In this study, we selected 10 susceptible SNPs loci to investigate their contribution to susceptibility to type 2 diabetes in Hart Chinese among Hubei population. We genotyped SNPs rs5219, rs1801282, rs1470579, rs1111...In this study, we selected 10 susceptible SNPs loci to investigate their contribution to susceptibility to type 2 diabetes in Hart Chinese among Hubei population. We genotyped SNPs rs5219, rs1801282, rs1470579, rs1111875, rs1081661, rs7754840, rs4506565, rs13266634, rs4402960, and rs5643981 by using the method of polymerase chain reaction-ligase detection reaction （PCR-LDR）. In a case-control study, we have genotyped the 10 candidate susceptibility SNP loci, and here, we reported that the SNP rs5219 in KCNJII was strongly associated with type 2 diabetes in Han Chinese in Hubei China There were significant differences in the TT genotype frequency （OR=1.6, 95%CI 1.1-2.3, p=0.01） and T allele frequency （OR=l.3, 95%C1 1.1-1.6, p-0.03） of SNP rs5219 between cases and controls. The other nine SNP loci did not show significant association with type 2 diabetes in Han Chinese in Hubei. The result suggests that KCNJ11 gene is a susceptibility gene of type 2 diabetes among this population.展开更多
文摘In this study, we selected 10 susceptible SNPs loci to investigate their contribution to susceptibility to type 2 diabetes in Hart Chinese among Hubei population. We genotyped SNPs rs5219, rs1801282, rs1470579, rs1111875, rs1081661, rs7754840, rs4506565, rs13266634, rs4402960, and rs5643981 by using the method of polymerase chain reaction-ligase detection reaction （PCR-LDR）. In a case-control study, we have genotyped the 10 candidate susceptibility SNP loci, and here, we reported that the SNP rs5219 in KCNJII was strongly associated with type 2 diabetes in Han Chinese in Hubei China There were significant differences in the TT genotype frequency （OR=1.6, 95%CI 1.1-2.3, p=0.01） and T allele frequency （OR=l.3, 95%C1 1.1-1.6, p-0.03） of SNP rs5219 between cases and controls. The other nine SNP loci did not show significant association with type 2 diabetes in Han Chinese in Hubei. The result suggests that KCNJ11 gene is a susceptibility gene of type 2 diabetes among this population.
