Our immune system is based on the close collaboration of the innate and adaptive immune systems for the rapid detection of any threats to the host. Recognition of pathogen-derived molecules is entrusted to specific ge...Our immune system is based on the close collaboration of the innate and adaptive immune systems for the rapid detection of any threats to the host. Recognition of pathogen-derived molecules is entrusted to specific germline- encoded signaling receptors. The same receptors have now also emerged as efficient detectors of misplaced or altered self-molecules that signal tissue damage and cell death following, for example, disruption of the blood supply and subsequent hypoxia. Many types of endogenous molecules have been shown to provoke such sterile inflammatory states when released from dying cells. However, a group of proteins referred to as alarmins have both intracellular and extracellular functions which have been the subject of intense research. Indeed, alarmins can either exert beneficial cell housekeeping functions, leading to tissue repair, or provoke deleterious uncontrolled inflammation. This group of proteins includes the high-mobility group box 1 protein （HMGB1）, interleukin （IL）-1α, IL-33 and the Ca^2＋-binding S100 proteins. These dual-function proteins share conserved regulatory mechanisms, such as secretory routes, post-translational modifications and enzymatic processing, that govern their extracellular functions in time and space. Release of alarmins from mesenchymal cells is a highly relevant mechanism by which immune cells can be alerted of tissue damage, and alarmins play a key role in the development of acute or chronic inflammatory diseases and in cancer development.展开更多
基于台站观测资料,评估了欧洲中期天气预报中心(ECMWF)最高时空分辨率的第五代大气再分析资料(ERA5)对1979~2018年间中国大陆区域10 m高度风速的气候特征及其变化趋势的再现能力,并同步对比分析了ERA5资料100 m高度风速的特征和长期趋...基于台站观测资料,评估了欧洲中期天气预报中心(ECMWF)最高时空分辨率的第五代大气再分析资料(ERA5)对1979~2018年间中国大陆区域10 m高度风速的气候特征及其变化趋势的再现能力,并同步对比分析了ERA5资料100 m高度风速的特征和长期趋势。结果表明,ERA5资料10 m和100 m风速在空间分布、年—季节—月尺度演变的气候特征方面与台站观测非常一致,10 m风速气候态空间相关系数达到0.66。观测和再分析资料均显示,中国近地层风速呈现出显著的区域性特征,风速大值区主要分布在内蒙古、东北地区西部、新疆北部以及青藏高原西部地区,上述区域的风速季节差异也相对明显,春季风速最大。台站观测、ERA5资料10 m和100 m全国平均风速在4月达到最大值,分别为2.6、3.0、4.5 m s^(-1),8月为最小值,分别为2.0、2.4、3.5 m s^(-1)。从月平均序列来看,ERA5资料的10 m风速较台站观测偏高0.3~0.5 m s^(-1),而100 m的风速较10 m风速整体偏高1.2~1.4 m s^(-1)。在风速变化方面,台站观测风速在中国陆地区域整体呈下降趋势–0.4 m s^(-1)(39 a)–1,春季下降趋势最显著[–0.5 m s^(-1)(39 a)–1],且1979~1992年冬季风速降幅最大[–0.7 m s^(-1)(14 a)–1],2013年以后风速逐渐增强。ERA5资料两个高度层的风速在整个中国区域均没有明显的长期变化趋势,4个季节风速变化趋势的空间分布与观测也存在差异,100m风速的长期变化趋势与10 m一致但变化幅度大于10 m风速。总之,ERA5资料对中国大陆区域气候平均风速具有较好的再现能力,但无法呈现台站观测风速的长期变化趋势。展开更多
The (100) texture of solidified fcc metals, caused by the preferential (100) dendrite growth, could be closeIy related to solid/melt interfaces which behave differently along different crystallographic orientation. Th...The (100) texture of solidified fcc metals, caused by the preferential (100) dendrite growth, could be closeIy related to solid/melt interfaces which behave differently along different crystallographic orientation. The stability and roughness of {111} and {100} solid/melt interfaces of fcc metals were investigated using a modified Temkin multi-layer model. It is demonstrated that {100}crystal/melt interface is more unstable and rougher than {111} interface. The effect of the stability of crystal/melt interface on the (100) texture formation in solidified fcc metals has been analysed and discussed.展开更多
本文对我国8 运会前3 名优秀男子蝶泳运动员和第26 届奥运会蝶泳比赛前6 名运动员的出发反应时、出发15 m ,途中游的划频与划幅,转身前后,7.5 m 技术以及冲刺到边进行了对比分析。结果表明,中国蝶泳运动员出发技术较好,划频能力不如国...本文对我国8 运会前3 名优秀男子蝶泳运动员和第26 届奥运会蝶泳比赛前6 名运动员的出发反应时、出发15 m ,途中游的划频与划幅,转身前后,7.5 m 技术以及冲刺到边进行了对比分析。结果表明,中国蝶泳运动员出发技术较好,划频能力不如国外优秀运动员,划幅较大,但划频与划幅的组合不尽合理;转身技术最为薄弱,表现在转身前减速,转身蹬前有停顿,与国外优秀运动员转身技术上存在一定差距;冲剌到边技术尚可,但仍有待精雕细刻。建议我国蝶泳运动员应重视基本技术和全面身体素质训练,根据个人技术、素质特点调整划频、划幅的组合;必须解决好转身技术环节。展开更多
文摘Our immune system is based on the close collaboration of the innate and adaptive immune systems for the rapid detection of any threats to the host. Recognition of pathogen-derived molecules is entrusted to specific germline- encoded signaling receptors. The same receptors have now also emerged as efficient detectors of misplaced or altered self-molecules that signal tissue damage and cell death following, for example, disruption of the blood supply and subsequent hypoxia. Many types of endogenous molecules have been shown to provoke such sterile inflammatory states when released from dying cells. However, a group of proteins referred to as alarmins have both intracellular and extracellular functions which have been the subject of intense research. Indeed, alarmins can either exert beneficial cell housekeeping functions, leading to tissue repair, or provoke deleterious uncontrolled inflammation. This group of proteins includes the high-mobility group box 1 protein （HMGB1）, interleukin （IL）-1α, IL-33 and the Ca^2＋-binding S100 proteins. These dual-function proteins share conserved regulatory mechanisms, such as secretory routes, post-translational modifications and enzymatic processing, that govern their extracellular functions in time and space. Release of alarmins from mesenchymal cells is a highly relevant mechanism by which immune cells can be alerted of tissue damage, and alarmins play a key role in the development of acute or chronic inflammatory diseases and in cancer development.
文摘基于台站观测资料,评估了欧洲中期天气预报中心(ECMWF)最高时空分辨率的第五代大气再分析资料(ERA5)对1979~2018年间中国大陆区域10 m高度风速的气候特征及其变化趋势的再现能力,并同步对比分析了ERA5资料100 m高度风速的特征和长期趋势。结果表明,ERA5资料10 m和100 m风速在空间分布、年—季节—月尺度演变的气候特征方面与台站观测非常一致,10 m风速气候态空间相关系数达到0.66。观测和再分析资料均显示,中国近地层风速呈现出显著的区域性特征,风速大值区主要分布在内蒙古、东北地区西部、新疆北部以及青藏高原西部地区,上述区域的风速季节差异也相对明显,春季风速最大。台站观测、ERA5资料10 m和100 m全国平均风速在4月达到最大值,分别为2.6、3.0、4.5 m s^(-1),8月为最小值,分别为2.0、2.4、3.5 m s^(-1)。从月平均序列来看,ERA5资料的10 m风速较台站观测偏高0.3~0.5 m s^(-1),而100 m的风速较10 m风速整体偏高1.2~1.4 m s^(-1)。在风速变化方面,台站观测风速在中国陆地区域整体呈下降趋势–0.4 m s^(-1)(39 a)–1,春季下降趋势最显著[–0.5 m s^(-1)(39 a)–1],且1979~1992年冬季风速降幅最大[–0.7 m s^(-1)(14 a)–1],2013年以后风速逐渐增强。ERA5资料两个高度层的风速在整个中国区域均没有明显的长期变化趋势,4个季节风速变化趋势的空间分布与观测也存在差异,100m风速的长期变化趋势与10 m一致但变化幅度大于10 m风速。总之,ERA5资料对中国大陆区域气候平均风速具有较好的再现能力,但无法呈现台站观测风速的长期变化趋势。
文摘The (100) texture of solidified fcc metals, caused by the preferential (100) dendrite growth, could be closeIy related to solid/melt interfaces which behave differently along different crystallographic orientation. The stability and roughness of {111} and {100} solid/melt interfaces of fcc metals were investigated using a modified Temkin multi-layer model. It is demonstrated that {100}crystal/melt interface is more unstable and rougher than {111} interface. The effect of the stability of crystal/melt interface on the (100) texture formation in solidified fcc metals has been analysed and discussed.
文摘本文对我国8 运会前3 名优秀男子蝶泳运动员和第26 届奥运会蝶泳比赛前6 名运动员的出发反应时、出发15 m ,途中游的划频与划幅,转身前后,7.5 m 技术以及冲刺到边进行了对比分析。结果表明,中国蝶泳运动员出发技术较好,划频能力不如国外优秀运动员,划幅较大,但划频与划幅的组合不尽合理;转身技术最为薄弱,表现在转身前减速,转身蹬前有停顿,与国外优秀运动员转身技术上存在一定差距;冲剌到边技术尚可,但仍有待精雕细刻。建议我国蝶泳运动员应重视基本技术和全面身体素质训练,根据个人技术、素质特点调整划频、划幅的组合;必须解决好转身技术环节。
