人呼吸道合胞病毒是引起婴幼儿支气管炎和肺炎的主要原因,也可导致免疫缺陷病人及老年人群显著发病和死亡.人呼吸道合胞病毒疫苗已被世界卫生组织(World Health Organization,WHO)列为全球最优先发展的疫苗之一.经过50多年的研究,尤其...人呼吸道合胞病毒是引起婴幼儿支气管炎和肺炎的主要原因,也可导致免疫缺陷病人及老年人群显著发病和死亡.人呼吸道合胞病毒疫苗已被世界卫生组织(World Health Organization,WHO)列为全球最优先发展的疫苗之一.经过50多年的研究,尤其是随着重组技术和反向遗传学的出现,对RSV疫苗的研究取得了重要进展,但尚未有疫苗上市.目前主要集中于亚单位疫苗及活疫苗等,其中活疫苗包括减毒活疫苗和活病毒载体疫苗,因其最有可能用于预防婴幼儿RSV感染,而受到了较大关注.以rA2cp248/404/1030ΔSH为代表的RSV减毒活疫苗临床试验显示,其有较好的安全性及免疫保护作用,不产生疾病增强作用是极有潜力的候选疫苗.因此,本文将重点介绍RSV活疫苗研究的主要进展和发展方向.展开更多
This research adds to the literature studying the effects of outward foreign direct investment(OF DI)on domestic innovation performance and the moderating effect of a technology gap between host and home countries.New...This research adds to the literature studying the effects of outward foreign direct investment(OF DI)on domestic innovation performance and the moderating effect of a technology gap between host and home countries.New definitions of observed technology gap and expected technology'gap are proposed.An observed technology gap captures the existing differences in technology level between establishments,regions or countries.An expected technology'gap is an indication of the effort of imitating and learning from technology leaders.The corresponding measures and effects of observed and expected technology gaps on OFDI-induced reverse technology spillover are analyzed.OFDI in developed countries promotes innovation performance.However,OFDI in emerging markets hampers innovation performance.It is also found that regions with a wider observed technology^gap and a narrower expected technology gap can benefit more from OFDI.展开更多
文摘人呼吸道合胞病毒是引起婴幼儿支气管炎和肺炎的主要原因,也可导致免疫缺陷病人及老年人群显著发病和死亡.人呼吸道合胞病毒疫苗已被世界卫生组织(World Health Organization,WHO)列为全球最优先发展的疫苗之一.经过50多年的研究,尤其是随着重组技术和反向遗传学的出现,对RSV疫苗的研究取得了重要进展,但尚未有疫苗上市.目前主要集中于亚单位疫苗及活疫苗等,其中活疫苗包括减毒活疫苗和活病毒载体疫苗,因其最有可能用于预防婴幼儿RSV感染,而受到了较大关注.以rA2cp248/404/1030ΔSH为代表的RSV减毒活疫苗临床试验显示,其有较好的安全性及免疫保护作用,不产生疾病增强作用是极有潜力的候选疫苗.因此,本文将重点介绍RSV活疫苗研究的主要进展和发展方向.
基金the National Natural Science Foundation of China(Nos.71172213 and 71572188).
文摘This research adds to the literature studying the effects of outward foreign direct investment(OF DI)on domestic innovation performance and the moderating effect of a technology gap between host and home countries.New definitions of observed technology gap and expected technology'gap are proposed.An observed technology gap captures the existing differences in technology level between establishments,regions or countries.An expected technology'gap is an indication of the effort of imitating and learning from technology leaders.The corresponding measures and effects of observed and expected technology gaps on OFDI-induced reverse technology spillover are analyzed.OFDI in developed countries promotes innovation performance.However,OFDI in emerging markets hampers innovation performance.It is also found that regions with a wider observed technology^gap and a narrower expected technology gap can benefit more from OFDI.
