In this research, we have performed pulse analysis on the data of 127 subjects collected from Department of Cardiology at Shandong Provincial Hospital in China. By taking the first and third derivatives of an entire p...In this research, we have performed pulse analysis on the data of 127 subjects collected from Department of Cardiology at Shandong Provincial Hospital in China. By taking the first and third derivatives of an entire pulse wave, we have firstly identified the locations of wave foot, systolic peak, and reflected point. Then we calculated Reverse Shoulder Index (RSI) and Ratio of Distance of the evaluated subjects, and correlated them to age, the history of hypertension, and different cardiovascular diseases of the subjects.展开更多
目的观察高血压患者及血压正常人群中心动脉血流动力学差异;探讨哪种血压指标与动脉僵硬度及血管损害标志物更密切相关。方法从北京地区社区人群中筛选出820名高血压患者,同时入选820名与之年龄、性别相匹配的血压正常者。采用脉搏波传...目的观察高血压患者及血压正常人群中心动脉血流动力学差异;探讨哪种血压指标与动脉僵硬度及血管损害标志物更密切相关。方法从北京地区社区人群中筛选出820名高血压患者,同时入选820名与之年龄、性别相匹配的血压正常者。采用脉搏波传播速度(PWV)自动测量系统测定颈-股动脉PWV和颈-桡动脉PWV;应用张力测量法测量中心动脉压和中心动脉脉搏波增强指数(AIx)。同时血浆同型半胱氨酸(HCY),高敏C反应蛋白(Hs CRP)及N末端脑利钠肽前体(NT-pro BNP)被测定。结果无论是高血压患者还是血压正常人群,中心动脉收缩压和脉压显著低于相应的肱动脉收缩压和脉压,这种脉压扩增在血压正常组9.85±6.55 mm Hg明显低于高血压组12.64±6.69 mm Hg,但在脉压扩增比上两组未见差异。大动脉僵硬度受血压及年龄的影响,高血压组具有较高的颈股动脉PWV和中心动脉AIx,脉压扩增比随年龄的增长而递减。单因素分析见中心脉压相对其它血压指标与动脉僵硬度和血管损害标志物的相关性更强;多元逐步回归分析显示颈股动脉PWV和中心动脉AIx受中心脉压的独立影响而外周平均动脉压及脉压未进入回归方程。结论中心动脉脉压相对其它血压指标可能是中心动脉僵硬度更直接的指示器和更好的血管老化的标志,未来的临床试验中可能更多地将中心动脉压作为治疗的靶目标值。展开更多
The reflected field of pulsed cylindrical waves from a liquid-solid interface is studied by the numerical method and the experimental method. The reflected field is calculated and shown in gray pictures. The calculate...The reflected field of pulsed cylindrical waves from a liquid-solid interface is studied by the numerical method and the experimental method. The reflected field is calculated and shown in gray pictures. The calculated incident angles θn (n=1, 2, 3, ...) of a series of minimums (or nulls) on the reflected wavefront are presented. The measured angle of the minimum from Schlieren photograph is consistent with that by calculation. The appearance of minimums is explained by the interference between the reflected wave and the head wave, and by the radiated dissipation of the head wave. The leading phase angle of the head wave to the reflected wave is proved to be about 3π/4 by the numerical calculation.展开更多
文摘In this research, we have performed pulse analysis on the data of 127 subjects collected from Department of Cardiology at Shandong Provincial Hospital in China. By taking the first and third derivatives of an entire pulse wave, we have firstly identified the locations of wave foot, systolic peak, and reflected point. Then we calculated Reverse Shoulder Index (RSI) and Ratio of Distance of the evaluated subjects, and correlated them to age, the history of hypertension, and different cardiovascular diseases of the subjects.
文摘目的观察高血压患者及血压正常人群中心动脉血流动力学差异;探讨哪种血压指标与动脉僵硬度及血管损害标志物更密切相关。方法从北京地区社区人群中筛选出820名高血压患者,同时入选820名与之年龄、性别相匹配的血压正常者。采用脉搏波传播速度(PWV)自动测量系统测定颈-股动脉PWV和颈-桡动脉PWV;应用张力测量法测量中心动脉压和中心动脉脉搏波增强指数(AIx)。同时血浆同型半胱氨酸(HCY),高敏C反应蛋白(Hs CRP)及N末端脑利钠肽前体(NT-pro BNP)被测定。结果无论是高血压患者还是血压正常人群,中心动脉收缩压和脉压显著低于相应的肱动脉收缩压和脉压,这种脉压扩增在血压正常组9.85±6.55 mm Hg明显低于高血压组12.64±6.69 mm Hg,但在脉压扩增比上两组未见差异。大动脉僵硬度受血压及年龄的影响,高血压组具有较高的颈股动脉PWV和中心动脉AIx,脉压扩增比随年龄的增长而递减。单因素分析见中心脉压相对其它血压指标与动脉僵硬度和血管损害标志物的相关性更强;多元逐步回归分析显示颈股动脉PWV和中心动脉AIx受中心脉压的独立影响而外周平均动脉压及脉压未进入回归方程。结论中心动脉脉压相对其它血压指标可能是中心动脉僵硬度更直接的指示器和更好的血管老化的标志,未来的临床试验中可能更多地将中心动脉压作为治疗的靶目标值。
基金This work was supported by the National Natural Science Foundation of China (Grant Nos. 19604008 and 10074039).
文摘The reflected field of pulsed cylindrical waves from a liquid-solid interface is studied by the numerical method and the experimental method. The reflected field is calculated and shown in gray pictures. The calculated incident angles θn (n=1, 2, 3, ...) of a series of minimums (or nulls) on the reflected wavefront are presented. The measured angle of the minimum from Schlieren photograph is consistent with that by calculation. The appearance of minimums is explained by the interference between the reflected wave and the head wave, and by the radiated dissipation of the head wave. The leading phase angle of the head wave to the reflected wave is proved to be about 3π/4 by the numerical calculation.
