The pathogenesis of the second major neurodegenerative disorder, Parkinson’s disease(PD), is closely associated with the dysfunction of potassium(K~+ ) channels. Therefore, PD is also considered to be an ion channel ...The pathogenesis of the second major neurodegenerative disorder, Parkinson’s disease(PD), is closely associated with the dysfunction of potassium(K~+ ) channels. Therefore, PD is also considered to be an ion channel disease or neuronal channelopathy. Mounting evidence has shown that K~+ channels play crucial roles in the regulations of neurotransmitter release, neuronal excitability, and cell volume. Inhibition of K~+ channels enhances the spontaneous firing frequency of nigral dopamine(DA)neurons, induces a transition from tonic firing to burst discharge, and promotes the release of DA in the striatum.Recently, three K~+ channels have been identified to protect DA neurons and to improve the motor and non-motor symptoms in PD animal models: small conductance(SK)channels, A-type K~+ channels, and KV7/KCNQ channels.In this review, we summarize the physiological and pharmacological effects of the three K~+ channels. We also describe in detail the laboratory investigations regarding K~+ channels as a potential therapeutic target for PD.展开更多
We introduce a set of criterions for classifying signature-only signature models. By the criterions, we classify signature models into 5 basic types and 69 general classes. Theoretically, 21141 kinds of signature mode...We introduce a set of criterions for classifying signature-only signature models. By the criterions, we classify signature models into 5 basic types and 69 general classes. Theoretically, 21141 kinds of signature models can be derived by appropriately combining different general classes. The result comprises almost existing signature models. It will be helpful for exploring new signature models. To the best of our knowledge, it is the first time for investigation of the problem of classification of signature-only signature models.展开更多
In this study, the SK, SK<sub>1</sub> and SK<sub>2</sub> indices are defined on weighted graphs. Then, the SK, SK<sub>1</sub> and SK<sub>2</sub> indices are defined on i...In this study, the SK, SK<sub>1</sub> and SK<sub>2</sub> indices are defined on weighted graphs. Then, the SK, SK<sub>1</sub> and SK<sub>2</sub> indices are defined on interval weighted graphs. Their behaviors are investigated under some graph operations by using these definitions.展开更多
基金supported by the National Natural Science Foundation of China(31671054 and 81430024)the Postdoctoral Science Foundation of China(2017M610412)the Bureau of Science and Technology of Qingdao Municipality,China(17-1-1-44-jch)
文摘The pathogenesis of the second major neurodegenerative disorder, Parkinson’s disease(PD), is closely associated with the dysfunction of potassium(K~+ ) channels. Therefore, PD is also considered to be an ion channel disease or neuronal channelopathy. Mounting evidence has shown that K~+ channels play crucial roles in the regulations of neurotransmitter release, neuronal excitability, and cell volume. Inhibition of K~+ channels enhances the spontaneous firing frequency of nigral dopamine(DA)neurons, induces a transition from tonic firing to burst discharge, and promotes the release of DA in the striatum.Recently, three K~+ channels have been identified to protect DA neurons and to improve the motor and non-motor symptoms in PD animal models: small conductance(SK)channels, A-type K~+ channels, and KV7/KCNQ channels.In this review, we summarize the physiological and pharmacological effects of the three K~+ channels. We also describe in detail the laboratory investigations regarding K~+ channels as a potential therapeutic target for PD.
基金the Major State Basic Research Development Program of China(973 Program)(Grant No.2004CB318000) the Innovation Fund of Shanghai University
文摘We introduce a set of criterions for classifying signature-only signature models. By the criterions, we classify signature models into 5 basic types and 69 general classes. Theoretically, 21141 kinds of signature models can be derived by appropriately combining different general classes. The result comprises almost existing signature models. It will be helpful for exploring new signature models. To the best of our knowledge, it is the first time for investigation of the problem of classification of signature-only signature models.
文摘In this study, the SK, SK<sub>1</sub> and SK<sub>2</sub> indices are defined on weighted graphs. Then, the SK, SK<sub>1</sub> and SK<sub>2</sub> indices are defined on interval weighted graphs. Their behaviors are investigated under some graph operations by using these definitions.
