Thermosensitive liposomes(TSLs) have been an important research area in the field of tumor targeted chemotherapy. Since the first TSLs appeared that using 1,2-dipalmitoyl-snglyce-ro-3-phosphocholine(DPPC) as the prima...Thermosensitive liposomes(TSLs) have been an important research area in the field of tumor targeted chemotherapy. Since the first TSLs appeared that using 1,2-dipalmitoyl-snglyce-ro-3-phosphocholine(DPPC) as the primary liposomal lipid, many studies have been done using this type of liposome from basic and practical aspects. While TSLs composed of DPPC enhance the cargo release near the phase transition temperature, it has been shown that many factors affect their temperature sensitivity. Thus numerous attempts have been undertaken to develop new TSLs for improving their thermal response performance. The main objective of this review is to introduce the development and recent update of innovative TSLs formulations, including combination of radiofrequency ablation(RFA), highintensity focused ultrasound(HIFU), magnetic resonance imaging(MRI) and alternating magnetic field(AMF). In addition, various factors affecting the design of TSLs, such as lipid composition, surfactant, size and serum components are also discussed.展开更多
长循环脂质体可以通过高通透性和滞留(enhanced permeability and retention,EPR)效应靶向传递药物进入肿瘤部位,但是靶向聚集的脂质体药物若不能从脂质体中释放出来则无法发挥药效。为解决此问题,长循环热敏脂质体已经成为目前的研究热...长循环脂质体可以通过高通透性和滞留(enhanced permeability and retention,EPR)效应靶向传递药物进入肿瘤部位,但是靶向聚集的脂质体药物若不能从脂质体中释放出来则无法发挥药效。为解决此问题,长循环热敏脂质体已经成为目前的研究热点,其既保留了传统长循环脂质体的靶向作用,又能在加热条件下触发药物的局部释放,从而提高药物的治疗效果。本文综述了抗肿瘤长循环热敏脂质体的研究进展。展开更多
基金National Natural Science Foundation of China (No.31671020) for financial support
文摘Thermosensitive liposomes(TSLs) have been an important research area in the field of tumor targeted chemotherapy. Since the first TSLs appeared that using 1,2-dipalmitoyl-snglyce-ro-3-phosphocholine(DPPC) as the primary liposomal lipid, many studies have been done using this type of liposome from basic and practical aspects. While TSLs composed of DPPC enhance the cargo release near the phase transition temperature, it has been shown that many factors affect their temperature sensitivity. Thus numerous attempts have been undertaken to develop new TSLs for improving their thermal response performance. The main objective of this review is to introduce the development and recent update of innovative TSLs formulations, including combination of radiofrequency ablation(RFA), highintensity focused ultrasound(HIFU), magnetic resonance imaging(MRI) and alternating magnetic field(AMF). In addition, various factors affecting the design of TSLs, such as lipid composition, surfactant, size and serum components are also discussed.
文摘长循环脂质体可以通过高通透性和滞留(enhanced permeability and retention,EPR)效应靶向传递药物进入肿瘤部位,但是靶向聚集的脂质体药物若不能从脂质体中释放出来则无法发挥药效。为解决此问题,长循环热敏脂质体已经成为目前的研究热点,其既保留了传统长循环脂质体的靶向作用,又能在加热条件下触发药物的局部释放,从而提高药物的治疗效果。本文综述了抗肿瘤长循环热敏脂质体的研究进展。
