In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World Health Organization(WHO) on 12 January 2020. For it is a n...In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.展开更多
背景:全身复发仍然是局部晚期直肠癌患者需要面临的难题。该研究是采用短程放疗后行化疗和延迟手术对比术前诱导治疗后直接手术疗效的临床试验(the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation,...背景:全身复发仍然是局部晚期直肠癌患者需要面临的难题。该研究是采用短程放疗后行化疗和延迟手术对比术前诱导治疗后直接手术疗效的临床试验(the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation,RAPIDO),旨在不影响局部控制效果的前提下减少远处转移。方法:在这项多中心、随机、开放的Ⅲ期试验中,参与者来自于荷兰、瑞典、西班牙、斯洛文尼亚、丹麦、挪威和美国的共54个医学中心。纳入患者年龄在18岁及以上,ECOG评分为0~1分,且为经活检确诊局部晚期原发直肠腺癌的初诊患者,盆腔MRI评估为高危(至少符合一项标准:cT4a或cT4b,壁外血管侵犯,cN2,直肠系膜筋膜受累,或侧方淋巴结增大)。患者具备化疗适应证,并可在随机分组前5周内完成分期评估。展开更多
Considerable research is now focusing on abrupt Holocene changes at millennial- and centennial-scales all over the world. This study shows that the changes in theHolocene summer monsoon can be divided into two main pe...Considerable research is now focusing on abrupt Holocene changes at millennial- and centennial-scales all over the world. This study shows that the changes in theHolocene summer monsoon can be divided into two main periods, based on climatic proxy records of lake sediments from the Sanjiaocheng section located at the NW boundary of the summer monsoon, Gansu Province. The early and middle Holocene was humid with stronger summer monsoon, while the late Holocene is dry with weak summer monsoon. Detailed results also show a series of millennial- and centennial-scale changes in the intensity of the summer monsoon, with a periodicity of 1600 years during the whole Holocene, and with a periodicity of 800 years during the early Holocene. Ten dry events during the Holocene are associated with the weakening of the summer monsoon. These rapid climatic changes may be representative of a global climatic change pattern during the Holocene.展开更多
Most of the important agronomic traits in crop plants, such as yield, quality and stress response, are quantitative and jointly controlled by many genomic loci or major genes. Improving these complex traits depends on...Most of the important agronomic traits in crop plants, such as yield, quality and stress response, are quantitative and jointly controlled by many genomic loci or major genes. Improving these complex traits depends on the combination of beneficial alleles at the quantitative trait loci （QTLs）. However, the conventional cross breeding method is extremely time-consuming and laborious for pyramiding multiple QTLs. In certain cases, this approach might be technically difficult because of close linkage between genes separately responsible for desirable and undesirable traits.展开更多
INTRODUCTION Sleep disturbance is one of the most common nonmotor symptoms in Parkinson's disease (PD).Sleep disturbance affects 40-98% of PD patients in the world. In China, the prevalence of PD patients with sle...INTRODUCTION Sleep disturbance is one of the most common nonmotor symptoms in Parkinson's disease (PD).Sleep disturbance affects 40-98% of PD patients in the world. In China, the prevalence of PD patients with sleep disturbance ranges from 47.66% to 89.10%. Sleep disturbance usually has adverse impact on the quality of life of PD patients. Apossible pathogenesis of PD with sleep disturbance include thalamocortical pathway degeneration and changes of neurotransmitter systems. The etiology of sleep disturbance is multifactorial,involving degeneration of areas regulating sleep,sleep structure affected by drugs,sleep disturbance induced by drug,and sleep fragmentation by multiple factors.展开更多
Aluminum becomes the most popular nonferrous metal and is widely used in many fields such as packaging,building transportation and electrical materials due to its rich resource, light weight, good mechanical propertie...Aluminum becomes the most popular nonferrous metal and is widely used in many fields such as packaging,building transportation and electrical materials due to its rich resource, light weight, good mechanical properties, suitable corrosion resistance and excellent electrical conductivity. Grain refinement, which is obtained by changing the size of grain structure by different techniques, is a preferred method to improve simultaneously the strength and plasticity of metallic materials. Therefore, grain refining of aluminum is regarded as a key technique in aluminum processing industry.Up to now, there have been a number of techniques for aluminum grain refining. All the techniques can be classified as four categories as follows： grain refining by vibration and stirring during solidification, rapid solidification, the addition of grain refiner and severe plastic deformation. Each of them has its own merits and demerits as well as applicable conditions, and there are still some arguments in the understanding of the mechanisms of these techniques. In this article, the research progresses and challenges encountered in the present techniques and the future research issues and directions are summarized.展开更多
The China Spallation Neutron Source (CSNS) is an accelerator-based facility. The accelerator of CSNS consists of a low energy linac, a Rapid Cycling Synchrotron (RCS) and two beam transport lines. The overall physics ...The China Spallation Neutron Source (CSNS) is an accelerator-based facility. The accelerator of CSNS consists of a low energy linac, a Rapid Cycling Synchrotron (RCS) and two beam transport lines. The overall physics design of CSNS accelerator is described, including the design principle, the choice of the main parameters and design of each part of accelerators. The key problems of the physics design, such as beam loss and control, are also discussed. The interface between the different parts of accelerator, as well as between accelerator and target, are introduced.展开更多
A growing number of three-dimensional(3D)-print- ing processes have been applied to tissue engineering. This paper presents a state-of-the-art study of 3D-printing technologies for tissue-engineering applications, wit...A growing number of three-dimensional(3D)-print- ing processes have been applied to tissue engineering. This paper presents a state-of-the-art study of 3D-printing technologies for tissue-engineering applications, with particular focus on the development of a computer-aided scaffold design system; the direct 3D printing of functionally graded scaffolds; the modeling of selective laser sintering(SLS) and fused deposition modeling(FDM) processes; the indirect additive manufacturing of scaffolds, with both micro and macro features; the development of a bioreactor; and 3D/4D bioprinting. Technological limitations will be discussed so as to highlight the possibility of future improvements for new 3D-printing methodologies for tissue engineering.展开更多
On the basis of Landsat TM data of the Yangtze River Delta （YRD） Economic Zone in 1991, 2001 and 2008, this article, taking 90 counties in this region as study units, built spatial data transformation models, ecosys...On the basis of Landsat TM data of the Yangtze River Delta （YRD） Economic Zone in 1991, 2001 and 2008, this article, taking 90 counties in this region as study units, built spatial data transformation models, ecosystem service value （ESV） and coordination degree of eco-economic system （CDES） models. With the aid of ArcGIS9.3, mass grid and vector data has been processed for spatial analyses. ESV and CDES indexes have demonstrated the relationship between economic development and eco-environment system and its evolu- tion characteristics in the researched areas. Furthermore, the indexes have also been used for functional zoning and pattern recognition. Some results can be shown as follows. Firstly, since 1991, land use in the YRD has greatly changed： urban land area has increased primar- ily from original paddy land, dry land, grassland, garden plot and other land. Secondly, the ESV model has proved the deterioration trend of the YRD ecological system from 1991 to 2001 and slower degradation trend during 2001-2008. Also, it is illustrated that land-use conversion from water area and paddy field to urban area and dry land could cause great damage to ecosystem stabilization. Thirdly, GDP in the central and southern parts of the YRD is higher than that in the northern part since 1991. GDP growth rate in the central part is higher than that in the northern part during 1991-2001. This growth rate in the central part is also higher than that in the southern and northern parts of the YRD from 2001 to 2008. Fourthly, the YRD could be categorized into 12 types of subregions in terms of CDES index. According to its spatial characteristic of CDES index value in the study area, eco-economic conflict area with low CDES value which is located in the central part is surrounded by eco-coordinated areas with high CDES values. This illustrates a core-periphery spatial structure exists in the YRD. During 1991-2001, the CDES value implied the convergent de- terioration trend of eco-economic system in the study area; whi展开更多
基金supported(in part)by the Entrusted Project of National Center for Medical Service Administration,National Health and Family Planning Commission China(No.[2019]099)the First Level Funding of the Second Medical Leading Talent Project in Hubei Provincethe Special Project for Emergency of the Ministry of Science and Technology(2020YFC0841300)。
文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.
文摘背景:全身复发仍然是局部晚期直肠癌患者需要面临的难题。该研究是采用短程放疗后行化疗和延迟手术对比术前诱导治疗后直接手术疗效的临床试验(the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation,RAPIDO),旨在不影响局部控制效果的前提下减少远处转移。方法:在这项多中心、随机、开放的Ⅲ期试验中,参与者来自于荷兰、瑞典、西班牙、斯洛文尼亚、丹麦、挪威和美国的共54个医学中心。纳入患者年龄在18岁及以上,ECOG评分为0~1分,且为经活检确诊局部晚期原发直肠腺癌的初诊患者,盆腔MRI评估为高危(至少符合一项标准:cT4a或cT4b,壁外血管侵犯,cN2,直肠系膜筋膜受累,或侧方淋巴结增大)。患者具备化疗适应证,并可在随机分组前5周内完成分期评估。
基金This study was supported by the National Natural Science Foundation of China (Grant No. 49731010)the National Key Basic Research Project on Western Chinese Arid Areas (Grant No. G1999043501).
文摘Considerable research is now focusing on abrupt Holocene changes at millennial- and centennial-scales all over the world. This study shows that the changes in theHolocene summer monsoon can be divided into two main periods, based on climatic proxy records of lake sediments from the Sanjiaocheng section located at the NW boundary of the summer monsoon, Gansu Province. The early and middle Holocene was humid with stronger summer monsoon, while the late Holocene is dry with weak summer monsoon. Detailed results also show a series of millennial- and centennial-scale changes in the intensity of the summer monsoon, with a periodicity of 1600 years during the whole Holocene, and with a periodicity of 800 years during the early Holocene. Ten dry events during the Holocene are associated with the weakening of the summer monsoon. These rapid climatic changes may be representative of a global climatic change pattern during the Holocene.
基金supported by Genetically Modified Breeding Major Projects(No.2016ZX08010-002-008)the National Natural Science Foundation of China(Nos.31501239 and 31401454)
文摘Most of the important agronomic traits in crop plants, such as yield, quality and stress response, are quantitative and jointly controlled by many genomic loci or major genes. Improving these complex traits depends on the combination of beneficial alleles at the quantitative trait loci （QTLs）. However, the conventional cross breeding method is extremely time-consuming and laborious for pyramiding multiple QTLs. In certain cases, this approach might be technically difficult because of close linkage between genes separately responsible for desirable and undesirable traits.
文摘INTRODUCTION Sleep disturbance is one of the most common nonmotor symptoms in Parkinson's disease (PD).Sleep disturbance affects 40-98% of PD patients in the world. In China, the prevalence of PD patients with sleep disturbance ranges from 47.66% to 89.10%. Sleep disturbance usually has adverse impact on the quality of life of PD patients. Apossible pathogenesis of PD with sleep disturbance include thalamocortical pathway degeneration and changes of neurotransmitter systems. The etiology of sleep disturbance is multifactorial,involving degeneration of areas regulating sleep,sleep structure affected by drugs,sleep disturbance induced by drug,and sleep fragmentation by multiple factors.
基金supports of the National Natural Science Foundation of China under Grant Nos.51474063,51674077 and 51504065
文摘Aluminum becomes the most popular nonferrous metal and is widely used in many fields such as packaging,building transportation and electrical materials due to its rich resource, light weight, good mechanical properties, suitable corrosion resistance and excellent electrical conductivity. Grain refinement, which is obtained by changing the size of grain structure by different techniques, is a preferred method to improve simultaneously the strength and plasticity of metallic materials. Therefore, grain refining of aluminum is regarded as a key technique in aluminum processing industry.Up to now, there have been a number of techniques for aluminum grain refining. All the techniques can be classified as four categories as follows： grain refining by vibration and stirring during solidification, rapid solidification, the addition of grain refiner and severe plastic deformation. Each of them has its own merits and demerits as well as applicable conditions, and there are still some arguments in the understanding of the mechanisms of these techniques. In this article, the research progresses and challenges encountered in the present techniques and the future research issues and directions are summarized.
文摘The China Spallation Neutron Source (CSNS) is an accelerator-based facility. The accelerator of CSNS consists of a low energy linac, a Rapid Cycling Synchrotron (RCS) and two beam transport lines. The overall physics design of CSNS accelerator is described, including the design principle, the choice of the main parameters and design of each part of accelerators. The key problems of the physics design, such as beam loss and control, are also discussed. The interface between the different parts of accelerator, as well as between accelerator and target, are introduced.
基金Singapore National Research Foundation (NRF) for funding the Singapore Centre for 3D Printing (SC3DP)
文摘A growing number of three-dimensional(3D)-print- ing processes have been applied to tissue engineering. This paper presents a state-of-the-art study of 3D-printing technologies for tissue-engineering applications, with particular focus on the development of a computer-aided scaffold design system; the direct 3D printing of functionally graded scaffolds; the modeling of selective laser sintering(SLS) and fused deposition modeling(FDM) processes; the indirect additive manufacturing of scaffolds, with both micro and macro features; the development of a bioreactor; and 3D/4D bioprinting. Technological limitations will be discussed so as to highlight the possibility of future improvements for new 3D-printing methodologies for tissue engineering.
基金National Youth Science Foundation, No.40971101 The Major Project of Science and Technology Research for the 1 lth Five-Year Plan of China, No.2006BAJ05A06
文摘On the basis of Landsat TM data of the Yangtze River Delta （YRD） Economic Zone in 1991, 2001 and 2008, this article, taking 90 counties in this region as study units, built spatial data transformation models, ecosystem service value （ESV） and coordination degree of eco-economic system （CDES） models. With the aid of ArcGIS9.3, mass grid and vector data has been processed for spatial analyses. ESV and CDES indexes have demonstrated the relationship between economic development and eco-environment system and its evolu- tion characteristics in the researched areas. Furthermore, the indexes have also been used for functional zoning and pattern recognition. Some results can be shown as follows. Firstly, since 1991, land use in the YRD has greatly changed： urban land area has increased primar- ily from original paddy land, dry land, grassland, garden plot and other land. Secondly, the ESV model has proved the deterioration trend of the YRD ecological system from 1991 to 2001 and slower degradation trend during 2001-2008. Also, it is illustrated that land-use conversion from water area and paddy field to urban area and dry land could cause great damage to ecosystem stabilization. Thirdly, GDP in the central and southern parts of the YRD is higher than that in the northern part since 1991. GDP growth rate in the central part is higher than that in the northern part during 1991-2001. This growth rate in the central part is also higher than that in the southern and northern parts of the YRD from 2001 to 2008. Fourthly, the YRD could be categorized into 12 types of subregions in terms of CDES index. According to its spatial characteristic of CDES index value in the study area, eco-economic conflict area with low CDES value which is located in the central part is surrounded by eco-coordinated areas with high CDES values. This illustrates a core-periphery spatial structure exists in the YRD. During 1991-2001, the CDES value implied the convergent de- terioration trend of eco-economic system in the study area; whi
