目的探讨上海国展中心方舱医院第一分院用中医药(traditional Chinese medicine,TCM)治疗新型冠状病毒奥密克戎变异株感染患者的用药特点,为大规模推广中医药抗疫提供策略。方法成立中医专家组,通过临床实践,结合文献检索,总结治疗经验...目的探讨上海国展中心方舱医院第一分院用中医药(traditional Chinese medicine,TCM)治疗新型冠状病毒奥密克戎变异株感染患者的用药特点,为大规模推广中医药抗疫提供策略。方法成立中医专家组,通过临床实践,结合文献检索,总结治疗经验。结果2022年4-5月上海疫情以无症状感染者、轻症患者居多,中医证候属“湿毒夹风”。95.89%的本院患者都使用“专病专方”,即采用荆银固表方与系列中成药进行综合治疗。对于4.68%的少数难治性病例,采用辨证施治的精准化中药治疗方法。结论“专病专方-综合治疗-中医辨证个体化治疗”的策略适用于大批量的新型冠状病毒感染者。展开更多
Recently, the definition of sepsis was concluded to be a life-threatening organ dysfunction caused by a dysregulated host response to infection. Severe patients always present with uncorrectable hypotension or hyperla...Recently, the definition of sepsis was concluded to be a life-threatening organ dysfunction caused by a dysregulated host response to infection. Severe patients always present with uncorrectable hypotension or hyperlactacidemia, which is defined as septic shock. The new definition emphasizes dysregulation of the host response and multiple organ dysfunction, which is partially attributed to metabolic disorders induced by energy crisis and oxidative stress. Mitochondria are a cellular organelle that are well known as the center of energy production, and mitochondrial damage or dysfunction is commonly induced in septic settings and is a predominant factor leading to a worse prognosis. In the present review, we determine the major mitochondrial disorders from morphology to functions in sepsis. In the following, several clinical or pre-clinical assays for monitoring mitochondrial function are demonstrated according to accumulated evidence, which is the first step of specific therapy targeting to modulate mitochondrial function. Accordingly, various reagents used for regulating mitochondrial enzyme activities and promoting biogenesis have been documented, among which mitochondriatargeted cation, TPP-conjugated antioxidants are the most valuable for future trials and clinical treatment to improve mitochondrial function as they may take advantage of the prognosis associated with septic complications.展开更多
文摘目的探讨上海国展中心方舱医院第一分院用中医药(traditional Chinese medicine,TCM)治疗新型冠状病毒奥密克戎变异株感染患者的用药特点,为大规模推广中医药抗疫提供策略。方法成立中医专家组,通过临床实践,结合文献检索,总结治疗经验。结果2022年4-5月上海疫情以无症状感染者、轻症患者居多,中医证候属“湿毒夹风”。95.89%的本院患者都使用“专病专方”,即采用荆银固表方与系列中成药进行综合治疗。对于4.68%的少数难治性病例,采用辨证施治的精准化中药治疗方法。结论“专病专方-综合治疗-中医辨证个体化治疗”的策略适用于大批量的新型冠状病毒感染者。
基金supported by grants from the National Natural Science Foundation of China(No.81730057,81501698)the National Key Research and Development Program of China(No.2017YFC11003302)the Shenzhen San-ming Project(No.SZSM20162011)
文摘Recently, the definition of sepsis was concluded to be a life-threatening organ dysfunction caused by a dysregulated host response to infection. Severe patients always present with uncorrectable hypotension or hyperlactacidemia, which is defined as septic shock. The new definition emphasizes dysregulation of the host response and multiple organ dysfunction, which is partially attributed to metabolic disorders induced by energy crisis and oxidative stress. Mitochondria are a cellular organelle that are well known as the center of energy production, and mitochondrial damage or dysfunction is commonly induced in septic settings and is a predominant factor leading to a worse prognosis. In the present review, we determine the major mitochondrial disorders from morphology to functions in sepsis. In the following, several clinical or pre-clinical assays for monitoring mitochondrial function are demonstrated according to accumulated evidence, which is the first step of specific therapy targeting to modulate mitochondrial function. Accordingly, various reagents used for regulating mitochondrial enzyme activities and promoting biogenesis have been documented, among which mitochondriatargeted cation, TPP-conjugated antioxidants are the most valuable for future trials and clinical treatment to improve mitochondrial function as they may take advantage of the prognosis associated with septic complications.
