Myocarditis is a relatively rare,possibly life-threatening disease characterized by the inflammation of the myocardium.111 The disease pathogenesis is primarily initiated by acute injury and necrosis of cardiomyocytes...Myocarditis is a relatively rare,possibly life-threatening disease characterized by the inflammation of the myocardium.111 The disease pathogenesis is primarily initiated by acute injury and necrosis of cardiomyocytes,leading to an inflammatory response mediated by the immune system that can potentially cause further aggravation of myocardial damage and organ dysfunction.Prognosis in patients with myocarditis depends on the clinical presentation,which ranges from an asymptomatic disease course to the concomitant development of cardiac arrhythmias,heart failure,cardiogenic shock and even the occurrence of death in extreme cases[1].展开更多
The public health problem created by multidrug resistant bacteria in the 21st century continues to receive attention by researchers all over the world. As the production of new antibiotics is not commeasurable with th...The public health problem created by multidrug resistant bacteria in the 21st century continues to receive attention by researchers all over the world. As the production of new antibiotics is not commeasurable with the rate of evolvement of MDR bacteria, the news of a proposed new antibiotic “Lugdunin” is much awaited and a welcomed development. Lugdunin is produced by Staphylococcus lugdunensis and has the ability to kill S. aureus. Both bacteria are nasal colonizers. The present investigation looks into the antibiotic susceptibility pattern of co-habitation of S. lugdunensis with methicillin and vancomycin resistant Staphylococcus aureus in laboratory bred Wister rats. Nasal swabs of anaesthetized rats were collected using a sterile cotton swab moistened in 0.9% saline solution. All swabs were inoculated into nutrient broth, cultured at 37°C for 24 hrs. Overnight bacterial growth plated on blood agar and incubated at 37°C for 24 hrs. Organism identification and antibiotic susceptibility test were by using BioMerieux VITEK 2 compact automated system (BioMerieux, Marcy I’Etoile France), according to the manufacturers guidelines. Results obtained showed co-habitation of S. aureus with co-agulase negative bacteria, inclusive of S. lugdunensis. All the isolates were resistant to methicillin with a 33.3% resistance to vancomycin. The difference between the number of antibiotic resistant or sensitive varied statistically among the Staphylococcal isolates. For S. aureus 1, the difference was significant with p-value 0.034 but not significant for isolates 2, 3 and 4 with p-values of 0.158, 0.477 and 0.158 respectively. A statistically significant difference was seen with S. lugdunensis. The result from the study therefore, showed that the colonization of the nasal snares of the laboratory bred rats with S. aureus and other co-agulase negative Staphylococci was not affected by the presence of S. lugdunensis.展开更多
Importance:Staphylococcus lugdunensis(S.lugdunensis)is a coagulase-negative staphylococcus(CoNS),found commonly as skin flora in humans.While most species of CoNS are clinically benign,S.lugdunensis can exhibit a simi...Importance:Staphylococcus lugdunensis(S.lugdunensis)is a coagulase-negative staphylococcus(CoNS),found commonly as skin flora in humans.While most species of CoNS are clinically benign,S.lugdunensis can exhibit a similar virulence to that ofS.aureus.However,there is scant data concerningS.lugdunensis infection in the pediatric population.Objective:To ascertain localS.lugdunensis infection rates and sensitivity patterns in the pediatric population.Methods:A retrospective analysis was undertaken of allS.lugdunensis isolates across a 6-year period from 2015 to 2020.Data were collected from electronic patient notes and laboratory records.Matrix-assisted laser desorption ionization and time of flight mass spectrometry were used to identify isolates.Results:Ninety-six isolates ofS.lugdunensis were identified from 86 patients.Of these,34 isolates were treated as an infection.Twenty-three(67.6%)were found to have skin as the primary source of infection.While the observed number was small,central nervous system(CNS)sources ofS.lugdunensis infection appear to be a significant source:all three isolates cultured from cerebrospinal fluid were clinically managed as infection.All three were associated with ventriculoperitoneal(VP)shunt infection.No cases ofS.lugdunensis infective endocarditis were identified.About 18.6%ofS.lugdunensis isolates were resistant to flucloxacillin.Interpretation:S.lugdunensis is an uncommon but significant cause of infection in the pediatric population and appears to be a rising cause of CNS infection,particularly when associated with VP shunts.Flucloxacillin is recommended locally as the first choice of antibiotic.展开更多
Objective:to describe the clinical fea-tures of a case of infective endocarditis caused by Staph-ylococcus lugdunensis,followed by cerebral embolism,spleen embolism and tendon rupture.Methods:the clin-ical data of a 2...Objective:to describe the clinical fea-tures of a case of infective endocarditis caused by Staph-ylococcus lugdunensis,followed by cerebral embolism,spleen embolism and tendon rupture.Methods:the clin-ical data of a 22-year-old female patient with aphasia hemiplegia and abdominal pain were collected.Relevant examinations such as routine blood test,myocardial en-zyme spectrum,electrocardiogram(ECG),cardiac color Doppler ultrasound,brain magnetic resonance,abdomi-nal computed tomography(CT)and blood culture were completed,and anti infection treatment was carried out according to the drug sensitivity test.Results:brain mag-netic resonance imaging(MRI)showed cerebral infarction in the left basal ganglia,cardiac color Doppler ultrasound showed mitral valve vegetation and abscess formation,and abdominal CT showed splenic infarction.After anti infection treatment,the patient’s condition gradually improved,but the patient had sudden arrhythmia in the recovery period.Color Doppler ultrasound showed rup-ture of the mitral tendinous cord and valve prolapse.The condition was improved after surgical treatment.Conclu-sion:the first manifestation of Staphylococcus lugdunen-sis infection is cerebral infarction,which is relatively rare in the clinic setting.The main manifestation of this case is aphasia hemiplegia with abdominal pain.Blood cul-ture and identification show Staphylococcus lugdunensis,which is rare in adolescent patients.The infection has a rapid onset,rapid progress and causes serious valve dam-age.Timely strain identification and drug sensitivity test are conducive to accurate diagnosis and treatment.Valve surgery is often necessary.展开更多
文摘Myocarditis is a relatively rare,possibly life-threatening disease characterized by the inflammation of the myocardium.111 The disease pathogenesis is primarily initiated by acute injury and necrosis of cardiomyocytes,leading to an inflammatory response mediated by the immune system that can potentially cause further aggravation of myocardial damage and organ dysfunction.Prognosis in patients with myocarditis depends on the clinical presentation,which ranges from an asymptomatic disease course to the concomitant development of cardiac arrhythmias,heart failure,cardiogenic shock and even the occurrence of death in extreme cases[1].
文摘The public health problem created by multidrug resistant bacteria in the 21st century continues to receive attention by researchers all over the world. As the production of new antibiotics is not commeasurable with the rate of evolvement of MDR bacteria, the news of a proposed new antibiotic “Lugdunin” is much awaited and a welcomed development. Lugdunin is produced by Staphylococcus lugdunensis and has the ability to kill S. aureus. Both bacteria are nasal colonizers. The present investigation looks into the antibiotic susceptibility pattern of co-habitation of S. lugdunensis with methicillin and vancomycin resistant Staphylococcus aureus in laboratory bred Wister rats. Nasal swabs of anaesthetized rats were collected using a sterile cotton swab moistened in 0.9% saline solution. All swabs were inoculated into nutrient broth, cultured at 37°C for 24 hrs. Overnight bacterial growth plated on blood agar and incubated at 37°C for 24 hrs. Organism identification and antibiotic susceptibility test were by using BioMerieux VITEK 2 compact automated system (BioMerieux, Marcy I’Etoile France), according to the manufacturers guidelines. Results obtained showed co-habitation of S. aureus with co-agulase negative bacteria, inclusive of S. lugdunensis. All the isolates were resistant to methicillin with a 33.3% resistance to vancomycin. The difference between the number of antibiotic resistant or sensitive varied statistically among the Staphylococcal isolates. For S. aureus 1, the difference was significant with p-value 0.034 but not significant for isolates 2, 3 and 4 with p-values of 0.158, 0.477 and 0.158 respectively. A statistically significant difference was seen with S. lugdunensis. The result from the study therefore, showed that the colonization of the nasal snares of the laboratory bred rats with S. aureus and other co-agulase negative Staphylococci was not affected by the presence of S. lugdunensis.
文摘Importance:Staphylococcus lugdunensis(S.lugdunensis)is a coagulase-negative staphylococcus(CoNS),found commonly as skin flora in humans.While most species of CoNS are clinically benign,S.lugdunensis can exhibit a similar virulence to that ofS.aureus.However,there is scant data concerningS.lugdunensis infection in the pediatric population.Objective:To ascertain localS.lugdunensis infection rates and sensitivity patterns in the pediatric population.Methods:A retrospective analysis was undertaken of allS.lugdunensis isolates across a 6-year period from 2015 to 2020.Data were collected from electronic patient notes and laboratory records.Matrix-assisted laser desorption ionization and time of flight mass spectrometry were used to identify isolates.Results:Ninety-six isolates ofS.lugdunensis were identified from 86 patients.Of these,34 isolates were treated as an infection.Twenty-three(67.6%)were found to have skin as the primary source of infection.While the observed number was small,central nervous system(CNS)sources ofS.lugdunensis infection appear to be a significant source:all three isolates cultured from cerebrospinal fluid were clinically managed as infection.All three were associated with ventriculoperitoneal(VP)shunt infection.No cases ofS.lugdunensis infective endocarditis were identified.About 18.6%ofS.lugdunensis isolates were resistant to flucloxacillin.Interpretation:S.lugdunensis is an uncommon but significant cause of infection in the pediatric population and appears to be a rising cause of CNS infection,particularly when associated with VP shunts.Flucloxacillin is recommended locally as the first choice of antibiotic.
基金Scientific Research Program of Hubei Provincial Department of Education in 2019(Q20192103).
文摘Objective:to describe the clinical fea-tures of a case of infective endocarditis caused by Staph-ylococcus lugdunensis,followed by cerebral embolism,spleen embolism and tendon rupture.Methods:the clin-ical data of a 22-year-old female patient with aphasia hemiplegia and abdominal pain were collected.Relevant examinations such as routine blood test,myocardial en-zyme spectrum,electrocardiogram(ECG),cardiac color Doppler ultrasound,brain magnetic resonance,abdomi-nal computed tomography(CT)and blood culture were completed,and anti infection treatment was carried out according to the drug sensitivity test.Results:brain mag-netic resonance imaging(MRI)showed cerebral infarction in the left basal ganglia,cardiac color Doppler ultrasound showed mitral valve vegetation and abscess formation,and abdominal CT showed splenic infarction.After anti infection treatment,the patient’s condition gradually improved,but the patient had sudden arrhythmia in the recovery period.Color Doppler ultrasound showed rup-ture of the mitral tendinous cord and valve prolapse.The condition was improved after surgical treatment.Conclu-sion:the first manifestation of Staphylococcus lugdunen-sis infection is cerebral infarction,which is relatively rare in the clinic setting.The main manifestation of this case is aphasia hemiplegia with abdominal pain.Blood cul-ture and identification show Staphylococcus lugdunensis,which is rare in adolescent patients.The infection has a rapid onset,rapid progress and causes serious valve dam-age.Timely strain identification and drug sensitivity test are conducive to accurate diagnosis and treatment.Valve surgery is often necessary.
