Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that might affect up to one-third of the adult population in industrialised countries. NAFLD incorporates histologically and clinically different no...Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that might affect up to one-third of the adult population in industrialised countries. NAFLD incorporates histologically and clinically different non-alcoholic entities; fatty liver (NAFL, steatosis hepatis) and steatohepatitis (NASH-characterised by hepatocyte ballooning and lobular inflammation ± fibrosis) might progress to cirrhosis and rarely to hepatocellular cancer. NAFL increasingly affects children (paediatric prevalence is 4.2%-9.6%). Type 2 diabetes mellitus (T2DM), insulin resistance (IR), obesity, metabolic syndrome and NAFLD are particularly closely related. Increased hepatic lipid storage is an early abnormality in insulin resistant women with a history of gestational diabetes mellitus. The accumulation of triacylglycerols in hepatocytes is predominantly derived from the plasma nonesterified fatty acid pool supplied largely by the adipose tissue. A few NAFLD susceptibility gene variants are associated with progressive liver disease, IR, T2DM and a higher risk for hepatocellular carcinoma. Although not approved, pharmacological approaches might be considered in NASH patients.展开更多
In the Western world, nonalcoholic fatty liver disease(NAFLD) is considered as one of the most significant liver diseases of the twenty-first century. Its development is certainly driven by environmental factors, but ...In the Western world, nonalcoholic fatty liver disease(NAFLD) is considered as one of the most significant liver diseases of the twenty-first century. Its development is certainly driven by environmental factors, but it is also regulated by genetic background. The role of heritability has been widely demonstratedby several epidemiological, familial, and twin studies and case series, and likely reflects the wide interindividual and inter-ethnic genetic variability in systemic metabolism and wound healing response processes. Consistent with this idea, genome-wide association studies have clearly identified Patatin-like phosholipase domain-containing 3 gene variant I148 M as a major player in the development and progression of NAFLD. More recently, the transmembrane 6 superfamily member 2 E167 K variant emerged as a relevant contributor in both NAFLD pathogenesis and cardiovascular outcomes. Furthermore, numerous casecontrol studies have been performed to elucidate the potential role of candidate genes in the pathogenesis and progression of fatty liver, although findings are sometimes contradictory. Accordingly, we performed a comprehensive literature search and review on the role of genetics in NAFLD. We emphasize the strengths and weaknesses of the available literature and outline the putative role of each genetic variant in influencing susceptibility and/or progression of the disease.展开更多
This study investigates the Stratosphere-Troposphere Exchange(STE) of water vapor,emphasizes its interdecadal variations over Asia in boreal summer,and discusses the influences of atmospheric heat sources over the Tib...This study investigates the Stratosphere-Troposphere Exchange(STE) of water vapor,emphasizes its interdecadal variations over Asia in boreal summer,and discusses the influences of atmospheric heat sources over the Tibetan Plateau and the tropical western North Pacific(WNP) on them by using the Wei method with reanalysis data from the European Centre for Medium-Range Weather Forecasts(ECMWF) for the years of 1958-2001.The climatology shows that the upward transport of water vapor across the tropopause in boreal summer is the most robust over the joining area of the South Asian Peninsula and Indian-Pacific Oceans(defined as AIPO).The upward transport over there can persistently convey the abundant water vapor into the stratosphere and then influence the distribution and variation of the stratospheric water vapor.The analysis shows that interdecadal variations of the water vapor exchange over the AIPO are significant,and its abrupt change occurred in the mid-1970s and the early 1990s.In these three periods,as important channels of the water vapor exchange,the effect of Bay of Bengal-East Asia as well as South China Sea was gradually weakening,while the role of the WNP becomes more and more important.Further studies show that atmospheric heat sources over the Tibetan Plateau and the WNP are two main factors in determining the interdecadal variations of water vapor exchange.The thermal influences over the Tibetan Plateau and the WNP have been greatly adjusted over the pass 44 years.Their synthesis influences the interdecadal variations of the water vapor exchange by changing the Asian summer monsoon,but their roles vary with time and regions.Especially after 1992,the influence of heat source over the Tibetan Plateau remarkably weakens,while the heat source over the WNP dominates the across-tropopause water vapor exchange.Results have important implications for understanding the transport of other components in the atmosphere and estimating the impact of human activities(emission) on global climate.展开更多
Gastrointestinal perforations, leaks and fistulas may be serious and life-threatening. The increasing number of endoscopic procedures with a high risk of perforation and the increasing incidence of leakage associated ...Gastrointestinal perforations, leaks and fistulas may be serious and life-threatening. The increasing number of endoscopic procedures with a high risk of perforation and the increasing incidence of leakage associated with bariatric operations call for a minimally invasive treatment for these complications. The therapeutic approach can vary greatly depending on the size,location, and timing of gastrointestinal wall defect recognition. Some asymptomatic patients can be treated conservatively, while patients with septic symptoms or cardio-pulmonary insufficiency may require intensive care and urgent surgical treatment.However, most gastrointestinal wall defects can be satisfactorily treated by endoscopy. Although the initial endoscopic closure rates of chronic fistulas is very high, the long-term results of these treatments remain a clinical problem. The efficacy of endoscopic therapy depends on several factors and the best mode of treatment will depend on a precise localization of the site, the extent of the leak and the endoscopic appearance of the lesion. Many endoscopic tools for effective closure of gastrointestinal wall defects are currently available. In this review, we summarized the basic principles of the management of acute iatrogenic perforations, as well as of postoperative leaks and chronic fistulas of the gastrointestinal tract. We also described the effectiveness of various endoscopic methods based on current research and our experience.展开更多
Recent advances in studies of the middle and upper atmosphere and their coupling with the lower atmosphere in China are briefly reviewed. This review emphasizes four aspects: (1) Development of instrumentation for mi... Recent advances in studies of the middle and upper atmosphere and their coupling with the lower atmosphere in China are briefly reviewed. This review emphasizes four aspects: (1) Development of instrumentation for middle and upper atmosphere observation; (2) Analyses and observation of middle and upper atmosphere; (3) Theoretical and modeling studies of planetary wave and gravity wave activities in the middle atmosphere and their relation to lower atmospheric processes; (4) Study on the coupling between the stratosphere and the troposphere.展开更多
A new method based on mass fluxes and observed ozone profiles was developed to estimate crosstropopause ozone flux. Using this method, we estimated the cross-tropopause ozone flux in a stratospheric-tropospheric excha...A new method based on mass fluxes and observed ozone profiles was developed to estimate crosstropopause ozone flux. Using this method, we estimated the cross-tropopause ozone flux in a stratospheric-tropospheric exchange event that occurred over East Asia in March 2001.The result revealed that the ozone flux across the tropopause in this event was an order of magnitude higher than the global and hemispheric average. Compared to the traditional method using a linear relationship between ozone mixing ratio and potential vorticity near the tropopause, the cross-tropopause ozone flux evaluated with ozonesonde data was somewhat higher, although the orders of the two values were the same.展开更多
Non-alcoholic fatty liver disease (NAFLD) is the most common and emerging form of chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis, whic...Non-alcoholic fatty liver disease (NAFLD) is the most common and emerging form of chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis, which may progress to cirrhosis, liver cancer, and liver mortality. Common metabolic diseases, which are well established cardiovascular risk factors, have been associated to NAFLD and cardiovascular disease is the single most important cause of morbidity and mortality in this patient population. The pathogenesis of NAFLD appears multifactorial and many mechanisms have been proposed as possible causes of fatty liver infiltration. Management of fatty liver has become a major challenge to healthcare systems as the consequence of the increasing rates of obesity worldwide. First-line management focuses on lifestyle modifications. Moderate weight reduction either by dietary restriction or by increased habitual physical activity is safe and highly recommended. Several therapeutic interventions have been proposed. These include insulin sensitizer agents, lipid lowering drugs, antioxidants such as vitamin E and supplementation of vitamin D<sub>3</sub>. However, therapeutic strategies have been largely empirical so far, and experimental trials have mostly been carried out in uncontrolled settings with small sample sizes. Metabolic conditions such as diabetes mellitus, obesity, hypertension and hyperlipidemia, should be strongly considered and a multidisciplinary approach should be personalized for individual patients. Treatment of co-morbidities should be regarded as of paramount importance in the management of these patients. The purpose of this review is to examine different approaches for the clinical management of non-alcoholic fatty liver disease.展开更多
Rates of non-alcoholic fatty liver disease(NAFLD) are increasing worldwide in tandem with the metabolic syndrome, with the progressive form of disease, nonalcoholic steatohepatitis(NASH) likely to become the most comm...Rates of non-alcoholic fatty liver disease(NAFLD) are increasing worldwide in tandem with the metabolic syndrome, with the progressive form of disease, nonalcoholic steatohepatitis(NASH) likely to become the most common cause of end stage liver disease in the not too distant future. Lifestyle modification and weight loss remain the main focus of management in NAFLD and NASH, however, there has been growing interest in the benefit of specific foods and dietary components on disease progression, with some foods showing protective properties. This article provides an overview of the foods that show the most promise and their potential benefits in NAFLD/NASH, specifically; oily fish/fish oil, coffee, nuts, tea, red wine, avocado and olive oil. Furthermore, it summarises results from animal and human trials and highlights potential areas for future research.展开更多
AIM: To investigate over-expression of Osteopontin (OPN) pathway expression and mechanisms of action in human alcoholic liver disease (ALD), in vivo and in vitro acute alcohol models.
To investigate the stratosphere-troposphere exchange(STE)process induced by the gravity waves(GWs)caused by Typhoon Molave(2020)in the upper troposphere and lower stratosphere,we analyzed the ERA5 reanalysis data prov...To investigate the stratosphere-troposphere exchange(STE)process induced by the gravity waves(GWs)caused by Typhoon Molave(2020)in the upper troposphere and lower stratosphere,we analyzed the ERA5 reanalysis data provided by the European Centre for Medium-Range Weather Forecasts and the CMA Tropical Cyclone Best Track Dataset.We also adopted the mesoscale forecast model Weather Research and Forecasting model V4.3 for numerical simulation.Most of the previous studies were about typhoon-induced STE and typhoon-induced GWs,while our research focused on the STE caused by typhoon-induced gravity waves.Our analysis shows that most of the time,the gravity wave signal of Typhoon Molave appeared below the tropopause.It was stronger on the east side of the typhoon center(10°-20°N,110°-120°E)than on the west side,suggesting an eastward tilted structure with height increase.When the GWs in the upper troposphere and lower stratosphere region on the west side of the typhoon center broke up,it produced strong turbulence,resulting in stratosphere-troposphere exchange.At this time,the average potential vorticity vertical flux increased with the average ozone mass mixing ratio.The gravity wave events and STE process simulated by the WRF model were basically consistent with the results of ERA5 reanalysis data,but the time of gravity wave breaking was different.This study indicates that after the breaking of the GWs induced by typhoons,turbulent mixing will also be generated,and thus the STE.展开更多
A set of borophosphate glasses doped with alkali and transition metal (TM) ions have been synthesized. The glasses were carried through;annealing, XRD, density, DC conductivity studies. Molar volume and density varied...A set of borophosphate glasses doped with alkali and transition metal (TM) ions have been synthesized. The glasses were carried through;annealing, XRD, density, DC conductivity studies. Molar volume and density varied nonlinearly. High temperature activation energy is analysed taking into consideration of Mott’s SPH model. The low temperature electrical conductivity was analysed by Mott and Greaves VRH. Several polaron hopping related parameters at high temperature region and density of states at low temperature region were computed. The high temperature DC activation energy measured by conductivity, calculated numerous pertained parameters varied nonlinearly with mole fraction of vanadium content. The Study exhibits DC electrical conduction is due to both alkali and transition metal ions and thus confirms the mixed conductivity. A crossover conduction mechanism from the ionic dominant region to polaronic predominant region has been also observed. Studies revealed the single transition effect at 0.4 mol fraction of V<sub>2</sub>O<sub>5</sub> content.展开更多
BACKGROUND Recent studies have demonstrated that mesenchymal stem cells(MSCs)can rescue injured target cells via mitochondrial transfer.However,it has not been fully understood how bone marrow-derived MSCs repair glom...BACKGROUND Recent studies have demonstrated that mesenchymal stem cells(MSCs)can rescue injured target cells via mitochondrial transfer.However,it has not been fully understood how bone marrow-derived MSCs repair glomeruli in diabetic kidney disease(DKD).AIM To explore the mitochondrial transfer involved in the rescue of injured glomerular endothelial cells(GECs)by MSCs,both in vitro and in vivo.METHODS In vitro experiments were performed to investigate the effect of co-culture with MSCs on high glucose-induced GECs.The transfer of mitochondria was visualized using fluorescent microscopy.GECs were freshly sorted and ultimately tested for apoptosis,viability,mRNA expression by real-time reverse transcriptase-polymerase chain reaction,protein expression by western blot,and mitochondrial function.Moreover,streptozotocin-induced DKD rats were infused with MSCs,and renal function and oxidative stress were detected with an automatic biochemical analyzer and related-detection kits after 2 wk.Kidney histology was analyzed by hematoxylin and eosin,periodic acid-Schiff,and immunohistochemical staining.RESULTS Fluorescence imaging confirmed that MSCs transferred mitochondria to injured GECs when cocultured in vitro.We found that the apoptosis,proliferation,and mitochondrial function of injured GECs were improved following co-culture.Additionally,MSCs decreased pro-inflammatory cytokines[interleukin(IL)-6,IL-1β,and tumor necrosis factor-α]and pro-apoptotic factors(caspase 3 and Bax).Mitochondrial transfer also enhanced the expression of superoxide dismutase 2,B cell lymphoma-2,glutathione peroxidase(GPx)3,and mitofusin 2 and inhibited reactive oxygen species(ROS)and dynamin-related protein 1 expression.Furthermore,MSCs significantly ameliorated functional parameters(blood urea nitrogen and serum creatinine)and decreased the production of malondialdehyde,advanced glycation end products,and ROS,whereas they increased the levels of GPx and superoxide dismutase in vivo.In addition,significant reductions in the glomerular basem展开更多
The State Transition Equation (STE) based method to automatically generate the parallel CRC circuits for any generator polynomial or required amount of parallelism is presented. The parallel CRC circuit so generate...The State Transition Equation (STE) based method to automatically generate the parallel CRC circuits for any generator polynomial or required amount of parallelism is presented. The parallel CRC circuit so generated is partially optimized before being fed to synthesis tools and works properly in our LAN transceiv-er. Compared with the cascading method, the proposed method gives better timing results and significantly re-duces the synthesis time, in particular.展开更多
AIM: To explore the therapeutic role of globular adiponectin (gAd) in high-fat diet/streptozotocin (STZ)-induced type 2 diabetic rats with nonalcoholic fatty liver disease (NAFLD).
文摘Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that might affect up to one-third of the adult population in industrialised countries. NAFLD incorporates histologically and clinically different non-alcoholic entities; fatty liver (NAFL, steatosis hepatis) and steatohepatitis (NASH-characterised by hepatocyte ballooning and lobular inflammation ± fibrosis) might progress to cirrhosis and rarely to hepatocellular cancer. NAFL increasingly affects children (paediatric prevalence is 4.2%-9.6%). Type 2 diabetes mellitus (T2DM), insulin resistance (IR), obesity, metabolic syndrome and NAFLD are particularly closely related. Increased hepatic lipid storage is an early abnormality in insulin resistant women with a history of gestational diabetes mellitus. The accumulation of triacylglycerols in hepatocytes is predominantly derived from the plasma nonesterified fatty acid pool supplied largely by the adipose tissue. A few NAFLD susceptibility gene variants are associated with progressive liver disease, IR, T2DM and a higher risk for hepatocellular carcinoma. Although not approved, pharmacological approaches might be considered in NASH patients.
文摘In the Western world, nonalcoholic fatty liver disease(NAFLD) is considered as one of the most significant liver diseases of the twenty-first century. Its development is certainly driven by environmental factors, but it is also regulated by genetic background. The role of heritability has been widely demonstratedby several epidemiological, familial, and twin studies and case series, and likely reflects the wide interindividual and inter-ethnic genetic variability in systemic metabolism and wound healing response processes. Consistent with this idea, genome-wide association studies have clearly identified Patatin-like phosholipase domain-containing 3 gene variant I148 M as a major player in the development and progression of NAFLD. More recently, the transmembrane 6 superfamily member 2 E167 K variant emerged as a relevant contributor in both NAFLD pathogenesis and cardiovascular outcomes. Furthermore, numerous casecontrol studies have been performed to elucidate the potential role of candidate genes in the pathogenesis and progression of fatty liver, although findings are sometimes contradictory. Accordingly, we performed a comprehensive literature search and review on the role of genetics in NAFLD. We emphasize the strengths and weaknesses of the available literature and outline the putative role of each genetic variant in influencing susceptibility and/or progression of the disease.
基金the National Basic Science Key Program in China (Grant No.2006CB403600)the National Natural Science Foundation of China (Grant Nos.40633018 and 40705023)
文摘This study investigates the Stratosphere-Troposphere Exchange(STE) of water vapor,emphasizes its interdecadal variations over Asia in boreal summer,and discusses the influences of atmospheric heat sources over the Tibetan Plateau and the tropical western North Pacific(WNP) on them by using the Wei method with reanalysis data from the European Centre for Medium-Range Weather Forecasts(ECMWF) for the years of 1958-2001.The climatology shows that the upward transport of water vapor across the tropopause in boreal summer is the most robust over the joining area of the South Asian Peninsula and Indian-Pacific Oceans(defined as AIPO).The upward transport over there can persistently convey the abundant water vapor into the stratosphere and then influence the distribution and variation of the stratospheric water vapor.The analysis shows that interdecadal variations of the water vapor exchange over the AIPO are significant,and its abrupt change occurred in the mid-1970s and the early 1990s.In these three periods,as important channels of the water vapor exchange,the effect of Bay of Bengal-East Asia as well as South China Sea was gradually weakening,while the role of the WNP becomes more and more important.Further studies show that atmospheric heat sources over the Tibetan Plateau and the WNP are two main factors in determining the interdecadal variations of water vapor exchange.The thermal influences over the Tibetan Plateau and the WNP have been greatly adjusted over the pass 44 years.Their synthesis influences the interdecadal variations of the water vapor exchange by changing the Asian summer monsoon,but their roles vary with time and regions.Especially after 1992,the influence of heat source over the Tibetan Plateau remarkably weakens,while the heat source over the WNP dominates the across-tropopause water vapor exchange.Results have important implications for understanding the transport of other components in the atmosphere and estimating the impact of human activities(emission) on global climate.
文摘Gastrointestinal perforations, leaks and fistulas may be serious and life-threatening. The increasing number of endoscopic procedures with a high risk of perforation and the increasing incidence of leakage associated with bariatric operations call for a minimally invasive treatment for these complications. The therapeutic approach can vary greatly depending on the size,location, and timing of gastrointestinal wall defect recognition. Some asymptomatic patients can be treated conservatively, while patients with septic symptoms or cardio-pulmonary insufficiency may require intensive care and urgent surgical treatment.However, most gastrointestinal wall defects can be satisfactorily treated by endoscopy. Although the initial endoscopic closure rates of chronic fistulas is very high, the long-term results of these treatments remain a clinical problem. The efficacy of endoscopic therapy depends on several factors and the best mode of treatment will depend on a precise localization of the site, the extent of the leak and the endoscopic appearance of the lesion. Many endoscopic tools for effective closure of gastrointestinal wall defects are currently available. In this review, we summarized the basic principles of the management of acute iatrogenic perforations, as well as of postoperative leaks and chronic fistulas of the gastrointestinal tract. We also described the effectiveness of various endoscopic methods based on current research and our experience.
基金supported by the National Natural Science Foundation of China under Grant Nos.40333034,40075007,and 40175002the.Chinese Academy of Sciences under Grant No.KZCX-SW-217.
文摘 Recent advances in studies of the middle and upper atmosphere and their coupling with the lower atmosphere in China are briefly reviewed. This review emphasizes four aspects: (1) Development of instrumentation for middle and upper atmosphere observation; (2) Analyses and observation of middle and upper atmosphere; (3) Theoretical and modeling studies of planetary wave and gravity wave activities in the middle atmosphere and their relation to lower atmospheric processes; (4) Study on the coupling between the stratosphere and the troposphere.
文摘A new method based on mass fluxes and observed ozone profiles was developed to estimate crosstropopause ozone flux. Using this method, we estimated the cross-tropopause ozone flux in a stratospheric-tropospheric exchange event that occurred over East Asia in March 2001.The result revealed that the ozone flux across the tropopause in this event was an order of magnitude higher than the global and hemispheric average. Compared to the traditional method using a linear relationship between ozone mixing ratio and potential vorticity near the tropopause, the cross-tropopause ozone flux evaluated with ozonesonde data was somewhat higher, although the orders of the two values were the same.
文摘Non-alcoholic fatty liver disease (NAFLD) is the most common and emerging form of chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis, which may progress to cirrhosis, liver cancer, and liver mortality. Common metabolic diseases, which are well established cardiovascular risk factors, have been associated to NAFLD and cardiovascular disease is the single most important cause of morbidity and mortality in this patient population. The pathogenesis of NAFLD appears multifactorial and many mechanisms have been proposed as possible causes of fatty liver infiltration. Management of fatty liver has become a major challenge to healthcare systems as the consequence of the increasing rates of obesity worldwide. First-line management focuses on lifestyle modifications. Moderate weight reduction either by dietary restriction or by increased habitual physical activity is safe and highly recommended. Several therapeutic interventions have been proposed. These include insulin sensitizer agents, lipid lowering drugs, antioxidants such as vitamin E and supplementation of vitamin D<sub>3</sub>. However, therapeutic strategies have been largely empirical so far, and experimental trials have mostly been carried out in uncontrolled settings with small sample sizes. Metabolic conditions such as diabetes mellitus, obesity, hypertension and hyperlipidemia, should be strongly considered and a multidisciplinary approach should be personalized for individual patients. Treatment of co-morbidities should be regarded as of paramount importance in the management of these patients. The purpose of this review is to examine different approaches for the clinical management of non-alcoholic fatty liver disease.
文摘Rates of non-alcoholic fatty liver disease(NAFLD) are increasing worldwide in tandem with the metabolic syndrome, with the progressive form of disease, nonalcoholic steatohepatitis(NASH) likely to become the most common cause of end stage liver disease in the not too distant future. Lifestyle modification and weight loss remain the main focus of management in NAFLD and NASH, however, there has been growing interest in the benefit of specific foods and dietary components on disease progression, with some foods showing protective properties. This article provides an overview of the foods that show the most promise and their potential benefits in NAFLD/NASH, specifically; oily fish/fish oil, coffee, nuts, tea, red wine, avocado and olive oil. Furthermore, it summarises results from animal and human trials and highlights potential areas for future research.
基金Supported by Philanthropic Anonymous Sourcethe University of Sydney Bridging Support Grant,in part for Honours ProjectSupported by the National Health and Medical Research Council,No.NHMRC Practitioner Research Fellowship for PH support
文摘AIM: To investigate over-expression of Osteopontin (OPN) pathway expression and mechanisms of action in human alcoholic liver disease (ALD), in vivo and in vitro acute alcohol models.
基金Guangdong Basic and Applied Basic Research Foundation(2023A1515011323)National Natural Science Foun-dation of China(42130604,42130605,72293604)+4 种基金Guangdong Provincial Observation and Research Station for Tropical Ocean Environment in Western Coastal Waters(GSTOEW)First-Class Discipline Plan of Guangdong Province(080503032101,231420003)Fundamental Research Funds for the Central Universities(202362001,202072010)China Scholarship Council(202208440223)Natural Science Foundation of Shanghai(23ZR1473800)。
文摘To investigate the stratosphere-troposphere exchange(STE)process induced by the gravity waves(GWs)caused by Typhoon Molave(2020)in the upper troposphere and lower stratosphere,we analyzed the ERA5 reanalysis data provided by the European Centre for Medium-Range Weather Forecasts and the CMA Tropical Cyclone Best Track Dataset.We also adopted the mesoscale forecast model Weather Research and Forecasting model V4.3 for numerical simulation.Most of the previous studies were about typhoon-induced STE and typhoon-induced GWs,while our research focused on the STE caused by typhoon-induced gravity waves.Our analysis shows that most of the time,the gravity wave signal of Typhoon Molave appeared below the tropopause.It was stronger on the east side of the typhoon center(10°-20°N,110°-120°E)than on the west side,suggesting an eastward tilted structure with height increase.When the GWs in the upper troposphere and lower stratosphere region on the west side of the typhoon center broke up,it produced strong turbulence,resulting in stratosphere-troposphere exchange.At this time,the average potential vorticity vertical flux increased with the average ozone mass mixing ratio.The gravity wave events and STE process simulated by the WRF model were basically consistent with the results of ERA5 reanalysis data,but the time of gravity wave breaking was different.This study indicates that after the breaking of the GWs induced by typhoons,turbulent mixing will also be generated,and thus the STE.
文摘A set of borophosphate glasses doped with alkali and transition metal (TM) ions have been synthesized. The glasses were carried through;annealing, XRD, density, DC conductivity studies. Molar volume and density varied nonlinearly. High temperature activation energy is analysed taking into consideration of Mott’s SPH model. The low temperature electrical conductivity was analysed by Mott and Greaves VRH. Several polaron hopping related parameters at high temperature region and density of states at low temperature region were computed. The high temperature DC activation energy measured by conductivity, calculated numerous pertained parameters varied nonlinearly with mole fraction of vanadium content. The Study exhibits DC electrical conduction is due to both alkali and transition metal ions and thus confirms the mixed conductivity. A crossover conduction mechanism from the ionic dominant region to polaronic predominant region has been also observed. Studies revealed the single transition effect at 0.4 mol fraction of V<sub>2</sub>O<sub>5</sub> content.
基金Supported by the Science and Technology Foundation of Jinhua,No.2021-4-190.
文摘BACKGROUND Recent studies have demonstrated that mesenchymal stem cells(MSCs)can rescue injured target cells via mitochondrial transfer.However,it has not been fully understood how bone marrow-derived MSCs repair glomeruli in diabetic kidney disease(DKD).AIM To explore the mitochondrial transfer involved in the rescue of injured glomerular endothelial cells(GECs)by MSCs,both in vitro and in vivo.METHODS In vitro experiments were performed to investigate the effect of co-culture with MSCs on high glucose-induced GECs.The transfer of mitochondria was visualized using fluorescent microscopy.GECs were freshly sorted and ultimately tested for apoptosis,viability,mRNA expression by real-time reverse transcriptase-polymerase chain reaction,protein expression by western blot,and mitochondrial function.Moreover,streptozotocin-induced DKD rats were infused with MSCs,and renal function and oxidative stress were detected with an automatic biochemical analyzer and related-detection kits after 2 wk.Kidney histology was analyzed by hematoxylin and eosin,periodic acid-Schiff,and immunohistochemical staining.RESULTS Fluorescence imaging confirmed that MSCs transferred mitochondria to injured GECs when cocultured in vitro.We found that the apoptosis,proliferation,and mitochondrial function of injured GECs were improved following co-culture.Additionally,MSCs decreased pro-inflammatory cytokines[interleukin(IL)-6,IL-1β,and tumor necrosis factor-α]and pro-apoptotic factors(caspase 3 and Bax).Mitochondrial transfer also enhanced the expression of superoxide dismutase 2,B cell lymphoma-2,glutathione peroxidase(GPx)3,and mitofusin 2 and inhibited reactive oxygen species(ROS)and dynamin-related protein 1 expression.Furthermore,MSCs significantly ameliorated functional parameters(blood urea nitrogen and serum creatinine)and decreased the production of malondialdehyde,advanced glycation end products,and ROS,whereas they increased the levels of GPx and superoxide dismutase in vivo.In addition,significant reductions in the glomerular basem
文摘The State Transition Equation (STE) based method to automatically generate the parallel CRC circuits for any generator polynomial or required amount of parallelism is presented. The parallel CRC circuit so generated is partially optimized before being fed to synthesis tools and works properly in our LAN transceiv-er. Compared with the cascading method, the proposed method gives better timing results and significantly re-duces the synthesis time, in particular.
基金Supported by Science and Technology Project of Xiamen,China,No.3502Z20114016
文摘AIM: To explore the therapeutic role of globular adiponectin (gAd) in high-fat diet/streptozotocin (STZ)-induced type 2 diabetic rats with nonalcoholic fatty liver disease (NAFLD).
