Background Surgical interventions for moyamoya disease include direct and indirect revascularizations. This study aimed to evaluate the therapeutic effect of superficial temporal artery-middle cerebral artery bypass c...Background Surgical interventions for moyamoya disease include direct and indirect revascularizations. This study aimed to evaluate the therapeutic effect of superficial temporal artery-middle cerebral artery bypass combined with an indirect revascularization procedure, encephalo-duro-myo-synangiosis, in the treatment of moyamoya disease. Methods From October 2005 to November 2009, we performed this combined revascularization procedure in 111 patients with different types and stages of moyamoya disease. The superficial temporal artery, middle meningeal artery and the deep temporal artery were evaluated for individualized surgical planning in these cases. The integrity of the deep temporal artery and the middle meningeal artery network, and the pre-existing spontaneous anastomoses of the distal branches of the external carotid artery with the cortical arteries were well preserved. The mean follow-up time was 72.5 months, all clinical and radiological data were retrospectively reviewed. Results A total of 198 stomas were performed in 122 hemispheres, all remaining patent until the last follow-up. The encephalo-duro-myo-synangiosis resulted in extensive anastomoses of the deep temporal artery （100%）, the middle meningeal artery （90.9%）, and the sphenopalatine artery （39.8%） with the cortical arteries, respectitvely. The superficial temporal artery, deep temporal artery, and the middle meningeal artery were significantly thickened in 88 patients as determined by digital subtraction angiography at follow-up. The relative cerebral blood flow increased significantly within one week after the operation. At 6 months post the operation, the relative cerebral blood flow was further increased by 15.5% from the gradual formation of anastomoses as a result of indirect revascularization. Transient ischemic attacks were effectively reduced or totally arrested. The neurological deficits significantly improved in 37 patients, with the National Institutes of Health Stroke Scale scores lowered by 2-8. There was no rehemo展开更多
目的 探讨颞浅动脉大脑中动脉血管吻合术联合颞肌贴敷术治疗成人缺血性烟雾病的临床效果。方法 回顾性分析行颞浅动脉大脑中动脉血管吻合术联合颞肌贴敷术治疗的成人缺血性烟雾病55例67侧的临床资料,观察手术结果及术后临床症状、神经...目的 探讨颞浅动脉大脑中动脉血管吻合术联合颞肌贴敷术治疗成人缺血性烟雾病的临床效果。方法 回顾性分析行颞浅动脉大脑中动脉血管吻合术联合颞肌贴敷术治疗的成人缺血性烟雾病55例67侧的临床资料,观察手术结果及术后临床症状、神经功能恢复情况,并详细记录手术后并发症情况。结果 55例67侧大脑半球均成功完成手术,平均手术时间3.9 h,平均出血量127 ml。术后1周螺旋CT血管造影(CT angiography, CTA)检查示62侧吻合桥动脉通畅,通畅率达92.54%。术前1周及术后1周、术后6个月,脑血流量(CBF)、脑血容量(CBV)、峰值时间(TTP)及平均通过时间(MTT)总体比较差异均有统计学意义( P <0.05)。术前1周及术后1周、术后6个月,随时间推移CBF、CBV逐渐增加,TTP、MTT逐渐缩短,除CBV术后6个月与术后1周比较差异无统计学意义外,余两两比较差异均有统计学意义( P <0.05)。术后1周,73.13%症状得以缓解,90.9%患者主诉主观感受改善。随访6个月,临床症状改善率达92.53%。术前1周及术后1周、术后6个月,mRS评分总体比较差异均有统计学意义( P <0.05)。术前1周及术后1周、术后6个月,mRS评分随时间推移逐渐降低,除术后6个月与术后1周比较差异无统计学意义外,余两两比较差异均有统计学意义( P <0.05)。本组术后发生并发症11例,包括硬脑膜下血肿和桥动脉闭塞各3例,吻合口动脉瘤2例,高灌注综合征、癫痫及脑梗死各1例。近期并发症多发生于术后2周内,均通过对症治疗得到缓解;远期并发症较少,主要为脑梗死和脑出血,经专科治疗病情好转,均遗留相关神经功能障碍。结论 颞浅动脉大脑中动脉血管吻合术联合颞肌贴敷术通过互补协同作用治疗成人缺血性烟雾病可增加患者脑血流量,改善患者临床症状,减少脑血管事件发生,并可预防复发性脑梗死。展开更多
The extracranial-intracranial （EC-IC） bypass surgery has been widely used in the treatment of cerebral ischemia,intracranial aneurysms,and other diseases for more than 40 years.In terms of treating atherosclerotic c...The extracranial-intracranial （EC-IC） bypass surgery has been widely used in the treatment of cerebral ischemia,intracranial aneurysms,and other diseases for more than 40 years.In terms of treating atherosclerotic cerebral ischemia,the surgery is presumed to be helpful for the subgroup of hemodynamic compromise in prevention of subsequent stroke.However,two multicenter trials presented with high perioperative stroke rate and failed to demonstrate the profit of the surgery.1-3 On this point,one of the crucial issues currently is how to lower down the perioperative stroke rate,the centerpiece of which is early postoperative infarction （EPI）.3展开更多
The authors are reporting on a study drawn from unpublished dissertation done by the corresponding author when he completed his neurosurgical training in Paris, France in 2004, few years before the advent of flow dive...The authors are reporting on a study drawn from unpublished dissertation done by the corresponding author when he completed his neurosurgical training in Paris, France in 2004, few years before the advent of flow diverters. The study was a retrospective review of giant intracranial aneurysms treated by superficial temporal artery to middle cerebral artery bypass combined with endovascular occlusion of the parent artery. From 1990 to 2003, 29 consecutive cases of giant cerebral aneurysms, not suitable to selective treatment were managed in that way. Twenty-one medical records had enough data to allow objective evaluation. Sixteen female and five male patients bearing 21 giant aneurysms were involved. Their mean age was 46 years. The aneurysm was revealed by mass effect in 13 cases and subarachnoid hemorrhage in one case. On admission 19 patients presented with unruptured aneurysms and two have sustained a subarachnoid hemorrhage. The balloon occlusion test before the bypass operation was not tolerated in 18 patients. The treatment was completed in 19 patients and 17 of them had parent artery occlusion with latex detachable balloons. The only death of the series occurred before the endovascular treatment. The mean follow-up period was 30 months. After completion of the treatment, 16 (84%) patients had no symptom. Aneurysm recanalization or rupture was not observed after the parent artery occlusion. With the combination of superficial temporal artery to middle cerebral artery bypass + endovascular parent artery occlusion, 90% of giant intracranial aneurysms untreatable selectively were permanently excluded with a good outcome in 95%.展开更多
基金grants from the National Natural Science Foundation of China，Natural Science Foundation of Shanghai Science and Technology Committee
文摘Background Surgical interventions for moyamoya disease include direct and indirect revascularizations. This study aimed to evaluate the therapeutic effect of superficial temporal artery-middle cerebral artery bypass combined with an indirect revascularization procedure, encephalo-duro-myo-synangiosis, in the treatment of moyamoya disease. Methods From October 2005 to November 2009, we performed this combined revascularization procedure in 111 patients with different types and stages of moyamoya disease. The superficial temporal artery, middle meningeal artery and the deep temporal artery were evaluated for individualized surgical planning in these cases. The integrity of the deep temporal artery and the middle meningeal artery network, and the pre-existing spontaneous anastomoses of the distal branches of the external carotid artery with the cortical arteries were well preserved. The mean follow-up time was 72.5 months, all clinical and radiological data were retrospectively reviewed. Results A total of 198 stomas were performed in 122 hemispheres, all remaining patent until the last follow-up. The encephalo-duro-myo-synangiosis resulted in extensive anastomoses of the deep temporal artery （100%）, the middle meningeal artery （90.9%）, and the sphenopalatine artery （39.8%） with the cortical arteries, respectitvely. The superficial temporal artery, deep temporal artery, and the middle meningeal artery were significantly thickened in 88 patients as determined by digital subtraction angiography at follow-up. The relative cerebral blood flow increased significantly within one week after the operation. At 6 months post the operation, the relative cerebral blood flow was further increased by 15.5% from the gradual formation of anastomoses as a result of indirect revascularization. Transient ischemic attacks were effectively reduced or totally arrested. The neurological deficits significantly improved in 37 patients, with the National Institutes of Health Stroke Scale scores lowered by 2-8. There was no rehemo
文摘目的 探讨颞浅动脉大脑中动脉血管吻合术联合颞肌贴敷术治疗成人缺血性烟雾病的临床效果。方法 回顾性分析行颞浅动脉大脑中动脉血管吻合术联合颞肌贴敷术治疗的成人缺血性烟雾病55例67侧的临床资料,观察手术结果及术后临床症状、神经功能恢复情况,并详细记录手术后并发症情况。结果 55例67侧大脑半球均成功完成手术,平均手术时间3.9 h,平均出血量127 ml。术后1周螺旋CT血管造影(CT angiography, CTA)检查示62侧吻合桥动脉通畅,通畅率达92.54%。术前1周及术后1周、术后6个月,脑血流量(CBF)、脑血容量(CBV)、峰值时间(TTP)及平均通过时间(MTT)总体比较差异均有统计学意义( P <0.05)。术前1周及术后1周、术后6个月,随时间推移CBF、CBV逐渐增加,TTP、MTT逐渐缩短,除CBV术后6个月与术后1周比较差异无统计学意义外,余两两比较差异均有统计学意义( P <0.05)。术后1周,73.13%症状得以缓解,90.9%患者主诉主观感受改善。随访6个月,临床症状改善率达92.53%。术前1周及术后1周、术后6个月,mRS评分总体比较差异均有统计学意义( P <0.05)。术前1周及术后1周、术后6个月,mRS评分随时间推移逐渐降低,除术后6个月与术后1周比较差异无统计学意义外,余两两比较差异均有统计学意义( P <0.05)。本组术后发生并发症11例,包括硬脑膜下血肿和桥动脉闭塞各3例,吻合口动脉瘤2例,高灌注综合征、癫痫及脑梗死各1例。近期并发症多发生于术后2周内,均通过对症治疗得到缓解;远期并发症较少,主要为脑梗死和脑出血,经专科治疗病情好转,均遗留相关神经功能障碍。结论 颞浅动脉大脑中动脉血管吻合术联合颞肌贴敷术通过互补协同作用治疗成人缺血性烟雾病可增加患者脑血流量,改善患者临床症状,减少脑血管事件发生,并可预防复发性脑梗死。
基金This research was supported by grants from the National Natural Science Foundation of China （No.81371292）,Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education （No.KZ201010025021）.
文摘The extracranial-intracranial （EC-IC） bypass surgery has been widely used in the treatment of cerebral ischemia,intracranial aneurysms,and other diseases for more than 40 years.In terms of treating atherosclerotic cerebral ischemia,the surgery is presumed to be helpful for the subgroup of hemodynamic compromise in prevention of subsequent stroke.However,two multicenter trials presented with high perioperative stroke rate and failed to demonstrate the profit of the surgery.1-3 On this point,one of the crucial issues currently is how to lower down the perioperative stroke rate,the centerpiece of which is early postoperative infarction （EPI）.3
文摘The authors are reporting on a study drawn from unpublished dissertation done by the corresponding author when he completed his neurosurgical training in Paris, France in 2004, few years before the advent of flow diverters. The study was a retrospective review of giant intracranial aneurysms treated by superficial temporal artery to middle cerebral artery bypass combined with endovascular occlusion of the parent artery. From 1990 to 2003, 29 consecutive cases of giant cerebral aneurysms, not suitable to selective treatment were managed in that way. Twenty-one medical records had enough data to allow objective evaluation. Sixteen female and five male patients bearing 21 giant aneurysms were involved. Their mean age was 46 years. The aneurysm was revealed by mass effect in 13 cases and subarachnoid hemorrhage in one case. On admission 19 patients presented with unruptured aneurysms and two have sustained a subarachnoid hemorrhage. The balloon occlusion test before the bypass operation was not tolerated in 18 patients. The treatment was completed in 19 patients and 17 of them had parent artery occlusion with latex detachable balloons. The only death of the series occurred before the endovascular treatment. The mean follow-up period was 30 months. After completion of the treatment, 16 (84%) patients had no symptom. Aneurysm recanalization or rupture was not observed after the parent artery occlusion. With the combination of superficial temporal artery to middle cerebral artery bypass + endovascular parent artery occlusion, 90% of giant intracranial aneurysms untreatable selectively were permanently excluded with a good outcome in 95%.
