A dimer of styrylpyrone derivative, leiocarpin E (1), was isolated from the bark of Goniothalamus leiocarpus. Its structures was elucidated by means of spectral and chemical methods. The cytotoxicity of leiocarpin E ...A dimer of styrylpyrone derivative, leiocarpin E (1), was isolated from the bark of Goniothalamus leiocarpus. Its structures was elucidated by means of spectral and chemical methods. The cytotoxicity of leiocarpin E against HL-60 cells was tested.展开更多
A short and efficient stereoselective synthesis of a styryllactone (-)-isoaltholactone has been achieved in seven steps and 33% overall yield, starting from the readily available carbohydrate D-mannose. The key steps ...A short and efficient stereoselective synthesis of a styryllactone (-)-isoaltholactone has been achieved in seven steps and 33% overall yield, starting from the readily available carbohydrate D-mannose. The key steps of our synthesis involve intramolecular tetrahydrofuran cyclization and one-pot acetonide deprotection-lactonization.展开更多
Two novel styryllactones,goniodilactone（1） and gonioheptenolactone（2）,were isolated from the leaves of Goniothalamus cheliensis Hu.Their structures were determined on the basis of spectroscopic data as well as X-r...Two novel styryllactones,goniodilactone（1） and gonioheptenolactone（2）,were isolated from the leaves of Goniothalamus cheliensis Hu.Their structures were determined on the basis of spectroscopic data as well as X-ray crystallography analysis. Compounds 1 and 2 exhibited significant cytotoxicities in a panel of human cancer cells,including DU-145,PC-3,MCF-7,A-549, KB and KBvin,with GI_（50）S in the range of 1.29-4.56μg/mL.展开更多
文摘A dimer of styrylpyrone derivative, leiocarpin E (1), was isolated from the bark of Goniothalamus leiocarpus. Its structures was elucidated by means of spectral and chemical methods. The cytotoxicity of leiocarpin E against HL-60 cells was tested.
基金supported by the MOST of China (2012ZX09502001-001)the National Natural Science Foundation of China (2012CB822101,21072217 and 21202193)
文摘A short and efficient stereoselective synthesis of a styryllactone (-)-isoaltholactone has been achieved in seven steps and 33% overall yield, starting from the readily available carbohydrate D-mannose. The key steps of our synthesis involve intramolecular tetrahydrofuran cyclization and one-pot acetonide deprotection-lactonization.
基金supported by the National Natural Science Foundation of China(No29572087)awarded to JGYupartially supported by NIH grant CA17625 awarded to KHLee
文摘Two novel styryllactones,goniodilactone（1） and gonioheptenolactone（2）,were isolated from the leaves of Goniothalamus cheliensis Hu.Their structures were determined on the basis of spectroscopic data as well as X-ray crystallography analysis. Compounds 1 and 2 exhibited significant cytotoxicities in a panel of human cancer cells,including DU-145,PC-3,MCF-7,A-549, KB and KBvin,with GI_（50）S in the range of 1.29-4.56μg/mL.
