目的探讨面部脂溢性皮炎患者皮肤生理参数的特征。方法 1分别对30例健康人和60例面部脂溢性皮炎患者行乳酸刺痛试验。2分别对30例健康人及60例面部脂溢性皮炎患者面部的油脂含量、弹性、表皮含水量及经表皮失水率(transepidermal water ...目的探讨面部脂溢性皮炎患者皮肤生理参数的特征。方法 1分别对30例健康人和60例面部脂溢性皮炎患者行乳酸刺痛试验。2分别对30例健康人及60例面部脂溢性皮炎患者面部的油脂含量、弹性、表皮含水量及经表皮失水率(transepidermal water loss,TEWL)进行测量,使用SPSS 19.0统计学软件进行分析。结果面部脂溢性皮炎患者与健康人比较,油脂含量及经表皮失水率(TEWL)明显高于健康对照组,弹性及表皮含水量明显低于健康对照组,两者有显著性差异。结论面部脂溢性皮炎患者存在皮肤屏障功能障碍。表现为TEWL、油脂含量增高,皮肤弹性、表皮含水量降低。展开更多
目的研究脂溢性皮炎患者健康相关生命质量(health related quality of life,HRQOL)评分,并统计健康相关生命质量的影响因素及其主次关系。方法以2015年2—8月在第三军医大学大坪医院就诊的脂溢性皮炎患者314名为研究对象使用生活质量评...目的研究脂溢性皮炎患者健康相关生命质量(health related quality of life,HRQOL)评分,并统计健康相关生命质量的影响因素及其主次关系。方法以2015年2—8月在第三军医大学大坪医院就诊的脂溢性皮炎患者314名为研究对象使用生活质量评价量表(short form 36 questionnaire,SF-36)测量HRQOL得分,并对脂溢性皮炎者的一般状况进行统计,同时使用单因素方差分析及多元逐步线性回归统计对HRQOL的影响因素进行分析。结果 SDS平均得分为51.45±9.42。研究显示无抑郁情绪占56.1%;轻度抑郁情绪占33.1%;中度抑郁情绪占7.0%;重度抑郁情绪占3.8%。不同的脂溢性皮炎病程、年龄、睡眠时间之间HRQOL得分差异有统计学意义(P<0.05);是否辛辣饮食、是否饮酒、是否吸烟、是否锻炼、是否治疗也会导致HRQOL得分产生差异(P<0.05)。其中病程越长、年龄越大、睡眠时间不足的脂溢性皮炎患者HRQOL得分较低;辛辣饮食、饮酒、吸烟会降低HRQOL得分,而锻炼和治疗可提高HRQOL得分。影响HRQOL评分的7个最主要因素为:治疗、SDS得分、辛辣饮食、脂溢性皮炎病程、锻炼、饮酒、睡眠时间。其中HRQOL得分与治疗、锻炼、睡眠时间呈正相关(P<0.05),与SDS得分、辛辣饮食、脂溢性皮炎病程、饮酒呈负相关(P<0.05)。结论脂溢性皮炎患者HRQOL不佳,部分伴发心理抑郁。应加大对心理抑郁、3年以上病程患者的关注和重视,积极给予中西医治疗,戒除辛辣饮食和饮酒,鼓励患者多运动锻炼,保证充沛的睡眠时间。展开更多
Background:Seborrheic dermatitis (SD) is a common inflammatory skin condition.The etiology is unclear,although overgrowth of Malassezia on the skin has been suggested to cause SD.This study investigated whether col...Background:Seborrheic dermatitis (SD) is a common inflammatory skin condition.The etiology is unclear,although overgrowth of Malassezia on the skin has been suggested to cause SD.This study investigated whether colonization with Staphylococcus plays a role in facial SD,which was not well addressed previously.Methods:The study was conducted from September 1,2011 to February 20,2012 in the First Hospital of China Medical University.In the first phase,the study evaluated the level of transepidennal water loss (TEWL) and the number of colony-forming units (CFU) of Staphylococcus in defined skin areas of SD patients who were human immunodeficiency virus (HIV) seropositive (HIV [+] SD [+] group,n =13),classical SD (HIV [-] SD [+] group,n =24) patients,H IV seropositive-non-SD (HIV [+] SD [-] group,n =16) patients,and healthy volunteers (HIV [-] SD [-] group,n 16).In the second phase,we enrolled another cohort of HIV (-) SD (+) patients who applied topical fusidic acid (n =15),tacrolimus (n =16),or moisturizer (n =12).Changes in the Seborrheic Dermatitis Area Severity Index (SDASI),TEWL,and Staphylococcus density were evaluated 2 weeks later.Comparisons of each index were performed using analysis of variance (ANOVA) and least significant difference method.Results:The level of TEWL was greater through lesional sites in the HIV (+) SD (+) group than that in HIV (+) SD (-) and HIV () SD (-) groups (95% confidence interval [CI]:18.873-47.071,P 〈 0.001 and 95% CI:28.755-55.936,P 〈 0.001,respectively).The number of CFU of Staphylococcus was greater in the HIV (+) SD (+) group than that in HIV (+) SD (-) and HIV (-) SD (-) groups (95% CI:37.487-142.744,P =0.001 and 95% CI:54.936-156.400,P 〈 0.001,respectively).TEWL was significantly more improved in patients treated with tacrolimus and fusidic acid than that in those treated with moisturizers (95% CI:7.560 38.987,P =0展开更多
文摘目的探讨面部脂溢性皮炎患者皮肤生理参数的特征。方法 1分别对30例健康人和60例面部脂溢性皮炎患者行乳酸刺痛试验。2分别对30例健康人及60例面部脂溢性皮炎患者面部的油脂含量、弹性、表皮含水量及经表皮失水率(transepidermal water loss,TEWL)进行测量,使用SPSS 19.0统计学软件进行分析。结果面部脂溢性皮炎患者与健康人比较,油脂含量及经表皮失水率(TEWL)明显高于健康对照组,弹性及表皮含水量明显低于健康对照组,两者有显著性差异。结论面部脂溢性皮炎患者存在皮肤屏障功能障碍。表现为TEWL、油脂含量增高,皮肤弹性、表皮含水量降低。
文摘目的研究脂溢性皮炎患者健康相关生命质量(health related quality of life,HRQOL)评分,并统计健康相关生命质量的影响因素及其主次关系。方法以2015年2—8月在第三军医大学大坪医院就诊的脂溢性皮炎患者314名为研究对象使用生活质量评价量表(short form 36 questionnaire,SF-36)测量HRQOL得分,并对脂溢性皮炎者的一般状况进行统计,同时使用单因素方差分析及多元逐步线性回归统计对HRQOL的影响因素进行分析。结果 SDS平均得分为51.45±9.42。研究显示无抑郁情绪占56.1%;轻度抑郁情绪占33.1%;中度抑郁情绪占7.0%;重度抑郁情绪占3.8%。不同的脂溢性皮炎病程、年龄、睡眠时间之间HRQOL得分差异有统计学意义(P<0.05);是否辛辣饮食、是否饮酒、是否吸烟、是否锻炼、是否治疗也会导致HRQOL得分产生差异(P<0.05)。其中病程越长、年龄越大、睡眠时间不足的脂溢性皮炎患者HRQOL得分较低;辛辣饮食、饮酒、吸烟会降低HRQOL得分,而锻炼和治疗可提高HRQOL得分。影响HRQOL评分的7个最主要因素为:治疗、SDS得分、辛辣饮食、脂溢性皮炎病程、锻炼、饮酒、睡眠时间。其中HRQOL得分与治疗、锻炼、睡眠时间呈正相关(P<0.05),与SDS得分、辛辣饮食、脂溢性皮炎病程、饮酒呈负相关(P<0.05)。结论脂溢性皮炎患者HRQOL不佳,部分伴发心理抑郁。应加大对心理抑郁、3年以上病程患者的关注和重视,积极给予中西医治疗,戒除辛辣饮食和饮酒,鼓励患者多运动锻炼,保证充沛的睡眠时间。
文摘Background:Seborrheic dermatitis (SD) is a common inflammatory skin condition.The etiology is unclear,although overgrowth of Malassezia on the skin has been suggested to cause SD.This study investigated whether colonization with Staphylococcus plays a role in facial SD,which was not well addressed previously.Methods:The study was conducted from September 1,2011 to February 20,2012 in the First Hospital of China Medical University.In the first phase,the study evaluated the level of transepidennal water loss (TEWL) and the number of colony-forming units (CFU) of Staphylococcus in defined skin areas of SD patients who were human immunodeficiency virus (HIV) seropositive (HIV [+] SD [+] group,n =13),classical SD (HIV [-] SD [+] group,n =24) patients,H IV seropositive-non-SD (HIV [+] SD [-] group,n =16) patients,and healthy volunteers (HIV [-] SD [-] group,n 16).In the second phase,we enrolled another cohort of HIV (-) SD (+) patients who applied topical fusidic acid (n =15),tacrolimus (n =16),or moisturizer (n =12).Changes in the Seborrheic Dermatitis Area Severity Index (SDASI),TEWL,and Staphylococcus density were evaluated 2 weeks later.Comparisons of each index were performed using analysis of variance (ANOVA) and least significant difference method.Results:The level of TEWL was greater through lesional sites in the HIV (+) SD (+) group than that in HIV (+) SD (-) and HIV () SD (-) groups (95% confidence interval [CI]:18.873-47.071,P 〈 0.001 and 95% CI:28.755-55.936,P 〈 0.001,respectively).The number of CFU of Staphylococcus was greater in the HIV (+) SD (+) group than that in HIV (+) SD (-) and HIV (-) SD (-) groups (95% CI:37.487-142.744,P =0.001 and 95% CI:54.936-156.400,P 〈 0.001,respectively).TEWL was significantly more improved in patients treated with tacrolimus and fusidic acid than that in those treated with moisturizers (95% CI:7.560 38.987,P =0