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阿瑞匹坦纳米胶囊的制备 被引量:1
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作者 王淑华 王明森 +1 位作者 林永强 邵建国 《药学研究》 CAS 2013年第1期4-5,共2页
目的介绍一种制备阿瑞匹坦纳米胶囊的制备方法。方法采用湿法介质研磨来降低药物粒度,制备药物胶态分散体,以药物胶态分散体为包衣材料进行Wurster包衣制备药物包衣球,筛分后装胶囊。结果所制阿瑞匹坦纳米胶囊的药物粒度D90小于216 nm,... 目的介绍一种制备阿瑞匹坦纳米胶囊的制备方法。方法采用湿法介质研磨来降低药物粒度,制备药物胶态分散体,以药物胶态分散体为包衣材料进行Wurster包衣制备药物包衣球,筛分后装胶囊。结果所制阿瑞匹坦纳米胶囊的药物粒度D90小于216 nm,与原研药物相当。结论该制备阿瑞匹坦纳米胶囊的工艺可行。 展开更多
关键词 阿瑞匹坦纳米胶囊 介质研磨 底喷包衣
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Polysiloxane coatings on microspheres based on Multiphase Flow with Interface Exchange-Discrete Element Modelling
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作者 Sanjay Kumar Devendhar Singh Jean-FranCois Dietiker Kathy Lu 《Particuology》 SCIE EI CAS CSCD 2022年第10期88-99,共12页
Polysiloxane coatings on yttria stabilized zirconia(YSZ)microspheres of 500μm were simulated in a spout fluidized bed coater using Multiphase Flow with Interface Exchange-Discrete Element Modelling(MFiX-DEM).Two diff... Polysiloxane coatings on yttria stabilized zirconia(YSZ)microspheres of 500μm were simulated in a spout fluidized bed coater using Multiphase Flow with Interface Exchange-Discrete Element Modelling(MFiX-DEM).Two different coater configurations were developed to study the influence of gas velocity and its distribution on particle dynamics.The presence of the Wurster tube not only enhances the dis-tribution but also increases the overall residence time of the particles.Investigations were also carried out with different Wurster tube positions(normal,10%and 20%lowered from its initial position).Among these,20%lowered Wurster tube position demonstrated the most effective coating process.The effects of gas inlet pressure on the average gas velocity and the distribution of particles were analyzed.More than 97%of the particles can be retained.The derived results,including average gas velocity,particle retention percentage,and distribution of particles with gas velocity,are being used to guide the experimental work in obtaining defect-free coatings for YSZ microspheres. 展开更多
关键词 Spouted bed wurster tube coating Yttria stabilized zirconia(YSZ) MFiX
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流化床包衣法制备100μm级马来酸氯苯那敏掩味微囊 被引量:8
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作者 刘东春 崔福德 +1 位作者 福森义信 市川秀喜 《沈阳药科大学学报》 CAS CSCD 北大核心 2006年第3期129-135,共7页
目的制备100μm级马来酸氯苯那敏掩味微囊。方法以自制的2种单体量比为9∶9∶10(Ⅰ)和8∶10∶8(Ⅱ)的聚(丙烯酸乙酯甲基丙烯酸甲酯甲基丙烯酸2羟乙酯)三元丙烯酸类树脂[poly(EA MMA HEMA)]乳胶液作为包衣液,采用Wurster式流化床包衣制... 目的制备100μm级马来酸氯苯那敏掩味微囊。方法以自制的2种单体量比为9∶9∶10(Ⅰ)和8∶10∶8(Ⅱ)的聚(丙烯酸乙酯甲基丙烯酸甲酯甲基丙烯酸2羟乙酯)三元丙烯酸类树脂[poly(EA MMA HEMA)]乳胶液作为包衣液,采用Wurster式流化床包衣制备微囊Ⅰ和微囊Ⅱ。测定了2种乳胶液的平均粒径、玻璃转化温度(tg)。通过测定微囊粒度分布、释放度及显微观察和志愿者口尝来评价制备的微囊及掩味效果。结果自制的2种包衣液的平均粒子径为83.4 nm和78.8 nm,tg为64.9℃和67.8℃。质量分数为50%的包衣水平微囊中超过90%的粒径小于106μm,质量分数为50%的包衣水平微囊Ⅰ和微囊Ⅱ的平均掩味时间分别为(33±12)s(n=6)和(51±16)s(n=6),30 min释放度90.1%、84.8%。结论合成的2种poly(EA MMA HEMA)适合制备100μm级的微囊,制得的微囊掩味时间大于30 s,且30 min药物释放度良好。 展开更多
关键词 微囊 掩味 马来酸氯苯那敏 包衣 wurster式流化床 丙烯酸树脂
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