随着器件沟道尺寸的减小,为了获得更好的性能参数,器件工艺窗口变得越来越窄。与此同时,单MOSFET(metal oxide semiconductor field effect transistor)封装缺少静电保护电路。对于敏感器件的封装,异常的电气参数时有出现。通过使用FMEA...随着器件沟道尺寸的减小,为了获得更好的性能参数,器件工艺窗口变得越来越窄。与此同时,单MOSFET(metal oxide semiconductor field effect transistor)封装缺少静电保护电路。对于敏感器件的封装,异常的电气参数时有出现。通过使用FMEA(failure mode and effects analysts)和DOE(design of experiments)等质量工具,确认该问题与封装键合顺序和黏合剂有关。通过调整键合顺序和更换所使用的黏合剂,有效地解决了敏感器件封装低良的问题。该案例为同行业提供了借鉴。展开更多
Objective To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient compliance.Methods In this study,we used gin...Objective To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient compliance.Methods In this study,we used ginger oil,a phytochemical with potential therapeutic properties,to prepare ginger oil patches.High-performance liquid chromatography(HPLC)was used to quantify the main active component of ginger oil,6-gingerol.Transdermal absorption experiments were conducted to optimize the various pressure-sensitive adhesives and permeation enhancers,including their type and concentration.Subsequently,the ginger oil patches were optimized and subjected to content determination and property evaluations.A PTSD mouse model was established using the foot-shock method.The therapeutic effect of ginger oil patches on PTSD was assessed through pathological sections,behavioral tests,and the evaluation of biomarkers such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),brain-derived neurotrophic factor(BDNF),and melatonin(MT).Results The results demonstrated that ginger oil patches exerted therapeutic effects against PTSD by inhibiting inflammatory responses and modulating MT and BDNF levels.Pharmacokinetic experiments revealed that ginger oil patches maintained a stable blood drug concentration for at least one day,addressing the rapid metabolism drawback of 6-gingerol and enhancing its therapeutic efficacy.Conclusions Ginger oil can be prepared as a transdermal drug patch that meets these requirements,and the bioavailability of the prepared patch is better than that of oral administration.It can improve PTSD with good patient compliance and ease of administration.Therefore,it is a promising therapeutic formulation for the treatment of PTSD.展开更多
Conductive adhesive tape is one kind of electromagnetic interference(EMI)shielding materials for electronic packaging.However,the inferior conductivity of the pressure-sensitive adhesive(PSA)layer results in serious e...Conductive adhesive tape is one kind of electromagnetic interference(EMI)shielding materials for electronic packaging.However,the inferior conductivity of the pressure-sensitive adhesive(PSA)layer results in serious electromagnetic leakage at the conjunctions between the conductive tapes and target objects.Adding conductive fillers is a traditional method for highly conductive adhesive tapes.However,the content of conductive fillers is needed to reach the percolation threshold,which is usually as high as tens of percent.High-content fillers result in significant loss of adhesive property and high fabrication cost.Herein,we introduce a rational architecture of conductive microsphere monolayer(CMM)in the PSA layer.The CMM connects the top and bottom surfaces of the PSA layer and improves its conductivity in the z-direction.Importantly,low contents of conductive microspheres(≤5%(mass fraction,w))can achieve the target of conductivity improvement,but not result in the serious loss of the adhesive property.Therefore,the strategy of CMMs can balance the tradeoff between the conductivity and the adhesive property of conductive PSA tapes.Finally,we demonstrate the superior EMI shielding performance of as-made conductive adhesive tapes,indicating their potential applications as the advanced EMI shielding materials in the electronic packaging.展开更多
Background:Hydrogen bonding interaction was considered to play a critical role in controlling drug release from transdermal patch.However,the quantitative evaluation of hydrogen bonding strength between drug and polar...Background:Hydrogen bonding interaction was considered to play a critical role in controlling drug release from transdermal patch.However,the quantitative evaluation of hydrogen bonding strength between drug and polar functional group was rarely reported,and the relationship between hydrogen bonding strength and controlled release capacity of pressure sensitive adhesive(PSA)was not well understood.The present study shed light on this relationship.Methods:Acrylate PSAs with amide group were synthesized by a free radical-initiated solution polymerization.Six drugs,i.e.,etodolac,ketoprofen,gemfibrozil,zolmitriptan,propranolol and lidocaine,were selected as model drugs.In vitro drug release and skin permeation experiments and in vivo pharmacokinetic experiment were performed.Partial correlation analysis,fourier-transform infrared spectroscopy and molecular simulation were conducted to provide molecular details of drug-PSA interactions.Mechanical test,rheology study,and modulated differential scanning calorimetry study were performed to scrutinize the free volume and molecular mobility of PSAs.Results:Release rate of all six drugs from amide PSAs decreased with the increase of amide group concentrations;however,only zolmitriptan and propranolol showed decreased skin permeation rate.It was found that drug release was controlled by amide group through hydrogen bonding,and controlled release extent was positively correlated with hydrogen bonding strength.Conclusion:From these results,we concluded that drugs with strong hydrogen bond forming ability and high skin permeation were suitable to use amide PSAs to regulate their release rate from patch.展开更多
A novel kind of fully bio-based PSAs we re obtained through the curing reaction between two components derived from the plant oils:carboxyl-terminated polyricinoleate(PRA) fro m the castor oil and epoxidized soybean o...A novel kind of fully bio-based PSAs we re obtained through the curing reaction between two components derived from the plant oils:carboxyl-terminated polyricinoleate(PRA) fro m the castor oil and epoxidized soybean oil(ESO).The get content,glass transition temperature(Tg),rheological behavior,tensile strength,creep resistance and 180° peel strength of the PSAs were feasibly tailored by adjusting the component ratio of ESO to PRA.At low cross-linking level,the PSAs behaved like a viscous liquid and did not possess enough cohesiveness to sustain the mechanical stress during peeling,The PSAs cross-linked at or near the optimal stoichiometric conditions displayed an adhesive(interfacial) failure between the substrate and the adhesive layer,which were associated with the lowest adhesion levels.The PSAs with the dosage amount of ESO ranging from 10.20 wt% were tacky and flexible,which exhibited 1800 peel strength ranging from 0.4~2.3 N/cm;and could be easily removed without any residues on the adherend.The process for the preparation of the fully bio-based PSAs was environmentally friendly without using any orga nic solve nt or other toxic chemical,herein showing the great potential as sustainable materials.展开更多
文摘随着器件沟道尺寸的减小,为了获得更好的性能参数,器件工艺窗口变得越来越窄。与此同时,单MOSFET(metal oxide semiconductor field effect transistor)封装缺少静电保护电路。对于敏感器件的封装,异常的电气参数时有出现。通过使用FMEA(failure mode and effects analysts)和DOE(design of experiments)等质量工具,确认该问题与封装键合顺序和黏合剂有关。通过调整键合顺序和更换所使用的黏合剂,有效地解决了敏感器件封装低良的问题。该案例为同行业提供了借鉴。
基金supported by the National Natural Scientific Foundation(82172186)Beijing Natural Scientific Foundation(L222126).
文摘Objective To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient compliance.Methods In this study,we used ginger oil,a phytochemical with potential therapeutic properties,to prepare ginger oil patches.High-performance liquid chromatography(HPLC)was used to quantify the main active component of ginger oil,6-gingerol.Transdermal absorption experiments were conducted to optimize the various pressure-sensitive adhesives and permeation enhancers,including their type and concentration.Subsequently,the ginger oil patches were optimized and subjected to content determination and property evaluations.A PTSD mouse model was established using the foot-shock method.The therapeutic effect of ginger oil patches on PTSD was assessed through pathological sections,behavioral tests,and the evaluation of biomarkers such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),brain-derived neurotrophic factor(BDNF),and melatonin(MT).Results The results demonstrated that ginger oil patches exerted therapeutic effects against PTSD by inhibiting inflammatory responses and modulating MT and BDNF levels.Pharmacokinetic experiments revealed that ginger oil patches maintained a stable blood drug concentration for at least one day,addressing the rapid metabolism drawback of 6-gingerol and enhancing its therapeutic efficacy.Conclusions Ginger oil can be prepared as a transdermal drug patch that meets these requirements,and the bioavailability of the prepared patch is better than that of oral administration.It can improve PTSD with good patient compliance and ease of administration.Therefore,it is a promising therapeutic formulation for the treatment of PTSD.
基金the financial support from the National Natural Science Foundation of China(Grant No.62074154)Shenzhen Science and Technology Program(Grant Nos.JSGG20210802153000002,JCYJ20210324102208023).
文摘Conductive adhesive tape is one kind of electromagnetic interference(EMI)shielding materials for electronic packaging.However,the inferior conductivity of the pressure-sensitive adhesive(PSA)layer results in serious electromagnetic leakage at the conjunctions between the conductive tapes and target objects.Adding conductive fillers is a traditional method for highly conductive adhesive tapes.However,the content of conductive fillers is needed to reach the percolation threshold,which is usually as high as tens of percent.High-content fillers result in significant loss of adhesive property and high fabrication cost.Herein,we introduce a rational architecture of conductive microsphere monolayer(CMM)in the PSA layer.The CMM connects the top and bottom surfaces of the PSA layer and improves its conductivity in the z-direction.Importantly,low contents of conductive microspheres(≤5%(mass fraction,w))can achieve the target of conductivity improvement,but not result in the serious loss of the adhesive property.Therefore,the strategy of CMMs can balance the tradeoff between the conductivity and the adhesive property of conductive PSA tapes.Finally,we demonstrate the superior EMI shielding performance of as-made conductive adhesive tapes,indicating their potential applications as the advanced EMI shielding materials in the electronic packaging.
基金supported by the National Natural Science Foundation of China(81773665)Natural Science Foundation of Liaoning Province(20170540861,China)
文摘Background:Hydrogen bonding interaction was considered to play a critical role in controlling drug release from transdermal patch.However,the quantitative evaluation of hydrogen bonding strength between drug and polar functional group was rarely reported,and the relationship between hydrogen bonding strength and controlled release capacity of pressure sensitive adhesive(PSA)was not well understood.The present study shed light on this relationship.Methods:Acrylate PSAs with amide group were synthesized by a free radical-initiated solution polymerization.Six drugs,i.e.,etodolac,ketoprofen,gemfibrozil,zolmitriptan,propranolol and lidocaine,were selected as model drugs.In vitro drug release and skin permeation experiments and in vivo pharmacokinetic experiment were performed.Partial correlation analysis,fourier-transform infrared spectroscopy and molecular simulation were conducted to provide molecular details of drug-PSA interactions.Mechanical test,rheology study,and modulated differential scanning calorimetry study were performed to scrutinize the free volume and molecular mobility of PSAs.Results:Release rate of all six drugs from amide PSAs decreased with the increase of amide group concentrations;however,only zolmitriptan and propranolol showed decreased skin permeation rate.It was found that drug release was controlled by amide group through hydrogen bonding,and controlled release extent was positively correlated with hydrogen bonding strength.Conclusion:From these results,we concluded that drugs with strong hydrogen bond forming ability and high skin permeation were suitable to use amide PSAs to regulate their release rate from patch.
基金Financial supports by the National Natural Science Foundation of China (Nos.51761135132 and 51822304) are sincerely acknowledged。
文摘A novel kind of fully bio-based PSAs we re obtained through the curing reaction between two components derived from the plant oils:carboxyl-terminated polyricinoleate(PRA) fro m the castor oil and epoxidized soybean oil(ESO).The get content,glass transition temperature(Tg),rheological behavior,tensile strength,creep resistance and 180° peel strength of the PSAs were feasibly tailored by adjusting the component ratio of ESO to PRA.At low cross-linking level,the PSAs behaved like a viscous liquid and did not possess enough cohesiveness to sustain the mechanical stress during peeling,The PSAs cross-linked at or near the optimal stoichiometric conditions displayed an adhesive(interfacial) failure between the substrate and the adhesive layer,which were associated with the lowest adhesion levels.The PSAs with the dosage amount of ESO ranging from 10.20 wt% were tacky and flexible,which exhibited 1800 peel strength ranging from 0.4~2.3 N/cm;and could be easily removed without any residues on the adherend.The process for the preparation of the fully bio-based PSAs was environmentally friendly without using any orga nic solve nt or other toxic chemical,herein showing the great potential as sustainable materials.
