[目的]系统评价半夏泻心汤治疗糖尿病胃轻瘫的临床疗效及安全性。[方法]计算机及手工检索2000年1月1日~2018年4月1日在Pubmed、Embase、Cochrane Library、SinoMed、CNKI、VIP及万方等数据库发表的以半夏泻心汤为主方的各种中药制剂治...[目的]系统评价半夏泻心汤治疗糖尿病胃轻瘫的临床疗效及安全性。[方法]计算机及手工检索2000年1月1日~2018年4月1日在Pubmed、Embase、Cochrane Library、SinoMed、CNKI、VIP及万方等数据库发表的以半夏泻心汤为主方的各种中药制剂治疗糖尿病胃轻瘫的随机对照试验(Randomized controlled trial,RCT),使用Cochrane协作网推荐的RCT的偏倚风险表(risk of bias table)对纳入的研究偏倚风险进行评价,应用Rev Man 5.3软件进行Meta分析。[结果]共纳入24个RCT研究,1801例患者。Meta分析结果显示,半夏泻心方组与西药组相比,临床总有效率更高,差异有统计学意义[RR=1.25,95%CI(1.19,1.32),P<0.00001];血清生化水平改善更明显,包括空腹血糖[WMD=-1.68,95%CI(-2.48,-0.88),P<0.0001]、餐后2h血糖[WMD=-1.46,95%CI(-2.06,-0.85),P<0.00001]、胃动素[WMD=-73.26,95%CI(-94.29,-52.22),P<0.00001];影像学改善更明显,其中胃排空率[WMD=6.66,95%CI(3.60,9.72),P<0.0001];复发率显著降低[RR=0.64,95%CI(0.44,0.94),P=0.02];现有证据表明2者不良反应发生率差异无统计学意义[OR=0.71,95%CI(0.29,1.77),P=0.46]。[结论]半夏泻心方组治疗糖尿病胃轻瘫临床疗效明显高于西药组,并具有较低的复发率,但不良反应发生率方面2者未见明显差异。鉴于纳入的试验质量较低且存在偏倚的可能,仍需进一步开展多中心、大样本、高质量、双盲的RCT研究进行进一步验证。展开更多
OBJECTIVE: To evaluate the effects of Guasha therapy on the rating of perceived exertion(RPE) scale score, and heart rate variability(HRV).METHODS: A randomized controlled trial of Guasha(skin scraping) was compared w...OBJECTIVE: To evaluate the effects of Guasha therapy on the rating of perceived exertion(RPE) scale score, and heart rate variability(HRV).METHODS: A randomized controlled trial of Guasha(skin scraping) was compared with a sham scraping group and control group. Sixteen sessions within an 8-week period were completed. Sixty-five male weightlifters who had undergone normal weightlifting training for a mean of 5 years before study commencement were recruited. The RPEscale score of "snatch", "clean and jerk" maneuvers(85% of one-repetition maximum), and HRV were measured before and after the intervention.RESULTS: The RPE scale score for snatch, clean and jerk were reduced significantly after intervention in the Guasha group and sham group. However, there was a significant difference in the low frequency(LF) domain and LF/high frequency(HF) ratio(P <0.05): the LF domain decreased, and the LF/HF ratio decreased.CONCLUSION: Guasha could be used to reduce the RPE scale score, and increase the response to HRV.Guasha could be considered as an alternative to some types of recovery from sports training.展开更多
OBJECTIVE： To document the therapeutic effects of Feiwei granules （FGs） for idiopathic pulmonary fi-brosis （IPF）.METHODS： One hundred cases with IPF were ran- domized into the treatment group （80） and control ...OBJECTIVE： To document the therapeutic effects of Feiwei granules （FGs） for idiopathic pulmonary fi-brosis （IPF）.METHODS： One hundred cases with IPF were ran- domized into the treatment group （80） and control group （20）. Both groups were given basic treat- ment with prednisone. The treatment group was given FGs, and the control group was given Jinshui- bao capsules （JCs）. Treatment lasted for 6 months. The Medical Research Council Dyspnea Scale （MRCDS）, the Saint George＇s Hospital Respiratory Questionnaire （SGHRQ）, pulmonary function, the Traditional Chinese Medicine Syndrome Score （TC- MSS）, 6-min walking test （6MWT） and blood gas analyses were recorded before the study as well as 3 months and 6 months after treatment.RESULTS： FGs showed greater efficacy than the control in certain parameters between before the study and 6 months, and between 3 months and 6 months, in the MRCDS, some indicators in the SGHRQ, and the TCMSS. There were no significant differences between the treatment group and con- trol group in the remainder of the indices evaluat- ed. In the treatment group, there were significant differences in before and after treatment in the MRCDS, SGHRQ, TCMSS and 6MWT.展开更多
文摘[目的]系统评价半夏泻心汤治疗糖尿病胃轻瘫的临床疗效及安全性。[方法]计算机及手工检索2000年1月1日~2018年4月1日在Pubmed、Embase、Cochrane Library、SinoMed、CNKI、VIP及万方等数据库发表的以半夏泻心汤为主方的各种中药制剂治疗糖尿病胃轻瘫的随机对照试验(Randomized controlled trial,RCT),使用Cochrane协作网推荐的RCT的偏倚风险表(risk of bias table)对纳入的研究偏倚风险进行评价,应用Rev Man 5.3软件进行Meta分析。[结果]共纳入24个RCT研究,1801例患者。Meta分析结果显示,半夏泻心方组与西药组相比,临床总有效率更高,差异有统计学意义[RR=1.25,95%CI(1.19,1.32),P<0.00001];血清生化水平改善更明显,包括空腹血糖[WMD=-1.68,95%CI(-2.48,-0.88),P<0.0001]、餐后2h血糖[WMD=-1.46,95%CI(-2.06,-0.85),P<0.00001]、胃动素[WMD=-73.26,95%CI(-94.29,-52.22),P<0.00001];影像学改善更明显,其中胃排空率[WMD=6.66,95%CI(3.60,9.72),P<0.0001];复发率显著降低[RR=0.64,95%CI(0.44,0.94),P=0.02];现有证据表明2者不良反应发生率差异无统计学意义[OR=0.71,95%CI(0.29,1.77),P=0.46]。[结论]半夏泻心方组治疗糖尿病胃轻瘫临床疗效明显高于西药组,并具有较低的复发率,但不良反应发生率方面2者未见明显差异。鉴于纳入的试验质量较低且存在偏倚的可能,仍需进一步开展多中心、大样本、高质量、双盲的RCT研究进行进一步验证。
基金the National Natural Science Foundation of China(Research of the Biological Effects and Mechanism of Different Guasha Therapies,No.30672720)the National Natural Science Foundation of China(Comparative Research of Different Acupuncture Stimulation Methods on The Expression of Effects in Acupoint Areas,No.81674079)
文摘OBJECTIVE: To evaluate the effects of Guasha therapy on the rating of perceived exertion(RPE) scale score, and heart rate variability(HRV).METHODS: A randomized controlled trial of Guasha(skin scraping) was compared with a sham scraping group and control group. Sixteen sessions within an 8-week period were completed. Sixty-five male weightlifters who had undergone normal weightlifting training for a mean of 5 years before study commencement were recruited. The RPEscale score of "snatch", "clean and jerk" maneuvers(85% of one-repetition maximum), and HRV were measured before and after the intervention.RESULTS: The RPE scale score for snatch, clean and jerk were reduced significantly after intervention in the Guasha group and sham group. However, there was a significant difference in the low frequency(LF) domain and LF/high frequency(HF) ratio(P <0.05): the LF domain decreased, and the LF/HF ratio decreased.CONCLUSION: Guasha could be used to reduce the RPE scale score, and increase the response to HRV.Guasha could be considered as an alternative to some types of recovery from sports training.
基金Supported by the Special Scientific Research for Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine of China:Effects of Feiwei Granules in the treatment of IPF(No.200807046)
文摘OBJECTIVE： To document the therapeutic effects of Feiwei granules （FGs） for idiopathic pulmonary fi-brosis （IPF）.METHODS： One hundred cases with IPF were ran- domized into the treatment group （80） and control group （20）. Both groups were given basic treat- ment with prednisone. The treatment group was given FGs, and the control group was given Jinshui- bao capsules （JCs）. Treatment lasted for 6 months. The Medical Research Council Dyspnea Scale （MRCDS）, the Saint George＇s Hospital Respiratory Questionnaire （SGHRQ）, pulmonary function, the Traditional Chinese Medicine Syndrome Score （TC- MSS）, 6-min walking test （6MWT） and blood gas analyses were recorded before the study as well as 3 months and 6 months after treatment.RESULTS： FGs showed greater efficacy than the control in certain parameters between before the study and 6 months, and between 3 months and 6 months, in the MRCDS, some indicators in the SGHRQ, and the TCMSS. There were no significant differences between the treatment group and con- trol group in the remainder of the indices evaluat- ed. In the treatment group, there were significant differences in before and after treatment in the MRCDS, SGHRQ, TCMSS and 6MWT.
