OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, c...OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients.展开更多
The generation of good pseudo-random numbers is the base of many important fields in scientific computing, such as randomized algorithms and numerical solution of stochastic differential equations. In this paper, a cl...The generation of good pseudo-random numbers is the base of many important fields in scientific computing, such as randomized algorithms and numerical solution of stochastic differential equations. In this paper, a class of random number generators （RNGs） based on Weyl sequence is proposed. The uniformity of those RNGs is proved theoretically. Statistical and numerical computations show the efficiency of the methods.展开更多
In this papert we give an approach for detecting one or more outliers inrandomized linear model.The likelihood ratio test statistic and its distributions underthe null hypothesis and the alternative hypothesis are giv...In this papert we give an approach for detecting one or more outliers inrandomized linear model.The likelihood ratio test statistic and its distributions underthe null hypothesis and the alternative hypothesis are given. Furthermore,the robustnessof the test statistic in a certain sense is proved. Finally,the optimality properties of thetest are derived.展开更多
We propose randomized inference(RI),a new statistical inference approach.RI may be realized through a randomized estimate(RE)of a parameter vector,which is a random vector that takes values in the parameter space with...We propose randomized inference(RI),a new statistical inference approach.RI may be realized through a randomized estimate(RE)of a parameter vector,which is a random vector that takes values in the parameter space with a probability density function(PDF)that depends on the sample or sufficient statistics,such as the posterior distributions in Bayesian inference.Based on the PDF of an RE of an unknown parameter,we propose a framework for both the vertical density representation(VDR)test and the construction of a confidence region.This approach is explained with the aid of examples.For the equality hypothesis of multiple normal means without the condition of variance homogeneity,we present an exact VDR test,which is shown as an extension of one-way analysis of variance(ANOVA).In the case of two populations,the PDF of the Welch statistics is given by using the RE.Furthermore,through simulations,we show that the empirical distribution function,the approximated t,and the RE distribution function of Welch statistics are almost equal.The VDR test of the homogeneity of variance is shown to be more efficient than both the Bartlett test and the revised Bartlett test.Finally,we discuss the prospects of RI.展开更多
[目的]通过对针灸治疗膝关节骨性关节炎(knee osteoarthritis, KOA)在中国知网(China National Knowledge Infrastructure,CNKI)核心期刊源的随机对照试验(randomized controlled trial,RCT)论文的研究特点分析,为针灸临床RCT文章的规...[目的]通过对针灸治疗膝关节骨性关节炎(knee osteoarthritis, KOA)在中国知网(China National Knowledge Infrastructure,CNKI)核心期刊源的随机对照试验(randomized controlled trial,RCT)论文的研究特点分析,为针灸临床RCT文章的规范撰写提供参考。[方法]检索CNKI获取2000—2018针灸治疗KOA的文献,筛选出符合条件的文献,参考临床试验报告的统一标准(Consolidated Standards of Reporting Trials,CONSORT)2010声明和针刺临床试验干预措施报告的标准(Standards for Reporting Interventions in Controlled Trials of Acupuncture,STRICTA)对纳入文献质量进行评价。[结果]共纳入7篇文献,研究表明针灸治疗KOA的文献在试验设计或表述上大体上遵循了CONSORT 2010声明和STRICTA标准,但对于细节方面的描述严谨度尚待进一步增强,如描述了研究背景,但缺乏研究假设;重视纳入、排除、诊断标准,但是经常将其混淆;详细描述受试者的招募情况,但对随访重视不够;均采用随机方法,但缺乏对样本量估算、随机方法实施和分配隐蔽的描述;忽视对伦理审批、临床试验注册的描述;对结果的解释缺乏国内外对照,较为单一;在针刺细节和针具细节方面描述详细,但缺乏针具生产厂商和针具材料的描述。[结论]针灸临床RCT文献的撰写还需遵循CONSORT 2010声明与STRICTA标准,提高文献报告质量,为明确针灸治疗KOA的临床优效性方案,形成安全有效、易于推广的针灸治疗KOA的方案做铺垫。展开更多
基金Supported by National Key Technology R&D Programs in the 11th Five-Year Plan of China:Study on Comprehensive Evaluation Method of Integral Effect of Traditional Chinese Medicine Treatment for Heart Failure(No.2006BAI08B02-01)Ministry of Education of People's Republic of China"Program for Innovative Research Team in University"–Research on TCM for the Prevention and Treatment of Cardiovascular Diseases(No.IRT_16R54)Tianjin Science and Technology Program:Tianjin TCM Clinical Medicine Research Center(No.15ZXLCSY00020)
文摘OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients.
基金Supported by National Natural Science Foundation of China （19871047）and National Key Basic Research Special Fund（1998020306）.
文摘The generation of good pseudo-random numbers is the base of many important fields in scientific computing, such as randomized algorithms and numerical solution of stochastic differential equations. In this paper, a class of random number generators （RNGs） based on Weyl sequence is proposed. The uniformity of those RNGs is proved theoretically. Statistical and numerical computations show the efficiency of the methods.
文摘In this papert we give an approach for detecting one or more outliers inrandomized linear model.The likelihood ratio test statistic and its distributions underthe null hypothesis and the alternative hypothesis are given. Furthermore,the robustnessof the test statistic in a certain sense is proved. Finally,the optimality properties of thetest are derived.
基金supported by National Natural Science Foundation of China(Grant No.11771032)。
文摘We propose randomized inference(RI),a new statistical inference approach.RI may be realized through a randomized estimate(RE)of a parameter vector,which is a random vector that takes values in the parameter space with a probability density function(PDF)that depends on the sample or sufficient statistics,such as the posterior distributions in Bayesian inference.Based on the PDF of an RE of an unknown parameter,we propose a framework for both the vertical density representation(VDR)test and the construction of a confidence region.This approach is explained with the aid of examples.For the equality hypothesis of multiple normal means without the condition of variance homogeneity,we present an exact VDR test,which is shown as an extension of one-way analysis of variance(ANOVA).In the case of two populations,the PDF of the Welch statistics is given by using the RE.Furthermore,through simulations,we show that the empirical distribution function,the approximated t,and the RE distribution function of Welch statistics are almost equal.The VDR test of the homogeneity of variance is shown to be more efficient than both the Bartlett test and the revised Bartlett test.Finally,we discuss the prospects of RI.
文摘[目的]通过对针灸治疗膝关节骨性关节炎(knee osteoarthritis, KOA)在中国知网(China National Knowledge Infrastructure,CNKI)核心期刊源的随机对照试验(randomized controlled trial,RCT)论文的研究特点分析,为针灸临床RCT文章的规范撰写提供参考。[方法]检索CNKI获取2000—2018针灸治疗KOA的文献,筛选出符合条件的文献,参考临床试验报告的统一标准(Consolidated Standards of Reporting Trials,CONSORT)2010声明和针刺临床试验干预措施报告的标准(Standards for Reporting Interventions in Controlled Trials of Acupuncture,STRICTA)对纳入文献质量进行评价。[结果]共纳入7篇文献,研究表明针灸治疗KOA的文献在试验设计或表述上大体上遵循了CONSORT 2010声明和STRICTA标准,但对于细节方面的描述严谨度尚待进一步增强,如描述了研究背景,但缺乏研究假设;重视纳入、排除、诊断标准,但是经常将其混淆;详细描述受试者的招募情况,但对随访重视不够;均采用随机方法,但缺乏对样本量估算、随机方法实施和分配隐蔽的描述;忽视对伦理审批、临床试验注册的描述;对结果的解释缺乏国内外对照,较为单一;在针刺细节和针具细节方面描述详细,但缺乏针具生产厂商和针具材料的描述。[结论]针灸临床RCT文献的撰写还需遵循CONSORT 2010声明与STRICTA标准,提高文献报告质量,为明确针灸治疗KOA的临床优效性方案,形成安全有效、易于推广的针灸治疗KOA的方案做铺垫。
