This study demonstrated that damage to the cerebral microvasculature, the formation of microthrombi and swelling of vascular endothelial cells occur early and peak 12 hours after injury in a rat model of diffuse axona...This study demonstrated that damage to the cerebral microvasculature, the formation of microthrombi and swelling of vascular endothelial cells occur early and peak 12 hours after injury in a rat model of diffuse axonal injury. Moreover, these pathological changes were most evident in the cerebral cortex. Cerebral microcirculatory dysfunction peaked later and had a shorter duration than axonal injury. In addition, the radioactive imaging agent, 99Tcm-4, 9-diaza-2, 3, 10, 10- tetramethyldodecan-2, 11 -dione dioxime, was used to visualize the dynamic changes that occur in tissue with cerebral hypoxia. The results demonstrated that cerebral hypoxia occurs at an early stage in diffuse axonal injury. Cerebral hypoxia was evident 12 hours after injury and declined slightly 24 hours after injury, but was significantly higher than in the control group. The pathological changes that underpin microcirculatory dysfunction did not occur at the same time as axonal injury, but did occur simultaneously with neuronal injury. Cerebral hypoxia plays a key role in promoting the secondary brain injury that occurs after diffuse axonal injury.展开更多
This paper gives a detailed description of a radiological accident of ^(192)Ir source occurring on May 7,2014 in Nanjing,China(the 5⋅7 accident),encompassing a combination of accident overview,emergency response,inves...This paper gives a detailed description of a radiological accident of ^(192)Ir source occurring on May 7,2014 in Nanjing,China(the 5⋅7 accident),encompassing a combination of accident overview,emergency response,investigation process and results,dose estimation,medical treatment,experience and lessons learnt.The investigation showed that the accident was mainly caused by insufficient attention to the radiation safety,non-compliance with licensing conditions and employment of untrained temporary radiographer without equipped with alarm dosimeters.Additionally,no area radiation survey meter was used to verify whether the source would have retracted to radiography camera after every exposure.It therefore is the important means to strengthen the management of radioactive source safety and put the strict management measures in place,implement the requirements for personnel qualification management,strengthen regulatory inspection and actively poster safety culture,which are necessary to avoid accidents.This paper aims to provide experience and reference for the emergency response and countermeasure of radiological accidents involving industrial radioactive sources.展开更多
基金the National Natural Science Foundationof China, No. 30471774the Program for New Century Excellent Talents in University, Ministry of Education,China, No. NCET-05-0831
文摘This study demonstrated that damage to the cerebral microvasculature, the formation of microthrombi and swelling of vascular endothelial cells occur early and peak 12 hours after injury in a rat model of diffuse axonal injury. Moreover, these pathological changes were most evident in the cerebral cortex. Cerebral microcirculatory dysfunction peaked later and had a shorter duration than axonal injury. In addition, the radioactive imaging agent, 99Tcm-4, 9-diaza-2, 3, 10, 10- tetramethyldodecan-2, 11 -dione dioxime, was used to visualize the dynamic changes that occur in tissue with cerebral hypoxia. The results demonstrated that cerebral hypoxia occurs at an early stage in diffuse axonal injury. Cerebral hypoxia was evident 12 hours after injury and declined slightly 24 hours after injury, but was significantly higher than in the control group. The pathological changes that underpin microcirculatory dysfunction did not occur at the same time as axonal injury, but did occur simultaneously with neuronal injury. Cerebral hypoxia plays a key role in promoting the secondary brain injury that occurs after diffuse axonal injury.
文摘This paper gives a detailed description of a radiological accident of ^(192)Ir source occurring on May 7,2014 in Nanjing,China(the 5⋅7 accident),encompassing a combination of accident overview,emergency response,investigation process and results,dose estimation,medical treatment,experience and lessons learnt.The investigation showed that the accident was mainly caused by insufficient attention to the radiation safety,non-compliance with licensing conditions and employment of untrained temporary radiographer without equipped with alarm dosimeters.Additionally,no area radiation survey meter was used to verify whether the source would have retracted to radiography camera after every exposure.It therefore is the important means to strengthen the management of radioactive source safety and put the strict management measures in place,implement the requirements for personnel qualification management,strengthen regulatory inspection and actively poster safety culture,which are necessary to avoid accidents.This paper aims to provide experience and reference for the emergency response and countermeasure of radiological accidents involving industrial radioactive sources.
文摘目的探究直肠正常组织放射性损伤相关基因并讨论其潜在的作用机制。方法利用基因表达数据库(gene expression omnibus,GEO)的GSE15781中直肠癌旁正常组织样本表达谱芯片组,通过limma包比较正常直肠组织在放疗前后的差异基因,接着对差异基因进行功能富集分析和构建蛋白相互作用网络发现放射性损伤相关的作用机制。结果筛选出正常直肠组织在放疗前后的122个差异基因,其中上调基因86个,下调基因36个。基因本体(gene ontology,GO)富集分析显示差异基因参与改变直肠组织对类固醇激素、糖皮质激素、皮质类固醇反应,多种免疫细胞(单核细胞、髓样细胞、白细胞)趋化和迁移等生物学行为变化;影响DNA结合转录激活因子活性、氧化还原酶活性和受体配体活性等分子功能。京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)通路富集分析显示差异基因介导TNF信号通路等,与直肠放射性损伤存在一定相关性。蛋白相互作用网络则提示IL6、FOS、JUN、CCL2、PTGS2等基因在直肠放射性损失中发挥关键作用。结论本研究发现直肠癌旁正常组织放疗后IL6、FOS、JUN、CCL2等基因失调,从而改变直肠黏膜炎症及免疫细胞浸润并介导TNF信号通路,从而在直肠放射性损伤中发挥重要作用。
