Objective：To observe the effects of Tongguan Capsule（通冠胶囊,TGC） on post-myocardial infarction ventricular remodeling and heart function in rats.Methods：A rat model of acute myocardial infarction （AMI） was est...Objective：To observe the effects of Tongguan Capsule（通冠胶囊,TGC） on post-myocardial infarction ventricular remodeling and heart function in rats.Methods：A rat model of acute myocardial infarction （AMI） was established by coronary ligation.Experimental rats were randomized to 4 groups including three model groups（Group A：captopril 5 mg/kg·day,n=7;Group B：TGC 10 g/kg·day,n=7;and Group C：placebo, n=8）,and a sham-control group（Group D：blank control,n=6）.Animals were treated for 4 weeks.The cardiac function of rats was assessed at the end of the experiment based on left ventricular ejection fraction（LVEF） and left ventricular short axis fractional shortening（LVFS） detected by colored echocardiography;meanwhile, the condition of ventricular remodeling was observed through the levels of left ventricular mass（LVM）,plasma aldosterone（ALD）,myocardial angiotensinⅡ（AngⅡ） and myocardial collagen measurements.Results：At the end of the experiment,LVEF and LVFS in Group A and B were improved significantly,while those in Group C were unchanged,the LVEF in Group A,B,C,and D was 0.57±0.46,0.61±0.08,0.36±0.55 and 0.76±0.02,respectively;and their LVFS was 0.31±0.52,0.34±0.04,0.23±0.57 and 0.45±0.03,respectively.The difference was statistically significant when comparing the two indexes in Group A and B with those in Group C and D（P〈0.05）.LVM,levels of plasma ALD and myocardial AngⅡwere lower in Group A and B than in Group C,but a comparison between Group A and B showed an insignificant difference in lowering LVM and ALD,while the lowering of AngⅡwas more significant in Group B than in Group A（754.7±18.7 pg/mL vs 952.6±17.6 pg/ mL,P〈0.05）.Morphological examination showed that in Group A and B the swollen myocardial cells had shrunk, with regularly arranged myocardial fibers and decreased collagen proliferation,but the improvements in Group B were more significant.Conclusion：TGC could markedly improve the post-infarction ventricular remodeling and展开更多
文摘Objective：To observe the effects of Tongguan Capsule（通冠胶囊,TGC） on post-myocardial infarction ventricular remodeling and heart function in rats.Methods：A rat model of acute myocardial infarction （AMI） was established by coronary ligation.Experimental rats were randomized to 4 groups including three model groups（Group A：captopril 5 mg/kg·day,n=7;Group B：TGC 10 g/kg·day,n=7;and Group C：placebo, n=8）,and a sham-control group（Group D：blank control,n=6）.Animals were treated for 4 weeks.The cardiac function of rats was assessed at the end of the experiment based on left ventricular ejection fraction（LVEF） and left ventricular short axis fractional shortening（LVFS） detected by colored echocardiography;meanwhile, the condition of ventricular remodeling was observed through the levels of left ventricular mass（LVM）,plasma aldosterone（ALD）,myocardial angiotensinⅡ（AngⅡ） and myocardial collagen measurements.Results：At the end of the experiment,LVEF and LVFS in Group A and B were improved significantly,while those in Group C were unchanged,the LVEF in Group A,B,C,and D was 0.57±0.46,0.61±0.08,0.36±0.55 and 0.76±0.02,respectively;and their LVFS was 0.31±0.52,0.34±0.04,0.23±0.57 and 0.45±0.03,respectively.The difference was statistically significant when comparing the two indexes in Group A and B with those in Group C and D（P〈0.05）.LVM,levels of plasma ALD and myocardial AngⅡwere lower in Group A and B than in Group C,but a comparison between Group A and B showed an insignificant difference in lowering LVM and ALD,while the lowering of AngⅡwas more significant in Group B than in Group A（754.7±18.7 pg/mL vs 952.6±17.6 pg/ mL,P〈0.05）.Morphological examination showed that in Group A and B the swollen myocardial cells had shrunk, with regularly arranged myocardial fibers and decreased collagen proliferation,but the improvements in Group B were more significant.Conclusion：TGC could markedly improve the post-infarction ventricular remodeling and
