AIM: To examine the effect of ibutilide on novel indexes of repolarization in patients with persistent atrial fibrillation (AF). METHODS: We studied consecutive patients scheduled for elective electrical cardioversion...AIM: To examine the effect of ibutilide on novel indexes of repolarization in patients with persistent atrial fibrillation (AF). METHODS: We studied consecutive patients scheduled for elective electrical cardioversion. Intravenous ibutilide (1+1mg) was administered before the electrical cardioversion while close electrocardiographic (ECG) monitoring was performed. ECG indexes such as corrected QT interval (QTc), the interval from the peak until the end of T wave (Tpe), and the Tpe/QT ratio were measured before ibutilide infusion and 10 min after the end of infusion. RESULTS: The final study population consisted of 20 patients (mean age: 67.1±9.9 years, 10 men). Six patients were cardioverted pharmacologically and did not proceed to electrical cardioversion. Two patientsdeveloped short non-sustained episodes of torsades de pointes ventricular tachycardia. All but one of the aforementioned ECG indexes increased significantly after ibutilide administration. In specific, the QTc interval increased from 442 ± 29 to 471 ± 37 ms (P=0.037), the Tpe interval in precordial leads from 96 ms (range 80-108 ms) to 101 ms (range 91-119 ms) (P=0.021), the Tpe interval in lead Ⅱ from 79 ms (range 70-88 ms) to 100 ms (range 87-104 ms) (P<0.001), the Tpe/QT ratio in precordial leads from 0.23 ms (range 0.18-0.26 ms) to 0.26 ms (range 0.23-0.28 ms) (P=0.028), and the Tpe interval dispersion from 25 ms (range 23-30 ms) to 35 ms (range 27-39 ms) (P=0.012). However, the Tpe/QT ratio in lead II did not change significantly. CONCLUSION: Ibutilide increases the duration and dispersion of ventricular repolarization. The prognostic value of Tpe and Tpe/QT in the setting of drug-induced proarrhythmia needs further study.展开更多
Opening windows in coach buses is a practical approach to improving natural ventilation and mitigating infection risk(IR).Due to human behavior and weather conditions,the intermittent window opening strategy(IWOS)is a...Opening windows in coach buses is a practical approach to improving natural ventilation and mitigating infection risk(IR).Due to human behavior and weather conditions,the intermittent window opening strategy(IWOS)is a more common practice than keeping windows constantly open.Despite its prevalence,there are no studies exploring IWOS specifically in vehicles.We employed indoor-outdoor coupled CFD simulations to assess the effects of various IWOS on pathogen-laden droplet(PLD)dispersion and IR in a coach bus that occurred a COVID-19 outbreak in Hunan,China.Results reveal that after ventilating through two skylights for 600–1800 s,opening front and rear windows(FW+RW)or FW with a wind catcher(FW+WCH)for just 40 s can reduce PLD concentration(Cave)to 5%of its initial level and the intake fraction of the infector’s neighbor(IFn)drops by 95%.Upon closing FW+RW or FW+WCH,Cave and IFn take over 580 s to return to the pre-opening level.Moreover,intermittent FW opening halves Cave and IFn within 7 min,but leads to rapid increases upon window closure.Therefore,opening FW+RW and FW+WCH intermittently have pronounced impacts on indoor PLD concentration and are applicable approaches to control respiratory disease transmission in vehicles.According to the inhaled viral dose,it is recommended to open windows when driving time is over 12 minutes to reduce infection risk.In scenarios like epidemiological surveys and risk assessments,where assessing passenger infection risk is vital,some behaviors of opening windows cannot be overlooked and necessitate extra attention.展开更多
This paper presents a theoretical analysis of a pulsed bicomponent contaminant emission into a flee-surface wetland flow. The basic equations are for the bicomponent contaminant transport in the wetland flow under the...This paper presents a theoretical analysis of a pulsed bicomponent contaminant emission into a flee-surface wetland flow. The basic equations are for the bicomponent contaminant transport in the wetland flow under the combined action of advection, mass dispersion, and ecological reaction at the phase averaged scale. The effect of the ecological reaction is separated from the hydrodynamic effect via a set of widely used transforms. The analytical solution for the evolution of the depth-averaged concentration is rigorously derived, with a limiting case covering the known solution for the single component contaminant transport. It is found that the depth-averaged species concentration of the bicomponent contaminant can approach an equilibrium state determined by the distribution coefficient.展开更多
文摘AIM: To examine the effect of ibutilide on novel indexes of repolarization in patients with persistent atrial fibrillation (AF). METHODS: We studied consecutive patients scheduled for elective electrical cardioversion. Intravenous ibutilide (1+1mg) was administered before the electrical cardioversion while close electrocardiographic (ECG) monitoring was performed. ECG indexes such as corrected QT interval (QTc), the interval from the peak until the end of T wave (Tpe), and the Tpe/QT ratio were measured before ibutilide infusion and 10 min after the end of infusion. RESULTS: The final study population consisted of 20 patients (mean age: 67.1±9.9 years, 10 men). Six patients were cardioverted pharmacologically and did not proceed to electrical cardioversion. Two patientsdeveloped short non-sustained episodes of torsades de pointes ventricular tachycardia. All but one of the aforementioned ECG indexes increased significantly after ibutilide administration. In specific, the QTc interval increased from 442 ± 29 to 471 ± 37 ms (P=0.037), the Tpe interval in precordial leads from 96 ms (range 80-108 ms) to 101 ms (range 91-119 ms) (P=0.021), the Tpe interval in lead Ⅱ from 79 ms (range 70-88 ms) to 100 ms (range 87-104 ms) (P<0.001), the Tpe/QT ratio in precordial leads from 0.23 ms (range 0.18-0.26 ms) to 0.26 ms (range 0.23-0.28 ms) (P=0.028), and the Tpe interval dispersion from 25 ms (range 23-30 ms) to 35 ms (range 27-39 ms) (P=0.012). However, the Tpe/QT ratio in lead II did not change significantly. CONCLUSION: Ibutilide increases the duration and dispersion of ventricular repolarization. The prognostic value of Tpe and Tpe/QT in the setting of drug-induced proarrhythmia needs further study.
基金supported by the National Natural Science Foundation of China(No.42175095,No.42005069,and No.42175180)support from Guangdong Major Project of Basic and Applied Basic Research(2020B0301030004,2021B0301030007)the UK GCRF Rapid Response Grant on“Transmission of SARS-CoV-2 virus in crowded indoor environment”,and the Innovation Group Project of the Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(No.311020001)are also gratefully acknowledged.
文摘Opening windows in coach buses is a practical approach to improving natural ventilation and mitigating infection risk(IR).Due to human behavior and weather conditions,the intermittent window opening strategy(IWOS)is a more common practice than keeping windows constantly open.Despite its prevalence,there are no studies exploring IWOS specifically in vehicles.We employed indoor-outdoor coupled CFD simulations to assess the effects of various IWOS on pathogen-laden droplet(PLD)dispersion and IR in a coach bus that occurred a COVID-19 outbreak in Hunan,China.Results reveal that after ventilating through two skylights for 600–1800 s,opening front and rear windows(FW+RW)or FW with a wind catcher(FW+WCH)for just 40 s can reduce PLD concentration(Cave)to 5%of its initial level and the intake fraction of the infector’s neighbor(IFn)drops by 95%.Upon closing FW+RW or FW+WCH,Cave and IFn take over 580 s to return to the pre-opening level.Moreover,intermittent FW opening halves Cave and IFn within 7 min,but leads to rapid increases upon window closure.Therefore,opening FW+RW and FW+WCH intermittently have pronounced impacts on indoor PLD concentration and are applicable approaches to control respiratory disease transmission in vehicles.According to the inhaled viral dose,it is recommended to open windows when driving time is over 12 minutes to reduce infection risk.In scenarios like epidemiological surveys and risk assessments,where assessing passenger infection risk is vital,some behaviors of opening windows cannot be overlooked and necessitate extra attention.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.10972009,50939001and41271543)supported by the Special Foundation of China Institute of Water Resources and Hydropower Research(Contract No.SJ1239)
文摘This paper presents a theoretical analysis of a pulsed bicomponent contaminant emission into a flee-surface wetland flow. The basic equations are for the bicomponent contaminant transport in the wetland flow under the combined action of advection, mass dispersion, and ecological reaction at the phase averaged scale. The effect of the ecological reaction is separated from the hydrodynamic effect via a set of widely used transforms. The analytical solution for the evolution of the depth-averaged concentration is rigorously derived, with a limiting case covering the known solution for the single component contaminant transport. It is found that the depth-averaged species concentration of the bicomponent contaminant can approach an equilibrium state determined by the distribution coefficient.
