A novel hybrid type photosensitive resin for stereolithography in 3D printing was prepared with bisphenol A type epoxy diacrylate （EA-612）, tripropylene glycol diacrylate （TPGDA）,ethoxylated trimethyolpropane tria...A novel hybrid type photosensitive resin for stereolithography in 3D printing was prepared with bisphenol A type epoxy diacrylate （EA-612）, tripropylene glycol diacrylate （TPGDA）,ethoxylated trimethyolpropane triacrylate（EO3TMPTA）, cycloaliphatic diepoxide（ERL-4221）,polycaprolactonepolyol（Polyol-0301）,1-hydroxy-cyclohphenyl ketone（Irgacure184）, and a mixture of triarylsulfonium hexafluoroantimonate salts （Ar3SSbF6）. The novel hybrid type photosensitive resin was the photosensitive resin of an epoxy-acrylate hybrid system, which proceeded free radical polymerization and cationic polymerization in ultraviolet （UV） laser. Cuboid parts and double-cantilever parts were fabricated by using a stereolithography apparatus with the novel hybrid type photosensitive resin as the processing material,and the dimension shrinkage factor and the curl factor were tested. The shrinkage factor was less than 2.00%,and the curl factor was less than 8.00%, which showed that the accuracy of the fabricated parts was high with the photosensitive resin for stereolithography in 3D printing.展开更多
The first Raman spectra of HIV1- HIV2 in human sera and hypericin-induced pho- tosensitive damage of the virus have been obtained. The prominent Raman lines in the spectra are assigned respectively to the carbohydrate...The first Raman spectra of HIV1- HIV2 in human sera and hypericin-induced pho- tosensitive damage of the virus have been obtained. The prominent Raman lines in the spectra are assigned respectively to the carbohydrates of viral glycoprotein, RNA, protein and lipid. The spectra are dominated by Raman scattering of the carbohydrates. The lines of D-Mannose and N-acetylglucosamine in carbohydrates are obvious and there is a β-configuration in the anomeric C1 position in D-Mannose. The viral RNA duplexes bound assumes an A-form geometry. The lines of backbone phosphate group, bases (involving interbase hydrogen bonding) and ribose of the RNA are complete and distinct. The secondary structure of the viral protein maintains α-helix, β-sheet, β-turn and random coil. Its side chains are rich and vary from tryptophan, phenylalanine and “buried” tyrosine; the stable conformation of the S-S bond of gauche-gauche-gauche; the two forms of C-S bonds of gauche and trans ; to sulfhydrl group and ionized and unionized carboxyl groups. The viral lipid bilayer molecules are probably in the liquid ordered phase or the gel phase. It was observed that the hypericin-induced photosensitive damage of HIV1-HIV2 in human sera changed various components of HIV1-HIV2 in different degrees : The orderly A-form viral RNA would become a disordered viral RNA. There were a breakage of interbase hydrogen bonds and disruption of vertical base-base stacking interactions. In addition, the groups of ribos and four bases were damaged obviously. A decrease in ordered structure (α-helix and β-sheet) of viral protein is accompanied by an increase in random coil. The Tyr buried in the three-dimensional structure of protein was damaged, but it was still “buried” and the damage of C-S bond of trans form was stronger. The groups of carbohydrates, including D-Mannos and N-acetyl glucosamine, in viral envelope glycoprotein had also been changed. The hydrophilic C-N bond of choline in viral lipid was damaged, which was the possible binding site to h展开更多
Laser Raman spectroscopy provided the direct evidence for microcosmic photodamage in space structure of DNA molecule. When photosensitive damage was made to space structure of calf thymus DNA by hypocrellins A and B, ...Laser Raman spectroscopy provided the direct evidence for microcosmic photodamage in space structure of DNA molecule. When photosensitive damage was made to space structure of calf thymus DNA by hypocrellins A and B, the Raman characteristic frequencies and the intensities of the bands assigned to various groups of the components of DNA (phosphate backbone deoxyribose and four bases) changed at various degrees. There were not only the strand breakage, but also the breakage of some H bonds and disruption of vertical base base stacking interactions. The photosensitive damage of hypocrellin B on DNA was stronger than that of hypocrellin A on DNA.展开更多
Photosensitive peptide hydrogels(PPHs) which allow photo-modulation on the self-assembly of peptides were broadly developed over the recent decades. The real-time and spatial modulation of hydrogel properties upon non...Photosensitive peptide hydrogels(PPHs) which allow photo-modulation on the self-assembly of peptides were broadly developed over the recent decades. The real-time and spatial modulation of hydrogel properties upon non-contact light illumination, allow the PPHs serving as super "smart" soft materials.Herein, we briefly summarized the PPHs preparing from the integration of diverse photosensitive moieties with peptides through gelation abilities, "smart" manner and applications. Moreover, a novel type of PPHs based on intramolecular biorthogonal photo-click reaction developed by our group has been demonstrated with relative mechanism and applications.展开更多
Raman spectroscopic characteristics of microcosmic and photosensitive damage on space structure of DPPC liposomes sensitized by hypocrellin and its derivatives are obvious. The trans conformation decreased and the gau...Raman spectroscopic characteristics of microcosmic and photosensitive damage on space structure of DPPC liposomes sensitized by hypocrellin and its derivatives are obvious. The trans conformation decreased and the gauche conformation increased. The longitudinal order_parameter in chains and the lateral order_parameter between chains decreased in different degrees. The lateral packing became loose. Photodamage on the liposomes sensitized by 5 Br hypocrellin B was stronger than that by hypocrellins A and B.展开更多
基金Funded by the National Natural Science Foundation of China(No.51563017)the Natural Science Foundation of Jiangxi Province(No.20142BAB206029)
文摘A novel hybrid type photosensitive resin for stereolithography in 3D printing was prepared with bisphenol A type epoxy diacrylate （EA-612）, tripropylene glycol diacrylate （TPGDA）,ethoxylated trimethyolpropane triacrylate（EO3TMPTA）, cycloaliphatic diepoxide（ERL-4221）,polycaprolactonepolyol（Polyol-0301）,1-hydroxy-cyclohphenyl ketone（Irgacure184）, and a mixture of triarylsulfonium hexafluoroantimonate salts （Ar3SSbF6）. The novel hybrid type photosensitive resin was the photosensitive resin of an epoxy-acrylate hybrid system, which proceeded free radical polymerization and cationic polymerization in ultraviolet （UV） laser. Cuboid parts and double-cantilever parts were fabricated by using a stereolithography apparatus with the novel hybrid type photosensitive resin as the processing material,and the dimension shrinkage factor and the curl factor were tested. The shrinkage factor was less than 2.00%,and the curl factor was less than 8.00%, which showed that the accuracy of the fabricated parts was high with the photosensitive resin for stereolithography in 3D printing.
基金This work was supported by the National Natural Science Foundation of China(Grant No.39570189).
文摘The first Raman spectra of HIV1- HIV2 in human sera and hypericin-induced pho- tosensitive damage of the virus have been obtained. The prominent Raman lines in the spectra are assigned respectively to the carbohydrates of viral glycoprotein, RNA, protein and lipid. The spectra are dominated by Raman scattering of the carbohydrates. The lines of D-Mannose and N-acetylglucosamine in carbohydrates are obvious and there is a β-configuration in the anomeric C1 position in D-Mannose. The viral RNA duplexes bound assumes an A-form geometry. The lines of backbone phosphate group, bases (involving interbase hydrogen bonding) and ribose of the RNA are complete and distinct. The secondary structure of the viral protein maintains α-helix, β-sheet, β-turn and random coil. Its side chains are rich and vary from tryptophan, phenylalanine and “buried” tyrosine; the stable conformation of the S-S bond of gauche-gauche-gauche; the two forms of C-S bonds of gauche and trans ; to sulfhydrl group and ionized and unionized carboxyl groups. The viral lipid bilayer molecules are probably in the liquid ordered phase or the gel phase. It was observed that the hypericin-induced photosensitive damage of HIV1-HIV2 in human sera changed various components of HIV1-HIV2 in different degrees : The orderly A-form viral RNA would become a disordered viral RNA. There were a breakage of interbase hydrogen bonds and disruption of vertical base-base stacking interactions. In addition, the groups of ribos and four bases were damaged obviously. A decrease in ordered structure (α-helix and β-sheet) of viral protein is accompanied by an increase in random coil. The Tyr buried in the three-dimensional structure of protein was damaged, but it was still “buried” and the damage of C-S bond of trans form was stronger. The groups of carbohydrates, including D-Mannos and N-acetyl glucosamine, in viral envelope glycoprotein had also been changed. The hydrophilic C-N bond of choline in viral lipid was damaged, which was the possible binding site to h
文摘Laser Raman spectroscopy provided the direct evidence for microcosmic photodamage in space structure of DNA molecule. When photosensitive damage was made to space structure of calf thymus DNA by hypocrellins A and B, the Raman characteristic frequencies and the intensities of the bands assigned to various groups of the components of DNA (phosphate backbone deoxyribose and four bases) changed at various degrees. There were not only the strand breakage, but also the breakage of some H bonds and disruption of vertical base base stacking interactions. The photosensitive damage of hypocrellin B on DNA was stronger than that of hypocrellin A on DNA.
基金the financial support from the National Natural Science Foundation of China(Nos. 21572102, 21672103,21302093)the International Scientific Partnership Program ISPP at King Saud University for funding the research work through ISPP#0101
文摘Photosensitive peptide hydrogels(PPHs) which allow photo-modulation on the self-assembly of peptides were broadly developed over the recent decades. The real-time and spatial modulation of hydrogel properties upon non-contact light illumination, allow the PPHs serving as super "smart" soft materials.Herein, we briefly summarized the PPHs preparing from the integration of diverse photosensitive moieties with peptides through gelation abilities, "smart" manner and applications. Moreover, a novel type of PPHs based on intramolecular biorthogonal photo-click reaction developed by our group has been demonstrated with relative mechanism and applications.
文摘Raman spectroscopic characteristics of microcosmic and photosensitive damage on space structure of DPPC liposomes sensitized by hypocrellin and its derivatives are obvious. The trans conformation decreased and the gauche conformation increased. The longitudinal order_parameter in chains and the lateral order_parameter between chains decreased in different degrees. The lateral packing became loose. Photodamage on the liposomes sensitized by 5 Br hypocrellin B was stronger than that by hypocrellins A and B.
