Traditional information systems are passive, i.e., data or knowledge is created, retrieved, modified, updated, and deleted only in response to operations issued by users or application programs, and the systems only c...Traditional information systems are passive, i.e., data or knowledge is created, retrieved, modified, updated, and deleted only in response to operations issued by users or application programs, and the systems only can execute queries or transactions explicitly submitted by users or application programs but have no ability to do something actively by themselves. Unlike a traditional information system serving just as a storehouse of data or knowledge and working passively according to queries or transactions explicitly issued by users and application programs, an autonomous evolutionary information system serves as an autonomous and evolutionary partner of its users that discovers new knowledge from its database or knowledge base autonomously, cooperates with its users in solving problems actively by providing the users with advices, and has a certain mechanism to improve its own state of “knowing” and ability of “working”. This paper seminally defines what is an autonomous evolutionary information system, explain why autonomous evolutionary information systems are needed, and presents some new issues, fundamental considerations, and research directions in design and development of autonomous evolutionary information systems.展开更多
Osteoarthritis(OA),a common disabling joint disease,is highly associated with microenvironmental changes in the cartilage and subchondral bone.Elevated reactive oxygen species(ROS)in the cartilage and subchondral bone...Osteoarthritis(OA),a common disabling joint disease,is highly associated with microenvironmental changes in the cartilage and subchondral bone.Elevated reactive oxygen species(ROS)in the cartilage and subchondral bone angiogenesis accelerate articular cartilage erosion.New cartilage-targeting drug deliv-ery systems that are aimed at preventing ROS production and angiogenesis may be of clinical significance for OA treatment.Herein,an ROS scavenger and an inflammatory-responsive nanocarrier are designed by immobilizing the natural polyphenol(curcumin)in chitosan-catechol nanoformulations(Cur-CS-C NPs)via boronate ester.The robust cartilage-targeting effects and ROS scavenging capacities of Cur-CS-C NPs were respectively determined in cartilage explants and chondrocytes.Intra-articular injection of Cur-CS-C NPs in OA rat models efficiently suppressed angiogenesis and cartilage degradation partially via the ROS-mediated NF-κB/PI3K-Akt signaling pathway.The developed curcumin-functionalized nanocarriers can significantly delay OA progression and provide a promising therapeutic strategy for other inflamma-tory diseases that are characterized by oxidative stress and angiogenesis.展开更多
This work proposes a 12 kW three-phase grid-connected single stage PWM DC-AC converter destined to process the energy provided by a photovoltaic array composed of 57 KC200GT PV modules with high power factor for any s...This work proposes a 12 kW three-phase grid-connected single stage PWM DC-AC converter destined to process the energy provided by a photovoltaic array composed of 57 KC200GT PV modules with high power factor for any solar radiation. The PWM inverter modeling and the control strategy, using dqO transformation, are proposed in order to also allow the system operation as an active power filter, capable to compensate harmonic components and react power generated by the non-linear loads connected to the mains grid. An input voltage clamping technique is proposed to impose the photovoltaic operation on the maximum power point. Simulation and experimental results are presented to validate the proposed methodology for grid connected photovoltaic generation system.展开更多
This paper presents a pooled-neighbor swarm intelligence approach (PNSIA) to optimal reactive power dispatch and voltage control of power systems. The proposed approach uses more particles’ information to control the...This paper presents a pooled-neighbor swarm intelligence approach (PNSIA) to optimal reactive power dispatch and voltage control of power systems. The proposed approach uses more particles’ information to control the mutation operation. The proposed PNSIA algorithm is also extended to handle mixed variables, such as transformer taps and reactive power source in- stallation, using a simple scheme. PNSIA applied for optimal power system reactive power dispatch is evaluated on an IEEE 30-bus power system and a practical 118-bus power system in which the control of bus voltages, tap position of transformers and reactive power sources are involved to minimize the transmission loss of the power system. Simulation results showed that the proposed approach is superior to current methods for finding the optimal solution, in terms of both solution quality and algorithm robustness.展开更多
基金Supported in part by The Ministry of EducationCulture+1 种基金SportsScience and Technology of Japan under Grant-in-Aid for Scient
文摘Traditional information systems are passive, i.e., data or knowledge is created, retrieved, modified, updated, and deleted only in response to operations issued by users or application programs, and the systems only can execute queries or transactions explicitly submitted by users or application programs but have no ability to do something actively by themselves. Unlike a traditional information system serving just as a storehouse of data or knowledge and working passively according to queries or transactions explicitly issued by users and application programs, an autonomous evolutionary information system serves as an autonomous and evolutionary partner of its users that discovers new knowledge from its database or knowledge base autonomously, cooperates with its users in solving problems actively by providing the users with advices, and has a certain mechanism to improve its own state of “knowing” and ability of “working”. This paper seminally defines what is an autonomous evolutionary information system, explain why autonomous evolutionary information systems are needed, and presents some new issues, fundamental considerations, and research directions in design and development of autonomous evolutionary information systems.
基金financially supported by the National Natural Science Foundation of China (Nos.11532004 and 11832008)the Innovation and Attracting Talents Program for College and Univer-sity (“111”Project) (No.B06023).
文摘Osteoarthritis(OA),a common disabling joint disease,is highly associated with microenvironmental changes in the cartilage and subchondral bone.Elevated reactive oxygen species(ROS)in the cartilage and subchondral bone angiogenesis accelerate articular cartilage erosion.New cartilage-targeting drug deliv-ery systems that are aimed at preventing ROS production and angiogenesis may be of clinical significance for OA treatment.Herein,an ROS scavenger and an inflammatory-responsive nanocarrier are designed by immobilizing the natural polyphenol(curcumin)in chitosan-catechol nanoformulations(Cur-CS-C NPs)via boronate ester.The robust cartilage-targeting effects and ROS scavenging capacities of Cur-CS-C NPs were respectively determined in cartilage explants and chondrocytes.Intra-articular injection of Cur-CS-C NPs in OA rat models efficiently suppressed angiogenesis and cartilage degradation partially via the ROS-mediated NF-κB/PI3K-Akt signaling pathway.The developed curcumin-functionalized nanocarriers can significantly delay OA progression and provide a promising therapeutic strategy for other inflamma-tory diseases that are characterized by oxidative stress and angiogenesis.
文摘This work proposes a 12 kW three-phase grid-connected single stage PWM DC-AC converter destined to process the energy provided by a photovoltaic array composed of 57 KC200GT PV modules with high power factor for any solar radiation. The PWM inverter modeling and the control strategy, using dqO transformation, are proposed in order to also allow the system operation as an active power filter, capable to compensate harmonic components and react power generated by the non-linear loads connected to the mains grid. An input voltage clamping technique is proposed to impose the photovoltaic operation on the maximum power point. Simulation and experimental results are presented to validate the proposed methodology for grid connected photovoltaic generation system.
基金Project supported by the National Natural Science Foundation ofChina (No. 60421002) and the Outstanding Young Research Inves-tigator Fund (No. 60225006), China
文摘This paper presents a pooled-neighbor swarm intelligence approach (PNSIA) to optimal reactive power dispatch and voltage control of power systems. The proposed approach uses more particles’ information to control the mutation operation. The proposed PNSIA algorithm is also extended to handle mixed variables, such as transformer taps and reactive power source in- stallation, using a simple scheme. PNSIA applied for optimal power system reactive power dispatch is evaluated on an IEEE 30-bus power system and a practical 118-bus power system in which the control of bus voltages, tap position of transformers and reactive power sources are involved to minimize the transmission loss of the power system. Simulation results showed that the proposed approach is superior to current methods for finding the optimal solution, in terms of both solution quality and algorithm robustness.
