Forty-six XX disorder of sex development is an uncommon medical condition observed at times during the evaluation of a man＇s fertility. The following is a case series and literature review of phenotypically normal me...Forty-six XX disorder of sex development is an uncommon medical condition observed at times during the evaluation of a man＇s fertility. The following is a case series and literature review of phenotypically normal men diagnosed with this karyotype. Our goal is to comprehend the patients＇ clinical presentation as well as their laboratory results aiming to explore options available for their management. A formal literature review through PubMed and MEDLINE databases was performed using ＂46 XX man＂ as a word search. A total of 55 patients, including those conveyed in this article were diagnosed with a 46 XX karyotype during their fertility evaluation. The patients＇ mean age _＋ s.d. was 34 ＋ 10 years and their mean height ＋ s.d. was 166 ＋ 6.5 cm. Overall, they presented with hypergonadotropic hypogonadism. Sexual dysfunction, reduced hair distribution, and gynecomastia were reported in 20% （4120）, 25.8% （8/31）, and 42% （13131） of the patients, respectively. The SRYgene was detected in 36 （83.7%） and was absent in the remaining seven （16.3%） patients. We found that a multidisciplinary approach to management is preferred in 46 XX patients. Screening for remnants of the mullerian ducts and for malignant transformation in dysgenetic gonads is imperative. Hypogonadism should be addressed, while fertility options are in vitro fertilization with donor sperm or adoption.展开更多
The characteristics of pairwise entanglement and local polarization (LP) are dis-cussed by studying the ground state (states) of the Heisenberg XX model. The re-sults show that: the ground state (states) is (are) comp...The characteristics of pairwise entanglement and local polarization (LP) are dis-cussed by studying the ground state (states) of the Heisenberg XX model. The re-sults show that: the ground state (states) is (are) composed of the micro states with the minimal polarization (0 for even qubit and 1/2 for odd qubit); LP and the prob-ability of the micro state have an intimate relation, i.e. the stronger the LP, the smaller the probability, and the same LP corresponds to the same probability; the pairwise entanglement of the ground state is the biggest in all eigenvectors. It is found that the pairwise entanglement is decreased by the state degeneracy and the system size. The concurrence approaches a fixed value of about 0.3412 (for odd-qubit chain) or 0.3491 (for even-qubit chain) if the qubit number is large enough.展开更多
Background: In disorders of sexual differentiation, sexual development may not conform to the chromosomal structure, thus forming different types of abnormalities. Among these abnormalities is syndrome 46, XX DSD wher...Background: In disorders of sexual differentiation, sexual development may not conform to the chromosomal structure, thus forming different types of abnormalities. Among these abnormalities is syndrome 46, XX DSD where most patients are female phenotype with clitoral hypertrophy that can go to complete masculinization especially in the presence of the SRY gene. Objective: The goal of this work is to demonstrate a relationship between the genotype and the phenotype in five patients karyotype 46, XX with the presence of the SRY gene. Methodology: The study involves five patients referred to the laboratory under suspicion of sexual development anomalies. The diagnosis took place through hormonal and echography examinations, a classic cytogenetic study (Barr chromatin and karyotype) and an amplification of the SRY gene located on the Y chromosome. The resulting PCR products were sent for sequencing. Results: Based on the results of clinical and paraclinical tests carried out it was found clitoral hypertrophy, the presence of clitoris penis for some, presence of normal penis for others. In addition, echography revealed a lack of female internal genitalia (P2, P3), and a presence of testicles (P3, P4, P5). Genetic analysis (chromosomal and molecular) showed a karyotype 46, XX SRY (+) for all patients. New mutations were found c.246 T > A, p.82 Asn82Lys and c.171 G > C, p.57 Gln57His. Conclusion: In our study, we were able to correlate each DSD with karyotype 46, XX to a pathology such as 46, XX DSD testicular, 46, XX DSD with clitoral hypertrophy and ovotestis 46, XX. The next step will undoubtedly be the integration of other molecular techniques (genotyping, FISH, CGH or even the CGH array) to further genetic exploration.展开更多
Based on the calculation of all the pairwise entanglements in the n （n ≤ 6）-qubit Heisenberg XX open chain with system impurity, we find an important result： pairwise entanglement can only be transferred by an ent...Based on the calculation of all the pairwise entanglements in the n （n ≤ 6）-qubit Heisenberg XX open chain with system impurity, we find an important result： pairwise entanglement can only be transferred by an entangled pair. The non-nearest pairwise entanglements will have the possibility to exist as long as there has been even number of qubits in their middle. This point indicates that we can obtain longer distance entanglement in a solid system.展开更多
1临床资料姓名：任××,出生日期：1989年12月14日,病案号：1507745第一次就诊,2006年11月14日,17岁,内分泌科。主诉：发现低血钾、高血压3年。现病史：近3年发现低血钾,最低1.35 mmol/L,间断静脉补钾及口服补钾。同时发现血压...1临床资料姓名：任××,出生日期：1989年12月14日,病案号：1507745第一次就诊,2006年11月14日,17岁,内分泌科。主诉：发现低血钾、高血压3年。现病史：近3年发现低血钾,最低1.35 mmol/L,间断静脉补钾及口服补钾。同时发现血压高,平时160/100 mm Hg,最高血压170/140 mm Hg。在当地医院住院治疗,可疑诊断为特发性醛固酮增多症或17α羟化酶缺乏症。展开更多
Mature wild-type yellow catfish( Pelteobagrus fulvidraco Richardson) individuals with excellent traits have been screened from the Yangtze River as broodstock to establish the germplasm bank of pure-line yellow catfis...Mature wild-type yellow catfish( Pelteobagrus fulvidraco Richardson) individuals with excellent traits have been screened from the Yangtze River as broodstock to establish the germplasm bank of pure-line yellow catfish by artificial gynogenesis technique and hormonal sex reversal method. Based on pure lines of yellow catfish,super-males and physiological females of yellow catfish were selected by GMT technique,hormonal sex reversal method and test-crossing to establish the germplasm bank of YY physiological females( YY♀). The propagation system of male yellow catfish( XY♂) was established based on the combination of super-males( YY♂) and pure-line female( XX♀) for large-scale production of pure-line yellow catfish males,which effectively overcome the disadvantages in the production of common fingerlings and male fingerlings using low-grade fish with slow growth and small size at the bottom of the fish grader as broodfish,such as progeny germplasm degeneration,loss of growth vigor and reduction of breeding benefits. The technical route of breeding pure-line YY physiological females( YY♀) and YY super-males( YY♂) laid the foundation for large-scale production of environmentally friendly yellow catfish males with pure germplasm and strong stress resistance,and provided an efficient,stable,healthy,environmentally friendly,energy-saving and income-increasing approach for sustainable development of yellow catfish breeding industry.展开更多
Sentence“bei”(“被”字句)and“bei xx”(被xx)provide syntactic and semantic basis for the generation of the construction“You Bei X Dao(有被x到)”.They are in a continuum and have family similarity.The sentence“bei...Sentence“bei”(“被”字句)and“bei xx”(被xx)provide syntactic and semantic basis for the generation of the construction“You Bei X Dao(有被x到)”.They are in a continuum and have family similarity.The sentence“bei”is a typical member,while“bei xx”is an atypical member.Because the construction“You Bei X Dao”has a single function and less attention,it is at the edge of the continuum and is a marginal member.However,it has certain research value in the inheritance and innovation of“bei”and“bei xx”.展开更多
In this paper, we study the quantum phase transition and the effect of impurity on the thermal entanglement between any two lattices in three-qubit Heisenberg XX chain in a uniform magnetic field. We show that the qua...In this paper, we study the quantum phase transition and the effect of impurity on the thermal entanglement between any two lattices in three-qubit Heisenberg XX chain in a uniform magnetic field. We show that the quantum phase transition always appears when impurity parameter is an arbitrary constant and unequal to zero, the external magnetic field and impurity parameters have a great effect on it. Also, there exists a relation between the quantum phase transition and the entanglement. By modulating the temperature, magnetic field and the impurity parameters, the entanglement between any two lattices can exhibit platform-like behaviour, which can be used to realize entanglement switch.展开更多
人类性别分化是由染色体遗传信息调控的复杂分子信号通路网络所控制的,这些通路信号驱动性腺的发育并调控性腺分泌激素促进第二性征的形成,从而表现为不同的性别^([1])。性发育异常疾病(disorders of sex development,DSD)是一类染色体...人类性别分化是由染色体遗传信息调控的复杂分子信号通路网络所控制的,这些通路信号驱动性腺的发育并调控性腺分泌激素促进第二性征的形成,从而表现为不同的性别^([1])。性发育异常疾病(disorders of sex development,DSD)是一类染色体、性腺和生殖器官发育不一致的罕见疾病的总称,这类疾病的特征在于染色体、性腺和生殖器官的性发育状态不一致,主要表现为性腺功能异常和生殖障碍。展开更多
By using the infinite time-evolving block decimation, we study quantum fidelity and entanglement entropy in the spin-1/2 Heisenberg alternating chain under an external magnetic field.The effects of the magnetic field ...By using the infinite time-evolving block decimation, we study quantum fidelity and entanglement entropy in the spin-1/2 Heisenberg alternating chain under an external magnetic field.The effects of the magnetic field on the fidelity are investigated, and its relation with the quantum phase transition(QPT) is analyzed.The phase diagram of the model is given accordingly, which supports the Haldane phase, the singlet-dimer phase, the Luttinger liquid phase and the paramagnetic phase.The scaling of entanglement entropy in the gapless Luttinger liquid phase is studied, and the central charge c = 1 is obtained.We also study the relationship between the quantum coherence, string order parameter and QPTs.Results obtained from these quantum information observations are consistent with the previous reports.展开更多
文摘Forty-six XX disorder of sex development is an uncommon medical condition observed at times during the evaluation of a man＇s fertility. The following is a case series and literature review of phenotypically normal men diagnosed with this karyotype. Our goal is to comprehend the patients＇ clinical presentation as well as their laboratory results aiming to explore options available for their management. A formal literature review through PubMed and MEDLINE databases was performed using ＂46 XX man＂ as a word search. A total of 55 patients, including those conveyed in this article were diagnosed with a 46 XX karyotype during their fertility evaluation. The patients＇ mean age _＋ s.d. was 34 ＋ 10 years and their mean height ＋ s.d. was 166 ＋ 6.5 cm. Overall, they presented with hypergonadotropic hypogonadism. Sexual dysfunction, reduced hair distribution, and gynecomastia were reported in 20% （4120）, 25.8% （8/31）, and 42% （13131） of the patients, respectively. The SRYgene was detected in 36 （83.7%） and was absent in the remaining seven （16.3%） patients. We found that a multidisciplinary approach to management is preferred in 46 XX patients. Screening for remnants of the mullerian ducts and for malignant transformation in dysgenetic gonads is imperative. Hypogonadism should be addressed, while fertility options are in vitro fertilization with donor sperm or adoption.
基金Supported by the National Natural Science Foundation of China (Grant Nos. 10547008, 90403034, 90403019, 90406017 and 60525417)the National Key Basic Research Special Foundation of China (Grant Nos. 2005CB724508 and 2006CB921400)+1 种基金the Foundation of Xi’an Institute of Post and Telecommunications (Grant No. 105-0414)the Natural Science Foundation of Shanxi Province (Grant No. 2004A15)
文摘The characteristics of pairwise entanglement and local polarization (LP) are dis-cussed by studying the ground state (states) of the Heisenberg XX model. The re-sults show that: the ground state (states) is (are) composed of the micro states with the minimal polarization (0 for even qubit and 1/2 for odd qubit); LP and the prob-ability of the micro state have an intimate relation, i.e. the stronger the LP, the smaller the probability, and the same LP corresponds to the same probability; the pairwise entanglement of the ground state is the biggest in all eigenvectors. It is found that the pairwise entanglement is decreased by the state degeneracy and the system size. The concurrence approaches a fixed value of about 0.3412 (for odd-qubit chain) or 0.3491 (for even-qubit chain) if the qubit number is large enough.
文摘Background: In disorders of sexual differentiation, sexual development may not conform to the chromosomal structure, thus forming different types of abnormalities. Among these abnormalities is syndrome 46, XX DSD where most patients are female phenotype with clitoral hypertrophy that can go to complete masculinization especially in the presence of the SRY gene. Objective: The goal of this work is to demonstrate a relationship between the genotype and the phenotype in five patients karyotype 46, XX with the presence of the SRY gene. Methodology: The study involves five patients referred to the laboratory under suspicion of sexual development anomalies. The diagnosis took place through hormonal and echography examinations, a classic cytogenetic study (Barr chromatin and karyotype) and an amplification of the SRY gene located on the Y chromosome. The resulting PCR products were sent for sequencing. Results: Based on the results of clinical and paraclinical tests carried out it was found clitoral hypertrophy, the presence of clitoris penis for some, presence of normal penis for others. In addition, echography revealed a lack of female internal genitalia (P2, P3), and a presence of testicles (P3, P4, P5). Genetic analysis (chromosomal and molecular) showed a karyotype 46, XX SRY (+) for all patients. New mutations were found c.246 T > A, p.82 Asn82Lys and c.171 G > C, p.57 Gln57His. Conclusion: In our study, we were able to correlate each DSD with karyotype 46, XX to a pathology such as 46, XX DSD testicular, 46, XX DSD with clitoral hypertrophy and ovotestis 46, XX. The next step will undoubtedly be the integration of other molecular techniques (genotyping, FISH, CGH or even the CGH array) to further genetic exploration.
基金Project supported in part by the National Natural Science Foundation of China （Grant No 10547008）, and the Foundation of Xi＇an Institute of Posts and Telecommunications, China （Grant No 105-0414）.
文摘Based on the calculation of all the pairwise entanglements in the n （n ≤ 6）-qubit Heisenberg XX open chain with system impurity, we find an important result： pairwise entanglement can only be transferred by an entangled pair. The non-nearest pairwise entanglements will have the possibility to exist as long as there has been even number of qubits in their middle. This point indicates that we can obtain longer distance entanglement in a solid system.
文摘1临床资料姓名：任××,出生日期：1989年12月14日,病案号：1507745第一次就诊,2006年11月14日,17岁,内分泌科。主诉：发现低血钾、高血压3年。现病史：近3年发现低血钾,最低1.35 mmol/L,间断静脉补钾及口服补钾。同时发现血压高,平时160/100 mm Hg,最高血压170/140 mm Hg。在当地医院住院治疗,可疑诊断为特发性醛固酮增多症或17α羟化酶缺乏症。
基金Supported by Implementation Plan of Subsidy Project for the Reform and Construction of Grassroots Agricultural Technology Extension System
文摘Mature wild-type yellow catfish( Pelteobagrus fulvidraco Richardson) individuals with excellent traits have been screened from the Yangtze River as broodstock to establish the germplasm bank of pure-line yellow catfish by artificial gynogenesis technique and hormonal sex reversal method. Based on pure lines of yellow catfish,super-males and physiological females of yellow catfish were selected by GMT technique,hormonal sex reversal method and test-crossing to establish the germplasm bank of YY physiological females( YY♀). The propagation system of male yellow catfish( XY♂) was established based on the combination of super-males( YY♂) and pure-line female( XX♀) for large-scale production of pure-line yellow catfish males,which effectively overcome the disadvantages in the production of common fingerlings and male fingerlings using low-grade fish with slow growth and small size at the bottom of the fish grader as broodfish,such as progeny germplasm degeneration,loss of growth vigor and reduction of breeding benefits. The technical route of breeding pure-line YY physiological females( YY♀) and YY super-males( YY♂) laid the foundation for large-scale production of environmentally friendly yellow catfish males with pure germplasm and strong stress resistance,and provided an efficient,stable,healthy,environmentally friendly,energy-saving and income-increasing approach for sustainable development of yellow catfish breeding industry.
基金BLCU supported project for young researchers’program(supported by the Fundamental Research Funds for the Central Universities)(Project No.,22YCX083).
文摘Sentence“bei”(“被”字句)and“bei xx”(被xx)provide syntactic and semantic basis for the generation of the construction“You Bei X Dao(有被x到)”.They are in a continuum and have family similarity.The sentence“bei”is a typical member,while“bei xx”is an atypical member.Because the construction“You Bei X Dao”has a single function and less attention,it is at the edge of the continuum and is a marginal member.However,it has certain research value in the inheritance and innovation of“bei”and“bei xx”.
基金Project supported by the National Natural Science Foundation of China (Grant No. 10774088)the Key Program of the National Natural Science Foundation of China (Grant No. 10534030)
文摘In this paper, we study the quantum phase transition and the effect of impurity on the thermal entanglement between any two lattices in three-qubit Heisenberg XX chain in a uniform magnetic field. We show that the quantum phase transition always appears when impurity parameter is an arbitrary constant and unequal to zero, the external magnetic field and impurity parameters have a great effect on it. Also, there exists a relation between the quantum phase transition and the entanglement. By modulating the temperature, magnetic field and the impurity parameters, the entanglement between any two lattices can exhibit platform-like behaviour, which can be used to realize entanglement switch.
文摘人类性别分化是由染色体遗传信息调控的复杂分子信号通路网络所控制的,这些通路信号驱动性腺的发育并调控性腺分泌激素促进第二性征的形成,从而表现为不同的性别^([1])。性发育异常疾病(disorders of sex development,DSD)是一类染色体、性腺和生殖器官发育不一致的罕见疾病的总称,这类疾病的特征在于染色体、性腺和生殖器官的性发育状态不一致,主要表现为性腺功能异常和生殖障碍。
基金Supported by the National Natural Science Foundation of China under Grant Nos.11384012 and 11474211
文摘By using the infinite time-evolving block decimation, we study quantum fidelity and entanglement entropy in the spin-1/2 Heisenberg alternating chain under an external magnetic field.The effects of the magnetic field on the fidelity are investigated, and its relation with the quantum phase transition(QPT) is analyzed.The phase diagram of the model is given accordingly, which supports the Haldane phase, the singlet-dimer phase, the Luttinger liquid phase and the paramagnetic phase.The scaling of entanglement entropy in the gapless Luttinger liquid phase is studied, and the central charge c = 1 is obtained.We also study the relationship between the quantum coherence, string order parameter and QPTs.Results obtained from these quantum information observations are consistent with the previous reports.
