. The enantiomers were separated by chiral HPLC. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis, including 2D NMR, X-ray crystallography, and electronic CD（ECD） calculation. The proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1a and 1b are also discussed.展开更多
AIM: To assess the functional status and etiology of liver cirrhosis by quantitative 31p magnetic resonance spectroscopy (MRS).METHODS: A total of 80 patients with liver cirrhosis of different etiology and functional ...AIM: To assess the functional status and etiology of liver cirrhosis by quantitative 31p magnetic resonance spectroscopy (MRS).METHODS: A total of 80 patients with liver cirrhosis of different etiology and functional status described by Child-Pugh score were examined and compared to 11 healthy volunteers. MR examination was performed on a 1.5 T imager using a 1H/31P surface coil by the 2D chemical shift imaging technique.Absolute concentrations of phosphomonoesters (PME),phosphodiesters (PDE), inorganic phosphate (Pi) and adenosine triphosphate (ATP) were measured.RESULTS: MRS changes reflected the degree of liver dysfunction in all the patients as well as in individual etiological groups. The most important change was a decrease of PDE. It was possible to distinguish alcoholic,viral and cholestatic etiologies based on MR spectra.Alcoholic and viral etiology differed in PDE (alcoholic,viral, controls: 6.5±2.3, 6.5±3.1, 10.8±2.7 mmol/L,P＜0.001) and ATP (alcoholic, viral, controls: 2.9±0.8, 2.8±0.9, 3.7±1.0 mmol/L, P＜0.01) from the control group.Unlike viral etiology, patients with alcoholic etiology also differed in Pi (alcoholic, controls: 1.2±0.4, 1.6±0.6mmol/L, P＜0.05) from controls. No significant changes were found in patients with cholestatic disease and controls; nevertheless, this group differed from both alcoholic and viral groups (cholestatic, alcoholic, viral: 9.4±2.7, 6.5±2.3, 6.5±3.1 mmol/L, P＜0.005) in PDE.CONCLUSION: 31p MRS can significantly help in noninvasive separation of different etiological groups leading to liver cirrhosis. In addition, MRS changes reflect functional liver injury.展开更多
The spinning solar sail of large scale has been well developed in recent years. Such a solar sail can be considered as a rigid-flexible multibody system mainly composed of a spinning central rigid hub, a number of fle...The spinning solar sail of large scale has been well developed in recent years. Such a solar sail can be considered as a rigid-flexible multibody system mainly composed of a spinning central rigid hub, a number of flexible thin tethers, sail membranes, and tip masses. A simplified interplanetary kite-craft accelerated by radiation of the Sun （IKAROS） model is established in this study by using the absolute-coordinate-based （ACB） method that combines the natural coordinate formulation （NCF） describing the central rigid hub and the absolute nodal coordinate formulation （ANCF） describing flexible parts. The initial configuration of the system in the second-stage deployment is determined through both dynamic and static analyses. The huge set of stiff equations of system dynamics is solved by using the generalized-alpha method, and thus the deployment dynamics of the system can be well understood.展开更多
In this paper, we transform the Lurie indirect control systems into a nonlinear system with separating variables by a topological transformation and introduce a definition of absolute stability for partial variables. ...In this paper, we transform the Lurie indirect control systems into a nonlinear system with separating variables by a topological transformation and introduce a definition of absolute stability for partial variables. The necessary and sufficient conditions (NASC) for the absolute stability of Lurie indirect control systems are given and some sufficient conditions are obtained.展开更多
Three pairs of glycosidic 8,4′-oxyneolignane diastereoisomers, named isatioxyneolignosides A-F(1–6), were isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations wer...Three pairs of glycosidic 8,4′-oxyneolignane diastereoisomers, named isatioxyneolignosides A-F(1–6), were isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations were elucidated by comprehensive spectroscopic data analysis and enzyme hydrolysis. The validity of Δδ_(C8-C7) values to distinguish threo and erythro aryl glycerol units and Cotton effects at 235±5 nm to determine absolute configurations at C-8 in 1–6 and their aglycones(1a–6a) are discussed.展开更多
A fully relativistic distorted-wave program is developed based on the Grasp92 and Ratip packages to calculate electron impact excitation （EIE） cross sections. As a first application of the program, the EIE cross sec...A fully relativistic distorted-wave program is developed based on the Grasp92 and Ratip packages to calculate electron impact excitation （EIE） cross sections. As a first application of the program, the EIE cross sections of Be-like C^α＋ ions from the metastable 1s^22s2p^3 p to 1s^22p^2 ^3 p excitation and the inner-shell excitations are calculated systematically. Meanwhile, the correlation effects of target states are discussed. It is found that the correlation effects play an important role in the low energy EIE cross sections. An excellent agreement is found when the results are compared with previous calculations and recent measurements.展开更多
We present a simple but effective method for small-angle measurement based on optical feedback interferometry （or laser self-mixing interferometry）. The absolute zero angle can be defined at the biggest fringe ampli...We present a simple but effective method for small-angle measurement based on optical feedback interferometry （or laser self-mixing interferometry）. The absolute zero angle can be defined at the biggest fringe amplitude point, so this method can also achieve absolute angle measurement. In order to verify the method, we construct an angle measurement system. The Fourier-transform method is used to analysis the interference signal. Rotation angles are experimentally measured with a resolution of 10^-6 rad and a measurement range of approximately from -0.0007 to ＋0.0007 rad.展开更多
In this paper, nonlinear modeling for flexible multibody system with large deformation is investigated. Absolute nodal coordinates are employed to describe the displacement, and variational motion equations of a flexi...In this paper, nonlinear modeling for flexible multibody system with large deformation is investigated. Absolute nodal coordinates are employed to describe the displacement, and variational motion equations of a flexible body are derived on the basis of the geometric nonlinear theory, in which both the shear strain and the transverse normal strain are taken into account. By separating the inner and the boundary nodal coordinates, the motion equations of a flexible multibody system are assembled. The advantage of such formulation is that the constraint equations and the forward recursive equations become linear because the absolute nodal coordinates are used. A spatial double pendulum connected to the ground with a spherical joint is simulated to investigate the dynamic performance of flexible beams with large deformation. Finally, the resultant constant total energy validates the present formulation.展开更多
BACKGROUND Recent evidence shows that long non-coding RNAs(lncRNAs) are closely related to hepatogenesis and a few aggressive features of hepatocellular carcinoma(HCC). Increasing studies demonstrate that lncRNAs are ...BACKGROUND Recent evidence shows that long non-coding RNAs(lncRNAs) are closely related to hepatogenesis and a few aggressive features of hepatocellular carcinoma(HCC). Increasing studies demonstrate that lncRNAs are potential prognostic factors for HCC. Moreover, several studies reported the combination of lncRNAs for predicting the overall survival(OS) of HCC, but the results varied. Thus,more effort including more accurate statistical approaches is needed for exploring the prognostic value of lncRNAs in HCC.AIM To develop a robust lncRNA signature associated with HCC recurrence to improve prognosis prediction of HCC.METHODS Univariate COX regression analysis was performed to screen the lncRNAs significantly associated with recurrence-free survival(RFS) of HCC in GSE76427 for the least absolute shrinkage and selection operator(LASSO) modelling. The established lncRNA signature was validated and developed in The Cancer Genome Atlas(TCGA) series using Kaplan-Meier curves. The expression values of the identified lncRNAs were compared between the tumor and non-tumor tissues. Pathway enrichment of these lncRNAs was conducted based on the significantly co-expressed genes. A prognostic nomogram combining the lncRNA signature and clinical characteristics was constructed.RESULTS The lncRNA signature consisted of six lncRNAs: MSC-AS1, POLR2 J4, EIF3 J-AS1,SERHL, RMST, and PVT1. This risk model was significantly associated with the RFS of HCC in the TCGA cohort with a hazard ratio(HR) being 1.807(95%CI[confidence interval]: 1.329-2.457) and log-rank P-value being less than 0.001. The best candidates of the six-lncRNA signature were younger male patients with HBV infection in relatively early tumor-stage and better physical condition but with higher preoperative alpha-fetoprotein. All the lncRNAs were significantly upregulated in tumor samples compared to non-tumor samples(P < 0.05). The most significantly enriched pathways of the lncRNAs were TGF-β signaling pathway, cellular apoptosis-associated pathways, etc. The nomog展开更多
文摘The convection structure in a rectangular channel with a horizontal flow forΓ = 12 was studied. The simulations were preformed by solving the hydrodynamic equations using theSIMPLE method. The convective behavior in an absolutely and convectively unstable regime wasstudied. The results show that the two types of convection patterns in this system appear dependingon the convection intensity and horizontal flow. A periodically localized traveling wave state wasfound in this system.
基金supported in part by the National Natural Science Foundation of China(61772493)in part by the Guangdong Province Universities and College Pearl River Scholar Funded Scheme(2019)in part by the Natural Science Foundation of Chongqing(cstc2019jcyjjq X0013)。
文摘With the continuous improvement of automation,industrial robots have become an indispensable part of automated production lines.They widely used in a number of industrial production activities,such as spraying,welding,handling,etc.,and have a great role in these sectors.Recently,the robotic technology is developing towards high precision,high intelligence.Robot calibration technology has a great significance to improve the accuracy of robot.However,it has much work to be done in the identification of robot parameters.The parameter identification work of existing serial and parallel robots is introduced.On the one hand,it summarizes the methods for parameter calibration and discusses their advantages and disadvantages.On the other hand,the application of parameter identification is introduced.This overview has a great reference value for robot manufacturers to choose proper identification method,points further research areas for researchers.Finally,this paper analyzes the existing problems in robot calibration,which may be worth researching in the future.
基金Supported by the Fund of Institute of Seismology,CEA (No.IS200736026)
文摘This paper introduces the comparison of absolute gravity measurements in China during 2006-2008,and analyzing the survey and comparing the results,it shows that there is no obvious system error between the gravimeter of FG5/214 and FG5/232,the surveying accuracy is very high and repetition is good,and their inner surveying accuracy is about 2-3 microGal.
基金supported by the National Natural Science Foundation of China(Grants Nos.90914005,91014006,41174070)the Basic Pro-ject in the Ministry of Science and Technology(Grants No.2006FY1101100)
文摘Over the past 10 years, the number of broadband seismic stations in China has increased significantly. The broadband seismic records contain information about shear-wave splitting which plays an important role in revealing the upper mantle anisotropy in the Chinese mainland. Based on teleseismic SKS and SKKS phases recorded in the seismic stations, we used the analytical method of minimum transverse energy to determine the fast wave polarization direction and delay time of shear-wave splitting. We also collected results of shear-wave splitting in China and the surrounding regions from previously published papers. From the combined dataset we formed a shear-wave splitting dataset containing 1020 parameter pairs. These splitting parameters re- veal the complexity of the upper mantle anisotropy image. Our statistical analysis indicates stronger upper mantle anisotropy in the Chinese mainland, with an average shear-wave time delay of 0,95 s; the anisotropy in the western region is slightly larger （1.01 s） than in the eastern region （0.92 s）. On a larger scale, the SKS splitting and surface deformation data in the Tibetan Plateau and the Tianshan region jointly support the lithospheric deformation mode, i.e. the crust-lithospheric mantle coherent deformation. In eastern China, the average fast-wave direction is approximately parallel to the direction of the absolute plate motion; thus, the upper mantle anisotropy can be attributed to the asthenospheric flow. The area from the Ordos block to the Sichuan Basin in central China is the transition zone of deformation modes between the east and the west regions, where the anisotropy images are more complicated, exhibiting ＂fossil＂ anisotropy and/or two-layer anis^3trc^py. The c^llisi（3n between the Indian Plate and the Eurasian Plate is the main factor of upper mantle anisotropy in the western region of the Chinese mainland, while the upper mantle anisotropy in the eastern region is related to the subduction of the Pacific Plate and the Philippine Sea Plate be
基金Financial support from the National Natural Science Foundation of China(NNSFCNos.81373287 and 30825044)+1 种基金the Program for Changjiang Scholars and Innovative Research Team in University(PCSIRT,No.IRT1007)the National Science and Technology Project of China(Nos.2012ZX09301002-002 and 2011ZX0 9307-002-01)
文摘A pair of indole alkaloid enantiomers with a novel bisindolylacetamide skeleton, insatindibisindolamides A and B（1a and 1b）, was isolated from an aqueous extract of Isatis indigotica roots. The enantiomers were separated by chiral HPLC. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis, including 2D NMR, X-ray crystallography, and electronic CD（ECD） calculation. The proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1a and 1b are also discussed.
基金Supported by grant from Ministry of Health IGA 7853-3, and MZO 00023001, Czech Republic
文摘AIM: To assess the functional status and etiology of liver cirrhosis by quantitative 31p magnetic resonance spectroscopy (MRS).METHODS: A total of 80 patients with liver cirrhosis of different etiology and functional status described by Child-Pugh score were examined and compared to 11 healthy volunteers. MR examination was performed on a 1.5 T imager using a 1H/31P surface coil by the 2D chemical shift imaging technique.Absolute concentrations of phosphomonoesters (PME),phosphodiesters (PDE), inorganic phosphate (Pi) and adenosine triphosphate (ATP) were measured.RESULTS: MRS changes reflected the degree of liver dysfunction in all the patients as well as in individual etiological groups. The most important change was a decrease of PDE. It was possible to distinguish alcoholic,viral and cholestatic etiologies based on MR spectra.Alcoholic and viral etiology differed in PDE (alcoholic,viral, controls: 6.5±2.3, 6.5±3.1, 10.8±2.7 mmol/L,P＜0.001) and ATP (alcoholic, viral, controls: 2.9±0.8, 2.8±0.9, 3.7±1.0 mmol/L, P＜0.01) from the control group.Unlike viral etiology, patients with alcoholic etiology also differed in Pi (alcoholic, controls: 1.2±0.4, 1.6±0.6mmol/L, P＜0.05) from controls. No significant changes were found in patients with cholestatic disease and controls; nevertheless, this group differed from both alcoholic and viral groups (cholestatic, alcoholic, viral: 9.4±2.7, 6.5±2.3, 6.5±3.1 mmol/L, P＜0.005) in PDE.CONCLUSION: 31p MRS can significantly help in noninvasive separation of different etiological groups leading to liver cirrhosis. In addition, MRS changes reflect functional liver injury.
基金supported by the National Natural Science Foundation of China (11221202 and 51075032)Excellent Young Scholar Research Fund from Beijing Institute of Technology
文摘The spinning solar sail of large scale has been well developed in recent years. Such a solar sail can be considered as a rigid-flexible multibody system mainly composed of a spinning central rigid hub, a number of flexible thin tethers, sail membranes, and tip masses. A simplified interplanetary kite-craft accelerated by radiation of the Sun （IKAROS） model is established in this study by using the absolute-coordinate-based （ACB） method that combines the natural coordinate formulation （NCF） describing the central rigid hub and the absolute nodal coordinate formulation （ANCF） describing flexible parts. The initial configuration of the system in the second-stage deployment is determined through both dynamic and static analyses. The huge set of stiff equations of system dynamics is solved by using the generalized-alpha method, and thus the deployment dynamics of the system can be well understood.
基金Project supported by the National Natural Science Foundation of China.
文摘In this paper, we transform the Lurie indirect control systems into a nonlinear system with separating variables by a topological transformation and introduce a definition of absolute stability for partial variables. The necessary and sufficient conditions (NASC) for the absolute stability of Lurie indirect control systems are given and some sufficient conditions are obtained.
基金Financial support from the National Natural Sciences Foundation of China(NNSFCGrant Nos.81373287,81630094,and 30825044)
文摘Three pairs of glycosidic 8,4′-oxyneolignane diastereoisomers, named isatioxyneolignosides A-F(1–6), were isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations were elucidated by comprehensive spectroscopic data analysis and enzyme hydrolysis. The validity of Δδ_(C8-C7) values to distinguish threo and erythro aryl glycerol units and Cotton effects at 235±5 nm to determine absolute configurations at C-8 in 1–6 and their aglycones(1a–6a) are discussed.
基金Supported by the National Natural Science Foundation of China under Grant Nos 10376026 and 10434100, the Foundation for the Excellent Youth Scholars of the Ministry of Education of China.
文摘A fully relativistic distorted-wave program is developed based on the Grasp92 and Ratip packages to calculate electron impact excitation （EIE） cross sections. As a first application of the program, the EIE cross sections of Be-like C^α＋ ions from the metastable 1s^22s2p^3 p to 1s^22p^2 ^3 p excitation and the inner-shell excitations are calculated systematically. Meanwhile, the correlation effects of target states are discussed. It is found that the correlation effects play an important role in the low energy EIE cross sections. An excellent agreement is found when the results are compared with previous calculations and recent measurements.
基金supported by the National Natural Science Foundation of China under Grant No.60677019.
文摘We present a simple but effective method for small-angle measurement based on optical feedback interferometry （or laser self-mixing interferometry）. The absolute zero angle can be defined at the biggest fringe amplitude point, so this method can also achieve absolute angle measurement. In order to verify the method, we construct an angle measurement system. The Fourier-transform method is used to analysis the interference signal. Rotation angles are experimentally measured with a resolution of 10^-6 rad and a measurement range of approximately from -0.0007 to ＋0.0007 rad.
基金The project supported by the National Natural Science Foundation of China(10472066,10372057)The English text was polished by Yunming Chen.
文摘In this paper, nonlinear modeling for flexible multibody system with large deformation is investigated. Absolute nodal coordinates are employed to describe the displacement, and variational motion equations of a flexible body are derived on the basis of the geometric nonlinear theory, in which both the shear strain and the transverse normal strain are taken into account. By separating the inner and the boundary nodal coordinates, the motion equations of a flexible multibody system are assembled. The advantage of such formulation is that the constraint equations and the forward recursive equations become linear because the absolute nodal coordinates are used. A spatial double pendulum connected to the ground with a spherical joint is simulated to investigate the dynamic performance of flexible beams with large deformation. Finally, the resultant constant total energy validates the present formulation.
基金Supported by The National Natural Science Foundation of China,No.81773128 and No.81871998the Natural Science Basic Research Plan in Shaanxi Province of China,No.2017JM8039+1 种基金China Postdoctoral Science Foundation,No.2018m641000Research Fund for Young Star of Science and Technology in Shaanxi Province,No.2018KJXX-022
文摘BACKGROUND Recent evidence shows that long non-coding RNAs(lncRNAs) are closely related to hepatogenesis and a few aggressive features of hepatocellular carcinoma(HCC). Increasing studies demonstrate that lncRNAs are potential prognostic factors for HCC. Moreover, several studies reported the combination of lncRNAs for predicting the overall survival(OS) of HCC, but the results varied. Thus,more effort including more accurate statistical approaches is needed for exploring the prognostic value of lncRNAs in HCC.AIM To develop a robust lncRNA signature associated with HCC recurrence to improve prognosis prediction of HCC.METHODS Univariate COX regression analysis was performed to screen the lncRNAs significantly associated with recurrence-free survival(RFS) of HCC in GSE76427 for the least absolute shrinkage and selection operator(LASSO) modelling. The established lncRNA signature was validated and developed in The Cancer Genome Atlas(TCGA) series using Kaplan-Meier curves. The expression values of the identified lncRNAs were compared between the tumor and non-tumor tissues. Pathway enrichment of these lncRNAs was conducted based on the significantly co-expressed genes. A prognostic nomogram combining the lncRNA signature and clinical characteristics was constructed.RESULTS The lncRNA signature consisted of six lncRNAs: MSC-AS1, POLR2 J4, EIF3 J-AS1,SERHL, RMST, and PVT1. This risk model was significantly associated with the RFS of HCC in the TCGA cohort with a hazard ratio(HR) being 1.807(95%CI[confidence interval]: 1.329-2.457) and log-rank P-value being less than 0.001. The best candidates of the six-lncRNA signature were younger male patients with HBV infection in relatively early tumor-stage and better physical condition but with higher preoperative alpha-fetoprotein. All the lncRNAs were significantly upregulated in tumor samples compared to non-tumor samples(P < 0.05). The most significantly enriched pathways of the lncRNAs were TGF-β signaling pathway, cellular apoptosis-associated pathways, etc. The nomog
