A nickel-catalysed reduction of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine (TCT) in ecofriendly 2-methyltetrahydrofuran (2-MeTHF) is described. The phenol-TCT derivatives were readily prepared usin...A nickel-catalysed reduction of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine (TCT) in ecofriendly 2-methyltetrahydrofuran (2-MeTHF) is described. The phenol-TCT derivatives were readily prepared using grinding method in short time without further purification. This catalytic system allowed the facile C-O cleavage of phenol-TCT derivatives under mild reaction conditions with high efficiency and good functional group tolerance. Gram-scale reaction was also achieved. Particularly, sequential functionalization of phenol-TCT derivatives followed by C-O bond reduction could also be realized,affording the high value-added products in moderate to good yields.展开更多
It has been reported that 1,4-diazabicyclo[2,2,2] octane(DABCO) can form complexed crystals with lithium alkals. Our experimental results show that DABCO can also form cocrystals with phenol derivatives such as phenol...It has been reported that 1,4-diazabicyclo[2,2,2] octane(DABCO) can form complexed crystals with lithium alkals. Our experimental results show that DABCO can also form cocrystals with phenol derivatives such as phenol(2), o-cresol(3), m-cresol(4), p-cresol(5), p-chlorophenol(6), and p-nitrophenol(7). The separa-展开更多
基金financial support from the National Natural Science Foundation of China(Nos. 21302014 and 21676030)the Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology (No. BM2012110)+2 种基金the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutionsthe Advanced Catalysis and Green Manufacturing Collaborative Innovation Center of Changzhou UniversityTopnotch Academic Programs Project of Jiangsu Higher Education Institutions (No. PPZY2015B145)
文摘A nickel-catalysed reduction of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine (TCT) in ecofriendly 2-methyltetrahydrofuran (2-MeTHF) is described. The phenol-TCT derivatives were readily prepared using grinding method in short time without further purification. This catalytic system allowed the facile C-O cleavage of phenol-TCT derivatives under mild reaction conditions with high efficiency and good functional group tolerance. Gram-scale reaction was also achieved. Particularly, sequential functionalization of phenol-TCT derivatives followed by C-O bond reduction could also be realized,affording the high value-added products in moderate to good yields.
基金Supported by the Excellent Young Teachers' Foundation of the State Education Commission of China
文摘It has been reported that 1,4-diazabicyclo[2,2,2] octane(DABCO) can form complexed crystals with lithium alkals. Our experimental results show that DABCO can also form cocrystals with phenol derivatives such as phenol(2), o-cresol(3), m-cresol(4), p-cresol(5), p-chlorophenol(6), and p-nitrophenol(7). The separa-
