Bone marrow edema is a self-limiting, under-recognized condition. It mainly involves the lower limbs. It is characterized by pain and inability to bear weight. Diagnosis is most often based on imaging and by excluding...Bone marrow edema is a self-limiting, under-recognized condition. It mainly involves the lower limbs. It is characterized by pain and inability to bear weight. Diagnosis is most often based on imaging and by excluding other causes. Its exact pathogenesis is still debated and various theories are postulated. Treatment ranges from anti-inflammatories to restricted weight bearing. This overview has tried to revisit this rare and perhaps forgotten clinical-radiological condition.展开更多
Transient osteoporosis of the hip (TOH), also known as “Bone marrow edema Syndrome”, is a rare disorder mainly affecting pregnant women in their third trimester, as well as middle-aged, overweight men. A 30-year-old...Transient osteoporosis of the hip (TOH), also known as “Bone marrow edema Syndrome”, is a rare disorder mainly affecting pregnant women in their third trimester, as well as middle-aged, overweight men. A 30-year-old Caucasian female G2P2, with history of transient osteoporosis of both ankles and C-Section during the last pregnancy in 2011, presented progressively severe bilateral hip pain with onset already in the 12th gestational week. Imaging of the pelvis and bilateral hips with MRI obtained 6 days after the C-Section demonstrated bilateral bone-marrow edema of the hips. The patient was treated with a monthly single dose of 150 mg ibandronate acid per os, for 3 months and physiotherapy. Repeated MRI performed 5 months postpartum revealed a complete remission of the disease. In contrast to the first onset of transient osteoporosis during the first pregnancy, which was only treated conservatively without bisphosphonates, the remission of the disease and patient’s recovery with oral ibandronate therapy showed to be 4 months shorter. This case is unique in literature for both describing the onset of this rare disease twice in the same patient as well as its oral therapeutic approach.展开更多
目的探讨暂时性骨质疏松症(transient osteoporosis of thehip,TOH)与股骨头坏死继发骨髓水肿在临床症状及影像学上的差异。方法对2006年1月-2008年2月收治的5例(5髋)TOH及63例(67髋)股骨头坏死继发骨髓水肿患者分析其病因、发病诱因、...目的探讨暂时性骨质疏松症(transient osteoporosis of thehip,TOH)与股骨头坏死继发骨髓水肿在临床症状及影像学上的差异。方法对2006年1月-2008年2月收治的5例(5髋)TOH及63例(67髋)股骨头坏死继发骨髓水肿患者分析其病因、发病诱因、疼痛程度、持续时间及病情转归等方面的差异,并分析X线片、MRI和ECT改变的异同点。5例TOH患者,男1例,女4例;年龄29～42岁。63例(67髋)股骨头坏死继发骨髓水肿患者,男53例,女10例;年龄18～70岁;根据ARCO分期标准,Ⅱ期23髋,Ⅲ期43髋,Ⅳ期1髋。结果TOH与股骨头坏死继发骨髓水肿患者在发病诱因、疼痛程度、关节积液和ECT改变上无差异。TOH患者发病前无股骨头坏死相关病因;发病前无不适症状;2髋X线片表现为密度降低;MRI水肿信号改变在股骨头颈的上方或整个股骨头;治疗后5～11个月疼痛消失后无残留症状。65髋股骨头坏死继发骨髓水肿患者有股骨头坏死的相关诱因;10髋表现为疼痛加重;59髋X线片上有硬化改变;MRI水肿信号改变在股骨头坏死灶的外侧,水肿信号消退后仍有轻度疼痛。结论TOH与股骨头坏死继发骨髓水肿在临床表现、X线片及MRI图像改变上存在差异。展开更多
目的分析、总结髋关节一过性骨质疏松症(transient osteoporosis of the hip,TOH)的临床特点、影像学特点、诊断及鉴别诊断要点.以提高临床医师对TOH的认识和诊治水平。方法回顾性分析我院骨科2012年5月至2014年3月诊治的3例TOH患者的...目的分析、总结髋关节一过性骨质疏松症(transient osteoporosis of the hip,TOH)的临床特点、影像学特点、诊断及鉴别诊断要点.以提高临床医师对TOH的认识和诊治水平。方法回顾性分析我院骨科2012年5月至2014年3月诊治的3例TOH患者的临床资料,包括临床表现、髋部影像学检查、实验室检查、病理学检查等资料,并进行分析、总结。结果 TOH临床特点为主要表现为患髋关节周围疼痛及因疼痛引起的跛行步态,负重时疼痛加重,关节内收、外展及旋转活动轻度受限,MRI及X光片检查提示异常,3例患者均经MRI检查,1例病理学检查确诊为TOH。结论熟练掌握TOH的临床特点、影像学特征、诊断及鉴别诊断要点,有助于TOH的早期诊断,可明显减少其误诊、误治率。展开更多
目的探讨髋关节暂时性骨质疏松症(transient osteoporosis of the hip,TOH)的临床表现、诊断、鉴别诊断、治疗及预后。方法2003年8月至2009年8月治疗8例TOH患者,男2例,女6例;年龄22～43岁,平均34.9岁。患者均为单侧发病,左侧5例,右侧3...目的探讨髋关节暂时性骨质疏松症(transient osteoporosis of the hip,TOH)的临床表现、诊断、鉴别诊断、治疗及预后。方法2003年8月至2009年8月治疗8例TOH患者,男2例,女6例;年龄22～43岁,平均34.9岁。患者均为单侧发病,左侧5例,右侧3例。患者的患髋均表现有不同程度的突发急性疼痛或渐进性疼痛,同时伴有显著的跛行。患髋内旋轻度受限是主要的体征。症状出现后3～6周,X线片可见股骨头均匀广泛的骨质疏松,MR表现为弥散且一致的等低T1、长T2异常信号,脂肪抑制序列呈高信号。嘱患者在疼痛可忍受的条件下半负重行走,避免出现骨折等并发症;口服二膦酸盐和钙剂;剧烈疼痛时,可口服非甾体类抗炎药物缓解疼痛。结果临床治疗3个月后疼痛明显减轻,10个月后疼痛完全缓解,复查MR示病变完全消失。结论TOH是一种少见的疾病,无原因出现的髋关节疼痛和跛行是主要症状,X线片和MR可分别看到暂时性的骨质疏松和骨髓水肿。此病具有自限性,保守治疗可获得良好的结果,明确诊断是治疗的关键。展开更多
文摘Bone marrow edema is a self-limiting, under-recognized condition. It mainly involves the lower limbs. It is characterized by pain and inability to bear weight. Diagnosis is most often based on imaging and by excluding other causes. Its exact pathogenesis is still debated and various theories are postulated. Treatment ranges from anti-inflammatories to restricted weight bearing. This overview has tried to revisit this rare and perhaps forgotten clinical-radiological condition.
文摘Transient osteoporosis of the hip (TOH), also known as “Bone marrow edema Syndrome”, is a rare disorder mainly affecting pregnant women in their third trimester, as well as middle-aged, overweight men. A 30-year-old Caucasian female G2P2, with history of transient osteoporosis of both ankles and C-Section during the last pregnancy in 2011, presented progressively severe bilateral hip pain with onset already in the 12th gestational week. Imaging of the pelvis and bilateral hips with MRI obtained 6 days after the C-Section demonstrated bilateral bone-marrow edema of the hips. The patient was treated with a monthly single dose of 150 mg ibandronate acid per os, for 3 months and physiotherapy. Repeated MRI performed 5 months postpartum revealed a complete remission of the disease. In contrast to the first onset of transient osteoporosis during the first pregnancy, which was only treated conservatively without bisphosphonates, the remission of the disease and patient’s recovery with oral ibandronate therapy showed to be 4 months shorter. This case is unique in literature for both describing the onset of this rare disease twice in the same patient as well as its oral therapeutic approach.
文摘目的探讨暂时性骨质疏松症(transient osteoporosis of thehip,TOH)与股骨头坏死继发骨髓水肿在临床症状及影像学上的差异。方法对2006年1月-2008年2月收治的5例(5髋)TOH及63例(67髋)股骨头坏死继发骨髓水肿患者分析其病因、发病诱因、疼痛程度、持续时间及病情转归等方面的差异,并分析X线片、MRI和ECT改变的异同点。5例TOH患者,男1例,女4例;年龄29～42岁。63例(67髋)股骨头坏死继发骨髓水肿患者,男53例,女10例;年龄18～70岁;根据ARCO分期标准,Ⅱ期23髋,Ⅲ期43髋,Ⅳ期1髋。结果TOH与股骨头坏死继发骨髓水肿患者在发病诱因、疼痛程度、关节积液和ECT改变上无差异。TOH患者发病前无股骨头坏死相关病因;发病前无不适症状;2髋X线片表现为密度降低;MRI水肿信号改变在股骨头颈的上方或整个股骨头;治疗后5～11个月疼痛消失后无残留症状。65髋股骨头坏死继发骨髓水肿患者有股骨头坏死的相关诱因;10髋表现为疼痛加重;59髋X线片上有硬化改变;MRI水肿信号改变在股骨头坏死灶的外侧,水肿信号消退后仍有轻度疼痛。结论TOH与股骨头坏死继发骨髓水肿在临床表现、X线片及MRI图像改变上存在差异。
文摘目的分析、总结髋关节一过性骨质疏松症(transient osteoporosis of the hip,TOH)的临床特点、影像学特点、诊断及鉴别诊断要点.以提高临床医师对TOH的认识和诊治水平。方法回顾性分析我院骨科2012年5月至2014年3月诊治的3例TOH患者的临床资料,包括临床表现、髋部影像学检查、实验室检查、病理学检查等资料,并进行分析、总结。结果 TOH临床特点为主要表现为患髋关节周围疼痛及因疼痛引起的跛行步态,负重时疼痛加重,关节内收、外展及旋转活动轻度受限,MRI及X光片检查提示异常,3例患者均经MRI检查,1例病理学检查确诊为TOH。结论熟练掌握TOH的临床特点、影像学特征、诊断及鉴别诊断要点,有助于TOH的早期诊断,可明显减少其误诊、误治率。
文摘目的探讨髋关节暂时性骨质疏松症(transient osteoporosis of the hip,TOH)的临床表现、诊断、鉴别诊断、治疗及预后。方法2003年8月至2009年8月治疗8例TOH患者,男2例,女6例;年龄22～43岁,平均34.9岁。患者均为单侧发病,左侧5例,右侧3例。患者的患髋均表现有不同程度的突发急性疼痛或渐进性疼痛,同时伴有显著的跛行。患髋内旋轻度受限是主要的体征。症状出现后3～6周,X线片可见股骨头均匀广泛的骨质疏松,MR表现为弥散且一致的等低T1、长T2异常信号,脂肪抑制序列呈高信号。嘱患者在疼痛可忍受的条件下半负重行走,避免出现骨折等并发症;口服二膦酸盐和钙剂;剧烈疼痛时,可口服非甾体类抗炎药物缓解疼痛。结果临床治疗3个月后疼痛明显减轻,10个月后疼痛完全缓解,复查MR示病变完全消失。结论TOH是一种少见的疾病,无原因出现的髋关节疼痛和跛行是主要症状,X线片和MR可分别看到暂时性的骨质疏松和骨髓水肿。此病具有自限性,保守治疗可获得良好的结果,明确诊断是治疗的关键。
