TAZ, a transcriptional coactivator with PDZ-binding motif, is encoded by WWTR1 gene （WW domain containing transcription regulator 1）. TAZ is tightly regulated in the hippo pathway-dependent and -independent manner i...TAZ, a transcriptional coactivator with PDZ-binding motif, is encoded by WWTR1 gene （WW domain containing transcription regulator 1）. TAZ is tightly regulated in the hippo pathway-dependent and -independent manner in response to a wide range of extracellular and intrinsic signals, including cell density, cell polarity, F-actin related mechanical stress, ligands of G protein-coupled recep- tors （GPCRs）, cellular energy status, hypoxia and osmo- tic stress. Besides its role in normal tissue development, TAZ plays critical roles in cell proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition （EMT）, and stemness in multiple human cancers. We discuss here the regulators and regulation of TAT. We also highlight the tumorigenic roles of TAZ. and its potential therapeutic impact in human cancers.展开更多
文摘TAZ, a transcriptional coactivator with PDZ-binding motif, is encoded by WWTR1 gene （WW domain containing transcription regulator 1）. TAZ is tightly regulated in the hippo pathway-dependent and -independent manner in response to a wide range of extracellular and intrinsic signals, including cell density, cell polarity, F-actin related mechanical stress, ligands of G protein-coupled recep- tors （GPCRs）, cellular energy status, hypoxia and osmo- tic stress. Besides its role in normal tissue development, TAZ plays critical roles in cell proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition （EMT）, and stemness in multiple human cancers. We discuss here the regulators and regulation of TAT. We also highlight the tumorigenic roles of TAZ. and its potential therapeutic impact in human cancers.
