Objective: The aim of this study was to predict the active compounds, therapy targets, and diseases of Bu-Shen-Jian-Pi formula(BSJPF) through the system pharmacology-based approach.Methods: Traditional Chinese Medicin...Objective: The aim of this study was to predict the active compounds, therapy targets, and diseases of Bu-Shen-Jian-Pi formula(BSJPF) through the system pharmacology-based approach.Methods: Traditional Chinese Medicine Systems Pharmacology(TCMSP) and TCM Database@Taiwan Databases were used to obtain Chinese herbal medicine compounds.Oral bioavailability(OB) and drug-likeness(DL) based on the TCMSP database were used to screen the active compounds of BSJPF and related diseases.Therapy targets were defined according to the DrugBank database.The compounds-targets-disease network was constructed by Cytoscape and function and signaling pathways were also analyzed.Results: A total of 143 of 2106 compounds in BSJPF were screened out(OB ≥30%, DL index ≥0.18).Two hundred and sixty-five targets were found and 334 diseases were enriched.The diseases such as cancer, Alzheimer's disease, inflammation, and asthma were most closely correlated with the formula.BSJPF, Liu-Wei-Di-Huang decoction(LWDHD), and Si-Jun-Zi decoction(SJZD) could regulate cell proliferation and apoptosis; LWDHD also regulated biological processes and cellular processes and regulated stress on chemical stimuli and SJZD focused on the regulation of anabolic reaction.All had enriched the signaling pathways in cancer, nonsmall cell lung cancer, and thyroid cancer pathways.There were more pathways in both BSJPF and LWDHD, mainly including cancer, colorectal cancer pathways, toll-like receptors, T-cell receptors and P53 signaling pathways, and apoptosis.LWDHD was also involved in Wnt, natural killer cell cytotoxicity, and lymphocyte migration signaling pathways.SJZD had no separate pathways.In the tumor-related pathways, targets were more concentrated in the PI3K/Akt pathway and the MAPK/ERK signaling pathway.Conclusions: BSJPF owns multiple targets and pathways to treat various diseases under the guidance of "treating different diseases with the same method."展开更多
Objective:To find out the potential mechanisms of Si-Jun-Zi(SJZ)decoction in the treatment of gastric precancerous lesions(GPL).Methods:A network pharmacology approach was used to analyze the active compounds,drug tar...Objective:To find out the potential mechanisms of Si-Jun-Zi(SJZ)decoction in the treatment of gastric precancerous lesions(GPL).Methods:A network pharmacology approach was used to analyze the active compounds,drug targets and interacting pathways of SJZ decoction in treating GPL.The compounds and predicted targets of SJZ decoction were screened from TCMSP,and the disease targets were obtained from GeneCards.The therapeutic mechanisms of action of the SJZ decoction were analyzed by gene ontology(GO)enrichment,Kyoto encyclopedia of genes and genomes pathway enrichment analyses.Results:The results show that 111 compounds and 90 targets were obtained in this work.These targets were further mapped to 654 GO biological process terms and 21 remarkably pathways.Active compounds,targets,and pathways were used to construct a compound-target network,a target-pathways network,and an integrated GPL pathway.These results indicated that SJZ decoction may treat the dysfunctions of GPL mainly from intervening in the mucosal inflammation,cell apoptosis process,and cell proliferation.Conclusions:This work provided a novel approach to understand the pathogenesis of GPL and revealed the therapeutic mechanisms of SJZ decoction,which facilitate the modernization of herbal medicine for complex diseases in the future.展开更多
基金supported by the Key Program of National Science Foundation of People’s Republic of China(81330084)
文摘Objective: The aim of this study was to predict the active compounds, therapy targets, and diseases of Bu-Shen-Jian-Pi formula(BSJPF) through the system pharmacology-based approach.Methods: Traditional Chinese Medicine Systems Pharmacology(TCMSP) and TCM Database@Taiwan Databases were used to obtain Chinese herbal medicine compounds.Oral bioavailability(OB) and drug-likeness(DL) based on the TCMSP database were used to screen the active compounds of BSJPF and related diseases.Therapy targets were defined according to the DrugBank database.The compounds-targets-disease network was constructed by Cytoscape and function and signaling pathways were also analyzed.Results: A total of 143 of 2106 compounds in BSJPF were screened out(OB ≥30%, DL index ≥0.18).Two hundred and sixty-five targets were found and 334 diseases were enriched.The diseases such as cancer, Alzheimer's disease, inflammation, and asthma were most closely correlated with the formula.BSJPF, Liu-Wei-Di-Huang decoction(LWDHD), and Si-Jun-Zi decoction(SJZD) could regulate cell proliferation and apoptosis; LWDHD also regulated biological processes and cellular processes and regulated stress on chemical stimuli and SJZD focused on the regulation of anabolic reaction.All had enriched the signaling pathways in cancer, nonsmall cell lung cancer, and thyroid cancer pathways.There were more pathways in both BSJPF and LWDHD, mainly including cancer, colorectal cancer pathways, toll-like receptors, T-cell receptors and P53 signaling pathways, and apoptosis.LWDHD was also involved in Wnt, natural killer cell cytotoxicity, and lymphocyte migration signaling pathways.SJZD had no separate pathways.In the tumor-related pathways, targets were more concentrated in the PI3K/Akt pathway and the MAPK/ERK signaling pathway.Conclusions: BSJPF owns multiple targets and pathways to treat various diseases under the guidance of "treating different diseases with the same method."
文摘Objective:To find out the potential mechanisms of Si-Jun-Zi(SJZ)decoction in the treatment of gastric precancerous lesions(GPL).Methods:A network pharmacology approach was used to analyze the active compounds,drug targets and interacting pathways of SJZ decoction in treating GPL.The compounds and predicted targets of SJZ decoction were screened from TCMSP,and the disease targets were obtained from GeneCards.The therapeutic mechanisms of action of the SJZ decoction were analyzed by gene ontology(GO)enrichment,Kyoto encyclopedia of genes and genomes pathway enrichment analyses.Results:The results show that 111 compounds and 90 targets were obtained in this work.These targets were further mapped to 654 GO biological process terms and 21 remarkably pathways.Active compounds,targets,and pathways were used to construct a compound-target network,a target-pathways network,and an integrated GPL pathway.These results indicated that SJZ decoction may treat the dysfunctions of GPL mainly from intervening in the mucosal inflammation,cell apoptosis process,and cell proliferation.Conclusions:This work provided a novel approach to understand the pathogenesis of GPL and revealed the therapeutic mechanisms of SJZ decoction,which facilitate the modernization of herbal medicine for complex diseases in the future.
