目的:探讨通窍活血汤联合针刺治疗卒中后认知障碍(post-stroke cognitive impairment,PSCI)的临床疗效及其对患者神经递质和神经功能的影响。方法:选取2017年1月至2019年3月本院收治的122例PSCI患者,运用简单随机数字表法将其随机分成...目的:探讨通窍活血汤联合针刺治疗卒中后认知障碍(post-stroke cognitive impairment,PSCI)的临床疗效及其对患者神经递质和神经功能的影响。方法:选取2017年1月至2019年3月本院收治的122例PSCI患者,运用简单随机数字表法将其随机分成观察组与对照组,每组61例。两组患者均给予口服盐酸多奈哌齐片,对照组辅以针灸治疗,观察组予以通窍活血汤联合针刺治疗,所有受试者均连续治疗4周。比较两组临床疗效;治疗前后,运用简易精神状态检查(mini-mental state examination,MMSE)测试两组患者总体认知功能状况,分别使用美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS),Barthel指数(barthel index,BI)评估神经功能缺损程度和日常生活能力变化,采用酶联免疫吸附法测定血清神经递质[乙酰胆碱(acetylcholine,ACh),多巴胺(dopamine,DA),去甲肾上腺素(norepinephrine,NE),5-羟色胺(5-hydroxytryptamine,5-HT)]和神经损伤标志物[神经元特异性烯醇化酶(neuron-specific enolase,NSE),视锥蛋白样蛋白-1(visinin like protein-1,VILIP-1),髓鞘碱性蛋白(myelin basic protein,MBP)]水平;并汇总受试者副反应发生情况。结果:观察组总有效率为91.8%(56/61),高于对照组[78.7%(48/61),P<0.05]。与本组治疗前比较,两组治疗后MMSE,BI评分均明显升高(P<0.05),NIHHS评分均明显降低(P<0.05);且治疗后,观察组以上量表评分的改善效果均明显优于对照组同期(P<0.05)。两组治疗后血清ACh,DA,NE及5-HT含量均明显高于本组治疗前(P<0.05);且治疗后,观察组上述神经递质(ACh,DA,NE,5-HT)水平较对照组同期均明显更高(P<0.05)。与本组治疗前比较,两组治疗后血清NSE,VILIP-1,MBP水平均明显下降(P<0.05);治疗后观察组血清NSE,VILIP-1,MBP含量均明显低于对照组同期(P<0.05)。两组都未见严重不良事件。结论:通窍活血汤联合针刺能有效改善PSCI患者的认知功能,其机制可能与通过上调体展开更多
背景我国已进入全面老龄化社会,脑卒中是我国成人致死、致残的首位病因,脑卒中后认知障碍成为脑卒中患者长期残疾和生活质量下降的重要原因。目的通过Meta分析明确中国老年脑卒中患者认知障碍的患病率和影响因素。方法计算机检索中国知...背景我国已进入全面老龄化社会,脑卒中是我国成人致死、致残的首位病因,脑卒中后认知障碍成为脑卒中患者长期残疾和生活质量下降的重要原因。目的通过Meta分析明确中国老年脑卒中患者认知障碍的患病率和影响因素。方法计算机检索中国知网、万方数据知识服务平台、维普网、中国生物医学文献数据库(CBM)、PubMed、Embase、Cochrane Library、Web of Science,收集建库至2023-02-12发表的有关老年脑卒中患者认知障碍的影响因素的队列研究、病例对照研究和横断面研究。由2名研究者独立筛选文献、提取数据后,对纳入研究进行文献质量评估,采用Stata14.0软件对我国老年脑卒中患者认知障碍患病率和影响因素进行Meta分析。结果共纳入46篇文献,认知障碍患者3281例,涉及影响因素27项。Meta分析结果显示:我国老年脑卒中患者认知障碍患病率为42.4%[95%CI(36.6%,48.3%)]。女性[OR=4.167,95%CI(1.937,8.967),P<0.001]、高血压[OR=2.824,95%CI(2.292,3.481),P<0.001]、收缩压[OR=1.572,95%CI(1.444,1.711),P<0.001]、糖尿病[OR=3.344,95%CI(2.611,4.284),P<0.001]、高脂血症[OR=2.228,95%CI(1.091,4.547),P=0.028]、颈动脉斑块[OR=2.544,95%CI(1.076,6.014),P=0.033]、梗死灶位置(额叶、颞叶)[额叶:OR=1.615,95%CI(1.167,2.235),P=0.004;颞叶:OR=1.739,95%CI(1.246,2.427),P=0.001]、多发性脑梗死[OR=2.583,95%CI(2.009,3.321),P<0.001]、脑萎缩[OR=2.943,95%CI(1.938,4.469),P<0.001]、同型半胱氨酸(Hcy)[OR=2.209,95%CI(1.656,2.948),P<0.001]、高同型半胱氨酸血症[OR=3.043,95%CI(2.092,4.426),P<0.001]、超敏C反应蛋白(hs-CRP)[OR=4.331,95%CI(1.756,10.685),P=0.001]、美国国立卫生研究院脑卒中评定量表(NIHSS)评分>10分[OR=1.977,95%CI(1.320,2.961),P=0.001]为我国老年脑卒中患者认知障碍的影响因素。结论我国老年脑卒中患者认知障碍患病率较高(42.4%),且女性、高血压、收缩压、糖尿病、高脂血症、颈动脉斑块、梗死灶位置(�展开更多
BACKGROUND Post-stroke cognitive impairment(PSCI)is not only a common consequence of stroke but also an important factor for adverse prognosis of patients.Biochemical indicators such as blood lipids and blood pressure...BACKGROUND Post-stroke cognitive impairment(PSCI)is not only a common consequence of stroke but also an important factor for adverse prognosis of patients.Biochemical indicators such as blood lipids and blood pressure are affected by many factors,and the ability of evaluating the progress of patients with PSCI is insufficient.Therefore,it is necessary to find sensitive markers for predicting the progress of patients and avoiding PSCI.Recent studies have shown thatβ-amyloid protein 1-42(Aβ1-42)and thyroid hormone levels are closely related to PSCI,which may be the influencing factors of PSCI,but there are few related studies.AIM To investigate the relationship between serum levels of Aβand thyroid hormones in acute stage and PSCI and its predicted value.METHODS A total of 195 patients with acute cerebral infarction confirmed from June 2016 to January 2018 were enrolled in this study.Baseline data and serological indicators were recorded to assess cognitive function of patients.All patients were followed up for 1 year.Their cognitive functions were evaluated within 1 wk,3 mo,6 mo and 1 yr after stroke.At the end of follow-up,the patients were divided into PSCI and non-PSCI according to Montreal cognitive assessment score,and the relationship between biochemical indexes and the progression of PSCI was explored.RESULTS Compared with patients with non-PSCI,the levels of Aβ1-42,triiodothyronine(T3)and free thyroxin were lower in the patients with PSCI.Repeated measures analysis of variance showed that the overall content of Aβ1-42 and T3 in PSCI was also lower than that of the non-PSCI patients.Further analysis revealed that Aβ1-42(r=0.348),T3(r=0.273)and free thyroxin(r=0.214)were positively correlated with disease progression(P<0.05),suggesting that these indicators have the potential to predict disease progression and outcome.Cox regression analysis showed that Aβ1-42 and T3 were important factors of PSCI.Then stratified analysis showed that the lower the Aβ1-42 and T3,the higher risk of PSCI in patients who展开更多
文摘目的:探讨通窍活血汤联合针刺治疗卒中后认知障碍(post-stroke cognitive impairment,PSCI)的临床疗效及其对患者神经递质和神经功能的影响。方法:选取2017年1月至2019年3月本院收治的122例PSCI患者,运用简单随机数字表法将其随机分成观察组与对照组,每组61例。两组患者均给予口服盐酸多奈哌齐片,对照组辅以针灸治疗,观察组予以通窍活血汤联合针刺治疗,所有受试者均连续治疗4周。比较两组临床疗效;治疗前后,运用简易精神状态检查(mini-mental state examination,MMSE)测试两组患者总体认知功能状况,分别使用美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS),Barthel指数(barthel index,BI)评估神经功能缺损程度和日常生活能力变化,采用酶联免疫吸附法测定血清神经递质[乙酰胆碱(acetylcholine,ACh),多巴胺(dopamine,DA),去甲肾上腺素(norepinephrine,NE),5-羟色胺(5-hydroxytryptamine,5-HT)]和神经损伤标志物[神经元特异性烯醇化酶(neuron-specific enolase,NSE),视锥蛋白样蛋白-1(visinin like protein-1,VILIP-1),髓鞘碱性蛋白(myelin basic protein,MBP)]水平;并汇总受试者副反应发生情况。结果:观察组总有效率为91.8%(56/61),高于对照组[78.7%(48/61),P<0.05]。与本组治疗前比较,两组治疗后MMSE,BI评分均明显升高(P<0.05),NIHHS评分均明显降低(P<0.05);且治疗后,观察组以上量表评分的改善效果均明显优于对照组同期(P<0.05)。两组治疗后血清ACh,DA,NE及5-HT含量均明显高于本组治疗前(P<0.05);且治疗后,观察组上述神经递质(ACh,DA,NE,5-HT)水平较对照组同期均明显更高(P<0.05)。与本组治疗前比较,两组治疗后血清NSE,VILIP-1,MBP水平均明显下降(P<0.05);治疗后观察组血清NSE,VILIP-1,MBP含量均明显低于对照组同期(P<0.05)。两组都未见严重不良事件。结论:通窍活血汤联合针刺能有效改善PSCI患者的认知功能,其机制可能与通过上调体
文摘背景我国已进入全面老龄化社会,脑卒中是我国成人致死、致残的首位病因,脑卒中后认知障碍成为脑卒中患者长期残疾和生活质量下降的重要原因。目的通过Meta分析明确中国老年脑卒中患者认知障碍的患病率和影响因素。方法计算机检索中国知网、万方数据知识服务平台、维普网、中国生物医学文献数据库(CBM)、PubMed、Embase、Cochrane Library、Web of Science,收集建库至2023-02-12发表的有关老年脑卒中患者认知障碍的影响因素的队列研究、病例对照研究和横断面研究。由2名研究者独立筛选文献、提取数据后,对纳入研究进行文献质量评估,采用Stata14.0软件对我国老年脑卒中患者认知障碍患病率和影响因素进行Meta分析。结果共纳入46篇文献,认知障碍患者3281例,涉及影响因素27项。Meta分析结果显示:我国老年脑卒中患者认知障碍患病率为42.4%[95%CI(36.6%,48.3%)]。女性[OR=4.167,95%CI(1.937,8.967),P<0.001]、高血压[OR=2.824,95%CI(2.292,3.481),P<0.001]、收缩压[OR=1.572,95%CI(1.444,1.711),P<0.001]、糖尿病[OR=3.344,95%CI(2.611,4.284),P<0.001]、高脂血症[OR=2.228,95%CI(1.091,4.547),P=0.028]、颈动脉斑块[OR=2.544,95%CI(1.076,6.014),P=0.033]、梗死灶位置(额叶、颞叶)[额叶:OR=1.615,95%CI(1.167,2.235),P=0.004;颞叶:OR=1.739,95%CI(1.246,2.427),P=0.001]、多发性脑梗死[OR=2.583,95%CI(2.009,3.321),P<0.001]、脑萎缩[OR=2.943,95%CI(1.938,4.469),P<0.001]、同型半胱氨酸(Hcy)[OR=2.209,95%CI(1.656,2.948),P<0.001]、高同型半胱氨酸血症[OR=3.043,95%CI(2.092,4.426),P<0.001]、超敏C反应蛋白(hs-CRP)[OR=4.331,95%CI(1.756,10.685),P=0.001]、美国国立卫生研究院脑卒中评定量表(NIHSS)评分>10分[OR=1.977,95%CI(1.320,2.961),P=0.001]为我国老年脑卒中患者认知障碍的影响因素。结论我国老年脑卒中患者认知障碍患病率较高(42.4%),且女性、高血压、收缩压、糖尿病、高脂血症、颈动脉斑块、梗死灶位置(�
基金Supported by Science and Technology Support Projects in Biomedicine Field of Shanghai Science and Technology Commission,No.19441907500Naval Medical University Military Medical Innovation,No.2017JS07Science and Technology Action Innovation Program by Science and Technology Commission of Shanghai,No.17411950104
文摘BACKGROUND Post-stroke cognitive impairment(PSCI)is not only a common consequence of stroke but also an important factor for adverse prognosis of patients.Biochemical indicators such as blood lipids and blood pressure are affected by many factors,and the ability of evaluating the progress of patients with PSCI is insufficient.Therefore,it is necessary to find sensitive markers for predicting the progress of patients and avoiding PSCI.Recent studies have shown thatβ-amyloid protein 1-42(Aβ1-42)and thyroid hormone levels are closely related to PSCI,which may be the influencing factors of PSCI,but there are few related studies.AIM To investigate the relationship between serum levels of Aβand thyroid hormones in acute stage and PSCI and its predicted value.METHODS A total of 195 patients with acute cerebral infarction confirmed from June 2016 to January 2018 were enrolled in this study.Baseline data and serological indicators were recorded to assess cognitive function of patients.All patients were followed up for 1 year.Their cognitive functions were evaluated within 1 wk,3 mo,6 mo and 1 yr after stroke.At the end of follow-up,the patients were divided into PSCI and non-PSCI according to Montreal cognitive assessment score,and the relationship between biochemical indexes and the progression of PSCI was explored.RESULTS Compared with patients with non-PSCI,the levels of Aβ1-42,triiodothyronine(T3)and free thyroxin were lower in the patients with PSCI.Repeated measures analysis of variance showed that the overall content of Aβ1-42 and T3 in PSCI was also lower than that of the non-PSCI patients.Further analysis revealed that Aβ1-42(r=0.348),T3(r=0.273)and free thyroxin(r=0.214)were positively correlated with disease progression(P<0.05),suggesting that these indicators have the potential to predict disease progression and outcome.Cox regression analysis showed that Aβ1-42 and T3 were important factors of PSCI.Then stratified analysis showed that the lower the Aβ1-42 and T3,the higher risk of PSCI in patients who
