Synaptotagmin 7(Syt7), a presynaptic calcium sensor, has a significant role in the facilitation in shortterm synaptic plasticity: Syt7 knock out mice show a significant reduction in the facilitation. The functional im...Synaptotagmin 7(Syt7), a presynaptic calcium sensor, has a significant role in the facilitation in shortterm synaptic plasticity: Syt7 knock out mice show a significant reduction in the facilitation. The functional importance of short-term synaptic plasticity such as facilitation is not well understood. In this study, we attempt to investigate the potential functional relationship between the short-term synaptic plasticity and postsynaptic response by developing a mathematical model that captures the responses of both wild-type and Syt7 knock-out mice. We then studied the model behaviours of wild-type and Syt7 knock-out mice in response to multiple input action potentials. These behaviors could establish functional importance of short-term plasticity in regulating the postsynaptic response and related synaptic properties. In agreement with previous modeling studies, we show that release sites are governed by non-uniform release probabilities of neurotransmitters. The structure of non-uniform release of neurotransmitters makes shortterm synaptic plasticity to act as a high-pass filter. We also propose that Syt7 may be a modulator for the long-term changes of postsynaptic response that helps to train the target frequency of the filter. We have developed a mathematical model of short-term plasticity which explains the experimental data.展开更多
Ag/Ta_(2)O_(5)/CuO/Pt memristive devices with Ag point contacts at the interface exhibit forming-free and partial volatile analog resistive switching properties.Versatile synaptic functions,like the short-term plastic...Ag/Ta_(2)O_(5)/CuO/Pt memristive devices with Ag point contacts at the interface exhibit forming-free and partial volatile analog resistive switching properties.Versatile synaptic functions,like the short-term plasticity,the long-term potentiation and the paired-pulse facilitation,are emulated with these devices.The Ag point contacts in the Ta_(2)O_(5)layer are verified through transmission electron microscope(TEM)and X-ray photoelectron spectroscope(XPS).The Ag point contacts at the interface endow the device the transition from the electrochemical metallization mode to the valence change mode,and the analog resistive switching behavior and neuromorphic functions.This interface engineering of introducing point contacts at the interface provides a way for the development of neuromorphic devices with low power consumption.展开更多
The development of electronic devices that possess the functionality of biological synapses is a crucial step towards neuromorphic computing.In this work,we present a WOx-based memristive device that can emulate volta...The development of electronic devices that possess the functionality of biological synapses is a crucial step towards neuromorphic computing.In this work,we present a WOx-based memristive device that can emulate voltage-dependent synaptic plasticity.By adjusting the amplitude of the applied voltage,we were able to reproduce short-term plasticity(STP)and the transition from STP to long-term potentiation.The stimulation with high intensity induced long-term enhancement of conductance without any decay process,thus representing a permanent memory behavior.Moreover,the image Boolean operations(including intersection,subtraction,and union)were also demonstrated in the memristive synapse array based on the above voltage-dependent plasticity.The experimental achievements of this study provide a new insight into the successful mimicry of essential characteristics of synaptic behaviors.展开更多
Multi-terminal electric-double-layer transistors have recently attracted extensive interest in terms of mimicking synaptic and neural functions.In this work,an Ion-Gel gated graphene synaptic transistor was proposed t...Multi-terminal electric-double-layer transistors have recently attracted extensive interest in terms of mimicking synaptic and neural functions.In this work,an Ion-Gel gated graphene synaptic transistor was proposed to mimic the essential synaptic behaviors by exploiting the bipolar property of graphene and the ionic conductivity of Ion-Gel.The Ion-Gel dielectrics were deposited onto the graphene film by the spin coating process.We consider the top gate and graphene channel as a presynaptic and postsynaptic terminal,respectively.Basic synaptic functions were successfully mimicked,including the excitatory postsynaptic current(EPSC),the effect of spike amplitude and duration on EPSC,and paired-pulse facilitation(PPF).This work may facilitate the application of graphene synaptic transistors in flexible electronics.展开更多
An indium-zinc-oxide （IZO） based ionic/electronic hybrid synaptic transistor gated by field-configurable nanogranular SiO2 films was reported. The devices exhibited a high current ON/OFF ratio of above 107, a high e...An indium-zinc-oxide （IZO） based ionic/electronic hybrid synaptic transistor gated by field-configurable nanogranular SiO2 films was reported. The devices exhibited a high current ON/OFF ratio of above 107, a high electron mobility of ～14 cm2 V^-1 s^-1 and a low subthreshold swing of ～80 mV/decade. The gate bias would modulate the interplay between protons and electrons at the channel/dielectric interface. Due to the dynamic modulation of the transient protons flux within the nanogranular SiO2 films, the channel current would be modified dynamically. Short-term synaptic plasticities, such as short-term potentiation and short- term depression, were mimicked on the proposed IZO synaptic transistor. The results indicate that the synaptic transistor proposed here has potential applications in future neuromorphic devices.展开更多
基金supported by a grant from Lincoln University,New Zealand
文摘Synaptotagmin 7(Syt7), a presynaptic calcium sensor, has a significant role in the facilitation in shortterm synaptic plasticity: Syt7 knock out mice show a significant reduction in the facilitation. The functional importance of short-term synaptic plasticity such as facilitation is not well understood. In this study, we attempt to investigate the potential functional relationship between the short-term synaptic plasticity and postsynaptic response by developing a mathematical model that captures the responses of both wild-type and Syt7 knock-out mice. We then studied the model behaviours of wild-type and Syt7 knock-out mice in response to multiple input action potentials. These behaviors could establish functional importance of short-term plasticity in regulating the postsynaptic response and related synaptic properties. In agreement with previous modeling studies, we show that release sites are governed by non-uniform release probabilities of neurotransmitters. The structure of non-uniform release of neurotransmitters makes shortterm synaptic plasticity to act as a high-pass filter. We also propose that Syt7 may be a modulator for the long-term changes of postsynaptic response that helps to train the target frequency of the filter. We have developed a mathematical model of short-term plasticity which explains the experimental data.
基金This work is supported by the National Natural Science Foundation of China(Grant No.51772112,U1832116 and 51372094)Fundamental Research Funds for the Central Universities(HUST:2016YXZD058).
文摘Ag/Ta_(2)O_(5)/CuO/Pt memristive devices with Ag point contacts at the interface exhibit forming-free and partial volatile analog resistive switching properties.Versatile synaptic functions,like the short-term plasticity,the long-term potentiation and the paired-pulse facilitation,are emulated with these devices.The Ag point contacts in the Ta_(2)O_(5)layer are verified through transmission electron microscope(TEM)and X-ray photoelectron spectroscope(XPS).The Ag point contacts at the interface endow the device the transition from the electrochemical metallization mode to the valence change mode,and the analog resistive switching behavior and neuromorphic functions.This interface engineering of introducing point contacts at the interface provides a way for the development of neuromorphic devices with low power consumption.
基金the fund from Ministry of Science and Technology of China(Nos.2018YFE0118300 and 2019YFB2205100)the NSFC Program(Nos.11974072,51701037,51732003,51872043,51902048,61774031,61574031 and U19A2091)+4 种基金the“111”Project(No.B13013)the fund from Ministry of Education of China(No.6141A02033414)The fund from China Postdoctoral Science Foundation(No.2019M661185)The Fundamental Research Funds for the Central Universities(No.2412019QD015)the Fund from Jilin Province(JJKH20201163KJ).
文摘The development of electronic devices that possess the functionality of biological synapses is a crucial step towards neuromorphic computing.In this work,we present a WOx-based memristive device that can emulate voltage-dependent synaptic plasticity.By adjusting the amplitude of the applied voltage,we were able to reproduce short-term plasticity(STP)and the transition from STP to long-term potentiation.The stimulation with high intensity induced long-term enhancement of conductance without any decay process,thus representing a permanent memory behavior.Moreover,the image Boolean operations(including intersection,subtraction,and union)were also demonstrated in the memristive synapse array based on the above voltage-dependent plasticity.The experimental achievements of this study provide a new insight into the successful mimicry of essential characteristics of synaptic behaviors.
文摘Multi-terminal electric-double-layer transistors have recently attracted extensive interest in terms of mimicking synaptic and neural functions.In this work,an Ion-Gel gated graphene synaptic transistor was proposed to mimic the essential synaptic behaviors by exploiting the bipolar property of graphene and the ionic conductivity of Ion-Gel.The Ion-Gel dielectrics were deposited onto the graphene film by the spin coating process.We consider the top gate and graphene channel as a presynaptic and postsynaptic terminal,respectively.Basic synaptic functions were successfully mimicked,including the excitatory postsynaptic current(EPSC),the effect of spike amplitude and duration on EPSC,and paired-pulse facilitation(PPF).This work may facilitate the application of graphene synaptic transistors in flexible electronics.
基金supported by the National Program on Key Basic Research Project (No.2012CB933004)the Zhejiang Provincial Natural Science Foundation of China (No.LY14A040009)the Ningbo Natural Science Foundation (No.2013A610001)
文摘An indium-zinc-oxide （IZO） based ionic/electronic hybrid synaptic transistor gated by field-configurable nanogranular SiO2 films was reported. The devices exhibited a high current ON/OFF ratio of above 107, a high electron mobility of ～14 cm2 V^-1 s^-1 and a low subthreshold swing of ～80 mV/decade. The gate bias would modulate the interplay between protons and electrons at the channel/dielectric interface. Due to the dynamic modulation of the transient protons flux within the nanogranular SiO2 films, the channel current would be modified dynamically. Short-term synaptic plasticities, such as short-term potentiation and short- term depression, were mimicked on the proposed IZO synaptic transistor. The results indicate that the synaptic transistor proposed here has potential applications in future neuromorphic devices.
