期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Local Expression of Vaginal Th1 and Th2 Cytokines in Murine Vaginal Candidiasis under Different Immunity Conditions 被引量:3
1
作者 陈善娟 李少华 +2 位作者 吴艳 刘志香 李家文 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2008年第4期476-479,共4页
To investigate the expression of vaginal Th1 and Th2 cytokines in rats with experimental vaginal candidiasis under different immune conditions, ICR murine vaginal candidiasis model was established and immno-suppressed... To investigate the expression of vaginal Th1 and Th2 cytokines in rats with experimental vaginal candidiasis under different immune conditions, ICR murine vaginal candidiasis model was established and immno-suppressed murine models of vaginal cadidiasis were established in estrogen-treated mice. Non-estrogen-treated mice were used as controls. The mRNA level of Th1 (IL-2)/Th2 (IL-4, IL-10, TGF-β1) cytokines in murine vaginal tissues was determined by RT-PCR. The cykotine in local tissues was increased to different extent under normal immune condition. IL-2 mRNA was increased during early stage of infection, while IL-10 was increased transiently during late stage of infection. TGF-β1 production was found to be increased persistently. At same time, the expression of IL-2 mRNA was suppressed in immno-suppressed group, and the level of IL-4, IL-10, and TGF-β1 were higher than the normal immunity group to different degree during infection. The high level of IL-2 mRNA during early stage of infection was associated with clearance of mucosal Candidia albicans (C. albicans), and its expression suppressed leading to decreased clearance of mucosal C. albican in immuno-suppression. The over-expression of IL-4 and IL-10 could significantly enhance the susceptibility to C. albicans infection in mice. 展开更多
关键词 Candida albicans vaginal lavage murine model IMMUNO-SUPPRESSION th1/th2 cyto-kinese
下载PDF
妊娠滋养细胞疾病中Th1/Th2类细胞因子的表达与葡萄胎恶变关系的探讨 被引量:2
2
作者 许俐 乔云波 +2 位作者 宫露霞 王红 李卫国 《现代妇产科进展》 CSCD 2000年第1期22-24,共3页
目的:探讨妊娠滋养细胞疾病中Th1/Th2类细胞因子的表达及与葡萄胎恶变的关系。方法:以IL-2、IFN-γ代表Th1类细胞因子,以IL-4、IL-10、IL-13代表Th2类细胞因子,以β-actin为内参照,用逆转录聚合酶链反应(RT-PCR)方法检测未恶变的... 目的:探讨妊娠滋养细胞疾病中Th1/Th2类细胞因子的表达及与葡萄胎恶变的关系。方法:以IL-2、IFN-γ代表Th1类细胞因子,以IL-4、IL-10、IL-13代表Th2类细胞因子,以β-actin为内参照,用逆转录聚合酶链反应(RT-PCR)方法检测未恶变的葡萄胎12例,发生恶变的葡萄胎及绒癌38例中不同细胞因子的表达模式。结果:非恶变组IL-2及IFN-γ的表达率较恶变组高(P<001),细胞因子的表达以Th1类占优势,而恶变组IL-4、IL-10及IL-13的表达率较非恶变组高(P<005),细胞因子的表达以Th2类占优势。恶变组恶变前后相比较,恶变后IL-4、IL-10、IL-13的表达均有增高的趋势(P<005)。侵蚀性葡萄胎与不同来源的绒癌之间细胞因子的表达差异无显著性(P>005)。结论:Th2类细胞因子的高表达在妊娠滋养细胞疾病的发生、发展中起一定作用,Th1/Th2漂移对滋养细胞肿瘤的早期发现、患者预后判断及治疗有一定价值。 展开更多
关键词 妊娠滋养细胞病 th1/th2 聚合酶链反应
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部